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It is asure remedy for bleeding at the nose, or by wound, stops the menses, fluxes, ulcers in the reins and bladder, coughs, ulcers in the lungs, difficulty of breathing caulis, brassica hortensis, silvestris colewort, or cabbages, gardenand wild they are drying and binding, help dimness of the sight. Helpthe spleen, preserve from drunkenness, and help the evil effects of it:provoke the menses centaurium, majus, minus centaury the greater and less they say thegreater will do wonders in curing wounds. See the root the less is apresent remedy for the yellow jaundice, opens stoppings of the liver, gall, and spleen. Purges choler, helps gout, clears the sight, purgeththe stomach, helps the dropsy and green sickness it is only the topsand flowers which are useful, of which you may take a dram inwardly inpowder, or half a handful boiled in posset-drink at a time centinodium, &c knotgrass. Cold in the second degree, helps spittingand other evacuations of blood, stops the menses and all other fluxesof blood, vomiting of blood, gonorrhæa, or running of the reins, weakness of the back and joints, inflammations of the privities, andsuch as make water by drops, and it is an excellent remedy for hogsthat will not eat their meat your only way is to boil it, it is inits prime about the latter end of july, or beginning of august:at which time being gathered it may be kept dry all the year brassavolus, camerarius caryfolium vulgare et myrrhis common and great chervil.

And shall forfeit$100 for each violation, to be recovered in a civil action in the nameof and for the benefit of the charity hospital at new orleans, and inaddition shall be subject to criminal prosecution 6 exceptions - the act is not applicable to practitioners of medicine orsurgery residing and practising in other states, who may be summoned inspecial instances to attend patients in the state of louisiana by anyregistered physician 7 penalty - whoever shall practise or offer to practise medicine orsurgery, for pay, without complying with the foregoing act, is guiltyof a misdemeanor, punishable by a fine of not less than $50 orimprisonment for not more than three months, or both, at the discretionof the court act 1886, no 55, s 1 no criminal prosecution shall bar the imposition of a fine by civilprocess, nor shall the imposition of such fine bar criminal prosecution2 exceptions - this act is not applicable to practitioners of medicine orsurgery residing and practising in other states, who may be summonedin special instances to attend patients in the state by any registeredphysician 3 fees - to board of health, for every diploma certified, 50 cents1 to officer before whom affidavit is made, 50 cents 2, 3 recording same, $1 2 to clerk of court, for copy of original affidavit, 50 cents s 2 to state board of health, for copy of original affidavit, 50 cents3 maine qualification, penalty - no person who has not received a medicaldegree at a public medical institution in the united states, or alicense from the maine medical association, shall recover compensationfor medical or surgical services, unless previous to such service hehad obtained a certificate of good moral character from the municipalofficers of the town where he then resided rev stats , 1883, c 13, s 9 maryland qualification - by the act of 1892, c 296, s 1, 39, it is providedthat every person not now practising medicine and surgery, who shallhereafter begin to practise medicine and surgery in any of itsdewritingments, shall possess the qualifications required by the act there are two boards of examiners, representing the medical andchirurgical faculty of the state and the state homœopathic medicalsociety respectively. Each consists of seven members, appointedrespectively by those societies, physicians actually engaged in thepractice of medicine, and of recognized ability and honor. But nophysician having a pecuniary interest in the trade of pharmacy can beappointed 2 suitable provisions must be made by each examining board to prepare aschedule of written examination upon anatomy, physiology, chemistry, surgery, practice of medicine, materia medica and therapeutics, obstetrics, gynæcology, pathology, medical jurisprudence and hygiene;the same standard of excellence is required from all candidates.

Quiet for one-half hour writing services for college students. 1 5 hours twitching of muscles of whole body, lies on side, ataxia present died night of vii 9 19 one day experiment 8 -- 18 75 c c. Injected vi 25 19. Quiet. Reflexes good three hours essay loss of oil depressed and turns on side six hours died night of vi 25 19 one day postmortem. Lungs congested spleen and liver very dark red right kidney much darker red viscera normal d report of dr d rivasthe following are the results of experiments conducted by me, duringthe past four months, on the germicidal action of chlorlyptus chlorinated oil of eucalyptus, principal constituent c₁₀h₁₇ocl₂ invitro and in vivo, and comparison also with carbolic acid, oil ofeucalyptus and dichloramine in test for irritation and toxicity germicidal action -- based on the results obtained, chlorlyptus whenused in a 5 per cent paraffin oil solution was found to be a mildgermicidal against typhoid b, streptococcus and staphylococcus whenthese organisms were suspended in ordinary bouillon culture or sterilesalt solutions the germicidal action was found stronger when these micro-organismswere suspended in a sterile oily or lipoid substance, such as oliveoil the results of these experiments were not constant, owing probablyto the imperfect suspension of the bacteria thus, while in essay of theexperiments chlorlyptus in 1 per cent oil solution destroyed thesemicro-organisms, in other paper the same strength solution failed togive same result in same time the increased germicidal action of chlorlyptus on bacterial suspensionsin olive oil may be accounted for by the fact that chlorlyptus issoluble in olive oil and not an admixture, as in the case of paraffinoil chlorlyptus is not a coagulant, as are germicides of the phenol orhypochlorite types, and the germicidal action is therefore not strictlycomparable the germicidal action of chlorlyptus oil solution, on pathogenicbacteria, on streptococcus and staphylococcus, suspended in pus, wasfound to be stronger than when these micro-organisms were suspendedin ordinary bouillon culture or sterile salt solution in one of theexperiments, similar results were obtained when these micro-organismswere suspended in olive oil, chlorlyptus showing marked germicidalaction irritation and toxicity -- the irritating action was found to berelatively mild in tests on laboratory animals thus, from 0 5 to1 c c of chlorlyptus in paraffin oil 5 per cent solution, injectedinto peritoneal or pleural cavities of guinea-pigs weighing 400 gm wasfound to be without any appreciable disturbance in the health of theanimal, and in essay paper the injection of as much as 2 c c did notkill the animal therapeutic action -- guinea-pigs were inoculated with purulentmaterial containing streptococcus, staphylococcus and b coli inperitoneal and pleural cavities respectively, and after six hours1 c c of chlorlyptus 5 per cent in paraffin oil solution wasinjected other infected animals were similarly treated twenty-fourhours after inoculation, and another series forty-eight hours afterinoculation in essay of these paper the animals died from shock butin a clearly defined series in which the injection of 1 c c of thechlorlyptus solution was made in the peritoneum of the guinea-pigstwenty-four hours after the inoculation, the animals lived the controlanimal, inoculated with the purulent material and not treated withchlorlyptus oil solution, died in consideration that the injection of chlorlyptus oil solution sic, referee were made ?.

In theseexperiments the selenium-vanadium was supposed to be present incolloidal form 272 lewin, carl. Berl klin wchnschr , 1913, p 147. Berl klin wchnschr , 1913, p 541 273 werner and szécsi. Ztschr f chemotherap , 1913, orig , i, 358 szécsi. Ibid , ref , 1913, ii, 1060 within a comparatively brief period of time, therefore, it fell to thelot of a number of observers, using strikingly different substances, to produce therapeutic effects amounting in a certain percentage ofpaper even to cure in the experimental tumors of the lower animals the various procedures have little in common both metals andnonmetallic substances have been employed either in colloidal form orin combination with organic radicals in essay instances a diffusiblecarrier is combined with the basic substances. In others not all ofthe preparations appear to possess a high degree of toxicity, althoughadequate data on this very essential feature are almost invariablywithheld wassermann results with eosin-selenium were soon critically examinedby other observers uhlenhuth274 and contamin275 were unable toconfirm his observations, but their negative results are attributedby keysser to the fact that they were not in possession of the properformula for the preparation of the eosin-selenium compounds as usedby wassermann apolant, 276 however, in ehrlich name confirmedwassermann findings 274 uhlenhuth, dold and bindseil. Ref , münchen med wchnschr , 1912, p 1782 275 contamin, detoeuf and thomos. Bull de l’assn franç pourl’étude du cancer, vi, 62 276 apolant, h. Vi tag der freien vereinigung für mikrobiologie , berlin, 1912 ref münchen med wchnschr , 1912, p 659 the most important critique of eosin-selenium has been contributedby the subsequent investigations of one of wassermann originalcollaborators, f keysser 277 keysser publication contains a largenumber of very careful observations on the various forms of eosinsupplied by the german manufacturers, as well as on other matters whichcannot here be considered in detail he finally reached the conclusionthat the eosin furnished by the manufacturing house of sandoz wasthe most effective for his purposes, inasmuch as it combined thelowest grade of toxicity with the highest capacity for discoloringthe tissues the selenium he used in the form of selenio-vanadiumfurnished by clin of paris, which was the identical preparation usedby werner and szécsi in combination with borcholin the maximum doseof this selenio-vanadium is 0 06 c c for each gram of mouse eosin, 0 01 gm , dissolved in 0 5 c c of physiologic salt solution, is mixedwith 0 5 c c of the selenio-vanadium this mixture is then used forintravenous injections the results produced by the injection of thismixture are to all intents and purposes similar to those obtained bywassermann, except that keysser induced cure in a larger proportion ofanimals, namely, from 6 to 8 per cent it is evident from his carefuldescription of his experiments that the treatment is extremely toxic tothe animals the therapeutic dose is considerably greater than one-halfthe toxic dose this accounts for the fact that an extremely largeproportion of the animals perish during the course of the treatment the tumors failed to be influenced unless the dose given fell verylittle short of the fatal amount moreover, in order to accomplish acomplete cure, at least eight to ten injections must be given, and inessay instances not less than fourteen 277 keysser, f. Ztschr f chemotherap , 1914, orig , ii, 188 keysser most important conclusions, however, were obtained byfollowing an altogether different line of procedure it has beenpointed out by carl lewin272 that the therapeutic results obtainedfrom subcutaneous mouse tumors, however encouraging, could not belogically applied to the treatment of human cancers the subcutaneoustransplanted tumors, as is well known, are as a rule limited by adistinct capsule and show no tendency to infiltrative growth in thiswritingicular they present a most striking difference when comparedwith human tumors on the other hand, the metastases of mouse tumorsin the internal organs present an infiltrative mode of growth andthus approximate very much more closely to the human type of tumors keysser, therefore, determined to test the therapeutic effectivenessof his compounds on tumors implanted in various organs he developed atechnic which enabled him to implant tumors in the liver, the spleen, the kidneys and other writings of the mouse by means of injection throughspecial needles, often without the assistance of a cutting operation the tumors so implanted grew rapidly, and within from two tothree weeks reached the size of cherry pits the growth wascharacteristically infiltrative animals with these tumors were thensubmitted to intravenous injection of the therapeutic agents in exactlythe same fashion as the animals carrying subcutaneous tumors theresults, however, were absolutely different whereas the subcutaneoustumors invariably showed a much more intense discoloration than theother tissues of the mouse, this feature was entirely lacking in thecase of the internal tumors softening and liquefaction, which almostinvariably follows on the third or fourth injection in the case ofsubcutaneous tumors, and which is the first symptom of cure, neverpresented itself in the case of the internal tumors their consistencythroughout the treatment was indistinguishable from that of the tumorsof control animals the treatment, in fact, appeared to exercise notthe slightest influence on internal tumors there was neither cessationnor retardation in growth, but the tumors continued their normal rateof destructive increase with the production of metastases, leadingeventually to the death of the animal either during the course of thetreatment or shortly thereafter microscopic changes, such as had beenobserved by hansemann in the case of subcutaneous tumors, were entirelylacking no matter in what organ the tumors were implanted, theseresults remained the same no matter what type of tumor was employed, whether carcinoma, adenocarcinoma or sarcoma, the therapeutic outcomewas regularly and consistently nil these results induced keysser to determine whether or noteosin-selenium could actually be shown to exercise a deleteriouseffect on cancer cells outside the body in order to do this he made asuspension of mouse tumor cells in salt solution and mixed this withthe eosin-selenium-vanadium, using the latter in amounts equivalent tothree times the fatal dose for a mouse after the mixture had stoodfrom one to three hours, it was injected either subcutaneously orintravenously into mice in order to test the vitality of the cells in every instance the injections resulted in the production of tumorswhich could be in no way distinguished from the tumors produced byuntreated cancer cells in other words, the therapeutic preparation hadabsolutely no effect on the tumor cells in the same way keysser carried out experiments along the linesinaugurated by neuberg, using a combination of glycocoll and copper he also tested the combination of borcholin with selenium-vanadiumused by werner and szécsi he was able to confirm the fact that bothof these substances produced an unmistakable therapeutic effect onsubcutaneous tumors on the other hand, they were absolutely withoutinfluence on the internal tumors in this respect, therefore, they wereentirely comparable with the eosin-selenium compound the theoreticalbasis constructed by neuberg, which rests on the assumption that themetallic compounds stimulate autolytic processes in the tumors, wasalso subjected by keysser to destructive criticism finally, keysser showed that none of these therapeutic agents wereeffective even in the case of subcutaneous tumors, unless the latterhad reached at least the size of cherry pits if a therapeuticinjection were made immediately after inoculation of the tumors, noeffect was observed the tumors grew exactly as in the control animals, and the injected animals died in about the same period of time as they all of these facts, which taken together constitute a very remarkableand convincing piece of scientific investigation, permit of butone conclusion it is quite clearly established that none of thepreparations of which the therapeutic effectiveness has hitherto beenproclaimed exercise any direct influence on the life or developmentof the tumor under certain very definite and restricted conditions, however, they do appear to produce certain changes in the tumors, and in a small proportion even cures these results, however, areobtained only in the case of tumors which are subcutaneous in locationand not smaller than a cherry pit in size keysser interpretationof the striking differences between tumors is of interest in thisconnection he believes that the constant palpation and examinationof the subcutaneous tumors, which is prompted by interest in theexperiment, produces circulatory changes with hyperemia and hemorrhage these circulatory changes are responsible for the increased tendencyof the injected substances to lodge in the tumors, thereby possiblyincreasing the tendency to autolysis which the circulatory changes haveinaugurated it is, of course, questionable whether this explanationcan be regarded as final in a series of experiments which i performedthesis years ago, i was able to show that sodium iodid when injectedintravenously accumulates in tumors in larger amounts than in any othertissue of the body in rats a similar observation has been recordedby wells, de witt and corper 278 in the same way i found thatvarious dyes, such as congo red, when injected intravenously, could bedemonstrated in tumors long after the rest of the body had recoveredits normal color. The liver alone vied with the tumors in this respect the dyestuff was invariably sharply localized in the necrotic portionsof the tumor the conclusion seemed obvious that, owing to circulatoryconditions or possibly even to chemical conditions, the dye wasretained longest in the necrotic writings of the tumor this effect wasunquestionably not due to handling, inasmuch as the animals in myexperiments were not palpated from the time of injection until death 278 wells, h g , de witt, and corper. Ztschr f chemotherap , 1914, orig , ii, 110 i have, however, had an even more striking demonstration of the samefact i have given intravenous injections of dyes to patients sufferingwith various forms of internal tumors, as, for example, cancer of thebreast, in the hope of favorably influencing the growths at operation, the picture presented by the tumor is striking in the extreme itpresents areas of various size which are intensely discolored by thedye these areas, both to the naked eye and under the microscope, are the necrotic writings of the tumor the actively growing areas oftumor tissue and all the normal tissues of the organ present theirnormal color all of these observations lead to the conclusion thatthe necrotic areas in tumors either possess a higher affinity forsodium iodid and for the dyes than do the normal tissues, or thatthese substances are more slowly absorbed from the necrotic areasowing to the circulatory deficiency whichever of these explanationsis accepted, it is quite reasonable to believe that necrotic areasmight well undergo liquefaction under the influence of the varioussubstances which have been used for therapeutic injection such aresult is, of course, without direct effect on the growth or vitalityof the living writing of the tumor this fact is quite clearly evidencedby the experimental data, which show that the internal portions of thetumor might undergo liquefaction and yet the tumors were not cured indeed, löhe, who made microscopic examinations of the tumors treatedby caspari and neuberg, states writingicularly, with reference to a tumorwhich had been subjected to treatment, that “the central portion ofthe tumor showed softening, while the external margin was composed ofactively growing cells ” the central portions of implanted tumors are, of course, those which first undergo spontaneous necrosis it still remains to explain the small percentage of cures achieved bywassermann and by keysser it does not appear to me that this problempresents any insuperable difficulties the fact must be emphasizedthat practically 95 per cent of the animals die under the treatment, which sufficiently indicates the toxic effects of the agent used wemust remember that transplanted tumors are under all circumstancesat a certain disadvantage as compared with the normal tissues of thebody after all, they are implanted on a foreign soil their bloodsupply is impoverished and imperfect they have a natural tendency toundergo necrosis, and in thesis paper spontaneous retrogression it isnot strange, therefore, that they should prove in slight degree moresusceptible to toxic effects than are the normal tissues of the body if we remember that the various therapeutic agents introduced in allprobability reach a essaywhat higher degree of concentration in thenecrotic areas of the tumor than in the normal tissues of the body, anassumption which is entirely in accord with the facts as observed inthe case of sodium iodid and of various dyes, we may be quite preparedto believe that this factor is sufficient to induce the destruction ofthe marginal healthy and living cells of the tumor the fact that smallsubcutaneous tumors were found by keysser to be entirely refractoryto the treatment is entirely in accord with this assumption, in viewof the fact that tumors of this size present practically no centralnecrosis the same explanation holds of the observation previouslycited from caspari that the primary spontaneous tumors of animalsdo not yield to the treatment indeed, he himself states that thetreatment is effective only in tumors in which autolysis takes placeduring life the word autolysis, however, in this connection is amisnomer and represents a gratuitous assumption. As an actual fact, one is entitled to say only that such tumors undergo central necrosis, in all probably owing to defective circulatory supply the process isexactly similar to the coagulation necrosis described in the case oftubercles by weigert if autolysis occurs, it is only secondary to thepreceding necrosis this explanation, however, is confronted by the fact that the internaltumors produced by keysser showed no tendency to effect a localizationof the dyes, and correspondingly no tendency to be affected by thetherapeutic agents one might be permitted to inquire whether theseinternal tumors had undergone any necrosis keysser unfortunately makesno mention of this matter it is certainly true that the infiltrativemode of growth of the internal tumors, which is entirely differentfrom that of the subcutaneous implantations, is associated with amuch better blood supply and a lessened tendency to undergo necrosis that such tumors can undergo necrosis, however, is evidenced bycertain illustrations given by carl lewin in his paper on internaltumors but such changes usually occur only in advanced stages tojudge from his plates, keysser worked with relatively small tumors, an assumption which is rendered even more likely by the fact that hisinjections were undertaken in a fairly early stage of their growth inthis connection i may quote certain experiments of my own on internaltumors 279 the implantations made in my experiments were produced byintravenous injections of a tumor suspension into the jugular vein ofrats such injections resulted almost invariably in the production ofa large number of tumors in the lungs, which, as is well shown in thefigures accompanying the original article, differed very markedly insize the smaller of these tumors are composed throughout of activelygrowing cells, while the large tumors present an area of centralnecrosis exactly as do the subcutaneous tumors if such an animal begiven an intravenous injection of a dye such as congo red, it will befound that the larger tumors present an area of central discolorationcorresponding to the area of previous necrosis, while the smallertumors, like normal tissues, are not colored thus, it is clear thatthe internal tumors implanted in animals are subject to the same lawsconcerning the distribution of dyes and, of course, other substances asare the subcutaneous tumors as i have stated previously, an exactlyanalogous observation has been made in a human breast tumor in theabsence of any contradictory evidence, therefore, i think that it isperfectly justifiable to assume that keysser failed to achieve a resultin the internal growths simply owing to the fact that those growthspresented practically no areas of necrosis at the time of his injection 279 j m research, 1913, p 497 another theoretical question which bears closely on the recenttherapeutic investigations in human beings concerns the rôle ofcolloids, as such, in the procedure it is quite clear from what hasalready been said that all experiments with animal tumors have beenlargely influenced by the belief that metals in the colloidal formexercise a peculiar and characteristic influence on the destructionof tumors even when the therapeutic agents have been introducedin crystalline form, as by neuberg and caspari, the authors findthemselves compelled to assume that the metals are reduced to colloidalform within the tumors for the latter assumption there is absolutelyno evidence. It is due simply to the influence of the colloidal theory if one critically examines the data on which this theory is based, oneis forced to the conclusion that it has practically no establishedclaim to validity if we grant that colloidal metals have been shown tostimulate autolysis in the test tube, the same fact must be admitted ofmetals in noncolloidal solution the experiments, however, are very farfrom establishing either of these facts satisfactorily but even werethis the case, it is an unjustifiable inference that living tumor cellswould be influenced in anything like the same manner as are the deadcells observed in test tube experiments as an actual fact, we knowfrom the work of evans and schulemann that only the “scavenger cells”of the body take up foreign colloids, and to this class the tumor cellsdo not belong moreover, the form in which metals are introducedinto the circulation is not necessarily or even probably the form inwhich they act on the tissues colloidal solutions of the metals arecertainly subject to precipitation and other changes on entering theblood this fact i have shown experimentally in a previous study oncolloidal copper 280 in the same way it is probable, as has beenpointed out by wells, that metals when introduced in crystalloid formmay rapidly be altered so that they are carried throughout the body incolloidal form all of these considerations indicate how unjustifiableis the assumption that colloidal metals exercise a peculiar action ongrowing tumors it is hardly surprising that their empiric use hasfailed to measure up to expectations based on so slim a foundation offact 280 weil, richard. The effects of colloidal copper with an analysisof the therapeutic criteria in human cancer, j a m a 61:1034 sept 27 1913 clinical observationclinicians have not been slow in following the lead suggested by thetherapeutic experiments in animals it is perfectly proper that thisshould be the case in dealing with a disease of the character ofcancer, in thesis instances entirely beyond our power to influence, noone can question the advisability of trying any and every agent whichholds out the slightest promise unfortunately, a closer analysis ofthe animal experiments fails to vindicate even that degree of faith when one considers the facts which have been analyzed in the precedingdiscussion, it would appear not only futile but actually dangerous toattempt to benefit cancer sufferers by means of any of the agencieswhich have been employed in animal experimentation nevertheless, thefact remains that a variety of preparations have been used in the humanclinic the various types of preparations may be satisfactorily groupedunder four classes, namely:1 the crystalline salts of selenium 2 selenium in colloidal solution 3 other metals in colloidal solution 4 compounds of metals with organic radicals these substances have been administered by injection or by the mouth in the case of injection, the injections have been made either into thesubcutaneous tissues, intramuscularly, or intravenously, or finally, directly into the tumors before passing to a further considerationof this subject in detail, it may be well to recall the fact that inthe experimental tumors of animals, no matter what preparation hasbeen used, it has been possible to accomplish therapeutic effects onlyby the use of relatively enormous doses of the medicament, of doses, in fact, which were scarcely lower than the lethal dose certainexperimenters have noted that smaller doses actually stimulated thegrowth of the tumors in the second place, it has almost invariablybeen found necessary to administer the treatment intravenously, inasmuch as the other modes of administration failed of therapeuticeffect it is quite apparent that a procedure in human beings in anydegree analogous to that pursued in animals is entirely impossible thedoses used, with one notable exception to be subsequently mentioned, have invariably been relatively small hence it is apparent at theoutset that at least one fundamental condition of success in thetreatment of animal tumors has been necessarily excluded in theclinical application the salt used by wassermann is not stated in his original publication wolff281 speaks of it as a sodium salt, whereas keysser says that itwas a combination with potassium cyanid in only one instance, as faras i am aware, has the sodium salt been used therapeutically in humanbeings delbet282 states that he employed this salt intravenouslyin one case, and that its use was shortly followed by death unquestionably the salts of selenium are very much too toxic to be usedin this way 281 wolff. Die lehre von der krebs krankheit 3:1913 282 delbet, p. Bull de l’assn franç pour l’étude du cancer5:121, 1912.

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Large ecchymosis and infiltration of leftcheek writing services for college students. Extensive contusions on scrotum, with hemorrhagic infiltration, especially around right testicle veins of head engorged with blackfluid blood brain normal essay black fluid blood in right cavities ofheart, left side empty lungs black other organs normal causse andorfila concluded that the man had been suffocated and then hung thewife and son confessed that they had injured the testicle through thepantaloons. He then fainted. They then suffocated him with the woollencap placed over the mouth and nose. The son kneeled on the man belly, the body was then hung up and the head violently twisted 69 passauer. Viert f ger med und öff san , 1876, xxiv , pp 26-49 - woman found hanging in a kneeling position the ligature onthe neck was loose the necroscopy showed the following. Tongue betweenthe teeth. Eyelids swollen and livid. Livid spots on face and left ear;lower lip torn. A number of marks on neck. One red stripe not sharplylimited.