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Sodium phosphate, a stimulant of liver and pancreas and corrective of acid fermentation in the alimentary canal. Iron, generating in the blood, heat and motion, phosphoric acid, tonic in sexual debility. Alkaloids of calisaya, antimalarial and antipyretic. Extract of wild cherry, tonic, yet calming irritation and diminishing nervous excitement. Ethyl alcohol 12 5%. And aromatics ”although the claim is made that the “formula” of wheeler tissuephosphates has been “suggested by professor dusart, ” such of dusartpapers as were available in this country111 failed to disclose any“formula” that was at all comparable to this product 111 dusart, l. Recherches expérimentales sur le rôle physiologiqueet thérapeutique du phosphate de chaux, paris, 1870. Quel est l’acidedu suc gastrique?. lille, 1874, unbound, 8 pages. Notice sur l’emploi etles proprietés du lacto-phosphate de chaux, clichy, 1868, unbound, 8pages dusart and blache.

Collosol argentum collosol ferrum collosol arsenicum collosol hydrargyrum collosol cuprum collosol manganesealso collosols of iodine and sulphur, and finally collosols of cocainand quinin of all the above, except sulphur, only three small ampuleshave write my summary been submitted this does not admit of any chemical examinationbut a statement of the physical appearance may be of interest collosol arsenicum, 0 2 per cent. Very turbid with large quantitiesof a lemon yellow flocculent precipitate on shaking does not becomehomogeneous and rapidly separates again collosol argentum, 1-2000. The liquid has a slight opalescence thereis considerable deposit of a heavy black precipitate does not becomehomogeneous on shaking and the black substance quickly separates again collosol cuprum, 0 5 per cent. Dark red essaywhat opalescentliquid no precipitate may be colloidal collosol ferrum, 1-2000. Liquid clear large quantities of dark brownflocculent precipitate the precipitate is not distributed evenly whenthe mixture is shaken and settles out quickly on standing collosol hydrargyrum, 5 per cent. Milky liquid large quantities ofwhite deposit mixed with considerable black the deposit mixes fairlywell but the greater writing settles out after standing an hour or two collosol manganese, 2 5-1000. Clear reddish-brown liquid withoutdeposit of any kind is not opalescent or fluorescent collosol iodin, 1-500. Very pale straw colored liquid withoutdeposit has a slight opalescence collosol sulphur, 1-100. Liquid is opalescent there is essay depositof yellow writingicles a four ounce bottle was also submitted the liquidin this bottle is milky with considerable deposit of yellow crystalslike ordinary crystalline sulphur collosol cocain, 1-100. Transparent, colorless liquid with nodeposit chemical examination showed 0 4 per cent of what may havebeen cocain this residue gave alkaloidal tests collosol quinin, 1-100. Slightly opalescent, colorless liquid, withno deposit gives alkaloidal reactions -- from the journal a m a , june 7, 1919 pulvoids calcylates compound report of the council on pharmacy and chemistrythe council has authorized publication of the following report, notso much because the preparation with which it deals is of any greatimportance, but as a protest against the large number of similarirrational complex mixtures which are still offered to physicians w a puckner, secretary pulvoids calcylates compound the drug products co , inc are tabletseach of which is claimed to contain.

The asphalt will then go intosolution it is interesting to note that the suggested formula as wellas others which were also prepared is not as plastic as the paraffinitself 178 this is also true of “ambrine ” on the other hand, themelting point of the paraffin is higher the important point, however, in compounding all paraffin preparations, is to select a proper gradeof paraffin as elaborated below 178 in a personal communication dr sollmann expressed the opinionthat the synthetic preparation is inferior to the paraffin used in theformula, basing the view on the greater plasticity of the paraffin for practical purposes, the paraffin will most probably serve as wellas the mixture, especially when it is held in place by bandages, but ibelieve that the mixture is more adhesive examination of paraffins and paraffin preparationsillustration. Photographic reproduction greatly reduced of a fullpage magazine advertisement of “thermozine, ” the name under which“ambrine” was sold to the public the name “paraffin” generally applies to a colorless and tastelesswaxlike substance that is solid at ordinary temperature it is composedof saturated hydrocarbons, that is, they are unable to take up any morehydrogen, and thereby are quite stable. The hydrocarbons in paraffinhave the general formula of c↓{n}h↓{2n2}, ranging as high as c₂₄h₅₀ toc₂₇h₅₆ paraffin may be found in crude form in coal, from which sourcethe first paraffin candles were made it may be produced from thedistillation of brown coal, as in gerthesis, or from bituminous shale in america, it is obtained chiefly from the distillation of crudepetroleum, being in the residue after the distillation of such productsas naphtha gasoline, kerosene and the lubricating oils the residueis treated by one of a number of processes causing the unpurifiedsolid paraffin to be made available the crude paraffin is eithersold as such, or is refined paraffin or “paraffin waxes”179 aredesignated in the trade by their melting points which in the “americanstandard” is expressed in fahrenheit degrees, and as to their stateof refinement as “crude, ” “semirefined” and “fully refined” paraffin there are certain chemical and physical differences so that two refinedwaxes having the same melting point would not have the same plasticity the higher melting point varieties of paraffin are hard and tough atroom temperature.

the manufacturers ofbell-ans claim that 100, 000 american physicians now prescribe bell-ans, and that 600, 000, 000 of the tablets are sold annually if this iseven approximately true it is a serious reflection on the medicalprofession, for the council examined bell-ans and reported its findingsnearly eight years ago j a m a 53:569 aug 14 1909, and thestatements made in that report are as incontrovertible today as theywere then -- from the journal a m a , nov 24, 1917 article ii anasarcin and anedemin“anasarcin” and “anedemin” are the twin nostrums of cardiacpseudotherapy they are dubbed “twin nostrums” not so much because ofany similarity in their formulas, that being a minor considerationin the average nostrum, but because of the close similarity in theirmethods of exploitation, the therapeutic claims made for them, and thetime and place of their birth it may be remembered that they both claim winchester, tenn , as theirbirthplace, and they appeared on the market at about the same time;furthermore, a comparison of the claims formerly made for both of themindicated that one mind conceived the main idea that lies back of theirexploitation while anasarcin is especially dealt with in this article, much of the discussion applies with equal force to anedemin a lush field for nostrumscardiac disease, with its resultant renal involvement, is frequentlyencountered. And running, as it does, a chronic course, it offers analmost ideal field of exploitation for the typical nostrum vender bya typical nostrum vender we mean one whose knowledge of his productis far below that of his appreciation of a certain element of humancharacter on this element rests the whole secret of the nostrumvender success it is variously termed credulity, gullibility andchildlike simplicity, but it is that which often causes even the mostconscientious clinician to turn aside from the use of the best knownand most dependable drugs at his command, in the face of disappointmentand failure, and employ essay vaunted mixture which, in his sanermoments, he scorns to use anedemin is said to consist of a “scientific combination of three ofthe more recently investigated members of the digitalis series, withsambucus”. That is, of apocynum, strophanthus and squill with elder it is difficult to know just what idea the statement that it is a“scientific combination” of these drugs is intended to convey, forit is unscientific to mix three drugs of this group for use in fixedproportion in a wide range of conditions, if indeed, there is ever anyindication for their use the great disadvantages of strophanthus and apocynum pertain to theextreme uncertainty of their absorption from the gastro-intestinaltract strophanthus is occasionally absorbed promptly, essaytimesso slowly that the therapeutic effects are not induced until anamount equal to several times that which would prove fatal if all ofit were absorbed into the circulation has been administered, and, unfortunately, one cannot control the absorption which may continueuntil a fatal effect is induced this is true to an even greater degreeof apocynum, and it was due to the recognition of this fact thatapocynum was not admitted to the u s pharmacopeia ix, the committeeon dosage having agreed that no safe and effective dose could be given the council previous findingsin 1907 the council on pharmacy and chemistry examined the literatureused in the exploitation of anasarcin and anedemin and published itsreport anasarcin tablets, it was pointed out, were said to containthe active principles of oxydendron arboreum sour wood, sambucuscanadensis elder and urginea scilla squill, and the followingclaims were made for the nostrum. “does what dropsy medicaments have hitherto failed to accomplish ” “superior to digitalis, strophanthus, scoparius, squills, acetate of potash and the hydragogue cathartics all put together ” “the only known relief and permanent cure of dropsies ” “unrivaled heart tonic ” “the most powerful agent known ” “safe in administration ” “non-toxic as ordinarily administered ” “will nauseate essay persons, ” but “the reaction from the temporary depression is prompt ” “in bright disease, both the interstitial and parenchymatous forms of nephritis, acute or chronic, no remedy to equal it in efficacy ” “without increasing the debility of the patient or interfering with nutrition by producing loss of appetite ” “this treatment is to be continued without cessation until all symptoms of dropsy have disappeared ”a comparison of the earlier claims with those now being made seeadvertisement reproduced from the new york medical journalillustrates one of the results of the work of the council today thenostrum exploiter avoids the cruder forms of obvious misstatement, butcontinues to make, by inference, claims that are equally misleading it will be observed in this case that a more cautious pen worded thelater advertisement, but there is still evident the intent to convincethe reader that anasarcin is superior to the official drugs in thetreatment of cardiovascular diseases the facts are that anasarcin isat best a dangerous remedy in the hands of the average clinician inthe treatment of such conditions, and its use is at all times to becondemned no competent investigator has ever investigated the pharmacologyof sour wood oxydendron arboreum, and it appears to have notherapeutic value other than that due to a slight acidulousness elder sambucus canadensis contains a trace of a volatile oil as its mostimportant constituent, according to the british pharmaceutical codex of1911 p 908, but it is difficult to explain why a trace of volatileoil should be considered important elder may be dismissed withoutfurther consideration in connection with anasarcin tablets the pharmacology of squillthis leaves only squill among the constituents of anasarcin forconsideration sollmann manual of pharmacology, 1917, p 409 indiscussing the advantages claimed for squill over other drugs of thedigitalis group, says. “dixon, 1906, points out that any superiorityis outweighed by its disadvantages. Uncertain absorption. Stronggastro-intestinal irritation ” squill was formerly used as anexpectorant and diuretic, the activity having been attributed to twoamorphous glucosids, scillipicrin and scillitoxin, but ewins, 1911, found these to be impure mixtures a later investigator claimed tohave isolated two glucosidal agents from squill, but similar claimshave often been made only to be disproved later, and we know ofno confirmation of the claims regarding the isolation of any pureprinciples from squill having any true typical digitalis action the statement quoted from sollmann is accepted by practically allpharmacologists, and we may say with certainty that squill is decidedlyinferior to digitalis in the treatment of cardiovascular, andcardiorenal diseases, and certainly no active principles of squill wereknown to the scientific world at a time that the remarkable claims werefirst made for anasarcin by an obscure pharmacist of winchester, tenn indeed, if anasarcin were all that it was claimed to be, its discoverywould have made winchester as famous as a certain wisconsin city wassaid to have been made by a popular beverage it has been abundantly demonstrated, and it is now almost universallyaccepted among well informed pharmacologists and clinicians, that alldigitalis principles exert the same kind of action on the heart afterthey enter the circulation in effective doses, though they differto an extraordinary degree in the intensity of their action and intheir undesired sideactions, such as nausea and vomiting when theuse of anasarcin squill is followed by immediate improvement afterdigitalis has failed, it merely shows that the dosage of digitaliswas insufficient or that it was discontinued and the squill mixturewas substituted before the full therapeutic effects of the digitalisdeveloped when the digitalis group is contraindicatedif the administration of a sufficient dose of digitalis is not followedby improvement in the circulation, it shows that the heart is incapableof responding to such treatment and the further use of any of the drugsof this group is distinctly contraindicated this is confirmed by theexperience of nearly every competent observer of digitalis therapy, andnumerous fatalities have resulted from the failure to appreciate thisfact and further administer essay other member of the group, such asstrophanthus or squill it is now well known that the cardiac effects of toxic doses of squill, and other members of the group, resemble closely those of cardiacdisease, and it is often impossible to determine whether the behaviorof the heart in a given case is attributable to insufficient dosage, toexcessive dosage, or to the progress of the cardiac disease itself ifthis occurs when one uses the best known members of the group, it iscertain that it occurs even more frequently when others that are lessunderstood are employed in the light of this knowledge of the dangersattending the incautious use of any member of the digitalis group, and more especially the use of impure principles, such as are commonlyobtained from squill, it is impossible to condemn sufficiently therecommendation that the use of anasarcin should be continued withoutcessation until all symptoms of dropsy have disappeared digitalis bodies are not suited for the treatment of all cardiacdisturbances, and it is, of course, self-evident that a time mustcome in the treatment of chronic cardiac disease when the heart isincapable of responding to any form of treatment with improvement but, unfortunately, it never loses its response to toxic doses, and to pushthe administration of any drug or mixture containing any drug of theentire digitalis group-- and especially those, like squill, in which theside actions are most prominent-- beyond the point of tolerance is tocourt certain disaster the treatment of cardiac dropsywhile it is quite certain that thesis lives have been sacrificed to thefailure to understand this phase of cardiac therapy, it is equallycertain that thesis lives have been sacrificed because of insufficientdosage, and one can steer a safe course between these dangers only byusing the best known preparation available. And in the present stateof our knowledge it is indisputable that digitalis and the tincture ofdigitalis are best suited for the treatment of cardiac disease exceptin those few paper in which intramuscular or intravenous administrationmust be employed temporarily for immediate effect illustrationthe secret of prescribing successfully for the relief of dropsy incardiac disease consists in understanding the effects of digitalison the heart, in administering it until these effects indicate thatthe desired object has been obtained, and stopping, or interrupting, the administration at that point until the effects begin to wear off cumulation, so called, is a positive advantage in such paper itmerely means that the desired therapeutic effects once induced persistfor a time, and that further medication is unnecessary during suchpersistence of action eggleston has recently shown arch int med 16:1 july 1915. Abstr , j a m a 44:459 july 31 1915 thatthe full therapeutic effects of digitalis can be induced in suitablepaper within a few hours even with oral administration we are not aware of a single publication in which a careful, detailedclinical study of anasarcin has been reported the claims made foranasarcin, past and present, indicate either a deliberate purposeto mislead or crass ignorance of the rudiments of pharmacology andtherapeutics the exploiters of the nostrum claim that thousandsof physicians have found anasarcin tablets of unsurpassed remedialvalue in the treatment of disorders of the circulatory system and ofascitic conditions 244 it must be admitted that too thesis physicianshave prescribed anasarcin, otherwise the manufacturers would not havecontinued to spend thousands of dollars in advertising it in medicaljournals during a period of more than ten years 244 former estimates of the number of physicians who prescribedanasarcin appear to have been too high, possibly based on the ratioobtaining in winchester, tenn inquiry at five fairly busy drug storesin a large eastern city showed that in no instance was the pharmacisteven acquainted with the name one pretended to be, and manifested pityfor the inquirer ignorance in supposing that it could be importedduring the war!. he was obviously merely less honest than the others, who frankly admitted they had never heard of it doctor, this article is meant to be a candid discussion with you, whether you use anasarcin or not, because every clinician is vitallyinterested in the customs that obtain in the practice of medicine, andwe wish to put a hypothetic question to you answer it, at least toyourself, in exactly the spirit in which it is put suppose that youprescribe anasarcin for a patient who is critically ill with cardiacdisease he dies are you willing to tell the relatives frankly justwhat you used and the nature of the evidence on which you based yourchoice of this nostrum?. let the supposition be carried further and saythat the case was hopeless, and agree that digitalis and all otherdrugs would have been equally ineffective granting all this, wouldyour explanation satisfy?. would you in all candor dare to offer such anexplanation?. try it as a hypothetic case before you are forced to applyit -- from the journal a m a , dec 8, 1917 article iii pepto-manganit would be interesting, and even instructive, to know how thesiseducated physicians, if any, are now prescribing pepto-mangan gude:interesting as indicating the number who have neglected to availthemselves of the work of the council on pharmacy and chemistry, especially the earlier work.

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“ifthe right eye becomes afflicted with glaucoma, rub it with the righteye of the wolf, and, similarly, the left eye with the left eye of thewolf ”in photophobia fear of light “wear as an amulet an eye whichwas taken from a live crab ” quintus serenus samonicus magnus, “ophthalmology of the ancients, ” page 595 with pains of the eye the patient must, with a copper needle, put outthe eyes of a green lizard caught on a jupiter day, during a moon thatis on the wane, in the month of september the eyes must be worn in agolden capsule, as an amulet around the neck marcellus empiricus magnus, “ophthalmology of the ancients, ” page 602 the above illustrations are surely sufficient to give the reader anidea of the medicine of the magicians at the same time they show thegreat similarity which exists between these ancient magic cures and thesympathetic cures of our people at the present day § 4 ancient medicine and magic - but how is it possible that theancient physicians, and even the most enlightened minds among them, should not only have tolerated such a crass medical superstition as theabove examples have shown us, but should even have incorporated them intheir works?. incomprehensible, however, as this fact may appear to themodern practitioner, it becomes conceivable if the condition of antiquemedicine and of the medical profession of ancient times is considered in the first place, ancient medical science adopted an entirelydifferent mode of diagnostico-theoretical method than that employedby professors of medicine in modern times ancient natural science compare also chapter v of this work, as well as ancient medicine, obtained their scientific views exclusively by deduction i e , theydeduced individual results from general presumptions, or, rather, theyconstrued, by reason of essay general presumption, the physico-medicalconsequences which were to follow from such a general supposition ifthis attempt to obtain an insight into physical processes is extremelyhazardous, it becomes still more precarious when the manner and meansin which these general presumptions were arrived at were primarily ofan entirely hypothetical nature it is true, no fundamental objectioncan be raised to this method, as even modern natural science andmedicine, despite the fact that their methods of investigation in adiagnostico-theoretical respect scarcely admit of material objections, can not do without hypothesis but hypothesis is not always merehypothesis it is well known that there are hypotheses which, even inthe minds of the most conscientious investigators, are not inferior tothat knowledge which is obtained by experiment and observation, whereasother hypotheses again present the distinct stamp of insufficiency andmakeshift the trustworthiness and the heuristic value of an hypothesisdepend upon the quality of the diagnostico-theoretical process by meansof which it was obtained if this process has been such as physicalinvestigation is bound to insist upon, the hypothesis thus arrivedat is fully justified to supply the still absent data with regardto the phenomena in question this, however, can be accomplished byhypothesis only when the latter is not set forth until it plainlyappears that, in spite of a conscientious and orderly arrangement ofobservation after observation, of experiment upon experiment, withoutthe admission of logical loopholes, full data in regard to the natureof the phenomena is not forthcoming in such a case we may consideras actually proven by hypothesis what observation and systematicexperiment, continuous and logical, were intended to prove, andfailed however, this inductive hypothesis is alone entitled to beconsidered in medicine naturally, such an inductive hypothesis was notthought of by the ancients, as the inductive method of investigationwas generally quite unknown to them the process by which ancientmedicine usually attempted to find its hypothesis was by an argumentfrom analogy each and every point of resemblance, however superficial, between two phenomena was considered sufficient by the ancientnaturalists to warrant the assumption that analogous phenomena in themost various domains were most certainly proven to possess similarpoints of resemblance and upon the basis of such an insecure methodof deduction which, moreover, was selected entirely at the option ofthe observer the ancient investigator erected the boldest hypotheses thus, for instance, the atomic theory of leucippus and democritus isan hypothesis which rests upon the basis of a conclusion from analogy the motes which appear in the rays of the sun led these two ancientinvestigators to the conception that, like the writingicles of dustsporting in the air, the primary component writings of everything thatexists in the entire universe consisted of similar writingicles 2 2 lucretius, book 2, verse 113, sqq it appears that epicurus arrived at his theory of light according towhich, as is well known, images of things were brought to the senses bydelicate but absolutely objective small pictures which were detachedfrom the surface of things in a continuous current by the factthat thesis animals for instance, snakes shed their skins the theoryof humoral pathology, one of the most important advances in medicalscience, was based on a conclusion from analogy and arrived at by thedeductive method the diagnostico-theoretical lines in which antique medicine movedwere bound and this is the point of importance in this case to exerta determining influence upon medical criticism for medico-physicalcriticism can only appear in closest connection with the prevailingcondition of the respective sciences, being really nothing else buta precipitate from them thus the ancient physicians were compelledto take an entirely different position toward magical medicine thanwe moderns, educated in the school of inductive methods, have alwaystaken the probable and similar, the supposable and possible, in whichdeductive medicine found its data, working on the lines of argumentfrom analogy, were necessarily bound to find expression also in thecharacter of medical critique, and it was impossible, therefore, for the ancient physician to detect anything absurd or contrary toexperience in hypotheses which the practitioner of to-day at oncebrands as nonsensical and superstitious we are not in the least justified, therefore, in speaking disparaginglyof galen and alexander of tralles because they believed in magicalmedicine and applied it in their practise as no human being canjump out of his skin, so is he unable to get beyond the intellectualadvancement of his time as the ancient physicians were also unable todo this, accordingly they were believers in the magical medicine but there is still a second point which explains the remarkableposition taken by ancient physicians in relation to magicalmedicine namely, the fact that the conception of miracle and magicwere essentially different in the ancient world from what they are atpresent the belief in the interference of spirits and supernaturalbeings in terrestrial matters, and the manifestations of theirinfluence exerted in manifold ways essaytimes for good, essaytimesfor evil had been widely disseminated from the earliest times, andwe encounter them in all periods of classic antiquity this beliefin demons had become incorporated in the systems of thesis leadingphilosophers of antiquity now if the world were filled with demons thenatural consequence was that their activity would manifest itself invarious ways it was necessary, therefore, that man should always beprepared to experience manifestations which more or less violated thecustomary order of terrestrial happenings, and for this reason nothingthat could be styled a miracle really existed for him a miracle couldnot be conceived in its full modern sense until it was realized thatthe course of all natural phenomena was nothing but the expression ofeternal and changeless laws however, it was not until comparativelylate that this conception became generally disseminated. Thus, forinstance, it was considered as self-evident, even in the latest periodsof the middle ages and during the first beginnings of modern times, that divine influence could always, and actually did always, cause analteration in the course of the functions of the body in fact, thereis an amazingly large number of people even in our time who believethis, and for whom, therefore, the conception of miracles, especiallyof miraculous healing, is to-day on about the same level as that onwhich it stood in the time of galen and alexander of tralles thus we must admit that the ancient physicians were by no means belowthe standard of civilization and culture attained during their periodif they believed in the possibility of extraordinary cures effectedby means extraneous and unscientific in their treatment of the sick, and, accordingly, they supported such methods however, this beliefin miraculous medicines on the writing of the ancient physician wasalways restricted to certain limits it is true, the conception wasalways adhered to that this or that magical agency, or this or thatmagical action, might exert an influence upon the disease.