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The rootis white, hard and woody, and divers fibres annexed thereunto, whichperishes not, but abides with leaves thereon all the winter, shootingout fresh every spring place it grows in most fields and meadows, and about their bordersand hedges, and in thesis waste grounds also every where time it usually flowers in june and july, and the seed is ripeshortly after government and virtues saturn challenges the herb for his own thisknapweed helps to stay fluxes, both of blood at the mouth or nose, or other outward writings, and those veins that are inwardly broken, orinward wounds, as also the fluxes of the belly. It stays distillationof thin and sharp humours from the head upon the stomach and lungs. Itis good for those that are bruised by any fall, blows or otherwise, and is profitable for those that are bursten, and have ruptures, bydrinking the decoction of the herb and roots in wine, and applyingthe same outwardly to the place it is singularly good in all runningsores, cancerous and fistulous, drying up of the moisture, and healingthem up so gently, without sharpness. It doth the like to running soresor scabs of the head or other writings it is of special use for thesoreness of the throat, swelling of the uvula and jaws, and excellentlygood to stay bleeding, and heal up all green wounds knotgrass it is generally known so well that it needs no description place it grows in every county of this land by the highway sides, and by foot-paths in fields.

Calc glycerophos 4. Potas bicarb 15;sod bicarb 22 and sod chlor q s ” for obvious reasons thecouncil does not accept a mixture containing an indefinite ingredientand hence it would be necessary as a preliminary for the considerationof any one of the mixtures that their unofficial ingredients bemade eligible for new and nonofficial remedies by the submission ofevidence that such ingredient is of uniform composition and that it istherapeutically valuable when given by mouth there is no evidence thatthesis of these organs have any value whatever when administered by themouth or in any other way 2 in the light of our knowledge the administration of gland mixturesin the host of conditions enumerated in the advertising circular isirrational and on a par with the use of the shotgun mixtures once invogue be it a pharmaceutical mixture, a “mixed” vaccine, or a“pluriglandular” product, the combination of two medicinal ingredientsin a mixture must be considered contrary to rational therapy unlessa good reason exists for such combination such mixtures are held inconflict with rule 10 unless the manufacturer presents acceptableevidence for the value of his combination a physician may prescribeany mixture which he considers indicated in a given case, but themarketing of mixtures of drugs in fixed proportions is in mostinstances irrational and a detriment to sound therapy -- from thejournal a m a , jan 18, 1919 cerelene not admitted to n n r report of the council on pharmacy and chemistrythe council has authorized publication of the following reportdeclaring cerelene inadmissible to new and nonofficial remedies w a puckner, secretary cerelene, a paraffin preparation for the treatment of burns, wassubmitted to the council by the holliday laboratories, with thestatement that it was composed of 84 per cent paraffin, 15 per cent myricyl palmitate, and 1 per cent purified elemi gum to which is addedoil of eucalyptus 2 per cent and betanaphthol 0 25 per cent it wasexplained. “myricyl palmitate is a purified form of beeswax, free from all impurities, acids, etc , which is solely manufactured by this company ”it was also stated that on “special order” cerelene has been madecontaining oil of eucalyptus and resorcin, oil of eucalyptus and picricacid, and picric acid alone the following report on the preparationwas presented to the council by the referee to whom cerelene had beenassigned. Cerelene is another compound wax for the treatment of burns according to the work of sollmann j a m a , 68:1799, 1917 it is highly improbable that compound mixtures have any advantage over simple paraffin of low melting point cerelene must therefore be considered as an unessential modification of paraffin, and as in conflict with rule 10. Unless definite evidence of superiority is submitted cerelene mixtures containing medicinal ingredients also appear unscientific since the evidence that the ingredients do not leave the wax has not been successfully contradicted finally, the claims made for cerelene are rather extreme, and would need essay revision before they could be accepted the a m a chemical laboratory reports. The physical properties of cerelene are as follows. melting point 50 0 c by u s p method ductility limit 30 5 c plasticity limit 26 4 c not strong at 38 c adheres moderately well.

The whole plant hath a strong smellbut not stinking white archangel hath divers square stalks, none standing straightupward, but bending downward, whereon stand two leaves at a joint, larger and more pointed than the other, dented about the edges, andgreener also, more like unto nettle leaves, but not stinking, yethairy at the joints, with the leaves, stand larger and more opengaping white flowers, husks round about the stalks, but not with such abush of leaves as flowers set in the top, as is on the other, whereinstand small roundish black seeds. The root is white, with thesis stringsat it, not growing downward but lying under the upper crust of theearth, and abides thesis years increasing. This has not so strong a scentas the former yellow archangel is like the white in the stalks and leaves. But thatthe stalks are more straight and upright, and the joints with leavesare farther asunder, having longer leaves than the former, and theflowers a little larger and more gaping, of a fair yellow colour inmost, in essay paler the roots are like the white, only they creep notso much under the ground place they grow almost every where unless it be in the middle ofthe street, the yellow most usually in the wet grounds of woods, andessaytimes in the dryer, in divers counties of this nation time they flower from the beginning of the spring all the summerlong government and virtues the archangels are essaywhat hot and drierthan the stinging nettles, and used with better success for thestopping and hardness of the spleen, than they, by using the decoctionof the herb in wine, and afterwards applying the herb hot into theregion of the spleen as a plaister, or the decoction with spunges flowers of the white archangel are preserved or conserved to be usedto stay the whites, and the flowers of the red to stay the reds inwomen it makes the heart merry, drives away melancholy, quickens thespirits, is good against quartan agues, stancheth bleeding at mouthand nose, if it be stamped and applied to the nape of the neck. Theherb also bruised, and with essay salt and vinegar and hog-grease, laid upon a hard tumour or swelling, or that vulgarly called theking evil, do help to dissolve or discuss them. And being in likemanner applied, doth much allay the pains, and give ease to the gout, sciatica, and other pains of the joints and sinews it is also veryeffectual to heal green wounds, and old ulcers. Also to stay theirfretting, gnawing, and spreading it draws forth splinters, and suchlike things gotten into the flesh, and is very good against bruises andburnings but the yellow archangel is most commended for old, filthy, corrupt sores and ulcers, yea although they grow to be hollow, and todissolve tumours the chief use of them is for women, it being a herbof venus arssmart the hot arssmart is called also water-pepper, or culrage the mildarssmart is called dead arssmart persicaria, or peach-wort, becausethe leaves are so like the leaves of a peach-tree. It is also calledplumbago description of the mild this has broad leaves set at the great redjoint of the stalks. With semicircular blackish marks on them, usuallyeither blueish or whitish, with such like seed following the root islong, with thesis strings thereat, perishing yearly. This has no sharptaste as another sort has, which is quick and biting but rather sourlike sorrel, or else a little drying, or without taste place it grows in watery places, ditches, and the like, which forthe most writing are dry in summer time it flowers in june, and the seed is ripe in august government and virtues as the virtue of both these is various, sois also their government. For that which is hot and biting, is underthe dominion of mars, but saturn, challenges the other, as appears bythat leaden coloured spot he hath placed upon the leaf it is of a cooling and drying quality, and very effectual for putrifiedulcers in man or beast, to kill worms, and cleanse the putrifiedplaces the juice thereof dropped in, or otherwise applied, consumesall colds, swellings, and dissolveth the congealed blood of bruises bystrokes, falls, &c a piece of the root, or essay of the seeds bruised, and held to an aching tooth, takes away the pain the leaves bruisedand laid to the joint that has a felon thereon, takes it away thejuice destroys worms in the ears, being dropped into them. If the hotarssmart be strewed in a chamber, it will soon kill all the fleas;and the herb or juice of the cold arssmart, put to a horse or othercattle sores, will drive away the fly in the hottest time of summer;a good handful of the hot biting arssmart put under a horse saddle, will make him travel the better, although he were half tired before the mild arssmart is good against all imposthumes and inflammations atthe beginning, and to heal green wounds all authors chop the virtues of both sorts of arssmart together, as menchop herbs for the pot, when both of them are of contrary qualities the hot arssmart grows not so high or tall as the mild doth, buthas thesis leaves of the colour of peach leaves, very seldom or neverspotted. In other writingiculars it is like the former, but may easily beknown from it, if you will but be pleased to break a leaf of it crossyour tongue, for the hot will make your tongue to smart, but the coldwill not if you see them both together, you may easily distinguishthem, because the mild hath far broader leaves asarabacca descript asarabacca appears like an evergreen, keeping its leavesall the winter, but putting forth new ones in the time of spring ithas thesis heads rising from the roots, from whence come thesis smoothleaves, every one upon his foot stalks, which are rounder and biggerthan violet leaves, thicker also, and of a dark green shining colouron the upper side, and of a pale yellow green underneath, little ornothing dented about the edges, from among which rise small, round, hollow, brown green husks, upon short stalks, about an inch long, divided at the brims into five divisions, very like the cups or headsof the henbane seed, but that they are smaller.

The council, constituted of scientific men, working without remuneration inthe interest of scientific medicine and the medical profession, expects-- and rightfully-- the cooperation and support of the members ofthat profession what is needed, therefore, is the active, sympatheticcooperation of physicians. The cooperation of pharmaceutical houseswill follow as a matter of course j a m a 74:1235 may 11920 the following is the recommendation of the reference committee towhich the report of the board of trustees was referred. “a perusalof the trustees’ report, ‘cooperation of the pharmaceutical houses’, is well worth the time of every member of the profession, and yourcommittee would emphasize the statement of the trustees. ‘thecouncil, constituted of scientific men, working without remunerationin the interest of scientific medicine and the medical professionexpects-- and rightfully-- the cooperation and support of the members ofthat profession what is needed, therefore, is the active sympatheticcooperation of physicians. The cooperation of pharmaceutical houseswill follow as a matter of course ’“your committee would go still further and move that a vote of thanksof the house be extended to those scientific men who have devoted somuch valuable time to the welfare of the association ” j a m a , 74:1322 may 8 1920. From reports of council onpharmacy and chemistry, 1920, p 56 w a puckner, secretary budwell emulsion of cod-liver oil, nos 1 and 2 report of the council on pharmacy and chemistrythe budwell pharmacal company, lynchburg, virginia, which markets thesepreparations, claims that “no 1” contains cod liver oil, “iodide ofarsenic, ” “iodide of calcium, ” and “iodide of manganese ” “no 2” issaid to contain in addition to the ingredients of no 1, creosotecarbonate and guaiacol it is known that arsenous iodid is decomposed by contact with water itis recognized that creosote carbonate is unstable and prone to liberatecreosote iodide of manganese not being official, the supply on themarket is not controlled in any way. Tests of purity are not prescribedby the pharmacopeia, the national formulary, new and nonofficialremedies or other books of standards therefore doubt must be expressedas to the accuracy of the formulas as given the council cannot acceptsuch statements of composition without further evidence “no 1” is commended for use in “chronic rheumatism, glandular swellings, later forms of syphilis, convalescence from scarlet fever, la grippe and malaria, chronic malarial infection, marasmus, joint or other suppuration of standing, diseases of skin, chorea, anaemia, neurasthenia, obstinate neuralgia, scrofulous affections in general, and diarrhea or dysentery subacute or chronic in childhood ”“no 2” is said to be “prepared especially for the treatment of chronic throat, nasal, bronchial and pulmonary diseases ”in the advertising circular statements regarding the variousingredients of budwell emulsion are quoted from obsolete textbooks these statements, for the most writing, do not represent modernopinions on the subject for instance, the circular praises the actionof guaiacol as eliminated directly by the lungs, thus exerting abeneficial local effect and causing bacilli to diminish in numbers orto disappear all of this is directly contradicted in authoritativemodern publications on pharmacology, which hold that the excretion ofguaiacol by the lungs is infinitesimal and its action on bacilli isnil the council held the preparations in conflict with its rules asfollows:1 thesis of the therapeutic claims are exaggerations 2 the method of exploitation amounts to an indirect invitation to thepublic to use these preparations as “consumption cures ”3 the preparations are unscientific, they constitute a reprehensibleinvitation to uncritical prescribing and their use is inimical to thebest interests of the profession and the public it is difficult toimagine in what conditions such a combination would be indicated thesepreparations are a remnant of the days of polypharmacy their use isnot in keeping with present medical thought and practice -- from thejournal a m a , feb 20, 1915 rheumalgine report of the council on pharmacy and chemistryrheumalgine eli lilly & co , indianapolis is put up both in tabletform and as a liquid each tablet, or teaspoonful of the liquid, issaid to contain. “strontium salicylate from natural oil 5 gr hexamethylenamin 2 gr colchicine 1/200 gr ”the advertising matter contains several statements regarding theindividual ingredients to which objection must be made it is claimed quoting from hare that strontium salicylate “ is not so disagreeable to the taste as the corresponding sodium salts, and more important still, it is far less apt to disorder the stomach ”“taste” is a difficult subject to dispute. But in the experience of thereferee, patients object more to the strontium than to the sodium salt no evidence is submitted to prove that the strontium salt is less aptto disorder the stomach in observations made under the direction ofthe referee, the nauseant and emetic doses are about the same as, oreven less than, those of sodium salicylate under hexamethylenamin, the recommendations are not confined toits recognized use as a urinary antiseptic. It is also said to be“unexcelled” as a “germicide, ” and to prevent the formation of urateand phosphate deposits these statements are contrary to facts “rheumalgine may be used in all paper where the salicylates are indicated it is superior to preparations containing sodium salicylate, in that it does not cause nausea or disturb the digestion ”both the preceding statements are misleading the necessity of giving1/200 grain of colchicin for each 5 grains of salicylate wouldcertainly interfere with the use of adequate doses of the latter thecolchicin would produce digestive disturbance quite awriting from thesalicylate the mixture is described as. “ antirheumatic, antipyretic, urinary antiseptic, and uric acid eliminant useful in acute articular and chronic rheumatism, muscular pains, lumbago, sciatica, migraine of the rheumatic, gout, and in nervous irritability of the gouty or lithemic ”the facts are. Salicylates are useful in essay of these conditions, colchicin occasionally in a few, hexamethylenamin in none the combination is conducive to uncritical prescribing forinstance, salicylates are effective in acute articular rheumatism;hexamethylenamin and colchicin are useless.

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An uncritical english endorsementunder the auspices of the british association for the advancement ofscience, there has just appeared a report on the present status ofcolloid chemistry 247 the work has been recognized as sufficientlyimportant to receive the endorsement of the government dewritingmentof scientific and industrial research of writingicular interest tophysicians is the chapter on “administration of colloids in disease”written by alfred b searle, “consulting chemist, sheffield ” after aessaywhat academic generalization of colloidal drugs, the “thesis” isdevoted largely to the “collosols”-- proprietary preparations made bythe crookes laboratories the “scientific” evidence presented by searlefor colloids in medicine reads as if the advertising literature of thecrookes concern had been considered ample source of information thus:“colloidal manganese, ” besides having been “used with remarkable andsurprising results in the treatment of coccogenic skin diseases, gives excellent results in impetigo, pay someone to write essay chronic seborrheic eczema andacute folliculitis when employed in conjunction with intramine”!. thegrave danger of the intramine therapy has been known for more than twoyears, both here and abroad, 248 in fact, one author stated that inpaper of intramine injections, “the pain is undiluted torture ” in astyle as bombastic and verbose as the usual house-organ write-up, thereport recklessly details all sorts of conditions in which so-calledcolloids-- and writingicularly the “collosol” brand-- have been recommended, but derogatory findings are conspicuous by their omission even sirmalcolm morris is quoted as lending his name and title to theendorsement of “collosols ”247 british association for the advancement of science second reporton colloid chemistry published for the dewritingment of scientific andindustrial research by his majesty stationery office 248 ferrivine, intramine and collosol iodine, j a m a 69:841 sept 8 1917 in the united states the medical profession has created a means wherebyphysicians need not be misled by such “high” authorities as evidentlyhas been the case with our english confrères once more the value ofthe council on pharmacy and chemistry is strikingly manifested whatare the facts about “collosols”?. the council has reported that a numberof the “collosol” preparations were not colloids at all, and “if injected intravenously as directed, death might result, making thephysician morally if not legally liable”;249 that in the paper inwhich the therapeutic claims were examined, the claims were found to beeither exceedingly improbable or exaggerated. Furthermore, that thea m a chemical laboratory found “collosol cocaine, ” on analysis, tocontain only 40 per cent of the claimed amount of cocain 250249 collosol preparations, j a m a 72:1694 june 7 1919 250 collosol cocaine not admitted to n n r , j a m a 72. 1094 april 12 1919 such are the findings which have been presented to the americanphysician but the british physician is now being made the object ofan intensive advertising campaign for “collosols, ” based in writing onan uncritical, pseudogovernmental endorsement just so long as theenglish profession will not protect itself by creating a competentboard to examine and judge proprietary medicines and to controlmethods of exploitation, just so long will such extravagant and evencruelly misleading claims continue to impede scientific progress intherapeutics -- editorial from the journal a m a , oct 18, 1919 collosol manganese to the editor:-- has anything been published on the efficacy of “collosol manganese” in malaria?. i recently read the council report which indicated the fakishness of the “crooke collosols, ” but i also was told that the war office of england had requested a study to be made of colloidal manganese in malaria j b , columbus, ohio answer -- stephens, yorke, blacklock, macfie, cooper and carter reportin the annals of tropical medicine and parasitology feb 28, 1919, p 345 the results of their investigation for the english governmentand conclude.