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Oneenthusiastic writer says, “it must be recognized that we have nosatisfactory explanation of the action of vaccines, and their useat present is empirical ” one author dwelt on the superiority ofautogenous vaccines but admits that occasionally stock vaccines areindicated one vaccine therapist in concluding an article states, “itis simply impossible to practice modern urology without our modernbiologic products ” yet it is a well-known fact that thesis successfuland capable genito-urinary surgeons avoid the use of vaccines, mixed orsimple pertussis-combined-bacterin -- these reports are uniformly favorable, but are not controlled and their value is not to be compared witha recent report from the new york city dewritingment of health whichindicates that the vaccine is practically valueless it is noted, further, that one of the articles cited which dealt rather fully withthe treatment of pertussis did not mention vaccines streptococcus-rheumaticus-combined-bacterin -- the references citedin support of the preparations by the manufacturer give no supportwhatever for the use of mixed stock vaccines the first reference dealswith the relation of streptococcus viridans to arthritis deformans andendocarditis and reports the following paper. Case 1 -- vaccine case-- improvement after eight months case 2 -- slight improvement following use of vaccine case 3 -- slight improvement following use of vaccine case 4 -- marked improvement case 5 -- prompt improvement case 6 -- vaccine not mentioned case 7 -- vaccine followed by slight improvement in each of the paper other methods of treatment were used the papershows the etiologic relation of streptococcus viridans rather thanthe value of vaccines there is no indication that stock vaccineswere used, though the paper is not clear on this point the secondpaper deals with the application of vaccine therapy in the treatmentof arthritis this paper is by a man who is avowedly an enthusiast onvaccine therapy the indications are that he generally used a mixedautogenous vaccine, but the reports of paper are not always clear this writer apparently makes no serious attempt at the classificationof the joint conditions he treats the third reference is a purelyexperimental study and has no bearing on the use of vaccines intreatment the fourth article was admitted by the manufacturer to be“negative as regards evidence ” the fifth reference specifically statesthat “the vaccine must be autogenous ” the sixth reference deals withthe experimental production of appendicitis by the use of diplococci, and has not the most remote bearing on the use of vaccines in thetreatment of rheumatism streptococcus-viridans-combined-bacterin -- the article which bearsevidence of more care than the others admits that we are not inposition to state the value of vaccines in pyorrhea but the authorbelieves they may have value supplementary to local treatment it is not surprising that a large number of favorable reports canbe accumulated when we appreciate how promptly men report what theyconsider to be their successes and how commonly they leave theirfailures unrecorded bearing in mind the fact that these stock mixedvaccines, though before the profession for thesis years, have notbeen used, or continued in use, in hospitals where work is rigidlycontrolled and that they are used practically not at all in the largegovernment hospital service, a candid critic must hold that there isno substantial evidence in favor of the therapeutic use of a mixedvaccine, certainly not for stock “goods” and that probably there is buta limited field for the employment of autogenous vaccines the referee calls attention to a shift in the advertising matter onvaccines-- the tendency to recommend vaccines to be used in conjunctionwith drugs a heading in the abbott booklet reads, “the biologics donot replace drugs”. And the paragraph speaks of serums and bacterins as“new tools, supplemental to those we already have, but not replacingthem ” “we need them both ”the referee recommends that the several mixed vaccines discussed inthis report be not accepted on the grounds that satisfactory evidenceof their value is wanting having been endorsed by the committee on serumsand vaccines the council adopted the report anddeclared m catarrhalis-combined-bacterin, b coli-combined-bacterin, pertussis-combined-bacterin, streptococcus-rheumaticus-combined-bacterin andstreptococcus-viridans-combined-bacterin ineligible for admission tonew and nonofficial remedies catarrhal vaccine combined-lilly and influenza mixed vaccine-lillybecause of inquiry received, the council requested eli lilly andcompany to aid in determining the acceptability of the followingproducts for new and nonofficial remedies. “catarrhal vaccinecombined, ” said to contain killed cultures of the bacillus offriedländer, micrococcus catarrhalis, staphylococcus aureus andalbus, pneumococcus and streptococcus.

As also to resist theinfection of the plague, if essay of the same be also applied to thesores thereof the same also cools the heat of green wounds and oldulcers, and heals them, being bathed what are the best resume writing services therewith the distilled water ofthe green husks being ripe, when they are shelled from the nuts, anddrank with a little vinegar, is good for the place, so as before thetaking thereof a vein be opened the said water is very good againstthe quinsy, being gargled and bathed therewith, and wonderfully helpsdeafness, the noise, and other pains in the ears the distilled waterof the young green leaves in the end of may, performs a singular cureon foul running ulcers and sores, to be bathed, with wet cloths orspunges applied to them every morning wold, weld, or dyer weed the common kind grows bushing with thesis leaves, long, narrow andflat upon the ground. Of a dark blueish green colour, essaywhat likeunto woad, but nothing so large, a little crumpled, and as it wereround-pointed, which do so abide the first year. And the next springfrom among them, rise up divers round stalks, two or three feet high, beset with thesis such like leaves thereon, but smaller, and shootingforth small branches, which with the stalks carry thesis small yellowflowers, in a long spiked head at the top of them, where afterwardscome the seed, which is small and black, inclosed in heads that aredivided at the tops into four writings the root is long, white and thick, abiding the winter the whole herb changes to be yellow, after it hathbeen in flower awhile place it grows every where by the way sides, in moist grounds, aswell as dry, in corners of fields and bye lanes, and essaytimes all overthe field in sussex and kent they call it green weed time it flowers in june government and virtues matthiolus saith, that the root hereof curestough phlegm, digests raw phlegm, thins gross humours, dissolves hardtumours, and opens obstructions essay do highly commend it againstthe biting of venomous creatures, to be taken inwardly and appliedoutwardly to the hurt place. As also for the plague or pestilence thepeople in essay countries of this land, do use to bruise the herb, andlay it to cuts or wounds in the hands or legs, to heal them wheat all the several kinds thereof are so well known unto almost all people, that it is all together needless to write a description thereof government and virtues it is under venus dioscorides saith, thatto eat the corn of green wheat is hurtful to the stomach, and breedsworms pliny saith, that the corn of wheat, roasted upon an iron pan, and eaten, are a present remedy for those that are chilled with cold the oil pressed from wheat, between two thick plates of iron, or copperheated, heals all tetters and ring-worms, being used warm. And herebygalen saith, he hath known thesis to be cured matthiolus commends thesame to be put into hollow ulcers to heal them up, and it is good forchops in the hands and feet, and to make rugged skin smooth the greencorns of wheat being chewed, and applied to the place bitten by a maddog, heals it. Slices of wheat bread soaked in red rose water, andapplied to the eyes that are hot, red, and inflamed, or blood-shotten, helps them hot bread applied for an hour, at times, for three daystogether, perfectly heals the kernels in the throat, commonly calledthe king evil the flour of wheat mixed with the juice of henbane, stays the flux of humours to the joints, being laid thereon the saidmeal boiled in vinegar, helps the shrinking of the sinews, saith pliny;and mixed with vinegar, and boiled together, heals all freckles, spotsand pimples on the face wheat flour, mixed with the yolk of an egg, honey, and turpentine, doth draw, cleanse and heal any boil, plague, sore, or foul ulcer the bran of wheat meal steeped in sharp vinegar, and then bound in a linen cloth, and rubbed on those places that havethe scurf, morphew, scabs or leprosy, will take them away, the bodybeing first well purged and prepared the decoction of the bran ofwheat or barley, is of good use to bathe those places that are burstenby a rupture. And the said bran boiled in good vinegar, and appliedto swollen breasts, helps them, and stays all inflamations it helpsalso the biting of vipers which i take to be no other than our englishadder and all other venomous creatures the leaves of wheat mealapplied with essay salt, take away hardness of the skin, warts, and hardknots in the flesh wafers put in water, and drank, stays the laskand bloody flux, and are profitably used both inwardly and outwardlyfor the ruptures in children boiled in water unto a thick jelly, andtaken, it stays spitting of blood.

Aromatic arsenic compounds, ii, the amides and alkyl amides of n-- arylglycine arsonic acids, j am chem soc 41:1587 oct 1919 it may be appropriate to mention here that this substance and related compounds, described in the present and following papers of the series, are covered by u s patents nos 1280119-27 patents have also been applied for in foreign countries all discoveries made at the rockefeller institute are what are the best resume writing services made freely available to the public, in accordance with the philanthropic purposes of the institution in order to insure purity of product and protection against exploitation, it has been deemed necessary in certain instances to protect the discoveries by patents it is the purpose of the institute to permit any drugs which may prove of practical therapeutic value to be manufactured under license by suitable chemical firms and under conditions of production which will insure the biological qualities of the drugs and their marketing at reasonable prices other than through the issuance of license, the rockefeller institute does not writingicipate in any way in the commercial preparation or sale of the manufactured chemicals. And it receives no royalties or other pecuniary benefits from the licenses it issues here we have medicine at its best the altruism of pure scienceoperating for the benefit of the general public. Scientifictherapeutics freed from commercial domination -- editorial from thejournal a m a , oct 18, 1919 pharmaceutical barnumsdoes the public love to be humbugged?.

19, 1913 the synthetic drug situationbefore the war, the what are the best resume writing services american physician was literally bombarded with newand wonderful ?. coal-tar synthetics, most of which were originatedin gerthesis in fact, it seemed that if a by-product in the manufactureof dyes could not be used for a dye per se, then a place might befound for it in the ever increasing lists of medicaments by cleveradvertising and propaganda among physicians, an artificial stimulationfor coal-tar drugs was created which evidently yielded lucrativefinancial returns as a result of the war, it is interesting to observethat of all the synthetic drugs imported into this country from gerthesisand on which the american patents were controlled by the germans upto the time of our entrance into the war, the demand was reallysufficient enough to warrant the commercial manufacture of only fourof them by american firms of course, a larger number of nonpatenteddrugs, also imported from gerthesis, are now being made in sufficientquantities in this country. Thesis of the drugs in this class were neverpatented or are the ones which have survived after the patent hadexpired, such as acetanilid, acetphenetidin, and acetylsalicylic acid in view of the agitation to found an institute for cooperative researchas an aid to the american drug industry under the auspices of theamerican chemical society, it will be well for the medical professionto be on its guard against too enthusiastic propaganda on the writing ofthose engaged in the laudable enterprise of promoting american chemicalindustry unless it is, it may be inflicted in the future, as in thepast, with a large number of drugs that are either useless, harmful orunessential modifications of well-known pharmaceuticals it will bewell also for the chemists-- those engaged in this enterprise-- to besure that the product is of therapeutic value before asking its use asa medicine the american medical profession has learned that relativelyfew of the thesis german synthetics were really valuable or decidedimprovements over established drugs if american chemists desireto retain their prestige with the medical profession, they shouldearnestly endeavor to see that the advantages derived from the war andfrom such an institute as proposed are not abused in the worthy desireto popularize chemistry both educationally and commercially theyshould realize that physicians are in no receptive mood for a flood ofsynthetics, even though “american-made ”on the other hand, the constructive possibilities of chemistry in theservice of medicine should serve as a stimulus for american research notwithstanding all the pharmaceutical shrubbery which gerthesis sentto us, still it did contain essay synthetics that were worth while as therapeutics has been benefited by these organic chemicals, it islogical to reason by analogy that there remain other synthetics to bediscovered which will occupy places of equal distinction in the modernmateria medica for example, vaccines are of undoubted merit in thefield of immunology, but their action is, in the end, chemical. As soonas chemical technic is refined by medicochemical research, it is quitepossible that a definite chemical agent synthetic will supersedethe indefinite bacterial vaccine obviously the american chemist hasthe opportunity of showing his resourcefulness in aiding the publichealth of america and the world in this connection, a cooperativeinstitute devoted to purely scientific drug research, and governedin such a manner as to inspire confidence in its humanitarianismand unbiased judgment, should serve a most commendable purpose the hopes of american men of science are for a monumental researchinstitution-- cooperative with all the allied professions-- and, as thechicago chemical bulletin stated, “stripped of all professionalor commercial pettishness and not dominated by any one group ofscientists ”243243 proposed institute for drug research, editorial chicago chem bull , april, 1919, p 67 conclusionsas for the results of the work so far, they can be summed up in twosentences 1 american chemists are producing synthetic drugs formerly controlledby gerthesis, and thus have declared their independence of germanchemicals 2 judging from the evidence at hand, we can feel assured that thequality of american synthetics will be second to none -- from thejournal a m a , sept 6, 1919 writing iii contributions from the journal. Proprietary products nostrums in retrospect a series of nine articles reviewing worthless or unscientific proprietary mixtures previously criticized s q lapius, m d foreword -- it is more than twelve years since the council on pharmacyand chemistry of the american medical association was created sincethen there have been but few issues of the journal that have not calledthe attention of the medical profession to the debasing influenceon scientific medicine of unscientific or worthless proprietarymixtures advertised to physicians for their use in prescribing thecouncil on pharmacy and chemistry has investigated and shown thesis ofthese preparations to be fraudulent in one way or another, and thesereports have been published in the journal in spite of this, thesepreparations have been advertised continuously to physicians, throughmedical journals and otherwise, and prescribed by a large number ofphysicians one reason for this is that there are thesis physicians whohave never seen these reports-- who were not in active practice at thetime, or who were not reading the journal we probably have among ourreaders at the present time 35, 000 or 40, 000 physicians who were notamong the readers of the journal twelve years ago it is desirable, then, that we should take up, in more or less detail, several of themore widely advertised products that have been the subjects of previousreports it has been repeatedly stated in the journal that thesis of theproprietary mixtures-- the so-called ethical proprietaries advertisedto physicians-- were no better and no worse than “patent medicines”advertised to the public every physician who has the welfare of medicine at heart should putthese questions squarely to himself if he has not already taken a firmstand on this whole problem. What is my attitude toward the work ofthe council?. are its reports worthy of acceptance?. am i upholding thecouncil in its efforts to place therapeutics on a rational basis, notby blind faith alone, but by an honestly critical attitude toward it?. Am i following the path of indolence by taking the advice of nostrummakers without any serious effort to determine whether they are true orfalse?. in a word, am i really practicing medicine, or am i an unpaidagent and a dupe of nostrum makers?. there are other revolutions thanpolitical the public can be wronged just as certainly by the abuse ofits confidence in clinicians as by the usurpers of political power, andwhen the public is thoroughly aroused the heavy hand of retributionis not likely to be too discriminating that the sins of cliniciansare standing out plain for any one who wishes to read is becoming moreand more evident there is but one short and ugly word that properlycharacterizes the physician who accepts a fee for prescribing thatabout which he has no more knowledge than has the one for whom heprescribes it are you with the nostrum makers or with decent medicine?. The article below is the first of a series written for the journalby one who is thoroughly conversant with the work of the council onpharmacy and chemistry and can speak authoritatively on questionsdealing with the action of drugs and the treatment of diseases webelieve that these articles will prove of interest and profit and thatthey will help physicians to answer the questions just propounded article i bell-ans pa-pay-ans bellhh see also ?. ?. ?.

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