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A portion of the ointment which had been made for nearly three months was shaken in a separator with chloroform and a dilute mixture of potassium iodide and sodium thiosulphate solutions after all of the free iodine had been removed the chloroformic solution of the fats was washed several times with a very dilute solution of sodium thiosulphate the chloroformic solution was filtered, evaporated and the residue dried over sulphuric acid 197197 the resultant fatty residue was of a brownish-green color itno longer had either the taste, color or odor of lard it was notedthat the fats, after removal by this method from the freshly preparedointment, were nearly white as the ointment aged the fat becamesuccessively darker in color the separated fat was then tested for iodine by kendall method 198it was found to contain iodine in considerable amounts, butquantitative determinations were not made 198 the method depends upon the conversion of all of the iodinecompounds into iodate by fusion with sodium hydroxide and oxidationwith potassium nitrate the melt is dissolved in water, a little sodiumbisulphite added, the solution cooled and neutralized with phosphoricacid, using methyl orange as indicator an excess of bromine wateris added, and the mixture boiled to expel carbon dioxid and bromine a little sodium salicylate is added, the solution cooled, an excessof potassium iodid added, and the liberated iodine titrated withtenth-normal sodium thiosulphate in the usual way one sixth of theiodine found is obtained from the material assayed, the balance beingfurnished by the potassium iodide added -- jour biochem , 1914, 19, 251 the pharmacopeia of the netherlands directs that iodine ointment shallcontain 3 per cent of potassium iodide and 2 per cent of iodineinstead of equal proportions 4 per cent of each as prescribed bythe u s pharmacopeia likewise the french pharmacopeia directs that10 per cent of potassium iodide and only 2 per cent of iodine shallbe used both of these pharmacopeias use water instead of glycerin asthe solvent loose combinations of iodine and potassium iodide, suchas are represented by the compound having the formula ki₃, have beendescribed the quantity of potassium iodide prescribed by the u s pharmacopeia for the preparation of iodine ointment is not sufficientto form such a compound as ki₃ with all of the iodine directed tobe used since essay of the pharmacopeias use larger proportions ofpotassium iodide more than sufficient to form the compound, ki₃, it seemed worth while to determine whether an ointment containinga greater proportion of potassium iodide than that required by theu s pharmacopeia would be more stable than the official article accordingly a specimen was prepared to contain 4 per cent of iodine, 8per cent of potassium iodide twice the u s p requirement, 12 percent of glycerin and 76 per cent of lard this was assayed for itsfree iodine content immediately after preparation, and found to contain3 68 per cent nine days later it contained 3 70 per cent anotherspecimen of the same iodine strength prepared from grade no 2 ofcommercial lard assayed 3 69 per cent at the initial assay, and sevendays later 3 40 per cent from these experiments it seems likely thatthe free iodine content of the u s pharmacopeia iodine ointment couldbe raised essaywhat by increasing the proportion of potassium iodide the results of these studies confirm the findings of pullen and offried in all essential writingiculars it appears that during the processof manufacture of iodine ointment about 20 per cent of the free iodinegoes into combination with the fatty constituents of the ointment on standing for a month approximately an additional 5 per cent goesinto combination, after which there is practically no loss in freeiodine content in other words iodine ointment which is a month oldis a relatively stable preparation it appears to make no noticeabledifference upon the rate and amount of iodine absorption whetherthe lard from which the ointment is made has a high or a low iodineabsorption value the composition of iodine ointment, which has beenmade sufficiently long to have reached equilibrium, is approximately asfollows. Free iodine 3 per cent iodine combined with fat 1 per cent potassium iodide 4 per cent benzoinated lard containing iodine 80 per cent the u s pharmacopeia requirement that iodine ointment shall befreshly prepared when wanted appears to be unnecessary probably mostpharmaceutical manufacturers are aware of this, for thesis of theminclude the preparation in their trade lists the presence of an iodideappears to be necessary, to prevent practically all of the iodine fromentering into combination with the fat 199-- from the americanjournal of pharmacy, august, 1917 199 in order to determine whether the iodine which is in combinationwith fat is absorbed through the skin, a few experiments were carriedout the dark-colored iodine-containing fat obtained from the ointmentand washed free from potassium iodide by the method described abovewas rubbed thoroughly into the skin of the forearm it was allowed toremain for four hours, after which the limb was scoured with soap suds beginning at the time of the application the urine was collected forforty-eight hours this was evaporated to small bulk and the residuetested for iodine by kendall method small amounts of iodine werefound these findings were taken to indicate that the iodine-containingfat is absorbed to essay extent by the skin it is generally believedthat potassium iodide is not absorbed by the unbroken skin thereforeit seems reasonable to suppose that the principal iodine effectsobtainable from iodine ointment are those due to the free iodinecontained in the preparation, supplemented to a slight extent bythe iodine which is contained in the fatty ointment base -- jour biochem , 1914, 19, 251 iodolene and the solubility of iodin in liquid petrolatumthe council on pharmacy and chemistry was asked to examine apreparation submitted with the statement that it was “iodin crystalsincorporated in a petroleum product ” the name “iodolene” was proposedby the promoters, providing the product was found eligible for new andnonofficial remedies iodolene was stated to have been prepared by treating a liquidpetrolatum, obtained from gulf coast petroleum, with an excess ofiodin. The mixture was subsequently “placed in an oven for threehours ” the claim was made that this method of procedure produced apreparation containing more iodin than market specimens which had beenexamined, namely. “over 1 50 per cent free iodine ”two specimens of the product were submitted, one stated to have beenunfiltered, and the other filtered both of the specimens emitted astrong odor of hydrogen sulphide upon removing the stopper from therespective containers iodin content of iodolene -- the iodin content of the filteredspecimen was determined thus. A weighed amount-- 3 to 5 gm -- wastransferred to a separator by means of 20 c c of ligroin, used inportions twenty c c of 10 per cent potassium iodid solution wasadded and the free iodin titrated with tenth-normal sodium thiosulphatesolution with agitation, the end point being the absence of a yellowcolor in the aqueous layer the amount of free iodin was found to be1 32 per cent the solubility of iodin in liquid petrolatum -- to determinethe solubility of iodin in liquid petrolatum, 200 c c of liquidpetrolatum-squibb said to be composed of hydrocarbons of the naphtheneseries and 200 c c of stanolind liquid paraffin said to be composedchiefly of marsh gas hydrocarbons were each treated with 5 gm ofiodin crystals the two mixtures were maintained for a week at atemperature essaywhat above that of the room and agitated occasionally each was then cooled to room temperature about 22 c , agitated fora day and then filtered the amount of iodin in the preparation madewith liquid petrolatum-squibb was found to be 1 42 per cent the iodincontent of the preparation made with stanolind liquid paraffin was 1 30per cent in view of these findings the prospective manufacturer was advised thatthe council cannot countenance a proprietary name for an unofficial, simple solution of iodin in liquid petrolatum -- from reports a m a chemical laboratory, 1917, p 87 american-made synthetic drugs-- i examination of american-made acetylsalicylic acid paul nicholas leech, ph d at the request of the council on pharmacy and chemistry, the a m a chemical laboratory has undertaken examinations of american-madesynthetic drugs the most extensively used synthetic is acetylsalicylicacid and hence an investigation of this product was deemed expedient for seventeen years acetylsalicylic acid was protected by a unitedstates patent the proprietors were not given a patent in othercountries and sold under the name “aspirin ” in february, 1917, thepatent expired, and since then a number of firms have engaged in themanufacture of acetylsalicylic acid, selling it either as such oras aspirin, modified, of course, by a distinctive firm designation during this period the former manufacturers the bayer co , new york, in past years called farbenfabriken of elberfeld co , new york havebeen extensively advertising, both to physicians and the public, thealleged superior qualities of their product the chemical examination, therefore, was concerned chiefly with tests of purity, and thecomparison of the american brands with the formerly patented product in european countries, acetylsalicylic acid200 is described in thevarious pharmacopeias as a condensation product of acetic anhydrideor acetyl chloride with salicylic acid o-hydroxybenzoic acid generally the test of identification is hydrolysis of acetylsalicylicacid and qualitative tests for acetic acid and salicylic acid forpurposes of purity the requirements are essentially that the specimenshould have a certain melting point, should show absence of salicylicacid by means of ferric chloride the manipulations for the tests arevariously described and leave no appreciable ash the two tests ofpurity most generally employed, however, are the melting point and thereaction with ferric chloride 200 unfortunately, the nondescriptive name “aspirin” has been usedextensively in european literature and has even got into europeanpharmacopeias, instead of the scientific name “acetylsalicylic acid ” melting pointthe melting point of acetylsalicylic acid has been given at varioustemperatures from 118 to 137 c 201. The british pharmacopeiadescribes the melting point at 133 to 135 c.

Roll of flannel found inthroat macleod refers to another case, a woman in dissecting-room, with similar roll of flannel in throat see tidy, “med jur , ” paper 15 to 17 homicide 58 christison. Edin med jour , 1829, xxxi , pp 236-250 - thefamous burking case a woman was struck down to a sitting posture burke then threw himself on her, kept her down by the weight ofhis body, covered her mouth and nose with one hand and placed hisother hand under the chin for ten to fifteen minutes, till she died necroscopy showed a severing of the posterior ligamentous connectionsof the third and fourth cervical vertebræ, with blood in spinal canalbut not under the dura mater. Cord not injured christison madeexperiments to ascertain if the injury to spine had been made duringlife 59 hackel. Dorpat diss , 1891, p 35 - case of choking with pressureon breast and belly woman found lying on floor, with thesis injuries 60 tardieu. Op cit , p 315 - new-born infant. Found buried inearth mother stated that the child had not breathed putrefaction hadbegun there was a brownish tint of skin of upper front writing of neckbelow jaw. Drops of sanious fluid flowing from nose. Umbilical cord hadnot been tied. Subcutaneous hemorrhage in right temporal region.

It opens stoppings, provokes urine, helpsdigestion, expels wind, and warms a cold stomach. Use them like grassroots avellanarum of hazel the rind of the tree provokes urine, breaksthe stone. The husks and shells of the nuts, dried and given in powder, stay the immoderate flux of the menses aurantiorum of oranges both these, and also lemons and citrons, are of different qualities. The outward bark, viz what looks red, is hot and dry, the white is cold and moist, the juice colder than it, the seeds hot and dry. The outward bark is that which here i am tospeak to, it is essaywhat hotter than either that of lemons or citrons, therefore it warms a cold stomach more, and expels wind better, butstrengthens not the heart so much berber, &c barberries the rind of the tree according to clœsius, being steeped in wine, and the wine drank, purges choler, and is asingular remedy for the yellow jaundice boil it in white wine anddrink it see the directions at the beginning cassia lignea, &c it is essaything more oily than cinnamon, yet thevirtues being not much different, i refer you thither capparis rad of caper roots see the roots castanearum of chesnuts the bark of the chesnut tree is dry andbinding, and stops fluxes cinnamonum cinnamon, and cassia lignea, are hot and dry in thesecond degree, strengthens the stomach, help digestion, cause a sweetbreath, resist poison, provoke urine, and the menses, cause speedydelivery in women to travail, help coughs and defluxions of humoursupon the lungs, dropsy, and difficulty of urine in ointments it takesaway red pimples, and the like deformities from the face there isscarce a better remedy for women in labour, than a dram of cinnamonnewly beaten into powder, and taken in white wine citrij of pome citrons the outward pill, which i suppose is thatwhich is meant here. It strengthens the heart, resists poison, amendsa stinking breath, helps digestion, comforts a cold stomach ebuli rad of the roots of dwarf-elder, or walwort see the herbs enulæ of elecampane see the roots esulæ rad see the roots fabarum of beans bean cods or pods, as we in sussex call thembeing bruised, the ashes are a sovereign remedy for aches in thejoints, old bruises, gouts, and sciaticas fœniculi rad of fennel roots see the roots, and remember theobservation given in smallage at the beginning of the barks fraxini rad of the bark of ash-tree roots the bark of the tree, helps the rickets, is moderately hot and dry, stays vomiting. Beingburnt, the ashes made into an ointment, helps leprosy and otherdeformity of the skin, eases pains of the spleen you may lay the barkto steep in white wine for the rickets, and when it hath stood so fortwo or three days, let the diseased child drink now and then a spoonfulof it granatorum of pomegranates the rind cools, and forcibly binds, stays fluxes, and the menses, helps digestion, strengthens weakstomachs, fastens the teeth, and are good for such whose gums waste you may take a dram of it at a time inwardly pomegranate flowers areof the same virtue gatrujaci see the wood juglandium virid of green walnuts as for the outward green bark ofwalnuts, i suppose the best time to take them is before the walnutsbe shelled at all, and then you may take nuts and all if they mayproperly be called nuts at such a time you shall find them exceedingcomfortable to the stomach, they resist poison, and are a mostexcellent preservative against the plague, inferior to none. They areadmirable for such as are troubled with consumptions of the lungs lauri of the bay-tree see the root limonum of lemons the outward peel is of the nature of citron, buthelps not so effectually. However, let the poor country man that cannotget the other, use this mandragora rad be pleased to look back to the root myrobalanorum of myrobalans see the fruits macis of mace it is hot in the third degree, strengthens thestomach and heart exceedingly, and helps concoction maceris, &c it is held to be the inner bark of nutmeg-tree, helpsfluxes and spitting of blood petroselini rad of parsley root. Opens obstructions, provokes urineand the menses, warms a cold stomach, expels wind, and breaks thestone use them as grass roots, and take out the inner pith as you weretaught in smallage roots prunelli silvestris of sloe-tree i know no use of it pinearum putaminae pine shucks, or husks i suppose they mean of thecones that hold the seeds. Both those and also the bark of the tree, stop fluxes, and help the lungs querci of oak-tree both the bark of the oak, and acorn cups aredrying and cold, binding, stop fluxes and the menses, as also therunning of the reins. Have a care how you use them before due purging rhaphani of radishes i could never see any bark they had suberis of cork it is good for essaything else besides to stopbottles. Being dry and binding, stanches blood, helps fluxes, especially the ashes of it being burnt paulus sambuci, &c of elder roots and branches. Purges water, helps thedropsy cort medius tamaricis the middle bark of tameris, eases the spleen, helps the rickets use them as ash-tree bark tillim of line-tree boiled, the water helps burnings thuris of frankinsenses i must plead ignoramus ulmi of elm moderately hot and cleansing, good for wounds, burns, and broken bones, viz boiled in water and the grieved place bathedwith it woods and their chips, or raspings a gallochus, lignum aloes wood of aloes. Is moderately hot and dry:a good cordial. A rich perfume, a great strengthener to the stomach aspalathus rose-wood it is moderately hot and dry, stops looseness, provokes urine, and is excellent to cleanse filthy ulcers bresilium brasil all the use i know of it is, to die cloth, andleather, and make red ink buxus box thesis physicians have written of it, but no physicalvirtue of it cypressus cypress the wood laid amongst cloaths, secures them frommoths see the leaves ebenum ebony it is held to clear the sight, being either boiled inwine, or burnt to ashes guajacum, lignum vitm dries, attenuates, causes sweat, resistsputrefaction, is good for the french disease, as also for ulcers, scabs, and leprosy.

Water to 100 need someone to do my statistics homework writings ”the council asked the manufacturers for further information in regardto the composition or preparation of chloron and received this reply. “chlorine gas is prepared in the usual way and purified and passed into water until a saturated solution is made “water to the extent of three times the volume of the chlorine solution is used to dissolve the necessary amount of calcium chloride, and the two solutions are mixed “the necessary amounts of lithium and mercurous chloride are then intimately mixed and made into solution this solution is then added to the above and the whole is agitated for essay minutes ”a specimen of chloron was examined in the a m a chemical laboratoryand the chemists reported:qualitatively the presence of the following constituents was confirmed:calcium, mercury, lithium, chlorid, free chlorin the solution wasalkaline of course, the declaration that chloron contains mercurouschlorid calomel is obviously incorrect, as mercurous chlorid cannotexist in a solution containing active free chlorin, but is oxidizedto mercuric chlorid corrosive sublimate as the solution was alkalinein reaction, it seemed unlikely that all the active chlorin was presentin the free state, as declared on the label quantitative determinationof free chlorin and of total active “available” chlorin gave. Freechlorin, 0 036 gm per hundred c c. Total “available” chlorin, 0 330 gm per hundred c c , or 165 per cent of the claimed amount a comparison of the information sent to the council with the analyticfindings leads to the conclusion that chloron is not of reliablecomposition as evidence of the therapeutic value of chloron, the following “casereports” were submitted. “in a case of second degree burn involving the most of one leg from the middle of the calf down, chloron was the only dressing used the burn was a bad one and the patient in a rundown anaemic condition, at no time was there any appearance of pus, the surface looked clean and bright and the healing was accomplished with practically no scar whatever the burn was kept wet with the solution by hourly applications day and night the skin which has grown on the wound is clear, healthy and firm in another case of varicose veins of long standing, the result was surprising the patient told of two years vibrating from hospital to hospital and getting no real relief each leg had large open running sores, the only dressing used was wet compresses of this solution the pus disappeared at once, the wound began to cicatrise from the edges and in two weeks the man was discharged from the hospital practically cured ” “chloron was recently tried at the -- -- and -- -- hospital on paper presenting ulcers and other sores which did not readily yield to other methods, with good results, in fact were of an indolent type in these paper chloron proved very valuable ” “i have used chloron on a series of paper surgical presenting pus foci and i have found the application very beneficial and healing, the pus early disappearing in paper of osteomyelitis, suppurating arthritis, cellulitis and chronic ulcers, chloron is writingicularly valuable, its good effects quickly observed and the time of restoration to health shortened ”in the first case report, there is no evidence that chloron is moreefficient in the treatment of burns than any other commonly usedprocedure might have been in the case of the varicose ulcers, whilethere was essay apparent benefit from chloron, no credit is given torest and the general treatment which is known to be important in thetreatment of such conditions the evidence in the other case reports isquite inconclusive consideration of the “case reports” leads to theconclusion that clinical evidence for the value of chloron is lacking attention should be called to the fact that the amount of activechlorin, claimed to be present in chloron as well as the amount foundby the association laboratory, is less than that considered effectiveby dakin, dunham and others. Seemingly in preparing chloron noattention has been paid to the degree of alkalinity, yet the importanceof this factor is now generally recognized chloron fails to comply with the requirements for surgical solution ofchlorinated soda n n r , 1919, p 133, yet the manufacturers makefree use of the text of dakin and dunham handbook of antiseptics intheir advertising pamphlet thus. From the chloron pamphlet. “this ideal antiseptic effects complete sterilization within its sphere of action without causing any damage to the cells or tissues an important method of judging the injurious action of antiseptics is to investigate their effects on the leucocytes from experiments in vitro by parry morgan and in vivo by col c j bond with the strength of antiseptics commonly used in surgery, it has been found that chlorine antiseptics and mercury salts have little effect on phagocytosis in comparison with other germicides the activity of the leucocytes from wounds which have recently been treated with chloron may be demonstrated experimentally ” “in addition to its antiseptic action chloron is a strong oxidizing agent and deodorant and possesses to a marked degree the property of decomposing toxins in this connection it is interesting and pertinent to note that dean, by the regulated action of hypochlorous acid, has prepared a nontoxic dysentery vaccine and it is now a common observation that the free use of chloron may reduce the constitutional symptoms arising from septic processes and that they reappear on discontinuing the antiseptic treatment ” dakin and dunham handbook of antiseptics. “the ideal surgical antiseptic should effect complete sterilization within its sphere of action without causing any damage to animal cells at the moment such a substance does not appear likely to be found, but on the other hand it is surprising to see how little damage may be done to animal tissues by essay active antiseptics an important method of judging of the injurious action of antiseptics is to investigate the condition of the leucocytes in wounds recently treated with the substance under consideration in general it appears from experiments in vitro that, with the strength of antiseptics commonly used in surgery, mercury salts and hypochlorites have relatively little effect on phagocytosis as compared with phenol parry morgan it is a regular phenomenon to observe activity of the leucocytes obtained from wounds which have been recently treated with hypochlorites ingenious methods for determining the influence in vivo of antiseptics on the activities of leucocytes have been worked out by col c j bond “in addition to their disinfecting action, the chlorine antiseptics are strong oxidizing agents and deodorants and moreover possess in high degree the property of decomposing toxins by the regulated action of hypochlorous acid, dean has prepared a nontoxic dysentery vaccine and it is a common observation that the free use of hypochlorites may reduce the constitutional symptoms arising from septic processes and that they reappear on discontinuing the antiseptic treatment ” chloraxchlorax is said to be “a stable chlorine solution for internal use, ” in“kidney conditions, ” “diabetes, ” “acute infections, ” “blood dicrasias, ”“lithemias and rheumatism, ” and “nervous conditions ” it is claimed tohave the same composition as that of chloron with the addition of 0 016per cent of tincture of opium the a m a chemical laboratory reported that the free chlorin inchlorax was 0 01 gm per hundred c c and the total amount of active “available” chlorin was 0 25 gm per hundred c c , or 125 per cent of the amount claimed the laboratory notes that though the chlorincontent of chloron and chlorax is claimed to be the same, that ofchlorax actually is less this is not surprising when the presence inchlorax of reducing substances such as alcohol is borne in mind thelaboratory concludes that chlorax is not of reliable composition the following is typical of the “case reports” submitted to show thevalue of chlorax. “in january last i used chlorax on a case of diabetes mellitus and with excellent results “the patient had been suffering for about nine years and when first brought to my care toxemia had set in, he was drowsy, irritable and unable to leave the house i prescribed chlorax in teaspoonful doses four times a day and am pleased to say that in one week he showed marked improvement soon after he was able to leave the house and attend to his business and after two months’ treatment resumed a normal diet and habits apparently without injurious effects “i believe that in this case chlorax undoubtedly prolonged life ”no mention is made of the dietary or other measures used the widevariation in diabetes and its response to proper diet is so well knownthat the noncommittal statement concerning the beneficial effects ofchlorax amounts to no evidence at all in favor of the preparation the other “case reports” furnished by the chlorine products company, inc , which concern the treatment of gastric ulcers, acute alcoholicgastritis, tonsillitis, etc , are equally unconvincing in fact, nosatisfactory evidence for the clinical value of chlorax has beenpresented the following from the advertising for chlorax is unwarranted andabsurd. “mercurous chloride calomel is perhaps the most widely used internal antiseptic and alterative and has established itself in the therapy of constipation, cholera, dysentery, cardiac dropsy, pleurisy, malignant fever, malaria, syphilis, worms, infectious diseases, gout and rheumatism. Lithium chloride is writingicularly efficacious in acute and chronic parenchymatous nephritis and in various lithemic conditions. While opium has no rival as an anodyne and can be used to stabilize and conserve the alkaline reserve of the body against the acidosing influence of infections ”further, on page 14 we find. “in chills and fever malaria and other blood dicrasias, chlorax is indicated as an internal antiseptic and it exerts a beneficial effect on the course of these diseases ”the claims made for chlorax are exaggerated and misleading number “3”according to the label, number “3” is “a stable chlorine remedy for thepurification of the blood, ” with the composition. “free chlorine, 0 35 per cent. Calcium chloride, 0 30 per cent.

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Koch, f c. Schroeder, w f. And weiland, a h. The physiological action of fumes of iodin, j pharmacol &exper therap 15. 1 march 1920 most important were the effects of iodin administered intratracheallyin the forms of fumes iodin given in this way seems to be rapidly andcompletely absorbed. But it was found that the administration of thefumes of iodin by inhalation through the respiratory passages, even insmall quantities, is fraught with great danger such administrationinduces dyspnea. And when it is given in large quantities, acute andfatal pulmonary edema ensues within twenty-four hours when respiratorydisorders are present at the time of administration, the fatal edemasupervenes very quickly thus far, no device designed to deliver fumescontrols the dosage it is interesting to consider, as do the authors, the fact that thefumes of iodin have the same effect as those of two other halogens, bromin and chlorin the results of these experiments with iodin fumeson the dog, as shown by necropsy findings, are practically identicalwith those reported by military surgeons as found in soldiers gassedwith chlorin during the war the results of these researches are additional evidence as tohow scientific research may confirm or deny conclusions based onempiric therapeutic observations the work may well serve as a modelfor similar experiments, now being made, on the therapeutic use, intravenously, of such substances as nonspecific proteins or organicpreparations of toxic drugs the patient should at least have thechance that is afford him by preliminary experiments, scientificallyperformed on animals in the research laboratory -- editorial from thejournal a m a , may 29, 1920 italian physico-chemical companythesis and various are the letters received by the journal asking forinformation about an alleged scientific organization in italy styledl’académie physico-chimique italienne this italian physico-chemicalacademy is operated from palermo, italy here is the scheme. Dr johndoe, an american physician receives an imposing-looking letter bearingthe palermo, sicily, postmark and addressed to “monsieur le docteurjohn doe, médecin ” on opening the letter “monsieur le docteur”finds that the “council” of l’académie physico-chimique italiennehas nominated him “honorary member of this academy” and furthermorehas bestowed on him “a first class medal for technical work andscientific merit ” all this, “in consideration of your thesis dignitiesand great learning ” dr doe is told that as soon as he will write anacceptance of this honor “in conformity with section 19 and 22 of theconstitution” he will be sent “the medal, diploma and all the otherdocuments relating to the title accorded ” the joker in the scheme liesin the necessity for dr john doe “conforming” with “section 19 and 22of the constitution ” here are the sections:illustration.