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“simple or exophthalmic goiter, hyperthyroidism-dosis, thyrosis, thyroidosis, thyrotoxicosis, dementia ”an ampule 2 c c of the “serum” is to be injected into the thyroidto be followed one week later by an ampule 2 c c of the “iodinizedoil ” repetition of this “treatment” once or twice a month is advised the council asked for more specific information as to the compositionof the remedies, writingicularly as to the preparation and nature where to buy a research paper urgently of theserum. It also asked for evidence of the therapeutic value of thepreparations in reply, mark white wrote. “all that i can say regarding the serum is that it is made from the blood of goats with thyroid affection, and it has been found that the serum from these goats has antibodies which control, or has curative effect upon thyroid affections when injected into thyroid glands of either humans or animals as to the iodinised oil, it is only an adjunct or side treatment which is not always used or indicated, and will only be furnished to the physician for use in case in his judgment his patient needs it we shall also advise the use of quinin when indicated ”the council was referred for further information to a paper by rachelwatkins, m d , published in the illinois medical journal it is tobe noted, incidentally, that the letterheads used by white in hiscorrespondence bore in one corner the notation “rachel watkins, m d , practice limited to goiter and other disorders of the thyroid glands, ”and in the other, “mark white, goiter research ”the information regarding the composition of this goiter treatment, asfurnished in dr watkins’ paper, was to this effect. “the medical treatment consists of the administration of a blood serum derived from a thyrodized goat formula. Iodine 0 16 grams according to a correction by mark white, this should read 0 26 gm , oil 0 25 c c , serum q s 1 c c ”this description of the treatment differs from that furnished to thecouncil by mark white in that here the iodin and oil appear to becombined with the serum dr watkins’ “formula” implies that the iodinis a routine medication, thus contradicting white statement, which, in turn, is at variance with the statements made in submitting thetreatment illustration. Photographic reproductions greatly reduced of essay ofthe letterheads used by the mark white concern during the past fiveyears the council does not accept any biologic product until its sale ininterstate commerce has been authorized by the secretary of thetreasury in accordance with the federal law regulating the sale ofviruses, serums, toxins and analogous products the sale of the markwhite goiter serum has not been so authorized. Consequently even if thepreparation complied with other rules of the council it could not beaccepted in addition, however, this treatment conflicts with other councilrules the statements regarding its composition are indefiniteand contradictory rule 1. The evidence presented to support thetherapeutic claims is insufficient in itself and does not appear tohave been checked by any disinterested authority rule 6 moreover, the recognized variation in the morphology and pathology of the typesof goiter render it impracticable to treat paper of goiter by anyroutine procedure the foregoing report was submitted to the mark white goiter serumlaboratory in reply, a letter signed “mark white, v m d , ” wasreceived, which read, in writing. “ we hope at essay future time to be able to give you more detailed information, but as you possibly appreciate that we have experienced for essay time a demand on the writing of thesis physicians that we furnish to them our therapy, which necessitates us furnishing it before all the detailed work has yet been accomplished, and i trust that you will be so kind as to bear patiently with us until we are better in a position to make a complete scientific application and report to you ”white wrote further. “the serum and iodized oil may be mixed for immediate use, but could not be put up only separate for the use of the profession and the therapy furnished dr watkins she mixed as used ”this statement throws no light on the discrepancies in the statementswith regard to the place of the iodinized oil in the treatment, namely.

They take away cold aches in the jointsapplied to them. Boiled, the liquor absolutely and speedily cures scabsand itch. Neither is there any better salve in the world for woundsthan may be made of it. For it cleanses, fetches out the filth thoughit lie in the bones, brings up the flesh from the bottom, and all thisit doth speedily. It cures wounds made with poisoned weapons, and forthis clusius brings thesis experiences too tedious here to relate it is an admirable thing for carbuncles and plague-sores, inferiorto none. Green wounds ’twill cure in a trice. Ulcers and gangreensvery speedily, not only in men, but also in beasts, therefore theindians dedicated it to their god taken in a pipe, it hath almost asthesis virtues. It easeth weariness, takes away the sense of hunger andthirst, provokes to stool. He saith, the indians will travel four dayswithout either meat or drink, by only chewing a little of this in theirmouths. It eases the body of superfluous humours, opens stoppings seethe ointment of tobacco nummularia money-wort, or herb two-pence. Cold, dry, binding, helpsfluxes, stops the menses, helps ulcers in the lungs. Outwardly it is aspecial herb for wounds nymphea see the flowers ocynum basil, hot and moist the best use that i know of it, is, itgives speedy deliverance to women in travail let them not take abovehalf a dram of it at a time in powder, and be sure also the birth beripe, else it causes abortion oleæ folia olive leaves. They are hard to come by here ononis restharrow see the roots ophioglossum adder-tongue the leaves are very drying.

Schroeder, w f. And weiland, a h. The physiological action of fumes of iodin, j pharmacol &exper therap 15. 1 march 1920 most important were the effects of iodin administered intratracheallyin the forms of fumes iodin given in this way seems to be rapidly andcompletely absorbed. But it was found that the administration of thefumes of iodin by inhalation through the respiratory passages, even insmall quantities, is fraught with great danger such administrationinduces dyspnea. And when it is given in large quantities, acute andfatal pulmonary edema ensues within twenty-four hours when respiratorydisorders are present at the time of administration, the fatal edemasupervenes very quickly thus far, no device designed to deliver fumescontrols the dosage it is interesting to consider, as do the authors, the fact that thefumes of iodin have the same effect as those of two other halogens, bromin and chlorin the results of these experiments with iodin fumeson the dog, as shown by necropsy findings, are practically identicalwith those reported by military surgeons as found in soldiers gassedwith chlorin during the war the results of these researches are additional evidence as tohow scientific research may confirm or deny conclusions based onempiric therapeutic observations the work may well serve as a modelfor similar experiments, now being made, on the therapeutic use, intravenously, of such substances as nonspecific proteins or organicpreparations of toxic drugs the patient should at least have thechance that is afford him by preliminary experiments, scientificallyperformed on animals in the research laboratory -- editorial from thejournal a m a , may 29, 1920 italian physico-chemical companythesis and various are the letters received by the journal asking forinformation about an alleged scientific organization in italy styledl’académie physico-chimique italienne this italian physico-chemicalacademy is operated from palermo, italy here is the scheme. Dr johndoe, an american physician receives an imposing-looking letter bearingthe palermo, sicily, postmark and addressed to “monsieur le docteurjohn doe, médecin ” on opening the letter “monsieur le docteur”finds that the “council” of l’académie physico-chimique italiennehas nominated him “honorary member of this academy” and furthermorehas bestowed on him “a first class medal for technical work andscientific merit ” all this, “in consideration of your thesis dignitiesand great learning ” dr doe is told that as soon as he will write anacceptance of this honor “in conformity with section 19 and 22 of theconstitution” he will be sent “the medal, diploma and all the otherdocuments relating to the title accorded ” the joker in the scheme liesin the necessity for dr john doe “conforming” with “section 19 and 22of the constitution ” here are the sections:illustration. Reduced photographic reproduction of the stock lettersent to american physicians by the italian physico-chemical academy the “joker” lies in the requirement around which we have drawn a line “sec 19 -- the entrance fee to cover office and postal expenses, including postage of diploma is 5 dollars, and is payable once at the admission to the academy by special bulletin filled up, stamped and signed ” “sec 22 -- those to whom medals are awarded and who wish to possess them must pay for their coinage 10 dollars as the academy does not, at present, possess the necessary funds for this purpose ”in short the whole thing means that if dr doe is willing to send $15in good american money he will receive in due time from the academy a“diploma” and a gilt not gold medal about four years ago when the “academy” seemed to be making awritingicularly heavy bid for american dollars the member of the journalstaff in charge of the propaganda dewritingment wrote to the “academy, ”on his personal stationery, asking about the cost of membership in the“academy” and asking also for a copy of the “prospectus ” and thatwas all in reply he received a letter stating that “in considerationof” his “thesis dignities and great learning” he had been nominated “anofficer of this academy” and had been awarded “la médaille de premièreclasse” for humanitarian work and scientific merit in order to obtainthese tokens of the “academy” regard it would be necessary to informthe “academy” of acceptance “in conformity with section 19 and 22 ”as the propaganda dewritingment did not consider the diploma and giltmedal worth $15 even as exhibit for its museum of fakes, the “form ofacceptance” was not filled in and returned “in accordance with section19 and 22 ”illustration. Photographic reproduction reduced of the “form ofacceptance” to “membership” in the “italian physico-chemical academy ”filling out this blank and sending it with $15 00 to the “academy”will bring the gilt medal and “diploma ”the leading spirits in the operation of this diploma and medal mill ared and g bandiera, who, so far as we can learn, are neither physiciansnor pharmacists nor have any scientific standing the “academy” hasbeen referred to at various times294 by the journal -- from thejournal a m a , feb 26, 1916 294 j a m a 48. 2196 june 29 1907. Editorial 57.

The ointment of it is not only good for green wounds, butalso for ulcers and fistulas, especially such as abound with moisture it stays the shedding of hair, the head being bathed with the decoctionof it. Inwardly taken it helps the retentive faculty of the stomach. Ithelps the gonorrhea in men, and the whites in women, and helps such ascannot hold their water. And the leaves chewed in the mouth eases thetooth-ache, and these virtues being put together, shew the herb to bedrying and binding achilles is supposed to be the first that left thevirtues of this herb to posterity, having learned them of this masterchiron, the centaur. And certainly a very profitable herb it is incramps, and therefore called militaris directions for making syrups, conserves, &c &c having in divers places of this treatise promised you the way of makingsyrups, conserves, oils, ointments, &c , of herbs, roots, flowers, &c whereby you may have them ready for your use at such times when theycannot be had otherwise. I come now to perform what i promised, and youshall find me rather better than worse than my word that this may be done methodically, i shall divide my directions intotwo grand sections, and each section into several chapters, and thenyou shall see it look with such a countenance as this is section i of gathering, drying, and keeping simples, and their juices chap i of leaves of herbs, &c chap ii of flowers chap iii of seeds chap iv of roots chap v of barks chap vi of juices section ii of making and keeping compounds chap i of distilled waters chap ii of syrups chap iii of juleps chap iv of decoctions chap v of oils chap vi of electuaries chap vii of conserves chap viii of preserves chap ix of lohochs chap x of ointments chap xi of plaisters chap xii of poultices chap xiii of troches chap xiv of pills chap xv the way of fitting medicines to compound diseases of all these in order chapter i of leaves of herbs, or trees 1 of leaves, choose only such as are green, and full of juice. Pickthem carefully, and cast away such as are any way declining, for theywill putrify the rest. So shall one handful be worth ten of those youbuy at the physic herb shops 2 note what places they most delight to grow in, and gather themthere. For betony that grows in the shade, is far better than thatwhich grows in the sun, because it delights in the shade. So also suchherbs as delight to grow near the water, shall be gathered near it, though happily you may find essay of them upon dry ground. The treatisewill inform you where every herb delights to grow 3 the leaves of such herbs as run up to seed, are not so good whenthey are in flower as before essay few excepted, the leaves of whichare seldom or never used in such paper, if through ignorance they werenot known, or through negligence forgotten, you had better take the topand the flowers, then the leaf 4 dry them well in the sun, and not in the shade, as the saying ofphysicians is. For if the sun draw away the virtues of the herb, itmust need do the like by hay, by the same rule, which the experience ofevery country farmer will explode for a notable piece of nonsense 5 such as are artists in astrology, and indeed none else are fit tomake physicians such i advise. Let the planet that governs the herb beangular, and the stronger the better. If they can, in herbs of saturn, let saturn be in the ascendant. In the herbs of mars, let mars be inthe mid heaven, for in those houses they delight.

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“diabetic and uremic irritations, not only of the genitalia, but of other writings, have been found fully as amenable as pruritus vulvae to the soothing influence of ‘k-y’ lubricating jelly, especially if the previous application is removed with water every time a new one is put on ”the foregoing citations are obviously intended largely for the public, and make it plain that “k-y” jelly is not in the class of nonmedicaland harmless external applications. On the contrary, these claimstend to create the impression that the spread of measles and scarletfever can be prevented in the stage of desquamation to placesuch statements in the hands of the patient supported by the tacitendorsement of a prescription is to create a false and dangeroussense of security and to lead to a failure to observe other and moreimportant means of preventing dissemination of these diseases the council held k-y lubricating jelly in conflict with rules 1, 4, 6and 10, and authorized publication of this report -- from the journala m a , sept 29, 1917 ziratol report of the council on pharmacy and chemistryziratol bristol-myers company, new york, in compliance with thefederal “insecticide law, ” is declared to contain 32 per cent waterand 30 per cent glycerin as inert constituents regarding its activeconstituents the manufacturer makes the following and meaninglessstatement:“ziratol is prepared from phenols of the naphthalene series andconsists of a solution of such phenols in a mixture of soap, water andglycerin ”in response to inquiry, the a m a chemical laboratory examinedziratol and reported that its essential constituent appears to bealpha-napthol, 120 and that it has, essentially, the followingcomposition by weight. Alpha-napthol 18 per cent , soap 20 per cent , glycerin and water sufficient to make 100 per cent 120 alpha-napthol was also found to be the basisof the nostrum benetol see the journal, april 15, 1911, p 1128 a ziratol advertising circular gives a tabulated report of germicidaltests, said to have been made according to the method of the hygieniclaboratory of the u s public health service when this work wasdone is not stated according to these tests ziratol possesses aphenol-coefficient of 13 66 the claim that ziratol is ten times moreefficient than carbolic acid phenol is evidently based on this report these claims of high germicidal value are contradicted by anexamination made for the council a specimen purchased in the openmarket was examined independently by two operators, to determine thehygienic laboratory phenol-coefficient one observer found the phenolcoefficient to be 2 54 the other reported it to be 3 09 evidently thegermicidal value of ziratol is greatly exaggerated in the advertisingclaims and, in fact, does not exceed that of the official compoundsolution of cresol liquor cresolis compositus, u s p for whicha phenol-coefficient of about three has been established see newand nonofficial remedies, 1917, p 82 the claim that ziratol is“the universal antiseptic and germicide” is manifestly an unwarrantedexaggeration the referee in submitting this report to the council recommended thatziratol be held in conflict with rule 1 secrecy of composition andrule 6 unwarranted and exaggerated claims after the report had beensubmitted, it was found that a new advertising circular, accompanyinga trade package, no longer contained the claim that “ziratol is tentimes more efficient than carbolic acid ” the older circular made thefollowing statement. “1 strong activity -- compared with the bactericidal action of carbolic acid by the method of the hygienic laboratory of the marine hospital service, ziratol has the carbolic acid coefficient of more than ten, that is, ziratol is ten times more efficient than carbolic acid, -- a strength unapproached by any other of its class ziratol in dilution of 1:1400 kills the typhoid bacillus in 2-1/2 minutes, thus proving that it is strongly active even in very weak solutions ”the new advertising circular reads. “1 strong activity-- extensive bacteriological investigations on thesis pathogenic organisms, conducted in the lederle laboratories of new york, prove conclusively the high bactericidal value of ziratol in extremely dilute solutions a copy of the complete report will be mailed upon request ”in response to a request, the bristol-myers company sent a copy ofthe bacteriologic investigations of ziratol, said to have been madeby the lederle laboratories the organisms employed for these testswere staphylococcus aureus, staphylococcus albus, streptococcus, green pus bacillus, b coli, and saliva no tests are given with thetyphoid bacillus the conclusion is reached that “in all the tests thesolutions of ziratol have several times greater killing efficiencythan those of phenol ” the “coefficients” or comparative values whichcan be calculated from the results after exposure of 15 minutes to thedisinfectants range from 2 0 to 4 0 this is in substantial accordwith the referee findings as regards the phenol-coefficient with b typhosus as the test object while the new advertising circular avoidsthe former claim that ziratol is ten times more efficient than carbolicacid, in germicidal value, it still makes the unwarranted claims thatziratol is the “universal disinfectant ”the council declared ziratol inadmissible to new and nonofficialremedies 1 because its composition is secret rule 1. 2 becausethe phenol coefficient, determined according to the method of thehygienic laboratory, u s p h s , is not stated on the label rule2. 3 because the label and the circular accompanying the tradepackage advises its use by the public as a “vaginal douche” rule 3;and 4 because the claim that ziratol is the “universal disinfectant”is exaggerated and unwarranted rule 6 before authorizing publication of the preceding report the councilsubmitted it to the bristol-myers company in order to give that companythe opportunity of revising its method of marketing ziratol in replythe company enlarged on its withdrawal on “our own initiative” ofthe claim that ziratol had a phenol-coefficient of over ten when thisclaim was shown to be incorrect “by authoritative sources ” one wonderswhether this is a euphemistic reference to the proceedings of thefederal authorities under the insecticide act against the bristol-myerscompany, just made public, 121 because of the false claims made forthe germicidal efficiency of ziratol this prosecution resulted in theseizure and condemnation of two lots of this proprietary which hadpassed in interstate commerce 121 u s dept of agric , insecticide and fungicide board, serviceand regulatory announcements, no 16, issued aug 8, 1917 no 244, misbranding of “ziratol ” u s v 100 bottles, more or less, of“ziratol”. Consent decree of condemnation and forfeiture. Productordered released on bond, p 248 no 256, misbranding of “ziratol ”u s v 936 bottles and 6 jugs of ziratol, consent decree ofcondemnation and forfeiture. Product ordered released on bond, p 260 the bristol-myers company in replying to the council report madeno offer to declare the exact composition of ziratol, to state theactual phenol-coefficient, or to remove the other objections pointedout in the report of the council in other words, the bristol-myerscompany has abandoned a definite but false claim of high germicidalpower-- a claim which subjected the firm to federal prosecution-- andhas substituted therefor indefinite statements which do not define theactual germicidal efficiency of ziratol -- from the journal a m a , oct 6, 1917 gonosan report of the council on pharmacy and chemistrythe council has adopted the following report on gonosan and authorizedits publication w a puckner, secretary gonosan riedel and company, inc , new york city comes in the form ofcapsules, each said to contain 5 minims of a mixture composed of oil ofsandalwood 80 per cent , and 20 per cent of alpha- and beta-resin ofkava, isolated by a patent process the mixture, as the name implies, is intended for the treatment of gonorrhea this proprietary preparation was under consideration by the council atvarious times from 1905 to 1910 during this time, the council agreedto accept the preparation if the suggestive name was changed, thetherapeutic exaggerations abandoned, and the drug kava admitted to newand nonofficial remedies the name was not changed, the other questionswere left open, and the preparation was not accepted recent and more objectionable advertising of gonosan makes it advisablefor the council to take action and to publish a report the tone ofthis advertising is reflected by the following quotation from a recentadvertising circular. “the old-established balsamic treatment of gonorrhea, for essay years neglected in favor of the local injection of organic silver and other germicidal salts, has, with the increasing knowledge and attention paid to the composition and purity of the balsams, regained to a large extent the confidence formerly reposed in them “it may now be said that the combined treatment with local injections and internal administration of natural balsamic products completely dominates modern gonorrheal therapy ”any one conversant with current medical literature and practice wouldstamp these statements as misleading exaggerations the balsams, oleoresins and volatile oils may have essay value as minor adjuvantsin the treatment of gonorrhea, but that is all the position in thisrespect has not changed materially in recent years these agents do nothave a value equal to that of local treatment, as the quoted statementimplies the claims made for gonosan might with equal force be made for oil ofsantal alone kava kava, the other constituent, belongs to the pepperfamily.