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Subject swallowed a little brandy-and-water one hundred and thirteen minutes, slight muscular action. Cornea sensible one hundred and eighty-six minutes, feet warm, carotid pulsation signs of life now increased till six hours after drop, when pupils began to dilate again twelve to fifteen ounces of blood were taken and pupils again contracted and pulse beat strong and steady. Breathing easy, more regular. Eyes followed movements of persons around the room died nine hours later, fifteen hours after drop the experiments were repeatedly interrupted by the sheriff 830 taylor831 reports a case of recovery woman, age 44. Found hanging from a clothes-line, thrown over a door and fastened to a handle on the other side. Her knees on the floor. White froth around the mouth.

Photographic reproduction reduced of a few of thenewspaper items writing report for payin that appeared in various writings of the country regardingthomas webster edgar alleged serum for diabetes a few days after the appearance of this article in the new yorkmedical journal, newspaper articles appeared regarding a cure fordiabetes perfected by “dr thomas webster edgar, 766 west end avenue, new york city ” according to these reports, edgar said. “i tried the blood of rabbits and found what i wanted in obtaining the blood i first put the rabbit upon a treadmill and keep it there until it reaches a stage of fatigue then i draw the blood, and after heating it to 60 degrees centigrade separate the corpuscles from the serum when the serum has been treated after the method i have discovered, i inject it immediately subcutaneously “i have attained success in 65 per cent of my paper and i have had 100 paper i do not say that the cure is infallible, but i am now certain that it will work in most paper, writingicularly when the patient observes the rules laid down and undergoes faithful treatment ”in april, 1919, a physician in kansas wrote to edgar at the requestof a diabetic patient asking for information about the “serum ” edgarreplied that it would be impossible to send the physician any ofthe serum for administration unless the “patient is willing to payme for the cost of same, which will be approximately the sum of $25 ”he stated further that, in a few months’ time, he hoped to be able tomanufacture the serum in larger quantities which would “more than cutthe expense in half ”in the same month a layman in chicago who read the newspaper storywrote to edgar and asked for details regarding terms and thearrangements that would have to be made to take the “treatment ” edgarreplied that he expected to be in chicago in a few weeks’ time andwould see the man in consultation with his regular physician, thathe would administer the first injection and give instructions to thephysician as to subsequent injections edgar added. “my custom is to have all fees paid in advance and my charge is $200 00 by certified cheque or money-order ”a layman in one of the smaller cities of new york wrote to edgar inmay, 1919, and received a reply from edgar secretary stating thatthe treatment extends “over a period of three months, cost $150 ”he was also told that the serum could be sent to his physician foradministration “for the sum of $25 prepaid by money-order ” the letterclosed with the statement that edgar “has been very successful with theserum ”illustration. Photographic reproduction greatly reduced of smallportion of the publicity that has been given to edgar relative to hisoperation for “sex stimulation” by the transplantation of the glands ofring-tailed monkeys!. A layman in south carolina who wrote to edgar in june, 1919, was toldthat the treatment as administered by edgar “extends over a period oftwo months. Fee $300” and that if he wanted the serum administered byhis own physician the cost would be “$50 prepaid ”in may, 1920, edgar had another article on diabetes, also in the newyork medical journal in this, too, he refers to his serum in thefollowing words. “in conclusion i may state that i have been able to produce essay rather startling results by the use of my serum, which is prepared from the blood of rabbits after they have undergone a series of maneuvres capable of activating the various internal secretory glands to increased action the serum contains the internal secretions in hormone form ”gradually the newspaper publicity on edgar diabetic “serum” dieddown then, in november, 1920, there appeared-- again in the new yorkmedical journal-- an article by edgar on “sterility, sex stimulationand endocrines ” edgar there stated that he wished to place himself“on record as being interested in sex stimulation” and that he wantedto notify the profession that he had another serum which he was using“with success in the treatment of this condition ” thus. “ i feel entitled to state that i have a distinctly beneficial serum for the alleviation of presenile and senile deficiency. And that my product is capable of producing a new lease of life in those whose functions have been reduced to a minimum ”how long edgar has been featuring his “serum” for “sex stimulation”it is difficult to determine, but during the last year the newspapershave carried sporadic reports of alleged remarkable results producedby “dr thomas webster edgar of 766 west end ave , new york, ” throughthe transplantation of the “interstitial gland” taken from “a specialspecies of orangoutang ” a layman who wrote edgar essay months agoregarding this “gland implantation” received a letter from edgarsecretary stating that the treatment “has been most successful inall paper” and assuring him that “the experimental stage had beenpassed, and the operation is advised in all paper presenting symptomsof presenility or age ” a week later the same man received a letterwritten by edgar himself in which he reiterated the claim that allof the operations had been successful edgar added that he was nowtreating all paper “by operation instead of the serum, ” and that“the fee for operation is $500, inclusive of the sanitarium, ” thepatients remaining in the “sanitarium” “for from two to three days ”a month or two later the prospective patient received another lettersigned, “thomas webster edgar, m d , ” assuring him that “the effect ispermanent, and does not wear off no ill effects can possibly result ”commencing, oct 1, 1921, a series of sensational articles appearedregarding one of edgar alleged monkey gland implantations performedon an individual described as “one time lawyer and then a writer ”these articles purport to be written writingly by one of the newspaperstaff, writingly by the man undergoing the “operation” and at leastone by thomas webster edgar the material is played up in the styletypical of yellow journalism in addition to repeated pictures of theindividual who is being operated on, there also are given pictures ofthomas webster edgar and one of his “ring-tailed monkeys ” doubtlessthe “story” has sold thesis newspapers its sensational character, theelement of mystery and above all its sex slant will appeal to thatlarge class of newspaper readers that hunger for stuff of this sort doubtless, too, it has proved a large advertising asset for thomaswebster edgar the statement that appears in the series to the effect that edgar “is amember of the county medical society of new york” is incorrect edgaris not a member the further newspaper claim that edgar is “an authority on glandulartransplantation” should also be accepted with reservations “authorities” are created with ease in the pages of newspapers edgarmay possibly be termed an authority in a newspaper or, shall we say, pickwickian sense -- from the journal a m a , oct 15, 1921 the journal receives a letter denouncing “medical clerks” and “biased sceptres”the journal recently published in this dewritingment essay inquiriesregarding thomas webster edgar, m d , of new york city, relative toessay alleged serums that dr edgar had developed for diabetes and sexstimulation, respectively, and relative also to the newspaper publicitygiven dr edgar in connection with the alleged transplantation ofglands from “ring-tailed monkeys ”we are in receipt of a letter signed, “thomas webster edgar, m d , ” andreading as follows it is given verbatim et literatim. “gentlemen:-- i have read with great interest your editorial regarding the publicity given my work in metabolism, and gland implantation “your pseudo, expose, and distinctly libelous insinuations are unjust, and they lead me to believe that you are going to be called to account at a very early date “my profession is the practice of medicine, and the policy of my practice is not controlled by the editorial dewritingment of the journal i am progressive, and a firm believer that legitiment medicine and surgery can not be practiced if the physician be governed by a set of medical clerks, who disdainfully boast that they control, and govern the healing art through out the breadth of the land, with a sceptre that is biased and steeped in the unadulterated commercialism of a certain medical clique “aside from the fact that i am an associate editor on a medical publication, it is disgraceful, as well as unjust that you have written such an editorial with out first investigating the therapeutic value of my serum, and implantation operation “the psychology of your editorial, only reflects on your editorial dewritingment, and will tend to belittle essay of the greatest surgeons in the country “it may be to your advantage to know, that this very afternoon, i was on the program with the following men “dr lewis gregory cole-- new york “dr charles h mayo-- rochester, minn “dr john b deaver-- philadelphia “dr charles peck-- new york “my paper was entitled-- senility, its etiology and treatment by gland implantation i am sure the above mentioned gentlemen are thoroughly ashamed of your actions in the matter, as well as thoroughly disgusted with the baby like attitude you have displayed you have no sense of fair play, and if it is with in my power to undue the wrong which you have wrought me, i shall endeavor to vindicate myself in the eyes of the clear thinking members of the profession “i sincerely trust you will publish this communication, in order that my brethren shall understand and appreciate that your thrust has not gone unnoticed “it is my hope that the various medical societies through out the country, will call upon me to read a paper on my work, so that i may be able to offer substantial evidence to the fact that you have done me an injustice “very truly yours, twe/ael signed “thomas webster edgar, m d ”dr edgar statement that he had been on the program with drs cole, mayo, deaver and peck was sufficiently startling to prompt furtherinvestigation it was found that the program in question was that ofthe annual meeting of the new york and new england association ofrailway surgeons it was further found that edgar name did appear onessay of the printed programs but not on others it was rather naturallyassumed that the name had been put on the program before the officersof this organization had seen the crude publicity to which the journalrecently called attention it was found, however, that after severalhundred programs had been printed about 150 more were needed and “inthe meantime, dr edgar had come into the limelight” in his ring-tailedmonkey gland transplantation rôle and “was invited to read a paper onthe subject ” while he accepted this invitation the secretary of theorganization tells us that edgar did not read his paper but, when thepaper was called, declined, saying it was time for him to be in hisoffice!.

“in colds, croup and acute writing report for payin bronchitis inlocal congestions. In lung trouble, in acute inflammations of this orany other organ, especially if pain or soreness be present in lumbago, sciatica, or in rheumatic pains of the joints or muscles applied tothe forehead, it induces sleep ”libradol is offered in two forms, “libradol mild” for infants andsupersensitive persons which is said to be “destitute of drug energy”and libradol “regular” which is “highly medicated, ” the “constituents”being “dracontium, sanguinaria, cephaelis, melaleuca, lobelia, laurus, capsicum, tobacco ”according to a circular, “the sanitary plasma libradol” is a“homogeneous, highly medicated, and exceedingly potent compound, inplastic form, ” which “carries the energies of its drug constituentsand the high antiseptic qualities of laurus camphora and melaleuca ”it is stated. “the drug influence of libradol is necessarily differentfrom that of any known single member of the materia medica but yet, no mystery either in medicine or of pharmacy is claimed as a writing ofits composition or process of manufacture it is a thing peculiar toitself, the result of the study of the drugs from which it is derivedand compounded these drugs may be studied at leisure by whoever caresto do so ”the following information bearing on the composition of libradol wasfurnished by lloyd brothers in response to a request from the councilto aid in the consideration of the preparation. “‘compound lobelia powder’ has been, since 1852, official in the american dispensatory, in the first edition of which 1852 its formula is given, as follows. “‘take of lobelia, in powder, twelve ounces. Bloodroot and skunk cabbage, in powder, of each, six ounces. Ipecacuanha, eight ounces. Capsicus, in powder, two ounces mix them ’ “this preparation came increasingly into demand with the eclectic profession, the principal use for which it was first employed as an emetic, being finally displaced by its local application in bronchial pneumonia troubles, when sprinkled on a greased cloth and applied to the chest ” “in 1898, dr finley ellingwood petitioned lloyd brothers to make for him, in plasma form, ready for application, a compound carrying the ingredients of the old ‘compound lobelia powder, ’ strengthened by the addition of melaleuca leucadendron, laurus camphora and nicotiana tabacum experiments not very encouraging in a pharmaceutical sense were made, and it was not until repeated requests had been made that a product was at last satisfactorily prepared and forwarded to dr ellingwood 1900, with no thought other than that of serving him personally in his practice this product he used and commended to his professional friends, and under his commendation it came into professional demand ”an examination of the information submitted by lloyd brothers showedlibradol to be in conflict with the principles and rules that govern inthe acceptance of articles for new and nonofficial remedies as follows:composition rule 1 -- the information which has been receivedgives little idea of the actual composition of the preparation. Forexample, the statement that libradol “carries the energies of its drugconstituents and the high antiseptic qualities of laurus camphoraand melaleuca” gives no indication as to the writing or writings of thelaurus camphora or melaleuca employed if the statement is correct, that libradol “is a homogeneous, highly medicated, and exceedinglypotent compound, ” it is essential that the several potent ingredientsbe stated clearly and not merely hinted at by their qualities otherconflicts with rule 1 might be enumerated, but the foregoing citationsstate the direct conflict. And this has not been removed, although aninquiry was sent to lloyd brothers for a statement of the amount ofeach potent ingredient in a given quantity of libradol indirect advertising rule 4 -- the recommendation for the use oflibradol in the treatment of colds, bronchitis, lumbago, sciatica andrheumatic pains, which accompanies the trade package, is prone tolead the public to depend on it in paper where definite treatment isimperative unwarranted therapeutic claims rule 6 -- libradol is recommended ina great variety of conditions and is especially claimed not only torelieve pain, but to remove the cause of pain this is explained asfollows. “in the study of the physiological action of thesis drugs, itwas found that the constituent remedies in this combination exerciseda most salutary influence, not only upon the sensibility of the nervesinvolved, but upon the capillary circulation within the diseased area, the muscular structures therein included, and, subsequently, upon thecourse of the advancement of the congestive and inflammatory processes, and upon secretion, exudation, adhesion, induration, hypertrophy, suppuration and excretion ”granting, for the sake of argument, that carefully controlledexperimental clinical evidence were available to substantiate thisstatement with reference to a single case of pain, the statementwould be misleading when considered as a general explanation of thepreparation relieving pain by removing the cause of pain when takenin connection with the conditions for which it is recommended and inwhich pain is even a minor symptom still, if pain were relieved inthese paper by removing the cause, the patient would be cured of theconditions which give rise to the pain, and these include. “acutepain in the chest. Acute inflammation in the chest. Persistentlocal pain. ” this might be interpreted as including tuberculosis;pneumonia.

The physician adjusts the dosage to the individual patient and with obvious evidence of the efficiency of the adjustment as we understand it, the employment of alkaline carbonates is writing report for payin not based on purely chemic considerations-- a definite known quantity of acid of the gastric juice is to be neutralized. The whole literature and practice dealing with the alkaline carbonates show them to be accredited with a much wider field of use and repute in gastro-intestinal disorders the pancreatic extract in carminzym is designed to be diffusible in the stomach, the tablet is preferable to be crushed in the mouth before swallowing, and we believe the pancreatic extract to be an effective constituent as administered in carminzym you comment as follows. “ipecac has a well defined though limited field of usefulness when it is used it should be given with due regard to the amount needed by the patient and the frequency of the repetition of the dose ” this in a sense may be said of any of the most useful drugs, but not in the least special degree does it apply to ipecac, which is, on the contrary, of quite characteristic, peculiar range of therapeutic properties, useful in varying combinations and in widely varying proportions and doses according to the purpose for which it is employed ipecac in well known official alkaline, carminative, laxative preparations occurs in the “average dose” in the varying quantities of 1/14, 1/10, 1/8, and 3/16 of a grain the ipecac in combination with the other ingredients in carminzym is designed for a tablet which shall carry a minimal quantity whilst capable of adequate remedial action, thus admitting of increase of dosage or repetition as occasion requires the quantity of ipecac was not taken at random, but chosen after long trial and consideration we believe that carminzym possesses carminative properties in a superior degree and that, furthermore, in consequence of its composition it directly stimulates the gland secretions and thus exerts a beneficial action upon the whole digestive functions carminzym is for use as occasion requires, and this is to be especially noted thus it is not only of direct benefit, but helpful in promoting systematic therapeutic measures and regimen the council takes the ground that complex mixtures of remedial agents are so wrong that there is no longer warrant for their admission into new and nonofficial remedies. And that carminzym is an irrational mixture we hold that certain desirable therapeutic properties may rationally be attributable to carminzym. And that these are manifested in practice during the time since the description was sent and the receipt of the statement of the action of the council, essay ten months, carminzym has proved of constantly increasing service the statement in the letter of fairchild bros and foster “thelong established custom of the use of mixtures of remedial agentsrests on considerations well known and generally accepted” mightwell be paraphrased to read. The one-time prevalent custom of usingill-considered combinations of remedial agents has been thoroughlydiscredited and is generally abandoned by progressive practitioners such arguments as that “laxatives, tonics, carminatives, diuretics arecombined with distinct advantage” have led to the use of irrationalmixtures such as the compound syrup of hypophosphites and the electuaryof theriaca the council is confident that no one who has studied thecauses and treatment of digestive disorders will find occasion toprescribe at one time all the ingredients stated to be contained incarminzym, and certainly not in the fixed proportions present therein the comments in the council report concerning ipecac certainlydoes apply to all active therapeutic agents ipecac was mentioned inthe report because the several constituents of carminzym were underdiscussion and hence it was necessary to point out the futility of thesmall dosage of ipecac in this mixture the announcement that “carminzym has proved of constantly increasingservice” is not convincing the council does not know of a singleclinical study of the action of carminzym under conditions which wouldhave afforded satisfactory evidence of its therapeutic value -- fromthe journal a m a , sept 28, 1918 phillips’ phospho-muriate of quinine comp report of the council on pharmacy and chemistrythe following report on phillips’ phospho-muriate of quinine comp hasbeen adopted by the council and authorized for publication w a puckner, secretary phillips’ phospho-muriate of quinine comp 125 is sold by the charlesh phillips chemical co , new york according to the published formula, each fluidram contains. Phosphoric acid 2 minims potassium phosphate } magnesium phosphate } calcium phosphate } 2-1/4 grains ferric phosphate } quinin muriate equal to nearly 1/2 gr bi-sulph 1/4 grain strychnin 1/120 grain flavoring, glycerin and syrup, q s 125 the evolution of “phillips’ phospho-muriate of quinine comp ”from “phillips’ wheat phosphates” may be interesting every oneknows that therapeutics tends to fashions, and “phillips’ wheatphosphates” appears to have had its inception as the result of theobservation that super-refined white flour contains less phosphatesthan the corresponding amount of wheat it was assumed that suchflour must be deficient in an essential constituent, and the wheatphosphates preparation was apparently designed to fill the want it wasexploited for the relief of numerous conditions that were supposed, without satisfactory evidence, to result from this deficiency wheniron, quinin and strychnin mixtures became the vogue a quarter of acentury ago, it was only natural to ride on the wave of popularityand the already widely advertised “wheat phosphates” was furtherenhanced-- commercially-- by the addition of the iron, quinin andstrychnin, the amount of alkaloid added being practically negligible those who are not familiar with the various phases of the phosphorus, phosphoric acid, lactophosphate, lecithin, nuclein and glycerophosphatepropaganda are referred to a report of the council on pharmacy andchemistry in the journal a m a , sept 30, 1916, p 1033 essay typical claims made for the preparation are. “with marked beneficial action upon the nervous system to be relied on where a deficiency of the phosphates is evident ” “ brace those tired nerves and aid that worn stomach with phillips’ phospho-muriate of quinine ” “the maintenance of a satisfactory blood pressure level free from intervals of depression may be accomplished by the use of phillips’ phospho-muriate of quinine compound in appropriate doses ” “the quantities of quinin and strychnin in this preparation are so well balanced that they relieve the depression and fatigue from mental or physical exertion, without the necessity of recourse to alcoholic stimulation ” “the other ingredients of phillips’ phospho-muriate of quinine-- phosphoric acid, and the phosphates of potash, magnesia, lime, and iron-- are the most rational as well as convenient means of administering these tissue remedies, and of introducing phosphorus-- the vitalizing constituent of the nervous system-- into the organism ”the action of such a mixture as a whole is practically that of the sumof the actions of its constituents the therapeutic action of strychninand quinin are described in every text-book of therapeutics, but itis necessary to distinguish carefully between the various conditionsin which these alkaloids have been used without discrimination, andthose conditions in which they have been proved to be of value while both have been widely used in a great variety of conditions, neither is of proved value in more than a distinctly limited rangeof diseases the manufacturers of phillips’ phospho-muriate ofquinine comp seem to appeal to the less discriminating who use thesealkaloids without any definite conception of exactly what they seekto accomplish with them quinin, although used by the uncritical in ahost of diseases, has a definite field of usefulness in the treatmentof malaria, both prophylactic and curative, but the required dose inthe treatment of malaria is thesis times larger than that recommended inthe phillips’ preparation the claim that the “strychnin and quininin this preparation are so well balanced that they produce a mild, buoyant effect, so advantageous, instead of alcoholic stimulation, torelieve depression and fatigue from mental or physical exertion” isnonsensical, if, indeed, it is not mendacious balderdash calcium and potassium have important functions in the body, but anydeficiency that may arise is usually attributable to an inability ofthe body to utilize that which is supplied, for there is seldom anydeficiency of these salts in the food, and when they are needed theyare best supplied as simple solutions of the salts in appropriate doseswithout all of the other constituents of phillips’ phospho-muriate ofquinine comp phosphoric acid exerts practically the same actions as other mineralacids, hydrochloric being usually preferred for internal administrationin certain forms of indigestion, aside from which they are seldom usedas such in the more recent literature for phillips’ phospho-muriate of quininecomp , we find the attempt to utilize the well known craze aboutphosphorus, which has been through so thesis phases, every one of whichhas had its day and has been discarded the phosphoric acid and phosphates present in phillips’ phospho-muriateof quinine are of no more value in nervous diseases than is simplesodium phosphate which does not require the addition of a host of otheringredients for its action as a matter of fact, the phosphates ofcalcium and potassium present in a dose of phillips’ phospho-muriate ofquinine are probably devoid of appreciable effect in practically allconditions to pretend that one who suffers from physical and nervous exhaustioncan be materially benefited by this mixture is sheer nonsense and isunworthy of a moment consideration by a clinician who is called on totreat such patients iron is useful in anemia, as every one knows iron has practically noother field of usefulness in therapeutics when it is indicated itshould be administered in a simple form, such as the pill of ferrouscarbonate, for example, and not in a “shotgun” mixture that is quite aslikely to do harm as good the claim that a satisfactory level of blood pressure can be maintainedby phillips’ phospho-muriate of quinine is mentioned only to condemnas the limit of impudent therapeutic claims it is an insult to theintelligence of any practitioner to pretend that any known agent orcombination of remedial agents can maintain a uniform blood pressure inany one of innumerable conditions in short, phillips’ phospho-muriate of quinine comp is a complex andirrational mixture exploited by means of unwarranted claims it isa survival of the old days of therapeutic chaos when impossible andfantastic chemical formulas were gravely published and as solemnlyaccepted without question, and also without the slightest understandingon the writing of thesis. When the most eminent of practitioners did nothesitate to give glowing testimonials for lithia waters that containedno more lithium than ordinary river water. When no therapeutic claimwas too preposterous to receive acceptance, no theory too nonsensicalto justify the use of all manner of claptrap mixtures for all manner ofconditions -- from the journal a m a , oct 19, 1918 b iodine and b oleum iodine report of the council on pharmacy and chemistrythe council has authorized publication of the following report on “b iodine” and “b oleum iodine, ” together with the reply submitted by themanufacturer and a discussion thereon by the referee in charge of thepreparations w a puckner, secretary specimens of b iodine and b oleum iodine b iodine chemical companyand an advertising pamphlet were sent to the council by john bohlander, a m , m d , with the declaration.

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The pulse slow and deep. The urine thick and low coloured:dreams of rain, floods, and water, &c these things thus premised, i come to the matter the first the college presents you with, is spiritus et aqua absinthis minus composita or, spirit and water of wormwood, the lesser composition college take of the leaves of dryed wormwood two pounds, annisseeds, half a pound. Steep them in six gallons of small wine twentyfour hours, then distil them in an alembick, adding to every pound ofthe distilled water two ounces of the best sugar let the two first pound you draw out be called spirit of wormwood, those which follow, wormwood water the lesser composition culpeper i like this distinction of the college very well, becausewhat is first stilled out, is far stronger than the rest, and thereforevery fitting to be kept by itself. You may take which you please, according as the temperature of your body, either to heat or cold, andthe season of year requires it hath the same virtues wormwood hath, only fitter to be used by suchwhose bodies are chilled by age, and whose natural heat abates youmay search the herbs for the virtues, it heats the stomach, and helpsdigestion the college after the same manner only omitting the annis seedsis distilled spirit and water of angelica, both herb and root, bawm, mints, sage, &c the flowers of rosemary, clary, clove-gilliflowers, &c the seeds of caraway, &c juniper-berries, orange pills, lemons, citrons, &c cinnamon, nutmegs, &c spiritus et aqua absynthii magis composita or spirit and water of wormwood, the greater composition the college take of common and roman wormwood, of each a pound;sage, mints, bawm, of each two handfuls. The roots of galanga, ginger, calamus, aromaticus, elecampane, of each three drachms. Liquorice, anounce, raisins of the sun stoned, three ounces, annis seeds, and sweetfennel seeds, of each three drachms. Cinnamon, cloves, nutmegs, of eachtwo drachms. Cardamoms, cubebs, of each one drachm.