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The author then reports that 19 days later thereaction had become negative and, therefore, the change must be due tospirocide in several of the paper reported it is even questionableif the patients were syphilitic the consultant concluded that theevidence submitted by the spirocide corporation failed to prove theclaims made for spirocide he pointed out on the other hand thatpatients readily become salivated from the use of spirocide, oftenafter 8 or 10 treatments the second consultant replied that in his opinion the claim thatspirocide produces more “undoubted effect than any form of mercuryadministered by any method known to science without the usual danger, ”was not substantiated he believed that it was not as effective as essayother methods, that the dosage is not as exact, and, therefore, it isnot as free from danger when the drug is pushed the council two consultants were also asked whether or not, in theiropinion, the administration of mercury by inhalation is a method whichthe council should endorse to the extent of recognizing a preparationbased on this principle this inquiry was also sent to the members ofthe editorial board of the archives of dermatology and syphilology five replies were received one advised a thorough study of thedifferent methods of administering mercury by inhalation the otherfour were opposed to such recognition on the ground that as the dosageis not exact the effects, therefore, are not certain in consideration of the opinions expressed by its consultants, thecouncil declared spirocide inadmissible to new and nonofficial remediesbecause 1 the claims made for it are unproved and unwarranted, 2the routine use of an inexact method for the administration of mercuryis quality custom essays phone number detrimental to sound therapy and 3 the name is not descriptive ofits composition, thus failing to remind the physician who uses thesepastils that he is administering metallic mercury -- from the journala m a , jan 22, 1921 digifolin-ciba not admitted to n n r report of the council on pharmacy and chemistrythe council has authorized the publication of the following report, declaring digifolin-ciba inadmissible to new and nonofficial remedies w a puckner, secretary digifolin-ciba is a product of the society of chemical industryof basle, switzerland it is marketed in the united states by theciba company, 91 barclay street, new york city it is claimed thatdigifolin-ciba is “a preparation of digitalis leaves that has beenfreed from the useless and harmful principles such as digitonin saponin, coloring and inert matter, etc , but does contain all thereally valuable, therapeutically active constituents of the leaves, namely. Digitoxin and digitalein in their natural proportions ” thereis no evidence that digifolin contains all of the glucosides ofdigitalis as they exist in the leaf, and it is extremely improbablethat this is the case because one cannot remove saponin withoutaltering the other active principles of digitalis the ciba company sends out the following pamphlets relating todigifolin. “‘concerning digifolin-ciba, a new preparation of digitalis, ’ by c hartung, m d , ph d extracts from the work ‘ueber digifolin, ein neues digitalis-praeparat’ in the munich medical weekly, no 36, page 1944, 1912 ” “‘digitoxin contents of digifolin-ciba, ’ by c hartung, m d , ph d , basle, switzerland reprints from the pharmaceutical post, 1913 no 34, page 357 no 40, page 431 ” “‘pharmacological tests of digitalis, ’ by m j chevalier, chef des travaux pratiques de pharmacologie et matiere medicale, faculte de medecine de paris report presented to the societe de therapeutique at their meeting, may 28, 1913 ”in the reprint “concerning digifolin, ‘ciba ’” hartung lays stresson the presence of harmful and inert substances present in the leafand galenical preparations with the direct or implied statement thatdigifolin has an advantage in that these are absent from it this ismisleading it is true that boehm whom hartung cites, found saponin tobe irritating, but boehm states that it required 100 mg per kilogramof body weight to induce vomiting after its oral administration furthermore, saponin is present in traces only in infusion ofdigitalis, so that the therapeutic dose contains a wholly negligibleamount of it the following occurs in “pharmacological tests of digitalis, ” by m j chevalier.

Of the second were resisting, crepitant, and quite œdematous no subpleural ecchymoses in either the experiments on animals by corin812 led him to conclude that pressure on the pneumogastrics caused increased frequency of the heart-beat and slowing of respiration pellier813 considers the subject quite fully it would appear that the pressure on the pneumogastrics disposes to stop the action of the heart and cause rapid, perhaps instant death the pressure on the carotids causes cerebral anæmia and is then only a secondary cause levy814 does not think the action of the pneumogastrics is sufficiently well known tidy states that a dog lived for three hours suspended by a rope placedabove an opening in the windpipe. And that smith815 mentions the caseof a criminal who was hung. Chovet tried to save the man by making anopening in the trachea before the execution and introducing a smalltube the man was alive forty-five minutes after the drop, but couldnot be resuscitated, although the surgeon bled him in a small proportion of paper of hanging, homicidal and judicial, death occurs by dislocation of the spine this is said to have beenfirst noticed by the celebrated louis, who states that the parisexecutioner was in the habit of giving a violent rotary movement tothe body of the convict as the trap was sprung, causing a dislocationof the odontoid process and compression of the cord and almost instantdeath taylor816 says that for dislocation the body must be heavy andthe fall long and sudden devergie817 found this to occur in abouttwo per cent of paper it is said that the paris hangman placed theslip-knot under the chin in front, which is as dr haughton suggests death may occur from secondary causes after apparent recovery. Fromcongestion of brain and other lesions of the nervous system. These mayprove fatal at remote periods fracture of the odontoid process according to m de fosse is morecommon than dislocation, and the giving away of the intervertebralsubstance more likely than either of the others the phrenic andother respiratory nerves are likely to be paralyzed.

Distinctly acid c dropped on inside of cheek:chlorlyptus, 1/3 c c. After six minutes, litmus very red after ten minutes, faintly red after fifteen minutes, blue chlorlyptus oil, 1 c c after three minutes, faintly red after eight minutes, neutral conclusions -- on contact with living tissues, the acid of chlorlyptusis rapidly neutralized and absorbed the surface is neutral within ten or fifteen minutes it is therefore very improbable that the acidity is effectivelyantiseptic a comparison of chlorlyptus with dilute acetic acid shows that thechlorlyptus does not maintain the acidity even as well as 1 per cent acetic acid acetic acid chlorlyptus tongue, a drop of 5 per cent. Still neutral between five slightly acid to litmus after ten minutes. and ten minutes taste almost gone in two minutes gums, a few drops between cheeks and gums. neutral between ten five per cent still strongly acid in and fifteen minutes twelve minutes. Distinctly acid in seventeen minutes one per cent still strongly acid in twenty-one minutes -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -chlorlyptus. Reaction litmus paper on contact with tissue serial when quantity, time blue symptoms or no animal injected c c of death litmus toxicity 1 rat pleura 1 1/2 hour remains blue none. Killed. pleura not congested. lung spec 21. Slight congestion 2 rat pleura <1 1 hour remains blue negative 3 rat pleura 1 23 min remains blue almost at once bad gasping respiration and died in 23 m. Heart distend. possibly injection penetrated lung peritoneum 1 23 min turns red 4 rabbit pleura 1 died overnight 5 dog pleura 1 1/4 hour remains blue 20 m p m peritoneum 1 1/4 hour remains blue 20 m p m 6 dog pleura 1 3 min remains blue 45 m p m peritoneum 1 3 min remains blue 45 m p m 7 dog pleura 1 20 min remains blue 20 m p m peritoneum 1 20 min remains blue 20 m p m series b.

Iron, iodine, phosphorous, calcium and sodium each in separate basic combination ”according to the label, iodiphos is “alterative, tonic, nervine andanti-tubercular” and is “for treatment of blood, nerves and pulmonaryorgans ” an advertising circular129 asserts that “iodiphos exerts itsphysiological action rapidly in hardening of the arteries, high bloodpressure, anaemia, glandular swelling, neurasthenia, hypochondria, phthisis, bronchitis, asthma, pneumonia and as an intestinal antisepticand appetizer, ” and declares it to be “indispensable as a tonic andrestorative ”129 after publication of the foregoing report had been authorized bythe council, a letter was received from charles l heffner, advisingthat the distribution of the circulars has been discontinued in the advertising circular it is averred that in the production ofiodiphos “chemistry again aids the modern physician ” iodiphos isanother instance when a decadent polypharmacy proposes haphazardmedication and so obstructs the efforts of modern medicine to establishthe use of single drugs to meet definite indications iodiphos is inadmissible to new and nonofficial remedies because itis an irrational mixture of drugs sold with therapeutic claims thatare unwarranted, and under a name which is not descriptive of itscomposition -- from reports of council on pharmacy and chemistry, 1919, p 81 mervenol and armervenol not admitted to n n r report of the council on pharmacy and chemistrythe council has authorized publication of the report which appearsbelow declaring mervenol and armervenol, marketed by the hillelaboratories, inadmissible to new and nonofficial remedies w a puckner, secretary mervenol is stated by the proprietors-- the hille laboratories, chicago-- to be a hydrosol colloidal suspension of the sulphides ofmercury and copper, containing sufficient sodium chloride to make itisotonic with blood serum, and “inert proteid” and “carbohydrate” tostabilize the colloidal suspension. Each cubic centimeter is stated tocontain 0 005 gm mercury, 0 0016 gm copper, and 0 0016 gm sulphur it is claimed that this preparation is of value in pneumonia, influenza, and other conditions and diseases requiring increasedleukocytosis it is further claimed that the properties and therapeutic effects ofthis preparation are as follows. “practically non-irritant. Practicallynon-toxic. Lower temperature, often crisis like. Lower pulse, withbetter elimination. Greatly accelerated recovery from influenza;fewer pneumonia complications. Lower mortality rate in influenza andpneumonia. Remarkable leucocyte stimulation ” administration by mouthand by intramuscular and intravenous injection are advocated in the recent influenza epidemic, it is reported that therapeuticresults of essay value were obtained at the great lakes trainingstation and at fort sheridan the reports of certain medical officersindicate that this preparation seemed to have essay effect on thecourse of pneumonia and influenza, on the temperature, and on theleukocyte count but those conducting the experiments state that it was“absolutely impossible” to fulfil ideal conditions as to controls andother observations at the time the experiments were conducted so far as the council knows, no effort has been made to determine thepotent constituent, or constituents, of this preparation. Whether themercury, the copper, or the protein in the mixture was responsible forthe claimed benefits is an open question these reports were given careful consideration, but it was decidednot to accept this preparation because of 1 exaggerated therapeuticclaims, conflicting with rule 6 aside from the report of its usein influenza and pneumonia at the great lakes training station andthe post hospital at fort sheridan, which reports are of work doneand observations made under conditions which did not permit carefulcontrols, no evidence has been presented to the council supporting thetherapeutic claims and 2 being an irrational mixture, conflictingwith rule 10-- a mixture containing colloidal mercury, copper andsulphur with proteins and carbohydrates in addition, it is difficult topredict the changes which occur in such mixtures on standing samples of mervenol two 1-ounce bottles submitted by themanufacturer, june 5, 1919, were found when opened, aug 18, 1919, tohave undergone decomposition a very disagreeable odor had developed, the liquid was turbid, and a large amount of precipitate had formed armervenol is stated by the proprietors-- the hille laboratories, chicago-- to be a hydrosol colloidal suspension of“mercury-copper-sulpharsenite” containing sufficient sodium chloridto make it isotonic with blood serum and “inert proteid” and“carbohydrate” to stabilize the solution. Each cubic centimeter isdeclared to contain 0 0025 gm arsenic, 0 005 gm mercury, 0 0016 gm copper, and 0 0032 gm sulphur the use of armervenol as advised by the hille laboratories is the sameas that of mervenol, and in addition its use in syphilis is emphasized the criticisms of this mixture are similar in every respect to thosedirected against mervenol-- the addition of arsenic introduces stillanother factor of uncertainty after investigating these claims, it was decided not to accept thispreparation on the ground 1 that the therapeutic claims are unprovedand unwarranted, conflicting with rule 6, and 2 that the mixture isan irrational one, conflicting with rule 10 -- from reports of councilon pharmacy and chemistry, 1919, p 82 normal phenol serum cano and methyl-phenol serum cano not accepted for n n r report of the council on pharmacy and chemistrythe council has adopted the following statement declaring normal phenolserum cano and methyl-phenol serum cano ineligible to new andnonofficial remedies w a puckner, secretary no statement of the composition of these preparations was submittedto the council and none appears on the labels of the trade packages however, the advertising circular contains statements such as.

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If mars be in a virgin, in the nativity, they say he causes the cholic it is well god hath set essay body to pull down the pride of man hein the virgin troubles none with the cholic, but them that know notthemselves for who knows himself, may easily know all the world wormwood, an herb of quality custom essays phone number mars, is a present cure for it. And whether it bemost like a christian to love him for his good, or hate him for hisevil, judge ye i had almost forgotten, that charity thinks no evil iwas once in the tower and viewed the wardrobe, and there was a greatthesis fine clothes. i can give them no other title, for i was nevereither linen or woolen draper yet as brave as they looked, my opinionwas that the moths might consume them. Moths are under the dominion ofmars. This herb wormwood being laid among cloaths, will make a mothscorn to meddle with the cloaths, as much as a lion scorns to meddlewith a mouse, or an eagle with a fly you say mars is angry, and it istrue enough he is angry with thesis countrymen, for being such fools tobe led by the noses by the college of physicians, as they lead bears toparis garden melancholy men cannot endure to be wronged in point ofgood fame, and that doth sorely trouble old saturn, because they callhim the greatest infortunate. In the body of man he rules the spleen, and that makes covetous man so splenetic the poor old man lies cryingout of his left side father saturn angry, mars comes to him. Come, brother, i confess thou art evil spoken of, and so am i. Thou knowest ihave my exaltation in thy house, i give him an herb of mine, wormwood, to cure the old man. Saturn consented, but spoke little, and so marscured him by sympathy when mars was free from war, for he loves tobe fighting, and is the best friend a soldier hath i say, when marswas free from war, he called a council of war in his own brain, to knowhow he should do poor sinful man good, desiring to forget his abuses inbeing called an infortunate he musters up his own forces, and placesthem in battalia oh!. quoth he, why do i hurt a poor silly man orwoman?. his angel answers him, it is because they have offended theirgod, look back to adam.