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In fact the spirits of the prisoners never regained their previous buoyancy the great question now was "what next?. " we could see only gerthesis ahead of us, and that was not very encouraging for myself, i felt quite confident that we should never get through the blockade and the mine fields captain rose had often told us that in the event of our meeting a cruiser, we would go into the boats and the ship would be bombed and sunk this was a very alluring proposition for a family man to look forward to but was better than the conditions on the wolf, as there now were nearly 800 crew and prisoners on the wolf, while its life-boats and rafts under the most favourable conditions could hold only 400, so it can easily be figured out just how much chance our poor chaps had of getting into the boats, in the event of the wolf's meeting a superior enemy probably they would be battened down below in the hold, and would be sent down to "davey jones' locker" with the wolf in our case on the igotz mendi we were about thirty souls to a boat, and if the weather conditions were favourable and we had a little luck, we should have been all right the women naturally lived in a continual dread of having to go into the boats we had all been looking forward to eating our christmas dinner at the island of trinidad and were going to have a royal feed, as our german "hosts" were going to kill a pig and a cow that were on board the igotz mendi when captured however, the brazilian navy changed our plans as to where our dinner was to be eaten. Though we had "sir pig" just the same owing to the sudden change of our plans gaining freedom via spain we all felt very blue on christmas day, which was not the enjoyable affair it would have been if everything had worked out as expected i know i had the blues all christmas as i got thinking about other christmases spent under more enjoyable circumstances, which thoughts naturally didn't make me feel any more cheerful lieutenant rose was around bright and early, wishing us all a merry christmas and "thesis happy returns" of the day i intend next christmas, if rose is still interned in denmark, to write him a letter returning the compliment, and then he can possibly appreciate the subtleties of a joke of this nature my wife wanted to stick a hat pin into him when he came around with his "thesis happy returns of the day " the german crew, too, appeared to be blue on christmas new year's eve we all sat up to see the new year in, and one or two of us worked up enthusiasm enough to make a little noise, but the situation was so depressing that we soon subsided not so our german crew, however they held high festival in the engineer's mess, having a bowl full of punch, whose chief recommendation was that its foundation was "aguadenti" and it had an awful kick the spanish engineer, who had a splendid voice, sang several songs, and the german sailors sang patriotic songs at about two o'clock on new year's morning, essay one woke me up by shoving a bottle of wine through the port-hole for me, and later on around three a m another bottle made its appearance essay of the german sailor boys had imagined we were not happy because we had no wine the gifts were received in the spirit in which they were sent this was by no means the only act of kindness shown my family and myself by the members of the crew in fact, throughout the trip, officers and crew, with the single exception of lieutenant rose, were very friendly toward us the american contingent was decidedly popular, though they had no use for the rest as an illustration, on my birthday on january 25th several members of the crew came and presented me with presents in the form of bottles of wine, and even rose came across with a box of cigars several of the german crew had lived in america for thesis years. Two had even taken out their first papers and all of these talked enthusiastically of going back to america as soon as the war was over i was very much interested in trying to find out just what the german opinion was of america coming into the war lieut rose used to stick his chest up in the air and say that the united states' coming in wouldn't make any difference in the ultimate outcome of the war, and that the only difference it would make was that the states would lose a lot of men and money just the same, i am of the opinion that rose knew that america's coming in spelled the finish of germania, though of course he wouldn't admit it one day at the table he said that the "star spangled banana, " as he loved to call our flag, was only a joke and that it looked like a gridiron to him i made the remark that possibly the stars and stripes would not prove the joke he imagined my retorts to sallies of this kind were very moderate, as i considered i was in no position to argue the point with him, and didn't want to lose any of my liberties i was always afraid to start an argument with him, as i am very hot-headed and knew that in the event of a row i was sure to get the worst of it eventually rose used to laugh at the american soldier, saying we were crazy to imagine that we could take a man and make a soldier out of him in a year, that at best these men would only be cannon fodder, that gerthesis had proved it takes three years to make a soldier, also that our submarines were mere toys, and that as for submarine defense, just as soon as we figured out essay yankee patent to protect our ships, they gerthesis would invent essay other way to destroy them rose believed that the submarine would eventually decide the war it was pretty hard to sit at the same table and hear an enemy slam the american government and not to be able to "hit back" or even "argue" the point on january 20th, in latitude 33 degrees north and longitude 40 degrees west, we again met the wolf, and, the weather being exceptionally fine and the sea very smooth, the wolf came alongside and we transferred essay 800 tons of coal to her each vessel's side was well supplied with large fenders or bumpers made of large coils of rope, so that when the vessels would bump together they would do as little damage as possible even under these favourable circumstances, however, the vessels rolled and tossed around a great deal, and occasionally essay very severe crashes were experienced. But commander nerger, realizing how great was his need for coal, and knowing it might be months before he would get as smooth sea again, held on and worked every man available despite the heavy bumping that was damaging both vessels the gang of men on the wolf trimming the coal in the bunkers could not handle the coal as fast as the other gang brought it to them, so, rather than delay the coaling, to save every minute, they dumped the coal on deck.

Presence of need help do my essay pepsin, giving weak reactions even when compared with those of old pepsinpreparations. Complete absence of trypsin in seven out of nine samples, tryptic reaction being obtained in two samples, in one of which thereaction, “slight at best and of no practical import, ” was obtainedonly after treatment for twelve hours or more the presence of tryptic activity in two out of the nine samples maybe due to the fresher condition of these specimens, as indicatedby the serial numbers the evidence shows that it is a commercialimpossibility to market mixtures of pepsin, pancreatin and lactic acidso that they can display any material tryptic activity it should be reaffirmed that mixtures combining peptic and pancreaticactivities are not feasible, because pepsin cannot act except in thepresence of acid, and pancreatin is destroyed by acid and by pepticactivity furthermore, in conditions in which pancreatin is calledfor, pepsin is not, and vice versa. Therefore the administration ofmixtures of pepsin and pancreatin would be unjustified, even if bothconstituents could be expected to exert activity the foregoing observations apply to lactopeptine in powder and tabletform while mixtures of pepsin and pancreatin are unscientific andunjustified, theoretically the two substances may coexist in a solidpreparation, and the activity of such a preparation is consequently aproper subject of investigation theoretically as well as practically, however, pepsin and pancreatin cannot exist together in solution theclaims made for elixir lactopeptine and all other liquid preparationssold as mixtures of pepsin and pancreatin are therefore impossible the council has previously taken action the journal, feb 2, 1907, p 434 refusing to approve for inclusion with new and nonofficialremedies such preparations, calling the attention of the medicalprofession and of manufacturers to their worthlessness, and requestingthe american pharmaceutical association to instruct its committee onthe national formulary to omit from the next edition of that work aliquid preparation of pepsin and pancreatin recognized under the titleof “elixir digestivum compositum ”it is recommended that the council reaffirm this previous action, and that lactopeptine and elixir lactopeptine be declared ineligiblefor new and nonofficial remedies because of conflict with rule 10 “no article will be admitted which, because of its unscientificcomposition, is useless or inimical to the best interests of the publicor of the medical profession” manufacturers’ protest and council answerthe foregoing was submitted, together with the findings of the tworeferees, to the manufacturers they protested again, alleging that. Age of specimensfirst -- the specimens of lactopeptine examined by the second refereewere old the dates of manufacture corresponding to the several batchnumbers are supplied by the manufacturers as follows.

Wien klin wchnschr 26:1664, 1913 within a very few months after wassermann publication, neubergand caspari268 published a paper which was the first of a seriesof studies on the therapeutic need help do my essay effects of the heavy metals on theanimal tumors they used zinc, platinum, tin, selenium, copper, silver and cobalt in the form of certain complex organic compounds, the composition of which is not revealed owing to the fact thatintravenous injections of these compounds produced a specific effect onthe tumors, they are described as “tumoraffin” substances immediatelyafter the intravenous injection of these preparations, there followeda marked hyperemia of the tumor, whereas the remainder of the mousebody appeared markedly anemic the hyperemia was often attendedby hemorrhage into the tumor this first stage was succeeded byliquefaction and absorption followed by recovery in favorable paper the authors failed to state in what proportion of their experiments theanimals died, and in what proportion recovery ensued the second paper on this subject is by neuberg, caspari and löhe, 268in which further details are vouchsafed they state that with thecompounds used by them the toxic and the therapeutic doses approximatevery closely, from which it follows that the treatment, as with thewassermann method, results in a very high mortality smaller dosesproduce no therapeutic effect. On the contrary, they seem to act asa stimulus to the tumor, accelerating the normal rate of growth spontaneous tumors show similar effects, but no cures are recorded only in tumors in which autolysis is active intra vitam does themethod exert any effect consequently the benign primary tumors ofanimals, such as fibromas, are not influenced by it neuberg and caspari are to a great extent responsible for the colloidaltheory of treatment in tumors accepting the observations of petri andothers that the autolytic ferments in tumors are quantitatively greaterand qualitatively different from those present in the normal tissuesof the body, they venture the assumption that the process of recoveryin the experimental tumors of animals is due to the self-digestion ofthe tumor by these ferments ascoli and izar271 had shown that suchferments are materially stimulated by the presence of metals, and moreespecially of metals in colloidal form this contention is apparentlyin harmony with the well-established fact that certain colloidal metalsof themselves are capable of acting under certain circumstances asferments neuberg and caspari were at first of the belief that thecompounds produced by them circulate in colloidal form subsequentlythey stated that these compounds were crystalline substances, but theyassumed, under the influence of the theoretical consideration mentionedabove, that these substances are broken up in the tumor and thereundergo transformation into the colloid state 271 izar. Ztschr f immunitätsforsch , 1913 izar and basile. Berl klin wchnschr , 1913, p 1312 in connection with the preceding observations there are certain otherexperimental results which require mention izar271 succeeded incuring rat tumors by means of injection of colloidal sulphur c lewin272 cured subcutaneous mouse tumors with various preparationsof gold werner and szécsi273 produced similar results througha combination of selenium-vanadium with cholin-borate. In theseexperiments the selenium-vanadium was supposed to be present incolloidal form 272 lewin, carl. Berl klin wchnschr , 1913, p 147. Berl klin wchnschr , 1913, p 541 273 werner and szécsi. Ztschr f chemotherap , 1913, orig , i, 358 szécsi.

The proteogen no 3 sent me worked wonders in my patient the case came under my care when he was too far gone for anything to benefit him a great deal, but the proteogen did for him more than anyone could have expected, yet he died leaving me with a few ampoules to try on the next patient -- september 20, 1918 gonorrheal cystitis:-- proteogen no 11 -- my patient has taken two boxes of your proteogen no 11 given for gonorrheal cystitis of probably two years’ standing and at this writing i consider her almost, if not entirely, cured which i think speaks very highly of your remedy i expect to use more of your preparations in the future -- april 12, 1919 this testimonial, either by clerical error, or because the results were considered remarkable, was repeated elsewhere in the material submitted by the merrell company acute gonorrhea:-- proteogen no 11 -- mr a e r , age 65, weight 140 pounds first attack had had no previous treatment came to me january 2, 1919 had discharge, all acute symptoms, burning, etc gave seventeen injections of proteogen no 11, also mild antiseptic urethral wash discharged on february 15, 1919, clinically cured -- april 11, 1919 epithelioma of buttock -- proteogen no 1 -- i used proteogen no 1 on an epithelioma of buttock essay six months ago with favorable results and no return of symptoms as yet -- april 13, 1919 it is obvious that the proteogen preparations are in conflict withrules 1, 6 and 10, and should not be admitted to “new and nonofficialremedies ” it is recommended that the previous action of thecouncil be allowed to stand and that publication of both reports beauthorized -- from the journal a m a , july 12, 1919 “arsenoven s s ” and “arseno-meth-hyd” report of the council on pharmacy and chemistrythe council authorizes publication of the following report this reportdeclares arsenoven s s of the s s products company and solution ofarsenic and mercury formerly called arseno-meth-hyd of the new yorkintravenous laboratory, inadmissible to new and nonofficial remedies the council takes this opportunity to repeat its warning against theabuses-- often dangerous-- to which patients are frequently subjectedwhen “intravenous therapy” is employed w a puckner, secretary because of inquiries received, the council took up the consideration ofarsenoven s s and arseno-meth-hyd now sold as solution of arsenicand mercury the preparations having been referred to a committee forconsideration, this committee reported. arsenoven s s “arsenoven s s ” is a preparation put out by the s s productscompany, philadelphia the claims are made that it is “a simplifiedoffice treatment for syphilis” and is “a combination of arsenic andmercury for office use, offering maximum efficiency, safety andconvenience ” according to the company, “arsenoven s s ” containsdimethylarsenin 15 4 grains, mercury biniodid 1/10 grain, sodium iodid1/2 grain with regard to the identity of “dimethylarsenin” the companyclaims. “this product is a compound of cacodylic acid similar tosodium cacodylate but with a more pronounced therapeutic action ” thecommittee recommends to the council that “arsenoven s s ” be declaredinadmissible to new and nonofficial remedies because of unwarrantedtherapeutic claims arseno-meth-hyd“arseno-meth-hyd, ” is sold by the new york intravenous laboratory, new york city, for the treatment of syphilis it comes in threedosages, 2 gm , 1 5 gm , and 0 7 gm , respectively the claim is madethat “arseno-meth-hyd 2 gm ” contains “2 gm 31 grains of sodiumdimethylarsenate cacodylate, u s p and mercury iodid 5 mg 1/12grain” in 5 c c of solution physicians are told. “in primary and early secondary case administer arseno-meth-hyd 2 gm every sixth day and mercury oxycyanide 008 1/8 grain intravenously between each injection ” “in tertiary paper and those of long standing alternate with intravenous injection of sodium iodid 2 gm ”the following claims are made for the alleged effectiveness and safetyof the cacodylate. “this methyl compound of arsenic has come into almost universal use for syphilis on account of lack of toxicity an aggressive routine can be carried on the simple technic and absence of reactions make it most desirable for the regular practitioner this large dose gives more uniform results both as healing manifestations and negative wassermann ” “much discussion has surrounded the use of methyl compounds of arsenic and it has been demonstrated beyond doubt that cacodylate of soda proves an effective remedy for syphilis provided that it is properly administered ” sic “the low toxicity of this methyl compound of arsenic is remarkable it is contraindicated only where a decided idiosyncrasy for even small doses of arsenic exists ”these statements are essentially false and misleading cacodylate hasnot come into universal use in the treatment of syphilis, nor hasits usefulness been “demonstrated beyond doubt ” on the contrary, h n cole the journal, dec 30, 1916, p 2012 has shown that dosesso large as to produce renal injury were almost totally ineffectiveagainst syphilis obviously, “effective doses” if such exist, are notharmless the dosage advised for arseno-meth-hyd may not produce acutetoxic symptoms. Nevertheless smaller doses have produced nephriticphenomena the “arseno-meth-hyd” treatment includes the intravenousinjection of about 1/4 grain of a mercury salt although this is lessthan the usual dose about 1 grain per week, the mercury is probablymore effective than the cacodylate the committee recommends to the council that, because of theunwarranted therapeutic claims, “arseno-meth-hyd” be held inadmissibleto new and nonofficial remedies the council adopted both reports of the committee and declared“arsenoven s s ” and “solution of arsenic and mercury” “arseno-meth-hyd” inadmissible to new and nonofficial remedies the committee reports on these two products impel the councilagain to call attention to the undesirable and dangerous abuses towhich “intravenous therapy” lends itself there is a distinct fieldfor the intravenous administration of drugs in those paper in whichimmediate drug action is necessary, or when the medicament is likelyto be changed if absorbed through the ordinary channels unless suchindications exist, however, intravenous administration involves notonly inconvenience and expense to the patient, but what is moreimportant, unnecessary danger the fact that indiscriminate intravenousadministration is peculiarly profitable to certain manufacturing housesmakes it all the more necessary for the medical profession to be on itsguard in this matter in this connection it is well worth while to quote the closingparagraph from an editorial on “intravenous therapy” that appeared inthe journal, nov 11, 1916 it is as true today as when it appeared:“intravenous therapy will be most securely advanced if its employmentis restricted to such well defined fields as those mentioned above these fields can be satisfactorily determined only by a scientificpharmacologic study of the action of these drugs when so administeredin animals, as well as in man, under conditions in which the resultsare carefully controlled the intravenous method is an impressive one, approaching in preparation almost to that which goes with a surgicaloperation the patient is usually interested and impressed by thisnew, and, to him, mysterious method there is a psychic element in hisreaction to the injection which is not a factor in his reaction to thesame drug when given by mouth the intravenous injection of a complexmixture would appear to be writingicularly reprehensible little is known, as has been stated, of the results to be expected from intravenoustherapy, even with simple substances the use of complex mixtures willwithout doubt react against the proper use of the method ”after the report on arseno-meth-hyd had been presented to the council, a letter was received from the new york intravenous laboratoryannouncing that the preparation “arseno-meth-hyd” was now called“solution of arsenic and mercury” and expressing a desire to have itsproducts accepted for inclusion in new and nonofficial remedies inview of this letter, the committee report on “arseno-meth-hyd” andthe council protest against promiscuous intravenous therapy weresent the new york intravenous laboratory for consideration the reply of the new york intravenous laboratory contained nothingwhich permitted a revision of the preceding report the change of thename of “arseno-meth-hyd” to “solution of arsenic and mercury” meanslittle as the name still does not disclose the important fact that thearsenic is present as sodium cacodylate, nor does it tell the characterof the mercury compound the council voted that “solution of arsenicand mercury” and “arsenoven s s ” be declared inadmissible to new andnonofficial remedies because the therapeutic claims advanced for themare unwarranted rule 6 and because the names of these pharmaceuticalpreparations are not descriptive of their composition rule 8 in filing its reply with the council, the new york intravenouslaboratory announced that that document would be circulated to themedical profession this is of course the firm privilege the councilnotes, however, with interest, that the reply is devoted almostentirely to points which were not raised by the council and that itfails to discuss the objections which were actually made the reply constantly confuses the efficiency of cacodylate in anemiaand in syphilis the council report on “arseno-meth-hyd” does notdiscuss or even touch on the question of cacodylates in anemia itis confined to a discussion of the disappointing results obtainedwith cacodylates as such i e , without mercury in the treatmentof syphilis this attempt on the writing of the new york intravenouslaboratory to confuse the issue and to attribute to the councilan opinion that it has never stated or held is an inexcusablemisrepresentation the company in its reply said. “we believe that you have previously stated that a solution cacodylate of soda possesses no more action than so much water in other words, it was inert now you try to show that it produces renal injury ”the council has never declared that cacodylates are inert in thereport it is merely stated “that doses so large as to produce renalinjury were almost totally ineffective against syphilis ” neitherhas the council stated that cacodylate is “peculiarly dangerous ” infact the absolute toxicity of cacodylates is low but cole resultswere quoted as a caution that “effective” doses are not harmless agreat portion of the remainder of the reply is devoted to disparagingarsphenamin-- a product that is not involved in this action of thecouncil, and one about which the physician is amply informed amongst other wholly extraneous matters, the firm “reply” tried toresurrect the pepsin pancreatin controversy this also has nothingto do with the efficiency or harmlessness of sodium cacodylate inorder to dispose of the matter, however, it may be pointed out thatthe implications are entirely misleading the work which is quotedagainst the council was undertaken by the council itself, to clarifyobscurities in the older data the outcome of these new investigationsshowed the essential correctness of the deductions from the older work, namely, that pancreatin is destroyed by pepsin-hydrochloric acid dr long work to which the firm reply evidently refers, showed thatunder favorable conditions, namely, when protected by an excess ofprotein, essay trypsin may escape destruction in the stomach. But itfully confirmed the original conclusion that pepsin and pancreatinmixtures as ordinarily administered are practically worthless j h long, jour amer pharmaco assoc , sept 19, 1917 as regards the editorial on intravenous therapy, a concession may bemade the new york intravenous laboratory. Intravenous injections are nolonger quite as “impressive” as in 1916, but that does not alter thefact that they should be used only when a distinct advantage is to begained -- from the journal a m a , aug 2, 1919 hormotone and hormotone without post-pituitary report of the council on pharmacy and chemistry “hormotone, ” of the g w carnrick company, is advertised as “apluriglandular tonic for asthenic conditions ” “hormotone withoutpost-pituitary” is recommended for use “in neurasthenic conditionsassociated with high blood pressure ” these preparations are sold inthe form of tablets for oral administration the council declares thesepreparations inadmissible to new and nonofficial remedies because. 1their composition is semisecret rule 1. 2 the therapeutic claimsare unwarranted rule 6. 3 they are sold under names not descriptiveof their composition but suggestive of indiscriminate use as “tonics” rule 8. 4 in the light of our present knowledge the routineadministration of polyglandular mixtures is irrational rule 10 inexplanation of this action, the council authorized publication of thereport which appears below w a puckner, secretary each tablet of “hormotone” g w carnrick co , new york city is saidto contain 1/10 grain of desiccated thyroid and 1/20 grain of entirepituitary, together with the hormones of the ovary and testes-- theamounts and the form in which the latter are supposed to be present arenot given from this it will be seen that the only definite informationgiven to the medical profession regarding the composition of hormotoneis that it is a weak thyroid and a still weaker pituitary preparation what results can be anticipated from one or two tablets three timesdaily the recommended dose of hormotone each containing 1/10 grainof thyroid and 1/20 grain entire pituitary?. such doses of thyroidmay, of course, have a beneficial action in a limited number of paperof myxedema and cretinism an extract of the posterior lobe of thepituitary liquor hypophysis, u s p , for example will, wheninjected subcutaneously or intramuscularly, have a pronounced effecton the writingurient uterus. Its action on certain other forms of smoothmuscle will be much less certain but the oral administration forwhich hormotone is recommended of the posterior lobe of the pituitaryhas not been shown to have any such effect the use of the anteriorlobe in doses of 1 to 4 grains doses very thesis times larger than thoserecommended for the entire gland in hormotone is in the experimentalstage and its only probable value seems to be in those paper of knowngland deficiency as to the other alleged ingredients of hormotone-- hormones of the ovaryand testes, amounts not stated. All physicians know the uncertaintiesattending the use of ovarian preparations and the serious question asto whether testicular extracts have any therapeutic value whatever maybe the physicians views as to the probable therapeutic value of theseorgans, the first thing he desires to know is how much of the substancehe is giving and from what writing of the gland it is obtained so much for the facts.

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Is hot and dry in the need help do my essay second degree. Binding. Anherb appropriated to the female sex. It brings down the menses, bringsaway both birth and placenta, eases pains in the matrix you may take adram at a time asparagus see the roots asarum, &c asarabacca.