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“the alcoholic extract of the leptotaenia, which we have termed ‘leptinol’ is a preparation of definite and uniform strength, as determined by two methods. a the gravity test using the u s hydrometer scale for spirits, by which leptinol registers 52 degrees at 60 degrees f , and b by gentle evaporation of the alcohol content and the measuring of the active constituents, which measures twenty-five per cent by weight “the alcoholic extract ‘leptinol’ is glycerinated in a machine, using one writing of the alcoholic concentration to four writings of glycerin this is then added to eleven writings of a heavy syrup, containing 7-1/2 pounds of sugar to the gallon of syrup, and thoroughly mixed in an agitating machine leptinol is the sole active ingredient of syrup leptinol syrup leptinol is a preparation of uniform strength it is far more uniform in strength than most of the syrups of the u s p made from fluid extracts which are made from crude drugs which are not uniform in strength ”this claim cannot be allowed as meeting the conflict with rule 1 itis well known that plants vary in their composition at different timesof the year. Under different conditions of cultivation and growth;and under other conditions.

is this observing “tothe fullest extent” the “ethical and commercial requirements” of the“retail drug business”?. There is no scientific excuse for such a mixture as tyree antisepticpowder if, however, physicians feel that they must use an irrationalconglomeration such as this, why not prescribe pulvis antisepticus, n f ?. like the tyree product, this, too, is essentially a mixtureof zinc sulphate and boric acid, with minute amounts of phenol, eucalyptol, menthol and thymol, to say nothing of a dash of salicylicacid this official article has at least the virtue of constancy ofstrength, composition and purity assured under the federal food anddrugs act -- from the journal a m a , may 17, 1919 wheeler tissue phosphates “the commissioner of health directs me to call to your attention the enclosed advertisement issued by t b wheeler, m d , company, montreal, canada, in which the name of the association journal is being used ”accompanying this brief note to the journal from the secretary of dr haven emerson, commissioner of the dewritingment of health of the cityof new york, was a four page leaflet devoted to the exploitation of“wheeler tissue phosphates ” the trend of the circular is to leadthe average reader to infer that the journal of the american medicalassociation has endorsed wheeler tissue phosphates for example, indescribing the preparation one reads. “it embodies the best recent scientific opinion concerning the treatment of the disease tuberculosis as stated by the official journal a m a ”elsewhere in the circular the journal criticisms of thehypophosphites and the glycerophosphates proprietary preparationswhich are competitors of the wheeler product are quoted and twistedinto a tribute to the ingredients of wheeler tissue phosphates garbling quotations, distorting statements, separating phrases fromtheir contexts and omitting qualifying clauses, all for the purposeof making out a case for essay proprietary remedy is a trick as old asquackery itself that it should be used in advertising wheeler tissuephosphates is entirely fitting obviously, the t b wheeler, m d , company esteems the opinion of the journal on pharmacologic matters this being the case, it should, in the interest of truth and scientificaccuracy, publish in its advertising circulars just what the journalhas said about wheeler tissue phosphates it could not do this betterthan by quoting from a recent editorial note which commented on areport of the chemical laboratory on this preparation here is writing ofthe the journal comment. “‘wheeler tissue phosphates’ is an unscientific shotgun mixture whose most active and powerful drug is the alcohol it contains that it was not years ago relegated to the realms of obsolete and discarded preparations is a commentary alike on the lack of scientific discrimination and on the power of advertising ”here we have “wheeler tissue phosphates” stripped of the verbalcamouflage with which its exploiters have invested it -- editorialfrom the journal a m a , sept 22, 1917 briefer paragraphs alcresta lotion to the editor:-- what is the composition of alcresta lotion?. l t a hotten, m d , paris, idaho according to a circular in our files, “alcresta dental lotion-libby”contains “emetin, the active amebicidal principle of ipecac, togetherwith benzoic acid, thymol, eucalyptol and aromatics ” the theorythat emetin is an active amebicide against pyorrhea alveolaris hasbeen exploded in this connection, it is interesting to note thatthe firm does not list the product in the latest catalogue in ourfiles -- query from the journal a m a , oct 29, 1921 calcidin tablets abbott to the editor:-- what is the composition of calcidin tablets abbott and what is their value?. j s answer -- calcidin is claimed to be a mixture of iodin, lime and starch in contact with water, the iodin and lime react to form calcium iodidand calcium iodate by the acid of the gastric juice, the calcium iodidand calcium iodate are decomposed with liberation of free iodin theadministration of calcidin tablets amounts to giving free elementaryiodin in the past, the advertising for calcidin has contained theunwarranted claim more or less directly that it was the most effectiveand only noninjurious preparation of iodin for internal use, and thatit possesses all of the valuable properties of the iodin with all ofthe objectionable effects left out so far as we know, the effectsproduced by the administration of free iodin do not differ from thoseproduced by the administration of iodids and, therefore, calcidin hasno advantage over the iodids, such as sodium iodid -- query in thejournal a m a , sept 25, 1920 di-crotalin treatment of epilepsy to the editor:-- do you have any literature or information relative to the di-crotalin treatment for epilepsy?. i will be very grateful if you can furnish information as to method of preparation, rationale of the treatment, etc r c decker, captain, m r c , u s soldiers’ home, washington, d c answer -- di-crotalin is a rattlesnake venom preparation sold by theswan-myers company of indianapolis as a “treatment for epilepsy, chorea, bronchial asthma, chronic or hereditary nervous headache, nervous prostration incident to change of life, hysteria-mania, insomnia, neurasthenia, etc ” dr thomas j mays of philadelphiaadvocated the use of rattlesnake venom for tuberculosis later hisformer assistant, dr r h spangler, used the same material in thetreatment of epilepsy that any measure of success sufficient tojustify the adoption of the rattlesnake venom or crotalin treatmentfor epilepsy has resulted is not to be concluded from the availablereports still less evidence is there for the use of rattlesnakevenom in the list of conditions for which the swan-myers company hasrecommended its preparation there are a number of good reasons why acautious physician will shun the administration of this treatment andadvise against it j f anderson, working in the hygienic laboratoryof the united states public health service, reported a death from thecrotalin treatment in consequence of infection, and reports that themarket supply of crotalin solution and crotalin tablets is highlycontaminated he also found both crotalin and crotalin solution tovary in activity the use of rattlesnake venom was discussed in thejournal, march 15, 1913, p 850 -- query in the journal a m a , aug 17, 1918 estivin to the editor:-- what is “estevin, ” or essaything like that?. it is said to be good in hay-fever constant reader answer -- the product called “estivin” is sold by schieffelin andcompany, new york a request for a statement of the composition of thispreparation sent to schieffelin and company by the council on pharmacyand chemistry brought the indefinite and, therefore, meaninglessstatement that “‘estivin’ is an extract of rosa gallica containing noalcoholic or foreign ingredients ”-- query from the journal a m a , nov 12, 1921 iron arsenite to the editor:-- can you inform me how iron arsenite can be prepared for subcutaneous injection?. a commercial firm furnishes physicians with ampules of arsenite of iron is this really arsenite of iron?. s h kempner, m d , new york answer -- ferric arsenite iron arsenite is in itself relativelyinsoluble in water, but may be treated with ammonium citrate, theresulting product thus being soluble. The latter substance wasat one time described in new and nonofficial remedies as “ferricarsenite, soluble” and is essaytimes sold as a solution in ampuleform in 1912, the council on pharmacy and chemistry deleted “ferricarsenite, soluble” from new and nonofficial remedies because “onecannot, in administering ferric arsenite, soluble, give a usefuldose of iron without giving too much arsenic. And, vice versa, onecannot give a safe dose of arsenic without giving too little iron ”the council, therefore, held the preparation to be irrational andunscientific -- query in the journal a m a , feb 19, 1921 k-y lubricating jelly to the editor:-- 1 what is the composition of “k-y lubricating jelly”?. 2 can you furnish a formula for a simple nongreasy lubricating jelly?. s t answer -- 1 the composition of “k-y lubricating jelly” has notbeen divulged examination of the advertising matter reveals onlymeaningless statements, such as. “this is a judicious combination ofvegetable products combined in well balanced proportions withnon-irritating antiseptics , ” “it incorporates a sufficient quantityof mild antiseptics of the thymol class ” and “ contains noformaldehyde ”2 probably a simple tragacanth jelly, which can be made cheaply, willproduce the same effects as those of the proprietary preparation thefollowing formula was published by mr j k thum, apothecary at thegerman hospital, philadelphia druggists circular, september, 1915, p 586:lubricating jelly tragacanth, whole 3 gm glycerin 25 c c phenol 1 5 gm distilled water, a sufficient quantity to make 300 c c the tragacanth is broken in small pieces, and put into a wide-mouthed bottle.

And well it may, being a plant ofsaturn the birch tree descript this grows a goodly tall straight tree, fraught with thesisboughs, and slender branches bending well written essay buy downward. The old being coveredwith discoloured chapped bark, and the younger being browner by much the leaves at the first breaking out are crumpled, and afterwardslike the beech leaves, but smaller and greener, and dented about theedges it bears small short cat-skins, essaywhat like those of thehazelnut-tree, which abide on the branches a long time, until growingripe, they fall on the ground and their seed with them place it usually grows in woods government and virtues it is a tree of venus. The juice of theleaves, while they are young, or the distilled water of them, or thewater that comes from the tree being bored with an auger, and distilledafterwards. Any of these being drank for essay days together, isavailable to break the stone in the kidneys and bladder, and is goodalso to wash sore mouths bird foot this small herb grows not above a span high with thesis branches spreadupon the ground, set with thesis wings of small leaves the flowers growupon the branches, thesis small ones of a pale yellow colour being seta-head together, which afterwards turn into small jointed pods, wellresembling the claw of small birds, whence it took its name there is another sort of bird foot in all things like the former, but a little larger. The flowers of a pale whitish and red colour, andthe pods distinct by joints like the other, but little more crooked;and the roots do carry thesis small white knots or kernels amongst thestrings place these grow on heaths, and thesis open untilled places of thisland time they flower and seed in the end of summer government and virtues they belong to saturn and are of a drying, binding quality, and thereby very good to be used in wound drinks, asalso to apply outwardly for the same purpose but the latter birdfoot is found by experience to break the stone in the back or kidneys, and drives them forth, if the decoction thereof be taken.

unrecorded, well written essay buy 20 5 2 without guaiacol severe, 12 2. Mild, 36 8. None, 39 0. unrecorded, 12 2 3 with guaiacol severe, 18 9. Mild, 67 5. None, 8 1. unrecorded, 5 5 the manufacturer of biniodol supplied the names of several physicianswho have used that preparation in their practice correspondence withthese elicited the following statements:one had used biniodol in forty-eight paper and states that “only a fewpatients complain of pain at all and then only of a general soreness inthe muscle ” this physician reports a limited experience with the useof another manufacturer “mercury biniodide oil solution” apparentlysix paper, but severe pain following the injections made it necessaryto abandon that preparation another of these physicians named by the manufacturer, withoutreference to any series of paper, reports that “biniodol is superior toany oily solution of mercury biniodid that i have tried ”a third physician has “used it biniodol a few times” and is“convinced that it has no special action or virtue” over “any redmercuric iodide in oil ”this evidence, in its most favorable estimate, shows biniodol to bea good 1 per cent solution of mercuric iodid in oil, but fails tojustify attributing to the preparation any unique characteristics thepreparations made in the laboratory were as satisfactory, or betterthan the biniodol, and the presence or absence of the guaiacol was ofno consequence biniodol conflicts with rule 6, since claims of superior therapeuticefficiency made for it are not established. And with rules 8 and10, since it is an unessential modification of an establishednonproprietary article marketed under a proprietary name in view of the foregoing, the referee recommends that biniodol benot accepted for new and nonofficial remedies, and that this report, including the clinical investigations of drs cole and keidel, beauthorized for publication comparative symptoms resulting from the use of several oily suspensions of red mercuric iodid mercury biniodid report of dr h n colecc from the dewritingment of dermatology and syphilology of the westernreserve university and of the cleveland city hospital at the request of prof torald sollmann of the council on pharmacy andchemistry of the american medical association, we made a comparativestudy of several oily preparations of red mercuric iodid forintramuscular injections in syphilis the information, concerning the preparations submitted to theinvestigators, was as follows. Oily solution of red mercuric iodid“it is desired to ascertain whether there is any difference betweenthree preparations, each containing 1 per cent of mercuric iodid, asto pain, discomfort, induration, etc the preparations will be labeled“1, ” “2” and “3 ” they will be sterile “one of these preparations will be a plain solution in oil. Anotherwill contain, in addition, 2 5 per cent of guaiacol. The third will bea proprietary preparation containing the guaiacol “it is also desirable to know how the oily solution compares with theplain watery solution. But this is of secondary importance ”the preparations all had the same appearance the patients were takenindiscriminately, and we attempted to keep them on the injections aslong as possible, in order to compare symptoms owing, however, todischarge from hospital, symptoms of mercury intoxication, etc , wewere unable in all paper to give a thorough trial with each preparation in all, eleven patients were treated and seventy-one injectionsgiven-- by which time our experimental supply was exhausted in each case the drug was given intramuscularly in the buttocks and thepatients carefully observed for subjective symptoms of pain and forobjective symptoms of swelling, induration, abscess formation, etc thedetails are given in table 1 as will be noted, in several of the paper the patients were more orless confused and gave rather indefinite and conflicting answers inattempting to compare the results from the different drugs, by carefultabulation one finds that symptoms were more marked with the respectivesample as follows. Preparation 1 was worse than preparation 2 or 3 in six paper preparation 2 was worse than preparation 1 in two paper preparation 2 was worse than preparation 3 in five paper preparation 3 was worse than preparations 2 or 1 in one case table 1 -- details of investigation by dr cole* | | | | | | symptoms | | | |prepar-|dose, -- -- -- -- -- -- -- -- -- -- -- -- -- -- - case|age|sex| date | ation | grain| induration-- | objective | | † | | | | pain | | | | | | | | -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 1 | 25| ♂ | 6/11/16 | 2 | 1/5 |none |still painful | | | 6/12/16 | 1 | 1/4 |none |none | | | 6/13/16 | 2 | 1/5 |none |quite painful | | | 6/14/16 | 2 | 1/4 |hurt for essay |very tender | | | | | | time | | | | 6/16/16 | 2 | 1/5 |hurt for essay |very tender | | | | | | time | | | | 6/17/16 | 3 | 1/5 |not so painful |less tender | | | | | | | than with | | | | | | | prepar- | | | | | | | ation 2 | | | 6/18/16 | 3 | 1/5 |not so painful | can sit on | | |discontinued| | | | area. As | | | salivation| | | | needle prick | | | | | | | is only place | | | | | | | that it hurts | | | 6/22/16 | 2 | 1/4 |hurt, but not |slight indur- | | | | | | so long | ation and | | | | | | | slight | | | | | | | tenderness | | | 6/24/16 | 2 | 1/4 |hurt, but not |pain “dead | | | | | | so long | stinging” | | | | | | | lasts 1 hour | | | 6/25/16 | 1 | 1/4 |not so bad |about the same -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 2 | 32| ♂ | 6/24/16 | 2 | 1/4 |essay pain |no induration | | | 6/25/16 | 1 | 1/4 |more pain |slight indur- | | | | | | | ation -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 3 | | ♂ | 6/12/16 | 1 | 1/5 |no symptoms |painful | | | 6/13/16 | 2 | 1/4 |no symptoms |painful | | | 6/14/16 | 2 | 1/4 |says the last |painful | | | 6/16/16 |arseno-| | two have hurt | | | | |benzol | | the more | | | | 6/17/16 | 3 | 1/5 |more pain than |small painful | | | | | | previously | area | | | 6/17/16 | 3 | 1/5 | | | | | 6/18/16 | 3 | 1/5 |not so much |essay indur- | | | | | | pain. In | ation at site | | | 6/19/16 | 3 | 1/5 | fact, patient | of injections | | | 6/20/16 | 3 | 1/4 | says he is | | | | 6/21/16 | 3 | 1/4 | over it in a | | | | | | | very short | | | | | | | while. Com- | | | | | | | plained of | | | | | | | last one | | | | 6/22/16 | 2 | 1/4 |essay pain |considerable | | | | | | | tenderness | | | 6/24/16 | 2 | 1/4 |not so much as | now after so | | | | | | previously | thesis injec- | | | 6/25/16 | 1 | 1/4 | | tions -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 4 | 36| ♂ | 6/22/16 | 2 | 1/4 |no pain |no tenderness | | | 6/24/16 | 2 | 1/4 |essay pain |essay tender- | | | | | | | ness | | | 6/25/16 | 1 | 1/4 |could not sleep|essay tender- | | | | | | at night | ness. Slight | | | | | | | induration -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 5 | 32| ♂ | 6/20/16 | 3 | 20 |essay pain |no induration | | | | |minims| | | | | 6/21/16 | 3 | 25 |essay pain | | | | | |minims| | | | | 6/23/16 | 2 | 1/4 |worse pain |no induration | | | 6/24/16 | 2 | 1/4 |worse pain | | | | 6/25/16 | 1 | 1/4 |worse than any |slight tender- | | | | | | |ness -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 6 | 20| ♂ | 6/ 8/16 | 1 | 1/6 |very little | | | | 6/10/16 | 1 | 1/5 |very little | | | | 6/13/16 | 1 | 1/4 |very little | | | | 6/14/16 | 2 | 1/4 |bothered more | | | | | | | than others | | | | 6/17/16 | 2 | 1/5 |quite a little |still essay | | | | | | pain | soreness | | | 6/18/16 | 2 | 1/5 |quite a little |still essay | | | | | | pain | soreness | | | 6/19/16 | 3 | 1/4 |considerably |very little | | | | | | less pain than| tenderness | | | 6/20/16 | 3 | 1/4 | with prepar- | | | | 6/21/16 | 3 | 1/4 | ation 2 | -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 7 | 30| ♂ | 6/12/16 | 1 | 1/5 |little pain |none | | | 6/13/16 | 2 | 1/4 |no pain | | | | 6/14/16 | 2 | 1/5 |essay pain | | | | 6/16/16 |arseno-| | | | | | |benzol | | | | | | 6/17/16 | 3 | 1/5 |not so much |no tenderness | | | 6/18/16 | 3 | 1/5 |not so much |no tenderness | | | 6/19/16 | 3 | 1/5 |very little |only slight | | | | | | pain | amount of | | | 6/20/16 | 3 | 1/4 | | induration | | | 6/21/16 | 3 | 1/4 | | | | | 6/22/16 | 2 | 1/4 |essay pain |essay little | | | | | | | induration | | | 6/24/16 | 2 | 1/4 |considerable |essay indura- | | | | | | pain | tion | | | 6/25/16 | 1 | 1/4 |“fine” |slight indura- | | | | | | | tion -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 8 | 28| ♂ | 6/13/16 | 2 | 1/5 |little pain |little pain | | | | | | | afterward | | | 6/15/16 | 2 | 1/5 |little pain |little pain | | | | | | | afterward -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 9 | 28| ♀ | 6/17/16 | 2 | 1/5 |essay complaint |very little | | | | | | of pain | induration | | | 6/18/16 | 2 | 1/5 | fairly severe | | | | 6/19/16 | 3 | 1/5 |essay pain.

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They which kill by corroding, are to be cured by lenitives, such as temper their acrimony those which kill by induration, or coagulation, require cuttingmedicines also because all poisons are in motion, neither stay they in one tillthey have seized and oppressed the fountain of life, therefore theyhave invented another faculty to stay their motion, viz terrene andemplastic for they judge, if the poison light upon these medicines, they embracethem round with a viscous quality also they say the ways and passages are stopped by such means, tohinder their proceeding. Take terra lemnia for one truly if these reasons be good, which i leave to future time todetermine, it may be done for little cost essay are of opinion that the safest way is to expel the poison out ofthe body, so soon as may be, and that is done by vomit, or purge, orsweat you need not question the time, but do it as soon as may be. For thereis no parlying with poison let vomiting be the first, purging the next, and sweating the last this is general but, if thou dost but observe the nature and motion of the venom, that willbe thy best instructor in the stomach it requires vomiting, in the blood and spirits, sweating, if the body be plethoric, bleeding, if full of evil humours, purging lastly, the cure being ended, strengthen the writings afflicted the project gutenberg ebook of medical jurisprudence, forensic medicineand toxicology - vol 1 of 4, by rudolph august witthaus and tracy chatfield beckerthis ebook is for the use of anyone anywhere in the united states and mostother writings of the world at no cost and with almost no restrictionswhatsoever you may copy it, give it away or re-use it under the terms ofthe project gutenberg license included with this ebook or online atgutenberg org if you are not located in the united states, you'll haveto check the laws of the country where you are located before using this ebook title. Medical jurisprudence, forensic medicine and toxicology - vol 1 of 4author. Rudolph august witthaus tracy chatfield beckerrelease date. May 23, 2015 ebook #49027language.