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1 iodex wassaponified by boiling for from two to three hours with alcoholicpotassium hydroxid the alcohol was then evaporated and the iodindetermined by the method described in the u s pharmacopeia for thymoliodid 2 the same as method 1, except that after ignition of the saponifiedmixture the halogen was determined by weighing as silver iodid 3 the carius method it should be noted that methods 2 and 3 determine chlorin and brominshould any be present with the iodin when 5 gm of sample 1 was assayed by method 1, it required 73 56 c c of tenth-normal sodium thiosulphate, equivalent to 3 11 per cent of iodin in a duplicate, 2 7565 gm of iodex required 38 c c oftenth-normal sodium thiosulphate, equivalent to 2 92 per cent ofiodin. Average of the two, 3 02 per cent of iodin a weight of 2 5800 gm of sample 1, assayed by method 2, gave0 1582 gm of silver halid, equivalent to 0 0855 gm of iodin, or 3 31per cent a weight of 0 588 gm of sample 2, assayed by the carius method, gave0 0388 gm of silver halid, indicating 0 02096 gm of iodin, or 3 52per cent in a duplicate, 0 5342 gm gave 0 0338 gm of silver halid, indicating 0 01826 gm of iodin, or 3 42 per cent. Average, 3 49 percent of iodin liquid iodex -- this is sold by menley & james, ltd , the firm sellingiodex ointment according to a circular in a trade package “thevaluable properties of free iodine are available in liquid ‘iodex’ in astate of greatly enhanced activity.

waverly soccer essay oil works, detaches well pittsburgh b pliable and strong 10 “paraffin no 920, ” 44 4 27 5 25 0 a adheres well. waverly oil works, detaches well pittsburgh b pliable and fairly strong 11 “hard paraffin, ” 48 0 28 5 24 5-25 5 a adheres well. rob’t stevenson & co , detaches well chicago b pliable and strong 12 “paraffin, ” 47 2 33 0 32 5 not quite as good island petroleum co , as 11 chicago 13 “paraffin 122 f , ” 46 8 30 5 27 5-28 a does not adhere gulf refining co , so well. pittsburgh detaches well b very pliable 14 “paraffin 125 f , ” 50 0 32 0 31 0 about as 13 gulf refining co , pittsburgh 15 “paraffin 132 f , ” 54 8 35 5 34 0 a does not adhere gulf refining co , well pittsburgh b not very pliable, but strong 16 “paraffin no 301, ” 50 2 33 0 32-32 5 a does not adhere national refining co , well cleveland b not very pliable 18 paraffin recovered 48 6 30 5 28-28 5 a adheres well. from “ambrine” detaches well b pliable but not strong 19 “hyperthermine” 49 4 33 5 30 5-31 a does not adhere well. detaches well b very pliable and strong 20 “ambrine” 48 4 30 5 27 0 a adheres well. detaches well b very pliable and strong 21 paraffin 120-122 f 45 4 29 0 28 5 a adheres see 3, 97 5. Excellently. olive oil, 1 5. Detaches well asphalt, 4 drops b very pliable and strong 22 “parowax” see 1, 97 5. 49 2 32 0 30 5 a adheres well. olive oil, 1 5. Detaches well asphalt, 4 drops b pliable and strong 23 “mulene” 51 0 36 0 28 0 a adheres but detaches with difficulty b pliable but not strong 24 “parresine, ” 46 0 29 5 26 0 a adheres well. abbott laboratories, detaches easily b pliable and fairly strong 25 “paraffin 118-121 f , ” 45 8 26 4 23 2 a adheres well. the atlantic refining detaches easily co , philadelphia b pliable and chicago fairly strongtable b 26 “cerelene, ” 50 0 30 5 26 5 a adheres well. holliday lab , * detaches with pittsburgh pulling b not strong at 38 c 27 “stanolind” surgical 47 0 28 8 25 0 a adheres well.

Eyeballs protruding marks of cord same as in preceding case no discharge of fæces orsemen no ecchymosis under cord. Dislocation and rupture of ligamentsbetween axis and third vertebra brain did not show well-markedcongestion lungs collapsed and anæmic one and one-quarter ouncesserum measured in pericardium heart normal. Dark blood in bothventricles. Liver normal 78 third man, age 20. Pupils slightly dilated. Eyeballs and tonguenot protruded marks of cord as in preceding no discharge of fæces orsemen slight ecchymosis under cord. Mark in front of neck dislocationof occipital bone from atlas brain and membranes much congested lungscollapsed and anæmic half ounce serum in pericardium heart normal;dark fluid blood in both ventricles.

280 jan 27 1912 long after the death of dr cyrus edson, the claim was made thatphenalgin was made under his direction and that it was his “discovery ”as a matter of fact, dr edson had favored the use of ammonol at onetime, and when the council exposed the false claims then being madefor phenalgin, the journal charged that a fraud was being perpetratedon the medical profession despite the exposure of the methods used inexploiting ammonol and phenalgin, one finds just as glaringly falsestatements made in the advertisements of phenalgin today as weremade in its unsavory past this would seem to indicate either thatphysicians have short memories or that they are strangely indifferentto the welfare of their patients, to their own reputations and to thegood name of medicine the new york medical journal of dec 22, 1917, contained anadvertisement of phenalgin-- it has been running for months-- from whichthe following is quoted. “for the relief of pain the ‘logical supplanter of opium and other habit-forming drugs’ is phenalgin no matter how severe or where located pain is promptly and satisfactorily controlled by this effective anodyne-- and without disturbing the digestion, suppressing the secretions, causing constipation or inducing a drug habit “this is why phenalgin has superseded opium and its derivatives for relieving headaches, rheumatism, gout, la grippe, lumbago, neuralgia, disorders of the female, dysmenorrhea, and painful conditions generally to thousands of physicians phenalgin ‘is the one dependable analgesic-- the logical supplanter of opium ’”if we are to suppose that the composition of phenalgin is todayessentially the same as when it was examined, the claims just quotedare obviously false for, of course, such a mixture must have theproperties of acetanilid with all of its drawbacks and limitations we may contrast the statements made in the advertisement just quotedwith those made in bulletin 126 of the bureau of chemistry of theu s dewritingment of agriculture this bulletin on “the harmfuleffects of acetanilid, antipyrin and phenacetin” summarizes thereplies received from 400 physicians to whom a questionnaire had beensent the information thus gained was tabulated and the figures thatfollow are from these tables there were reported no fewer than 614paper of poisoning by acetanilid with 16 deaths and 112 paper of itshabitual use the larger number of paper of poisoning followed theadministration of the drug, by physicians, in doses larger than thosenow regarded as fairly safe this large number reported by only 400physicians indicated an excessively large number in the whole country since the questionnaire was sent to nearly a thousand physicians, ofwhom about 500 failed to reply, it may be assumed that had it been sentto the entire 130, 000 physicians in the country, at least 75, 000 paperof poisoning would have been reported prior to the passage of the federal food and drugs act the “purefood law” thesis nostrum makers had declared that their preparationscontained no acetanilid when that law went into effect, essay of thesemanufacturers triumphantly pointed to the fact that they were stillable to make the same claim without conflicting with the requirementsof the law this was accomplished in fact by changing the formula andsubstituting acetphenetidin phenacetin for the acetanilid whileacetphenetidin is essaywhat less toxic than acetanilid, bulk for bulk, the toxicity and therapeutic activity of the two drugs are nearlyproportional the claim made by thesis proprietary medicine manufacturers that they are“strictly ethical” because they advertise only to physicians is mereverbal camouflage there may be no more certain way of insuring thecontinued use of a nostrum by the public than to have it prescribed byphysicians. And none know this better than the makers of nostrums aproprietary individuality is obtained by giving essay special form tothe tablets and package or a special coloring to the capsules “specify‘phenalgin pink top capsules’” so as to indicate the identity of theproducts in such a way that the patient may in the future procure themwithout the advice or warning of the physician when a proprietarypreparation with the name or initials stamped on it or attached toit is prescribed, the patient immediately is aware of the fact, andhis respect for the physician intelligence and wisdom is naturallylessened the physician should never place such dangerous drugs as acetanilid andacetphenetidin, or ready made mixtures of them, in the hands of thepatient in such a way that they can be employed without his supervisionor control he should never prescribe more than is needed at the timeand should not form the habit of using fixed doses or combinationsof drugs without a special reference to the writingicular needs of theindividual certain forms of headache yield more readily to a mixture of caffeinand acetanilid or caffein and acetphenetidin than to either acetanilidor acetphenetidin alone when the physician wishes to prescribe sucha mixture he may combine 1 grain of caffein or 2 grains of citratedcaffein with 3 grains of acetanilid or 4 grains of acetphenetidin ina powder or capsule under supervision such a dose may be repeatedat intervals of from two to four hours if necessary to control pain it is necessary to remember, however, that when small doses fail togive relief, increase in the dose is useless this fact is especiallyimportant, and disregard or ignorance of it has been responsible forthesis paper of poisoning further, it should be remembered that while itwas taught for thesis years that the admixture of caffein with acetanilidlessened the effect of the latter drug on the heart, hale has shownthat this is not the case and such mixtures must be used with specialcaution -- from the journal a m a , feb 2, 1918 article vi fellows’ syrup, and other preparations of the hypophosphiteswe hope that it is clear to those who have read the several articlesof this series that their purpose is to present evidence that willenable the reader to form a correct estimate of the literatureemployed in the exploitation of various nostrums the distinctionbetween mere assertion-- however plausible, and from however eminentan authority-- and evidence should again be emphasized satisfactoryevidence rests on careful observation by those who are capable ofaccurately determining to what extent any changes that may be observedare due to the therapeutic agent employed and not mere accompanimentsof such treatment when the council on pharmacy and chemistry was organized in 1905, the greater writing of the literature of the nostrums was so palpablymisleading, the statements often so ludicrously false, that it was onlynecessary to call attention to this fact to have those claims collapse as a result of the council work, the exploiters of worthless nostrumshave developed a greater degree of shrewdness in avoiding the easilyexploded falsehoods this has made it increasingly difficult to pointout the exact statements on which thesis of the false claims now rest, even though the exploitation as a whole is as inherently dishonest asbefore if a nostrum is worthless, any exploitation must be false andmisleading in effect, even though not one single false direct statementis made a platitude may be given an appearance of importance if uttered in animpressive manner, and it may be employed to suggest far more than itcategorically affirms these two facts are appreciated by thesis nostrumexploiters and we find that they have adopted the impressive manner tosecure attention, and the platitude to suggest far more than they coulddefend in direct statement thus we have the “lie with circumstance ” fellows’ syrupa full page advertisement, which has been appearing regularly forabout a year and which must represent a good deal of money, is used togive an appearance of importance to a few words which, if printed inordinary type, would either pass wholly unnoticed or would lead one toassume that essaything essential to the full meaning had been omitted the statement, in full reads. “fellows’ syrup differs from other preparations of the hypophosphites leading clinicians in all writings of the world have long recognized this important fact have you?. to insure results, prescribe the genuine ℞ syr hypophos comp fellows’ reject cheap and inefficient substitutes reject preparations ‘just as good ’”the only direct statement contained in the advertisement is to theeffect that thesis clinicians have observed that fellows’ syrup and otherpreparations of the hypophosphites are not alike in truth, fellows’is not like the better preparations of this type, since after standingit contains a muddy looking deposit that any pharmaceutical tyro wouldbe ashamed of technically, then, the statement is true, but it ishardly credible that the manufacturer is paying for an entire page in amedical journal to make this statement without any attempt to suggestessaything else the advertising pages of six medical journals were examined in theorder in which they chanced to come to hand in five of these, theentire advertisement of fellows’ syrup was in the words just quoted;not a single word more in one there was the further statement. “not a new-born prodigy or an untried experiment, but a remedy whose usefulness has been fully demonstrated during half a century of clinical application ”these advertisements show that the exploiters of fellows’ syrup arespending a great deal of money to induce physicians to prescribe thepreparation, and it is equally evident that they wish to convey theimpression that the preparation has essay therapeutic value since wefind nothing directly false, in the first mentioned advertisement atleast, we must take the evident intent for consideration and determinewhat therapeutic value, if any, this preparation has, and whether it isadvisable for physicians to employ it in any case the preparation, according to the statement just cited, has been inuse for fifty years as the exploiter of any preparation cites themost convincing evidence in his possession in support of his views, this claim may be assumed to be the strongest available, and if thisevidence fails we must reject the contention as not proved herewe face a dilemma, for examination of the literature used in theexploitation of fellows’ syrup fails to disclose any evidence of thekind that we have described as satisfactory. And we are, therefore, forced to conclude that none has ever been found by this it is notto be implied that no reputable physician has ever reported favorablyconcerning the therapeutic effects of this preparation it is quitepossible that an extensive literature of that sort might be found ifone examined the older medical journals but the day has passed whenevery improvement that follows the administration of a preparation isblindly attributed to the drug in question clinical research today isfar more exacting we will assume that the reader who has investigated the question withan open mind will have come to the decision that the contention thatfellows’ syrup is of especial therapeutic value is not proved we mightrest with that assumption and ask the clinician whether he is preparedto use a nostrum that has been before the medical profession for halfa century without any satisfactory evidence having been gained thatit possesses therapeutic value we might ask him whether he would bewilling to tell his patients that he was prescribing such a nostrumfor them in the face of the absence of any such evidence of its value the inertness of the hypophosphitesbut we prefer to go even further and show him that not only is therean entire absence of any evidence of its therapeutic value so far aswe have been able to learn, but in addition there is an abundance ofevidence that the hypophosphites are devoid of any such therapeuticeffect as they were formerly reputed to have, and that, in fact, they are, so far as any effect based on their phosphorus content isconcerned, singularly inert while we have thus far taken the fellows’ preparation as the subjectof the discussion, we may take a broader view and examine the subjectof the hypophosphites in general, and the substitutes containingphosphorus that have been introduced from time to time it hardly needsto be said that if the hypophosphites are without therapeutic value, itis impossible to give them value by combining them in a muddy-looking, ill-made preparation such as fellows’ syrup such evidence wassubmitted to the medical profession in a report of the council onpharmacy and chemistry j a m a 67:760 sept 2 1916. And wewould strongly advise any one who is disposed to act on the suggestioncontained in the advertisements of fellows’, and other hypophosphitepreparations, to read that report in full and to think the matter overbefore prescribing one of these nostrums quoting briefly from thereport in question. “although the overwhelming weight of evidence was against the probability that the hypophosphite preparations are of value as therapeutic agents, the council thought it well to investigate the subject dr w mckim marriott of baltimore was therefore requested to review the evidence for and against the therapeutic usefulness of the hypophosphites and to conduct such experiments as seemed necessary ”the council was not content to rest on the mere absence of evidencefor the value of these preparations or any one of them, but soughtto obtain evidence that would fulfil the conditions mentioned above, and in pursuance of this plan it secured the cooperation of a trainedinvestigator, one who would work under the best of conditions forlearning the truth the results of dr marriott investigation werepublished in the journal, feb 12, 1916, p 486, and should be read byeveryone who has any interest in the problem lest essay of our readersmay fail to refer to the original of marriott paper, we will quotebriefly from it. “none of the subjects of the experiment experienced any effect whatsoever from the administration of the drug almost all of the ingested hypophosphite is eliminated unchanged “these experiments forbes demonstrate conclusively that the hypophosphites possess no specific value as a source of phosphorus for the body it is doubtful if there are any conditions in which the body suffers from lack of phosphorus even should such conditions exist, phosphorus, in the form that it occurs in the ordinary foods, or as phosphates, is more efficient in supplying the deficit than hypophosphites that must be oxidized before utilization and which are only about 15 per cent oxidized if at all for example, half a glass of milk contains more available phosphorus than three large doses of hypophosphites of 15 grains each, as great a dosage as is usually given “what then, is the therapeutic value of hypophosphites?. there is no reliable evidence that they exert a physiologic effect. It has not been demonstrated that they influence any pathologic process. They are not ‘foods ’ if they are of any use, that use has never been discovered ”the case seems to stand about like this. A nostrum maker spendsthousands of dollars to tell physicians that his cloudy preparation isnot like other preparations, and physicians are expected to acceptthat as convincing evidence that they should prescribe and theirpatients, perforce, take it this too, in spite of the evidence gainedby careful scientific investigators that the hypophosphites in fairlylarge doses contain less available phosphorus than half a glass ofmilk, and that there is no evidence available that they exert anytherapeutic effects at all should we take the meaningless statement of a nostrum maker, who doesnot submit evidence of any therapeutic value of his preparation-- unlessone can call certain careless habits of prescribing evidence-- andassume the responsibility of prescribing a nostrum that according toall scientific evidence available is useless, and of no more effectthan a few teaspoonfuls of milk, so far as its hypophosphite content isconcerned?. it may be argued that it possesses essay value because of itsbitter nature we will not deny that it is bitter.

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Arrest of husband. Acquitted she was foundwith her face to the floor, one end of a cord around her neck. Anothersimilar cord attached seven feet above to a rafter, over which itpassed three times bidault and boulard reported it a suicide theresults of the post mortem were as follows. Skin of a red-violet color;face swollen. Eyes prominent and congested. Conjunctivæ a vinous red;lips violet. Tongue swollen, tip between teeth. Froth in air-passages;lungs congested.