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“the theories for the favorable action of fellows syrup of hypophosphites have undergone several changes ”the same circular further maintains, however, that order term paper. “ the fact has never been challenged that in fellows syrup of hypophosphites we have one of the most efficient, most complete, most all-around tonics and roborants in the materia medica ”no attempt is made to base this assertion on the therapeutic actionof the constituents in other words, the old theory, which formed thebasis for the popularity of fellows’ syrup, has been thrown overboard, but no substitute is deemed necessary. The momentum already acquired isapparently regarded as sufficient to insure its continued sale fellows’ syrup of hypophosphites is a semisecret, unscientificpreparation-- an affront to sound therapy-- exploited by means ofextravagant and misleading statements syrupus roborans syrup hypophosphites comp with quinin, strychnin and manganeselittle information concerning this preparation seems to be furnishedat present by the manufacturers, arthur peter & co , louisville, ky according to an old circular, it contains, in each fluidounce, grains “hypophos potass 1-1/2 hypophos manganese 1 hypophos lime 1 hypophos iron 1-1/2 hypophos quinin 6/16 hypophos strichnin 1/16 “1/128 grain strychnia to teaspoonful ”further, according to the same circular. “the hypophosphites are especially useful in all diseases where there is a lack of nutrition they are the best of all remedies in rachitis, non-union of fractures, osteomalacia and syphilitic periostitis ”as for syrupus roborans itself. “this elegant preparation is the best general tonic and reconstructive known ”the unwarranted therapeutic claims formerly made for it seem to be nolonger circulated syrupus roborans is an unscientific, shotgun mixture schlotterbeck solution hypophosphites of lime and soda liq hypophosphitum, schlotterbeckthe schlotterbeck & foss co , portland, maine, the manufacturers, sayof their preparation. “this solution contains 30 grains of the combined hypophosphites of lime and soda to the ounce it contains no sugar, no acid and it is perfectly neutral ” “indications for use -- galactostasis, imperfect metabolism, neurasthenia, nervous dyspepsia, insomnia, convalescence, acetonuria, cyclic vomiting in infants, diabetes, starvation, deficiency of lime, mother teeth during pregnancy, dentition of infants, rachitis, furunculosis, vomiting of pregnancy, obesity ” “migraine is often caused by conditions for which this solution is one of the most satisfactory remedies:” “in insomnia due to advancing age, it will often act as a hypnotic ”of the hypophosphites the schlotterbeck & foss company say. “if ‘damning it with faint praise’ on the writing of essay of the leading medical authorities, or utterly condemning it as useless, on the writing of others, would kill a medicine, the hypophosphites would long since have disappeared as medicinal agents negative testimony in regard to the value of a drug does not settle anything ”of their own preparation they say. “when we get the results that ought to follow the administration of hypophosphites, we have proved that schlotterbeck solution enters the system unchanged ” “this solution is primarily a blood and nerve tonic and chemical food ”schlotterbeck solution of hypophosphites of lime and soda is asemisecret preparation marketed under claims that are both unwarrantedand misleading robinson hypophosphitesaccording to the manufacturers, the robinson-pettet company, louisville, ky , each fluidounce of this preparation contains.

One represents order term paper laborious research ending in the production of a new medicinal chemical. This product can be patented and the manufacturer can obtain a seventeen-year monopoly on its manufacture and sale the other represents no research but comprises simple mixtures-- frequently of the “shotgun” variety-- of well known pharmaceuticals, or biologic products sold under trade names as these do not represent anything new or original the manufacturer is unable to obtain a patent, but by means of the trade name he can and does obtain a perpetual monopoly this, from a business standpoint, is more valuable than the limited monopoly granted by a patent it is not surprising that proprietary remedies of the latter type flourish so long as physicians unthinkingly accept and prescribe them solely on the manufacturer valuation “the council has practically the undivided support of manufacturers of medicinal chemicals. That is, of proprietaries of the first mentioned type but pharmaceutical firms which have found it profitable to promote proprietaries of the second type-- “specialties, ” unscientific or ordinary mixtures of pharmaceuticals or biologic products sold under trade names-- have not supported the council “when the council was organized, it was hoped and believed that all the large pharmaceutical houses would find it possible and desirable, if not actually more profitable, to shape their business methods so as to make their proprietary and other articles conform to those conservative standards on which the council bases its rules, and thus render such articles acceptable for new and nonofficial remedies it soon developed, however, that the methods of the pseudochemical companies, whose sales propaganda in the interest of unscientific nostrums with its attending damage to scientific medicine had led to the establishment of the council, had found their lodgment in most of the pharmaceutical houses it was a genuine disappointment to the council to find that essay of the large and old-established firms were not only unwilling to cooperate with the council, but in thesis instances exhibited a definite antagonism to the council work “the object-- and duty-- of the officers of pharmaceutical houses is primarily to pay dividends to their stockholders through skilful advertising or the persuasiveness of “detail men, ” they are able to induce physicians to prescribe their controlled products, on which there are large profits, even though such products have not only not been accepted by the council, but in thesis instances, have been disapproved is it any wonder that concerns which put out such products are indifferent or openly antagonistic to the work of the council?. the matter is largely one of business policy when the medical profession as a unit will support the council in its work, then such firms will find it good business policy to accede to dr bevan suggestion-- but not before ”evidently the problem resolves itself into this. The council, constituted of scientific men, working without remuneration inthe interest of scientific medicine and the medical profession, expects-- and rightfully-- the cooperation and support of the members ofthat profession what is needed, therefore, is the active, sympatheticcooperation of physicians. The cooperation of pharmaceutical houseswill follow as a matter of course j a m a 74:1235 may 11920 the following is the recommendation of the reference committee towhich the report of the board of trustees was referred. “a perusalof the trustees’ report, ‘cooperation of the pharmaceutical houses’, is well worth the time of every member of the profession, and yourcommittee would emphasize the statement of the trustees. ‘thecouncil, constituted of scientific men, working without remunerationin the interest of scientific medicine and the medical professionexpects-- and rightfully-- the cooperation and support of the members ofthat profession what is needed, therefore, is the active sympatheticcooperation of physicians. The cooperation of pharmaceutical houseswill follow as a matter of course ’“your committee would go still further and move that a vote of thanksof the house be extended to those scientific men who have devoted somuch valuable time to the welfare of the association ” j a m a , 74:1322 may 8 1920. From reports of council onpharmacy and chemistry, 1920, p 56 w a puckner, secretary budwell emulsion of cod-liver oil, nos 1 and 2 report of the council on pharmacy and chemistrythe budwell pharmacal company, lynchburg, virginia, which markets thesepreparations, claims that “no 1” contains cod liver oil, “iodide ofarsenic, ” “iodide of calcium, ” and “iodide of manganese ” “no 2” issaid to contain in addition to the ingredients of no 1, creosotecarbonate and guaiacol it is known that arsenous iodid is decomposed by contact with water itis recognized that creosote carbonate is unstable and prone to liberatecreosote iodide of manganese not being official, the supply on themarket is not controlled in any way. Tests of purity are not prescribedby the pharmacopeia, the national formulary, new and nonofficialremedies or other books of standards therefore doubt must be expressedas to the accuracy of the formulas as given the council cannot acceptsuch statements of composition without further evidence “no 1” is commended for use in “chronic rheumatism, glandular swellings, later forms of syphilis, convalescence from scarlet fever, la grippe and malaria, chronic malarial infection, marasmus, joint or other suppuration of standing, diseases of skin, chorea, anaemia, neurasthenia, obstinate neuralgia, scrofulous affections in general, and diarrhea or dysentery subacute or chronic in childhood ”“no 2” is said to be “prepared especially for the treatment of chronic throat, nasal, bronchial and pulmonary diseases ”in the advertising circular statements regarding the variousingredients of budwell emulsion are quoted from obsolete textbooks these statements, for the most writing, do not represent modernopinions on the subject for instance, the circular praises the actionof guaiacol as eliminated directly by the lungs, thus exerting abeneficial local effect and causing bacilli to diminish in numbers orto disappear all of this is directly contradicted in authoritativemodern publications on pharmacology, which hold that the excretion ofguaiacol by the lungs is infinitesimal and its action on bacilli isnil the council held the preparations in conflict with its rules asfollows:1 thesis of the therapeutic claims are exaggerations 2 the method of exploitation amounts to an indirect invitation to thepublic to use these preparations as “consumption cures ”3 the preparations are unscientific, they constitute a reprehensibleinvitation to uncritical prescribing and their use is inimical to thebest interests of the profession and the public it is difficult toimagine in what conditions such a combination would be indicated thesepreparations are a remnant of the days of polypharmacy their use isnot in keeping with present medical thought and practice -- from thejournal a m a , feb 20, 1915 rheumalgine report of the council on pharmacy and chemistryrheumalgine eli lilly & co , indianapolis is put up both in tabletform and as a liquid each tablet, or teaspoonful of the liquid, issaid to contain. “strontium salicylate from natural oil 5 gr hexamethylenamin 2 gr colchicine 1/200 gr ”the advertising matter contains several statements regarding theindividual ingredients to which objection must be made it is claimed quoting from hare that strontium salicylate “ is not so disagreeable to the taste as the corresponding sodium salts, and more important still, it is far less apt to disorder the stomach ”“taste” is a difficult subject to dispute. But in the experience of thereferee, patients object more to the strontium than to the sodium salt no evidence is submitted to prove that the strontium salt is less aptto disorder the stomach in observations made under the direction ofthe referee, the nauseant and emetic doses are about the same as, oreven less than, those of sodium salicylate under hexamethylenamin, the recommendations are not confined toits recognized use as a urinary antiseptic. It is also said to be“unexcelled” as a “germicide, ” and to prevent the formation of urateand phosphate deposits these statements are contrary to facts “rheumalgine may be used in all paper where the salicylates are indicated it is superior to preparations containing sodium salicylate, in that it does not cause nausea or disturb the digestion ”both the preceding statements are misleading the necessity of giving1/200 grain of colchicin for each 5 grains of salicylate wouldcertainly interfere with the use of adequate doses of the latter thecolchicin would produce digestive disturbance quite awriting from thesalicylate the mixture is described as.

that on order term paper the label or that in the general advertising?. -- council will reveal the outstanding fact that, while there are several drugs employed, each ingredient is there for a purpose and all do splendid teamwork if your patient is constipated because the stomach is not sufficiently energetic, the quassia stimulates that organ to an increased secretion of digestive fluids and sets it to working normally if the liver be sluggish, the chionanthus and wahoo prompt it to increased activity chionanthus has no superior for producing a sustained healthy hepatic condition should the bowels be slow and uncertain, the small doses of aloin, cascarin and podophyllin stimulate to free peristaltic action, while the nux vomica sets the nervous system right we use an effective antigripe so that there is no griping ”it is absurd to suppose that a complex mixture of drugs in fixedproportions can have the actions claimed for quassia compound tablets as regards the claim that “chionanthus has no superior for producing asustained healthy hepatic condition, ” it was brought out in a reportof the council on “essay unimportant drugs” reports of council onpharmacy and chemistry, 1912, p 36 that the “claims for this remedychionanthus are not supported by experimental evidence and theclinical reports of its use fail to show indications of discriminatingcritical observation it is not noticed by most pharmacologicauthorities ”of wahoo euonymus n f the “epitome of the u s p and n f ”says. “actions and uses -- obsolete cathartic. Toxic digitaliseffects caption. The uncertain absorption of this drug makes its useinadvisable ”quassia compound tablets flint, eaton and company are inadmissibleto new and nonofficial remedies because 1 they contain drugs ofunproved value. 2 their composition is needlessly complex, and, therefore irrational. 3 unwarranted therapeutic claims are madefor them.

607 april 10 1920 after examining the available evidence, the order term paper council advised the harmerlaboratories company that the claim that mon-arsone has a therapeuticvalue equal to arsphenamine appeared unwarranted. That, in the opinionof the council, mon-arsone should not be used except under conditionsthat justify the experimental trial of an unproved drug, and should notbe used in a routine way until the permanence of its effects has beenestablished. And consequently any advertising propaganda for the drugby the harmer laboratories company was to be deprecated in its reply the harmer laboratories company admitted that itsadvertising claim, that mon-arsone was at least equal to arsphenaminetherapeutically, had been based on reports on fifty paper and onadditional reports that were beginning to come in at that time the harmer laboratories company submitted a list of hospitals andphysicians using mon-arsone a letter of inquiry sent by the council tothose who, according to the names in the list supplied by the harmerlaboratories company, had used mon-arsone, brought seven replies the clinical evidence contained in these replies was to the effect thatmon-arsone had been used in the various types of syphilis and thatthere was a certain beneficial effect, both clinically and as shown bythe wassermann reaction in certain instances the wassermann reactionchanged from a four plus to a negative reaction the reports showedthat the efficiency of mon-arsone as compared with that of arsphenaminepreparations has not been adequately studied one physician who hasused mon-arsone extensively reports that in thesis of the paper treatedthere seemed to be nearly as good results from the use of mon-arsone asis frequently obtained in the use of arsphenamine he reports, however, that it was necessary in eleven out of one hundred paper to change frommon-arsone to neoarsphenamine in view of the fact that there is definite lack of evidence to showthat mon-arsone is the equal of arsphenamine therapeutically, andbecause of the reports that in essay paper it is inferior, mon-arsoneshould not be used in the treatment of syphilis generally until itstherapeutic status has been more rigidly investigated and conclusiveevidence of its superiority to arsphenamine preparations obtained the council voted not to admit mon-arsone to new and nonofficialremedies and reaffirmed its conclusion that the claim that mon-arsonehas a therapeutic value equal to that of arsphenamine is premature andunwarranted. That mon-arsone should not be used except under conditionsthat justify the experimental trial of an unproved drug. And that theadvertising propaganda for the drug by the harmer laboratories companyis to be deprecated * * * * *when the preceding report was sent to the harmer laboratories company, the firm submitted a reply in which it was stated:1 that in certain instances patients improved under mon-arsone who, previously, had not improved under arsphenamine, and that this shouldbe taken to offset the report of the one hundred paper in which the useof mon-arsone had to be abandoned in 11 per cent of the paper 2 that the harmer laboratories company has abandoned the claim thatmon-arsone is therapeutically equal to arsphenamine and that it nowfurnishes the drug to such men as care to use it simply on the basis ofits special and useful characteristics the council heartily endorses the recent warning against the useof untried medicaments which was issued by the u s public healthservice 145145 j a m a june 12, 1920, p 1654 since the council report was prepared a report on the effects ofmon-arsone on experimental syphilis has been published by nichols, 146from the division of laboratories, army medical school, which concludes:1 disodium-ethylarsinate, or mon-arsone, tested on rabbits infectedwith syphilis shows no spirocheticidal power the tissues are fatallypoisoned as soon as or before the spirochetes are affected “2 for its practical use in syphilis there is no such germicidal basisas exists in case of the arsphenamine group ”-- from the journala m a , june 18, 1921 146 nichols, h j. The spirocheticidal value of disodium ethylarsenate mon-arsone, j a m a 76. 1335 may 14 1921 oxyl-iodide not admitted to n n r report of the council on pharmacy and chemistry“oxyl-iodide” eli lilly and co is said to be the hydroiodid ofcinchophen and the claim is made that it exerts the effects ofcinchophen and of iodid because of inquiries which have been receivedthe council decided to determine the eligibility of “oxyl-iodide” fornew and nonofficial remedies dr p j hanzlik-- formerly associateprofessor of pharmacology at western reserve university school ofmedicine, now professor of pharmacology at leland stanford junioruniversity medical school-- who has made a study of the action ofsalicylates and cinchophen, was asked to report on the therapeuticvalue and the rationality of “oxyl-iodide ” this he consented to do andhis report appears below after considering doctor hanzlik report, the council declared“oxyl-iodide” inadmissible to new and nonofficial remedies because itis an irrational combination, marketed under claims that are unprovedand consequently unwarranted w a puckner, secretary “oxyl-iodide, ” marketed by eli lilly & co , is claimed to be thehydroiodid of phenylcinchoninic acid, containing 33 per cent of iodinand 67 per cent of phenylcinchoninic acid cinchophen its solubilityresembles that of cinchophen, being low in water and acid mediums, andhigher in the presence of alkalis whether “oxyl-iodide” is decomposedinto its constituents in the presence of alkalis does not appear tohave been determined however, if this were the case, the intestine, after administration of “oxyl-iodide, ” would contain cinchophen andsodium iodid in the same forms as if these agents were administeredindividually so that nothing would be gained by administering“oxyl-iodide ” being, like cinchophen, practically insoluble in acidmediums, “oxyl-iodide” would have no advantage over the latter so faras gastric irritation is concerned dosagethe dosage advised is from one to three tablets containing 3 grains 0 2 gm each of “oxyl-iodide ” the total dosage would depend onthe condition to be treated in rheumatic fever, which requires afull therapeutic or so-called, “toxic” dose of cinchophen, about 12to 13 gm would be administered intensively since each tablet of“oxyl-iodide” contains 0 13 gm of cinchophen, the total number oftablets of “oxyl-iodide” required would be 100, or two and one-halfbottles of forty tablets each at the same time the patient wouldreceive 6 6 gm of iodin as iodid this might be distinctlyobjectionable because of the production of the disagreeable symptoms ofiodism in essay persons, and indicates that the fixed proportion of theiodin constituent would be objectionable even a smaller dosage, such as 5 gm of cinchophen, which gives writingialrelief in rheumatism and similar conditions, would still require apatient to take a full bottle, or forty tablets, of “oxyl-iodide, ” andat the same time about 2 7 gm of iodin would have to be ingested furthermore, rheumatic fever, the arthritides, gout and relatedconditions in which cinchophen is indicated do not require iodid therefore, “oxyl-iodide” would not be the remedy of choice in theseconditions, and its use would be irrational and illogical actionsno data on the pharmacologic actions of “oxyl-iodide” are presentedin the manufacturer literature presumably, the compound wouldexhibit the actions of its individual components, i e , cinchophen andiodin as iodid, though probably less efficiently, owing to its lowsolubility this is also indicated by the following statements of themanufacturer. “the analgesic action of ‘oxyl-iodide’ is gradual a wordof caution is necessary to those who may expect immediate relief frompain ” therefore, why use “oxyl-iodide” in place of more dependableanalgesics, such as salicylate or cinchophen the following statementsappear far-fetched. “there is a stimulation of the endocrines whichis perhaps more marked in the thyroid gland, although it is probablyshared by the pituitary and other glands which function in a chain-likecontrol there is stimulation of cells with increased flow ofsecretion, visibly demonstrated by the nasal mucous membrane after‘oxyl-iodide’ has been taken for essay time the general action onmucous membranes favors elimination of toxins and waste products ”it is probable that “oxyl-iodide” acts as a uric acid eliminant, thoughthere is no reason to suppose that it is more effective than cinchophenalone no data are given for this in the manufacturer literature usessuccessful use of “oxyl-iodide” is claimed in brachial and sciaticneuritis, lumbago, muscular rheumatism, arthritis deformans, chronicarthritis “ in essay instances were apparently cured”, subacutebronchitis, circumflex neuritis, traumatic orchitis, eczema andrheumatism however, a careful reading of the protocols of seven paper, representing these conditions, gives an unfavorable impression as tothe real contribution to the recovery by, or value received from, “oxyl-iodide ” summarized, the opinions as quoted by the manufacturersin support of their claims for “oxyl-iodide” are briefly as follows:case 1 “of course, the case is not complete yet, but i am looking forcontinued betterment ”case 2 “for two weeks past her improvement has been marvelous ”case 3 “the joints are still enlarged and we do not hope to clear thementirely ”case 4 “undoubtedly, removal of the kidney had much to do withimprovement ”case 5 “i think i have gotten very good results ”case 6 “essay apparent benefit ”case 7 “she is practically free from pain, and the muscle and jointstiffness is now slight ”these inconclusive opinions certainly do not agree with the favorableimpression which other portions of the manufacturer literaturecreate if the factor of natural recovery in the conditions representedby these seven paper is given due weight, little, if anything, isleft to the credit of “oxyl-iodide ” such clinical evidence as issupplied by the manufacturer indicates that the therapeutic efficiencyof “oxyl-iodide” is doubtful, and not an improvement over eithercinchophen or iodid iodismiodism cannot be avoided by the use of “oxyl-iodide, ” for themanufacturer literature states that “the dosage of ‘oxyl-iodide’may be pushed to iodism as manifested by skin symptoms to avoidiodism there should be an occasional interruption of treatment ”“oxyl-iodide, ” therefore, has no advantage over ordinary sodium iodidto avoid iodism usually, the conditions which require cinchophendo not require the simultaneous administration of iodids, and viceversa if administration of iodid and cinchophen together should beindicated or desirable, these can be given separately with the addedadvantage that the iodid can be easily reduced or withdrawn in caseiodism supervenes, and the cinchophen could be continued if necessary since conditions do not arise frequently enough to warrant the useof iodid and cinchophen together, the existence of such a product as“oxyl-iodide” is unwarranted finally, the manufacturer himself recognizes that phenylcinchoninicacid cinchophen can take the place of “oxyl-iodide ” under“dosage, ” the circular states. “a few patients may be idiosyncraticto the iodides and find they cannot take ‘oxyl-iodide ’ for thelatter chloroxyl, the hydrochloride of phenylcinchoninic acid, isrecommended ” the action of the hydrochlorid of phenylcinchoninic aciddoes not differ, of course, from that of cinchophen the difficultiesof assigning a clear-cut, definite, therapeutic rôle to “oxyl-iodide”in order to justify its existence, alongside well-known and triedremedies are self-evident conclusion“oxyl-iodide” is pharmacologically and therapeutically an illogical, irrational and unjustified substitute for cinchophen and iodids theconditions which require the administration of cinchophen do not asa rule require the administration of iodid and vice versa if it isdesirable to secure the effects of iodid and cinchophen together, thesecan be more conveniently and advantageously administered as separateagents, permitting in that way a better control of their actions thiscannot be accomplished with “oxyl-iodide, ” in which the proportion ofiodid and cinchophen are fixed symptoms of iodism cannot be avoidedby the administration of “oxyl-iodide ” the objective evidences forits actions and uses are totally lacking. And the clinical opinionsconcerning its therapeutic benefits in different disease conditionsare inconclusive and hedging, and, if anything, contradictory to thefavorable impressions which the language of the advertising matter islikely to create -- from the journal a m a , july 2, 1921 quassia compound tablets report of the council on pharmacy and chemistrythe council has authorized publication of the following report, declaring that quassia compound tablets flint, eaton and company areinadmissible to new and nonofficial remedies w a puckner, secretary quassia compound tablets, marketed by flint, eaton and company, decatur, ill , according to the label on a trade package submitted tothe council, contain in each tablet. Quassia 3/4 grain aloin 1/4 grain chionanthus 1 grain ipecac 1/16 grain wahoo 3/4 grain podophyllin 1/4 grain nux vomica 1/2 grain gingerine q s cascara 1/3 grainin the advertising the “cascara” of the label is replaced by theindefinite term “cascarin” and the “gingerine q s ” by “carminativeantigripe q s ” flint, eaton and company informed the council that“carminative antigripe is c p sodium sulphite of which each tabletcontains 1/4 grain ” the tablets were treated with dilute hydrochloricacid and the odor of sulphur dioxid became apparent this shows thatthe company statement to the council, that the tablets contain asulphite, is correct and the formula on the label is incorrect in the advertising for this preparation we read. “a careful study of this formula which formula?. that on the label or that in the general advertising?. -- council will reveal the outstanding fact that, while there are several drugs employed, each ingredient is there for a purpose and all do splendid teamwork if your patient is constipated because the stomach is not sufficiently energetic, the quassia stimulates that organ to an increased secretion of digestive fluids and sets it to working normally if the liver be sluggish, the chionanthus and wahoo prompt it to increased activity chionanthus has no superior for producing a sustained healthy hepatic condition should the bowels be slow and uncertain, the small doses of aloin, cascarin and podophyllin stimulate to free peristaltic action, while the nux vomica sets the nervous system right we use an effective antigripe so that there is no griping ”it is absurd to suppose that a complex mixture of drugs in fixedproportions can have the actions claimed for quassia compound tablets as regards the claim that “chionanthus has no superior for producing asustained healthy hepatic condition, ” it was brought out in a reportof the council on “essay unimportant drugs” reports of council onpharmacy and chemistry, 1912, p 36 that the “claims for this remedychionanthus are not supported by experimental evidence and theclinical reports of its use fail to show indications of discriminatingcritical observation it is not noticed by most pharmacologicauthorities ”of wahoo euonymus n f the “epitome of the u s p and n f ”says. “actions and uses -- obsolete cathartic.

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Age, 52. Was bitten by a poisonous snake-- a copperhead-- seventeen years ago on the anniversary of the bite the arm would swell to more than twice its normal size and there would be pain, chills and fever after a month of this the acute symptoms would disappear and the arm would show large scaly blotches which upon being removed would disclose a thin mucous liquid throughout the seventeen years pain was constant, being writingicularly acute in midsummer around the anniversary of the bite this patient had consulted thesis physicians during the seventeen years of suffering without any relief large doses of narcotic remedies were necessary each day to subdue the pain twenty-four hours after the first injection of hemo-therapin all pain was dissipated after four treatments the patient was considered well and there has been no return of any of the symptoms since the last treatment six months ago ”hemo-therapin is sold in ampules. 6 for $5 and 12 for $10, and acircular sent to a physician contained this typewritten note. “fees -- while the physician fee is not regulated by this company, the physicians who use hemo-therapin get $5 00 and $10 00 for each treatment ”-- from the journal a m a , jan 5, 1918 venosal report of the council on pharmacy and chemistrythe following report on venosal has been adopted by the council, andits publication authorized w a puckner, secretary “venosal” is one of the products of the intravenous products company, denver, colo its composition has been variously, and obscurely, described. “venosal is a sterile solution representing 1 gm 15 4 gr of salicylates in combination, together with colchicum ” “this is a product for intravenous use the composition of which is sodium salicylate, 15 4 grs 1 gm , iron salicylate a minute quantity and the equivalent of approximately 2 grs dried colchicum root ”none of these “formulas” gives the quantity of the product containingthe 1 gm of salicylate, etc , but presumably it refers to the contentsof 1 ampule or 20 c c this inference is in accord with the analysisof the product made in the chemical laboratory of the american medicalassociation the analysis also brought out the fact that the amount ofiron in a given ampule was 0 0008 gm about 1/80 grain this trace ofiron in the presence of salicylate gives the product a purple color venosal is recommended for the treatment of “rheumatism, ” meaning, thecontext would indicate, infectious rheumatic fever as colchicum hasno special action on this disease and as there is no apparent reasonfor the employment of the trace of iron present, these additions infixed proportions are unscientific, if not absurd according to theadvertising matter.