History

Research Help


Supposed to have been murdered by her son therewere marks on research help the neck and other injuries, and hemorrhage into thebrain maschka concluded that the marks on the neck were not due tostrangulation 47 hackel. Dorpat diss , 1891, p 34 - man, age 48. Strangledhimself with writing of a mattress was found lying on his back, dead, holding the ends in his hand there was a double mark of ligature 48 binner. Zeitsch f med-beamte, 1888, i , pp 364-368 - woman;suicided by choking herself with her hands for other paper, see tidy, “med jur , ” paper 20 to 65. Maschka, “handbuch, ” p 625 accident 49 bédié. Rec de mém de méd , etc , paris, 1866, xvi , pp 482-484 - soldier, age 39, found dying, lying on his bed.

Pulv boric acid, eucalyptol sander, white vaseline “for local application in the treatment of affections of the nose and throat “the efficacy of these combinations of remedial agents is so well established as to preclude the necessity research help of more than passing mention what is obvious is that in acute coryza, in chronic and acute nasal catarrh, in dry catarrhal conditions especially, in both forms of chronic rhinitis-- atrophic and hypertrophic-- in the latter stages of the prevailing grippe colds, and even in hay fever, v-e-m unguentum eucalyptol compound affords pronounced relief and proves a most grateful application ”though the identity and purity of eucalyptol are provided for by thestandards of the u s pharmacopeia, the claim is made that the productcontained in these preparations “transcends in purity and efficiencyall other brands ”a package of v-e-m unguentum eucalyptol compound, recently sent to aphysician, contains the following. “if your head is all stuffed up to-night, or you feel a cold coming on, use v-e-m just before going to bed it will break up the cold, and you’ll wake up in the morning, with your head clear and feeling fine all over “if you suffer with chronic or acute catarrh, use v-e-m regularly night and morning you’ll be agreeably surprised at the relief it will give you in a short time “there is nothing quicker, nothing surer to alleviate rhinitis, grippe-colds, or hay fever “in a word-- v-e-m is the best antiseptic ointment for all diseased conditions of the nose ”the council declared these preparations in conflict with its rulesbecause unwarranted therapeutic claims were made for them rule 6;because the public was advised to depend on them in the treatment ofdiseases rule 4, and because these combinations of ingredients, infixed proportions, under proprietary names, are irrational rules 8and 10 -- from reports of council on pharmacy and chemistry, 1917, p 163 hemo-therapin report of the council on pharmacy and chemistrythe following report on hemo-therapin has been adopted by the council, and its publication authorized w a puckner, secretary according to the hemo-therapin laboratories of new york city. “hemo-therapin is a combination of highly refined creosols and phenols which have been detoxicated by special processes with salts of iron, potassium, sodium, phosphorus and calcium in minute but physiologic proportions-- the solution as a whole being designed to approximately closely in various fundamental details the chemistry of the blood ”no statement is made as to the quantities of the several ingredients, nor is any information given as to the identity of the “creosols”and “phenols, ” nor the nature of the processes whereby these are“detoxicated ” it is further claimed that it is. “ the composite character of hemo-therapin, the relative proportion and balance of its several ingredients, and the action of the compound as a whole, to which its potency is due ”and it is suggested that. “it will be apparent that the ingredients which enter into the composition of hemo-therapin, a remedy used intravenously exclusively, have been selected with the utmost care with the object of assuring not only maximum therapeutic potency but also absolute safety and freedom from all dangers of toxic or other unpleasant or harmful action ” italics in the original the advertising does not explain, however, why the complex preparationshould be therapeutically efficient or why the intravenousadministration of this mixture should be absolutely safe and free fromtoxic or harmful action of the origin of hemo-therapin it is said. “for thesis years dr e b witte, a prominent physician of trenton, n j apparently owner of the hemo-therapin laboratories has devoted himself to the study of the blood as a result of his researches, he early determined that when the blood is close to normal standards, the body is well nourished, the natural waste products are properly eliminated, an effective resistance is offered to the invasion of pathogenic bacteria, and the various functions of the body are kept normally active but when, for one reason or another, the blood falls away from normal standards, the nutrition of the body suffers, the elimination of waste products is impaired, the resistance to germ attack is weakened, and the various functions of the body become sadly deranged and perverted in other words, instead of the physiologic processes of the body being normally active, as soon as the blood is depreciated, they become depressed or deranged, with a loss of the physiologic harmony or equilibrium that constitutes a state of health “recognizing the relation of clinical conditions to these various phenomena, dr witte reached the conclusion that the correction of thesis aberrant or diseased conditions depended on restoring the blood to as near to its normal state as possible he accordingly applied himself especially to investigation of the chemistry of the blood, with the object of evolving a substance in liquid form that would so closely approximate normal blood in its essential chemical characteristics that when introduced into the circulation it would bring the blood nearer to the condition in which it exists in health ”after the usual “thesis years of hard painstaking labor, ” dr witteelaborated a “fluid meeting the foregoing conditions” and now thehemo-therapin laboratories inform us that 5 to 10 c c of thissynthetic blood administered once in one, two or three days in “acuteaffection” and at longer intervals in “chronic ills”-- once a week issaid to be usually sufficient-- will restore blood to a normality andempower it to overcome most ills while disclaiming that “hemo-therapinis an infallible panacea, ” the medical profession is asked to believethat. “in erysipelas, septicemia, pyemia, the acute fevers, puerperal infection, furunculosis, carbuncles, malaria, acute rheumatism, pneumonia, typhoid fever, and in various skin diseases, such as eczema, psoriasis, herpes zoster, etc , the results have been prompt and gratifying ”it is “no less effective” in such “chronic ailments” as.

“spirocide is administered by means of fumigation and inhalation the patient is disrobed to the waist and placed in a light chair, preferably with arms a pastil or tablet of spirocide is placed on a small plate, or open receptacle, after being ignited by holding in a gas or alcohol flame for a minute or so until it begins to smoulder the plate with the burning spirocide is then placed on the floor between the patient feet or just research help under the chair a small shelf or platform between the lower rounds of the chair is an excellent location for the plate containing the burning mass when all is in position a sheet should be thrown over the patient and arranged to enclose the whole the patient should breathe naturally and inhale the vapor, which will rise and fill the canopy surrounding him the treatment will require 15 to 30 minutes, or until the spirocide is burned up the patient may complain at first of a slight choking sensation, and there may be essay tendency to cough this can be removed by raising the sheet long enough to let in a little clear air the eyes should be closed or lightly bandaged to avoid smarting ”experiments conducted in the a m a chemical laboratory show thatspirocide, when ignited, burns slowly with consequent volatilizationof mercury the several organic constituents serve as fuel and thecopper sulphate possibly acts as a regulator of the combustion duringthe burning process the cypress cones, henna, etc , are consumed butmost, if not all, the copper remains behind, the mercury only beingvaporized it is asserted in the advertising pamphlet that spirocide isindicated in all stages of syphilis, primary, secondary and tertiary, and in all its complications or sequelae in these varying conditionsone tablet daily or every other day is recommended until six treatmentshave been taken, though it is stated that “occasionally, depending onthe severity or the duration of the disease, it may be wise to givenine treatments, the last three at intervals of two, three or moredays ”essay of the results which it is claimed are obtained with spirocide are. “at the completion of this course of treatment with spirocide, all signs or evidences of syphilis are removed, and in ten days to three months all wassermann tests prove negative any further treatments than the original course of fumigations are rarely needed wassermann will be found uniformly negative after a period which, according to the patient, may vary from ten days to three months these results have been obtained in paper in which salvarsan and kindred preparations have been employed without the slightest benefit ”in a letter to the council the “scientific observer” of the spirocidecorporation declared. “we do not claim that the vaporization method is new we do claim, however, that this combination of mercury produces more rapid volatilization, certain absorption and undoubted effect than any form of mercury administered by any method known to science without the usual danger that this is so we are willing to prove by comparison with other methods both by ourselves and thesis observers scattered over the united states ”to determine the validity of the claims made for spirocide, thecorporation was asked to present the evidence which it offered inreply, the corporation “scientific observer, ” dr j lewengood, submitted 83 case reports from a number of different observers, including those from military hospitals and a state institution, andalso a reprint of an article published by him in the new york medicaljournal, feb 21, 1920, wherein were reported eight paper whichreceived “spirocide treatment ” in no case were controls with othermethods of mercury administration carried out this material the council sent to two recognized syphilographers foran opinion one of the consultants reported that of the 83 paper, 20 dealt with patients who had also received arsphenamin medicationand, therefore, these 20 paper could not be considered as evidenceconcerning the value of spirocide as to the remaining paper, hefound on the whole that the history and data furnished were far fromsufficient to warrant the claims made in thesis of the paper emphasiswas laid on the wassermann test, as though this test were the onlything to be considered in a case of syphilis he pointed out that inone case the reaction changed from negative to strongly positive aftersix treatments and that in several paper the phenomena reported cannotbe explained by anything else than a desire to get a negative bloodtest for example, one case had spirocide treatment and a wassermann, 1 plus, 55 days after. The author then reports that 19 days later thereaction had become negative and, therefore, the change must be due tospirocide in several of the paper reported it is even questionableif the patients were syphilitic the consultant concluded that theevidence submitted by the spirocide corporation failed to prove theclaims made for spirocide he pointed out on the other hand thatpatients readily become salivated from the use of spirocide, oftenafter 8 or 10 treatments the second consultant replied that in his opinion the claim thatspirocide produces more “undoubted effect than any form of mercuryadministered by any method known to science without the usual danger, ”was not substantiated he believed that it was not as effective as essayother methods, that the dosage is not as exact, and, therefore, it isnot as free from danger when the drug is pushed the council two consultants were also asked whether or not, in theiropinion, the administration of mercury by inhalation is a method whichthe council should endorse to the extent of recognizing a preparationbased on this principle this inquiry was also sent to the members ofthe editorial board of the archives of dermatology and syphilology five replies were received one advised a thorough study of thedifferent methods of administering mercury by inhalation the otherfour were opposed to such recognition on the ground that as the dosageis not exact the effects, therefore, are not certain in consideration of the opinions expressed by its consultants, thecouncil declared spirocide inadmissible to new and nonofficial remediesbecause 1 the claims made for it are unproved and unwarranted, 2the routine use of an inexact method for the administration of mercuryis detrimental to sound therapy and 3 the name is not descriptive ofits composition, thus failing to remind the physician who uses thesepastils that he is administering metallic mercury -- from the journala m a , jan 22, 1921 digifolin-ciba not admitted to n n r report of the council on pharmacy and chemistrythe council has authorized the publication of the following report, declaring digifolin-ciba inadmissible to new and nonofficial remedies w a puckner, secretary digifolin-ciba is a product of the society of chemical industryof basle, switzerland it is marketed in the united states by theciba company, 91 barclay street, new york city it is claimed thatdigifolin-ciba is “a preparation of digitalis leaves that has beenfreed from the useless and harmful principles such as digitonin saponin, coloring and inert matter, etc , but does contain all thereally valuable, therapeutically active constituents of the leaves, namely. Digitoxin and digitalein in their natural proportions ” thereis no evidence that digifolin contains all of the glucosides ofdigitalis as they exist in the leaf, and it is extremely improbablethat this is the case because one cannot remove saponin withoutaltering the other active principles of digitalis the ciba company sends out the following pamphlets relating todigifolin. “‘concerning digifolin-ciba, a new preparation of digitalis, ’ by c hartung, m d , ph d extracts from the work ‘ueber digifolin, ein neues digitalis-praeparat’ in the munich medical weekly, no 36, page 1944, 1912 ” “‘digitoxin contents of digifolin-ciba, ’ by c hartung, m d , ph d , basle, switzerland reprints from the pharmaceutical post, 1913 no 34, page 357 no 40, page 431 ” “‘pharmacological tests of digitalis, ’ by m j chevalier, chef des travaux pratiques de pharmacologie et matiere medicale, faculte de medecine de paris report presented to the societe de therapeutique at their meeting, may 28, 1913 ”in the reprint “concerning digifolin, ‘ciba ’” hartung lays stresson the presence of harmful and inert substances present in the leafand galenical preparations with the direct or implied statement thatdigifolin has an advantage in that these are absent from it this ismisleading it is true that boehm whom hartung cites, found saponin tobe irritating, but boehm states that it required 100 mg per kilogramof body weight to induce vomiting after its oral administration furthermore, saponin is present in traces only in infusion ofdigitalis, so that the therapeutic dose contains a wholly negligibleamount of it the following occurs in “pharmacological tests of digitalis, ” by m j chevalier. “hartung digifolin merits our attention, especially because it seems to possess all the pharmacodynamic properties of galenic preparations of digitalis without showing any of their disadvantages ”this claim scarcely needs comment, since it is well established thatthe chief “disadvantages” of digitalis are inherent in the principleswhich produce the desired effects of digitalis and may be avoidedto a large extent by a carefully regulated dosage of any digitalispreparation in short, the advertising for digifolin asserts that thisdigitalis preparation has all the advantages of digitalis itself, butnone of its disadvantages this claim has been refuted so frequentlythat manufacturers must be aware that it is untenable further theclaims now made for digifolin are essentially those made nearly fouryears ago at which time the attention of the american agent was calledto their unwarranted character the council declared digifolin-ciba inadmissible to new and nonofficialremedies because the therapeutic claims advanced for it are misleadingand unwarranted -- from the journal a m a , april 2, 1921 essay of loeser intravenous solutions report of the council on pharmacy and chemistrythe council has authorized the publication of the following reporton “loeser intravenous solution of hexamethylenamin, ” “loeserintravenous solution of hexamethylenamin and sodium iodid, ” “loeserintravenous solution of sodium salicylate, ” “loeser intravenoussolution of salicylate and iodid, ” “loeser intravenous solution ofsodium iodid” and “loeser intravenous solution of mercury bichlorid, ”put out by the new york intravenous laboratory, inc w a puckner, secretary the intravenous solutions of “hexamethylenamin, ” “hexamethylenaminand sodium iodid, ” “sodium salicylate, ” “sodium salicylate and sodiumiodid, ” “sodium iodid” and “mercuric chlorid” marketed by the new yorkintravenous laboratory, inc , are solutions of official substances soldunder their official names they would, therefore, be outside the scopeof the council, were it not that special and general therapeutic claimsare made for them such special claims, for instance, are contained inan advertisement in the illinois medical journal for oct 20, 1920, which gives, under the various drugs, a list of diseases in which thedrugs are said to be “indicated ” the council is unable to agree withessay of these recommendations the fundamental objection, however, isthe general claim of superiority and safety of the intravenous method the intravenous solutions named above would naturally have little saleif such special claims were not made for them while the claims may notbe made directly, they are carried by such display phrases as “for theprogressive physician seeking improved clinical results” and “a safepractical office technique ”the council continues to hold that intravenous medication, generally, is not as safe as oral medication even with relatively harmlesssubstances a fact again illustrated by the results of hanzlik andkarsner, 1920, journal pharmacology and experimental therapeutics, 14, 379, and that it does not give “improved clinical results” exceptunder rather narrowly confined circumstances-- namely, if the drugundergoes decomposition in the alimentary tract, if it is not absorbed, if it causes serious direct local reaction or if time is an urgentelement each intravenous preparation for which advantage over oraladministration is claimed, directly or by implication, must be examinedfrom these points of view the council has recognized intravenous preparations which satisfiedthese requirements it is evident, however, that hexamethylenamin, sodium iodid and sodium salicylate do not when given orally they donot undergo material decomposition in the digestive tract, they arerapidly absorbed, they cause no direct local reaction, and in theconditions in which they are used the hour or so which is required forabsorption is immaterial, especially as they are used continuously foressay time mercuric chlorid does indeed produce essay local irritation, but there is as yet no convincing evidence that its intravenousinjection causes less injury than oral administration more experienceunder controlled conditions is needed before the intravenous use ofmercuric chlorid can be approved especially objectionable are thefixed proportion mixtures of sodium iodid with sodium salicylate andwith hexamethylenamin the dosage of all three drugs has to be adaptedto individual conditions this is impossible when giving them in fixedproportions the council voted not to accept “loeser intravenous solution ofhexamethylenamin, ” “loeser intravenous solution of hexamethylenaminand sodium iodid, ” “loeser intravenous solution of sodiumsalicylate, ” “loeser intravenous solution of salicylate and iodid, ”“loeser intravenous solution sodium iodid” and “loeser intravenoussolution of mercury bichlorid” for new and nonofficial remedies becausethey are sold under misleading claims regarding their alleged safetyand efficiency in view of this fundamental objection the individualclaims for each preparation were not passed on -- from the journala m a , april 16, 1921 “national iodine solution” not admitted to n n r report of the council on pharmacy and chemistrythe council has authorized publication of the following report w a puckner, secretary “national iodine solution” is a proprietary sold by the national drugco , philadelphia, pa from inquiries received by the council onpharmacy and chemistry it is evident that the product is extensivelybrought to the attention of physicians by means of circulars the nameimplies that it is a solution of iodin and the inference is given thatit has the advantages of iodin without the disadvantages compositionin view of the foregoing, the council took up the investigation of“national iodine solution, ” and in turn asked the a m a chemicallaboratory to analyze it the chemist report follows:according to the label of national iodine solution, “each fluidouncerepresents three grains proteo-albuminoid compound of iodin national”. Also an alcohol declaration of 7 per cent is made otherwise no information is given as to the composition either of the“solution” or of “proteo-albuminoid compound of iodine ”each bottle contained about 115 c c nearly 4 ounces of a yellowishsolution, acid in reaction, having an odor resembling witch hazel. Itsspecific gravity at 25 c was 0 9860 qualitative tests indicated thepresence of zinc, alcohol, sulphate, an iodin compound the solutiongave tests which indicated a very small amount of free iodin. Mostof the iodin was in the form of ordinary iodid, a small amount ofvegetable extractives, and traces of aluminum and potassium if anyprotein was present, it was in amounts too small to be identified, though a small amount of a nitrogenous compound was present the amountof solids in “national iodine solution” was equivalent to 0 72 percent, and the amount of ash, to 0 2 per cent quantitative estimationsyielded the following. Alcohol by volume 7 0 per cent zinc zn 0 096 per cent iodin free and combined 0 029 per cent sulphate so₄--    0 146 per cent protein n × 6 36 0 012 per cent the above findings indicate that each 100 c c contains about 7 c c ofalcohol, 0 5 gram of zinc sulphate u s p znso₄7h₂o , 0 03 gramof iodin, 0 01 gram of protein calculated as such from nitrogen timesthe factor 6 36 and essay hamamelis water expressed in equivalentapothecary terms, each fluidounce contains essentially. Zinc sulphate 2-1/3 grains iodin free and combined 1/8 grain protein 1/25 grain alcohol 34 minimsthis amount of alcohol is equivalent to about 3-1/2 fluidrams of witchhazel water although the label states that each fluidounce containsthree grains of “proteo-albuminoid compound of iodine, ” yet the sum ofthe protein calculated from nitrogen content and iodin components isequivalent to less than 1/5 grain “national iodine solution” appears to be very similar to “gonocol” thenational drug co , philadelphia, pa , which was analyzed by the bureauof chemistry of the u s dewritingment of agriculture the bureau statedthat “it gonocol consisted essentially of an aqueous solution of zincsulphate, hamamelis water, a small amount of alcohol, 0 38 grain ofiodin, and 0 36 grain of protein per fluidounce ”it is evident that “national iodine solution” is not a solution offree elementary iodin as the name suggests. Instead it appears to bea solution of zinc sulphate in witch hazel water containing less than0 03 per cent of combined iodin and not more than a trace of freeiodin “national iodine solution” is one more to be added to thatalready long list of proprietaries which makes capital of the highesteem in which physicians hold iodin the claimsan advertising circular sent to physicians begins. “dear doctor. We beg to suggest a line of treatment while using national iodine solution which our thesis years of experience has proven to us to give the best and quickest results in the treatment of inflammation of the urethral tract ”in it are given directions for the treatment of “acute gonorrhea, male, ” “anterior urethritis, ” “anterior-posterior urethritis, ” “ardorurinæ and chordee, ” etc , by means of national iodine solution andother proprietaries of the national drug company make in fact thesolution is claimed to be “indicated in all conditions of urethraaccompanied by a discharge ” comment and conclusionsthe therapeutic claims made for “national iodine solution” areunwarranted such a solution is not indicated in all conditions of theurethra accompanied by discharge the advice contained in the circularis equivalent to mail-order treatment of gonorrhea it is of interest to note that the claims for an identical or asimilar solution prepared by the national drug company as a treatmentfor gonorrhea and intended for use by the laity, has been adjudgedmisbranded by the federal authorities notice of judgment no 8150, issued jan 25, 1921 in that it misled and deceived the purchaseror purchasers thereof in the statements regarding the therapeuticor curative effects of the article, which falsely and fraudulentlyrepresent it to be indicated in all conditions of the urethraaccompanied with a discharge, “whereas in truth and in fact it was not ”the council would emphasize that if physicians give heed to advertisingsuch as that sent out by the national drug company for this preparationthe medical profession cannot with good grace protest against theroutine treatment of venereal diseases by quacks and “patent medicine”venders -- from the journal a m a , june 4, 1921 mon-arsone not admitted to n n r report of the council on pharmacy and chemistrythe council has authorized publication of the following report w a puckner, secretary mon-arsone is offered by the harmer laboratories company as “a newand non-toxic arsenical for the treatment of syphilis ” in theadvertisements for mon-arsone it has been claimed that with thisdrug “the toxic, corrosive and uncertain reactions attending the useof arsphenamine have been entirely eliminated” and that “it has atherapeutic value equal to arsphenamine, but extensive case reportsfail to record the slightest toxic reaction following its use ”according to the manufacturers, mons-arsone is disodiumethylarsonate, the sodium salt of ethylarsonic acid, derived from arsenic acid byreplacement of one hydroxyl group by the ethyl group-- aso ch₂ch₃ oh₂ mons-arsone is related to sodium cacodylate, which is the sodium saltof dimethyl-arsenic acid-- aso ch₃₂oh-- derived from arsenic acid byreplacement of two hydroxyl groups by two methyl groups ethylarsonicacid and its potassium salt were described by la coste139 more thanthirty-five years ago, and the use of the sodium salt of methylarsonicacid was proposed in france essay years ago the harmer laboratoriescompany claims originality for mons-arsone in that it was the firstto prepare the sodium salt of ethylarsonic acid and to propose itstherapeutic use 139 la coste.

These are ferments or enzymes the vegetable acids, metalloids and metals present in all plants in colloid form act biochemically among the metalloids are hydrogen, carbon, manganese, oxygen, sulphur, phosphorus and chlorine. The heavy metals are iron, potassium, sodium, magnesium and copper these biochemic principles are always present in plants as colloids ”it is claimed by the merrell company that. “proteogens stimulate the cytogenic mechanism to higher activity. Therefore, indirectly cleave the invading microorganism and eliminate their special toxins proteogens swing the disturbed metabolism back to normal and, by natural processes, build up effective defenses against recurrent bacterial attacks ”proteogen no 1 was first introduced as “plantex, ” and at that time themerrell company referred to a preparation that was the result of “aseries of studies” carried out by a “noted biologist” with a view of“evolving a cancer remedy” that was “to be autolytic in character, ” andannounced. “the house of merrell always interested in the progress of plant therapy, began pharmacological experimentations to reproduce this same substance the qualitative and quantitative analysis of the substance as used in new york having been published simplified matters a essaywhat similar remedy has now been prepared it consists of the following substances-- menyanthes trifoliata buckbean, melilotus officinalis yellow sweet clover, mentha crispa curled mint, brassica alba white mustard, anemone hepatica liver leaf, viola tricolor pansy, anthemis roman chamomile, fructus colocynthidis colocynth, lignum quassiæ quassia, urtica dioica nettle, radix rhei rhubarb root, hedge hyssop these substances are in approximately equal proportions with the exception of the mustard which forms 20 per cent of the mixture, and the colocynth fruit which is 5 per cent ”with respect also to the other proteogens listed above, study ofmedical literature revealed no evidence establishing their therapeuticvalue. In fact, no evidence was found other than that appearing inthe advertising matter of the manufacturer the range of diseases inwhich proteogens are recommended is so wide as to make obvious thelack of scientific judgment which characterizes their exploitation acircular letter, received january, 1919, reminded the physician thatabout a year ago his attention had been directed to proteogen no 1for cancer, that later developments enabled the firm to recommend forhis consideration “a series of proteogens nos 2 to 9, ” and that now“in response to an insistent demand, dr a s horowitz has preparedtwo new proteogens-- no 10 for syphilis and no 11 for gonorrhea ”a postscript to this circular letter announced another preparation, “proteogen no 12 for influenza and pneumonia, ” a “development out ofthe present influenza epidemic, ” and admitted that “it has not hadthe clinical experimentation that precedes our introduction of a newproduct ”the introduction of no 12 was effected by means of a special bulletinwhich consists exclusively of clinical reports from seven physicians, all from chicago save one, and all purporting to show most favorableresults from no 12 they describe paper which any physician withexperience with influenza can duplicate without any special treatment it is difficult to give serious consideration to a set of allegedremedies when the only evidence is that furnished by the proponents ofthe alleged remedies this is writingicularly true when the alleged remedydoes not make a sufficient appeal to one sense of the rational intherapeutics to lead one to feel justified in asking a trial at thehands of careful clinical observers considering the grave nature ofthe diseases for which proteogens are recommended, writingicularly cancer, tuberculosis, and pernicious anemia, the want of a rational basisfor the method of treatment and the general tenor of the advertisingmatter, it appears safe to conclude that these agents do not representany definite advance in therapeutics as the use of preparations, secret in composition, and of noestablished value, is contrary to rational therapy, it is recommendedthat the proteogen preparations be declared in conflict with rules 1, 6and 10 report of second referee reviewing manufacturers’ replythe report declaring the proteogens of the william s merrell companyinadmissible to new and nonofficial remedies was adopted by thecouncil, but before publication it was sent to the merrell companyfor such comments as it might desire to make in due time the replyof the firm was received it consisted of two volumes bound in limpmorocco, each stamped in gold. “report proteogen therapy requested bythe american medical association, 1919. The wm s merrell company ”the first volume contained 79 pages of typewritten material. The secondvolume contained 76 pages of typewritten material and a number ofadvertising booklets put out by the wm s merrell company, exploitingthe proteogens among the typewritten material was a 14-page report on “proteogentherapy” by its originator, a s horowitz following this thereare several pages devoted to what is termed “a short qualitativedescription of the ingredients of major importance in proteogens ”then follows a page describing the advertising of proteogens, andthe remainder of the two books is devoted to testimonials, laudingthe benefit of proteogens in diseases such as cancer, tuberculosis, rheumatism, asthma, influenza, enlarged prostate, rheumaticendocarditis, syphilis, eczema, psoriasis, diabetes, secondary anemia, gonococcic infections, etc finally, there are attached samples ofadvertising pamphlets the dissertation by a s horowitz contains little actual informationconcerning these substances, but is concerned principally withdiscussion of foreign proteins, “antiferments, ” “non-specificproteins, ” “anti-virolins” and speculations on their hypotheticalactions and interactions on each other and on the organs of the bodyand on bacteria the report contains thesis questionable statements one finds in this report but few definite statements of facts whichare known to be accurate or which could be accepted without question the qualitative description of the proteins and their components isas vague as the previous discussion the differentiation between thevarious proteogens is extremely indefinite. That for tuberculosis, no 3 is described as “polyvalent, non-specific protein which rapidlyattacks the acid-fast, encapsulated tubercle bacilli”. Proteogen no 10 for syphilis is said to be a combination of “non-specific plantproteins and different chemicals which has the power to paralyze anddestroy living spirochete ” it is stated that proteogens are scientificpreparations based on standard ingredients and that the standardizationis more accurate than in serums, vaccines or toxins, etc the reportgives no proof of such statements the testimonials that are submitted are typical of “reports” thatmanufacturers are able to obtain from essay physicians, to prove theefficacy of almost any preparation in any disease each consists, practically, of the opinion of the individual who has employed theproteogens or the opinion of the patient who has been treated few dataare given in these reports from which an imwritingial conclusion might bedrawn a few of the testimonials presented by the william s merrellcompany follow the valuelessness of such material as scientificevidence is obvious. Rheumatism:-- proteogen no 2 -- the doctor has one case being treated with no 2 she has improved so rapidly she cannot express her pleasure, and will continue for essay time on the treatments she is a patient who was confined during the time she suffered from a rheumatic illness, and it seemed to affect her mental condition this condition is clearing up also, very much to the pleasure of both patient and doctor -- november 27, 1918 influenza:-- proteogen no 12 -- first day, temperature 102, gave 1 c c proteogen no 12. Second day, temperature 100, gave 1 c c proteogen no 12.

  • how to quote dialogue in an essay
  • college admission essay editing services
  • should police wear body cameras essay
  • buy persuasive essay
  • do my accounting assignment for me
  • civil war essay
  • the best essay writers
  • custom papers essay
  • buy movie reviews paper
  • article ghostwriter
  • essay on education
  • third person essay
  • what is happiness essay
  • pay someone to do your essay
  • essay writing service on
  • online essay writers
  • shut down your screen week essay
  • dental personal statement writing services
  • anatomy and physiology case study help
  • how to transition in an essay
  • essay writer generator

And while it is unnecessary to reproduce all of these here, a few may be given in order to suggest suitable methods of prescribingiron when it cannot be given in sufficient amounts in the food in chlorosis hunter advises that that form of iron which experience hasshown to be least disturbing to the patient stomach should be used, and he suggests separate stomachic mixtures to be used simultaneously, not mixed with the iron itself when constipation exists-- and this is avery common accompaniment of chlorosis-- he gives the following aperientiron combination. gm or c c ℞  ferrous sulphate |25 gr iv magnesium sulphate 4| ʒ i aromatic sulphuric acid |5 ♏ vii tincture of ginger |7 ♏ x compound infusion of gentian b p q s , ad 30| ℥ ithis, constituting a single dose, is to be taken twice daily-- at11 a m and 6 p m a little compound tincture of gentian andwater may be used in place of the compound infusion of the britishpharmacopeia he modifies this essaywhat as occasion demands by usingsodium sulphate and adding sodium bicarbonate which converts thesulphate of iron into ferrous carbonate and adds 10 minims of spiritof chloroform to act as a stomachic hunter also suggests the use of pills of aloes and iron in place ofthe mixture described above, and when constipation has been corrected, the aloes may be omitted and the pill of ferrous carbonate alone maybe used for the iron hunter comment regarding this pill is, “verysatisfactory ”the same form of iron is available in the compound iron mixture, formerly official, which hunter says is exceedingly good in thiscountry the compound solution of iron and ammonium acetate, bashammixture, so called, has long enjoyed a wide reputation as causing verylittle disturbance of the stomach, and the homely tincture of ferricchlorid is probably useful in a large majority of paper in which thestomach is not especially irritable we may say with assurance that one of the forms suggested herewill suffice for practically every case in which it is necessaryto reinforce the amount of iron available in the food by essaypharmaceutical preparation if these do not satisfy your requirements, consult a really competent pharmacist and enlist his aid in devisinga mixture especially suited to your individual patient -- from thejournal a m a , dec 29, 1917 article iv cactina pilletsthis preparation may be considered briefly in view of the recentdiscussion in this series of articles of the pharmacology of thedigitalis group and the principles of treatment in cardiovasculardisease the manufacturers maintain that cactina is wholly unlikedigitalis, and that is the truth, as we shall show. But since theyclaim that it is useful in certain conditions of the heart in whichdigitalis is commonly employed by well informed clinicians, it isnecessary to consider its cardiac actions-- or its lack of them!. it isdifficult to determine just what action cactina is supposed to exert onthe heart for example, one advertisement contains the following. “cactina pillets a gentle cardiac tonic that supports and sustains the heart through its capacity to improve cardiac nutrition ”just how the cardiac nutrition is to be improved without an improvedcoronary circulation is not explained it would be interesting to knowin what other way this is to be accomplished, and how an improvedcoronary circulation can be induced without acting on the heart orvessels but that is what digitalis does, and you should remember thatcactina is so very different from digitalis!. then again.