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dried ?. cereals, pulses, etc. Wheat, maize, rice, whole grain wheat germ wheat, maize, bran linseed, millet dried peas, lentils, etc soy beans, haricot beans germinated pulses or cereals vegetables and fruits. Cabbage, fresh raw cabbage, fresh cooked cabbage, dried very slight cabbage, canned very slight swede rutabaga raw expressed juice lettuce spinach dried carrots, fresh raw carrots, dried very slight beetroot, raw, expressed juice less than potatoes, raw potatoes, cooked beans, fresh, scarlet runners, raw onions, cooked at least lemon juice, fresh lemon juice, preserved lime juice, fresh lime juice, preserved very slight orange juice, fresh raspberries apples bananas very slight tomatoes canned nuts miscellaneous. Yeast, dried yeast, extract and autolyzed ?.

Right auricle showed full andregular contractions and dilatations the spinal cord was then divided one hundred and twenty minutes, heart-beats forty per minute thesepulsations of right auricle continued at intervals for three and a halfhours longer. Readily excited by point of scalpel heart normal. Leftventricle contracted. Right ventricle not so. No coagulation brainnormal. Lungs collapsed. Liver and spleen congested. Mucous membraneof small intestine pinkish. Other organs normal in the discussion, dr gay thought the absence of cerebral congestion was due to thecirculation continuing in the left carotid 90 hofmann. Wien med woch , 1880, xxx , pp 477-480 - man, acriminal, hung. After hanging ten minutes, the body was cut down examination half-hour after drop fell he was resuscitated and writinglyregained consciousness, but died three days afterward of œdema oflungs after repeated severe convulsions he had tumors of the neckwhich probably interfered with the compression of the trachea see alsoallg wien med zeit , 1880, xxv , p 161, and wien med blät , 1880, i , pp 423-430. Translated in ann mal oreill and larynx, paris, 1880, vi , pp 99-112 91 kinkhead. Lancet, and 701-703 - paper of hanging in one, thebody of the third cervical vertebra was broken across and the twopieces separated. In another case dislocation of second and thirdcervical vertebræ 92 nelson.

In form they resemblea tongue, in colour they are black, and they hang bobbing downwards the seed contained within these husks if it be a little chewed givesan azure colour the root is white and long place it is sowed in fields for the benefit of it, where thosethat sow it, cut it three times a year time it flowers in june, but it is long after before the seed isripe government and virtues it is a cold and dry plant of saturn essaypeople affirm the plant to be destructive to bees, and fluxes them, which, if it be, i cannot help it i should rather think, unless beesbe contrary to other creatures, it possesses them with the contrarydisease, the herb being exceeding dry and binding however, if any beesbe diseased thereby, the cure is, to set urine by them, but set it ina vessel, that they cannot drown themselves, which may be remedied, ifyou put pieces of cork in it the herb is so drying and binding, thatit is not fit to be given inwardly an ointment made thereof stanchesbleeding a plaister made thereof, and applied to the region of thespleen which lies on the left side, takes away the hardness and painsthereof the ointment is excellently good in such ulcers as abound withmoisture, and takes away the corroding and fretting humours. It coolsinflammations, quenches st anthony fire, and stays defluxion of theblood to any writing of the body woodbine, or honey-suckles it is a plant so common, that every one that hath eyes knows it, and hethat hath none, cannot read a description, if i should write it time they flower in june, and the fruit is ripe in august government and virtues doctor tradition, that grand introducer oferrors, that hater of truth, lover of folly, and the mortal foe to dr reason, hath taught the common people to use the leaves or flowers ofthis plant in mouth-water, and by long continuance of time, hath sogrounded it in the brains of the vulgar, that you cannot beat it outwith a beetle. All mouth-waters ought to be cooling and drying, buthoney suckles are cleansing, consuming and digesting, and thereforefit for inflammations. Thus dr reason again if you please, we willleave dr reason a while, and come to dr experience, a learnedgentleman, and his brother take a leaf and chew it in your mouth, andyou will quickly find it likelier to cause a sore mouth and throatthan to cure it well then, if it be not good for this, what is itgood for?. it is good for essaything, for god and nature made nothing invain it is an herb of mercury, and appropriated to the lungs. Crabclaims dominion over it. Neither is it a foe to the lion. If the lungsbe afflicted by jupiter, this is your cure. It is fitting a conservemade of the flowers of it were kept in every gentlewoman house. Iknow no better cure for an asthma than this. Besides, it takes awaythe evil of the spleen, provokes urine, procures speedy deliveryof women in travail, helps cramps, convulsions, and palsies, andwhatsoever griefs come of cold or stopping. If you please to make useof it as an ointment, it will clear your skin of morphew, freckles, and sun-burnings, or whatsoever else discolours it, and then the maidswill love it authors say, the flowers are of more effect than theleaves, and that is true. But they say the seeds are least effectualof all but dr reason told me, that there was a vital spirit in everyseed to beget its like. And dr experience told me, that there was agreater heat in the seed than there was in any other writing of the plant;and withal, that heat was the mother of action, and then judge if olddr tradition who may well be honoured for his age, but not for hisgoodness hath not so poisoned the world with errors before i was born, that it was never well in its wits since, and there is a great fear itwill die mad wormwood three wormwoods are familiar with us. One i shall not describe, anotheri shall describe, and the third be critical at. And i care not greatlyif i begin with the last first sea wormwood hath gotten as thesis names as virtues, and perhaps onemore seriphian, santomeon, belchion, narbinense, hantonicon, misneule, and a matter of twenty more which i shall not blot paper withal apapist got the toy by the end, and he called it holy wormwood.

All tubes remained sterile the germicidal action of chlorlyptus on streptococcus suspended in oil was almost at once and with certainty after five minutes when added in the proportion of 1, 5 and 10 per cent experiment 8 -- germicidal action of chlorlyptus on staphylococcus, suspended in sterile olive oil -- the technic employed was the same as in experiment 5, except that a culture of staphylococcus was used result. All tubes remained sterile the germicidal action of chlorlyptus was almost at once in the proportions of 1, 5 and 10 per cent remarks. By repeating this experiment the result showed essay variations the discrepancy was probably due to an imperfect suspension of the micro-organism in the oil experiment 9 -- germicidal action of carbolic acid on streptococcus suspended in olive oil -- the technic employed was the same as in experiment 5, except that carbolic acid was used instead of chlorlyptus result. The germicidal action of carbolic acid of streptococcus suspended in olive oil was almost at once in the proportions of 1, 5 and 10 experiment 10 -- germicidal action of chlorlyptus on staphylococcus -- the technic employed was the same as in experiment 6 except that the carbolic acid was used instead of chlorlyptus result. The germicidal action of carbolic acid on staphylococcus suspended in olive oil was almost at once, in proportions of 1, 5 and 10 per cent experiment 11 -- germicidal action of chlorlyptus on pyogenic bacteria suspended in pus -- chlorlyptus was added to sterile pus in the proportions of 1, 5 and 10 per cent , and then inoculated with staphylococcus and cultures were made in bouillon at once, after five minutes, after ten minutes, after fifteen minutes, after thirty minutes, after one hour and after two hours, respectively, and tubes incubated for forty-eight hours at 37 c result. Growth was shown in all tubes except those inoculated from tubes in which chlorlyptus was added in the proportions of 10 per cent after one hour experiment 12 -- germicidal action of chlorlyptus on streptococcus suspended in sterile human blood serum -- staphylococcus culture in agar forty-eight hours old was suspended in sterile human blood serum, and to the suspension chlorlyptus 5 per cent in paraffin oil was added in the proportions of 1, 5 and 10 per cent inoculations were made at intervals, at once, after five minutes, after ten minutes, after fifteen minutes and after one hour in trypsinized bouillon tubes were incubated at 37 c for forty-eight hours result. Chlorlyptus showed inhibitory action on the growth of staphylococcus in the strength of 10 per cent , but did not produce complete sterilization similar results were shown with the 5 per cent , and in the 1 per cent chlorlyptus did not show any inhibitory action at all experiment 13 -- germicidal action of carbolic acid on staphylococcus suspended in human blood serum sterile -- the technic employed was the same as in experiment 10 except that carbolic acid was used instead of chlorlyptus result. Carbolic acid produced a complete sterilization in the strength of 10 per cent almost at once, and with certainty after five minutes similar results were produced with the 5 per cent the 1 per cent carbolic acid did not show any appreciable germicidal action on staphylococcus experiment 14 -- toxic and irritant action of chlorlyptus -- six normal guinea-pigs were used for the experiment guinea-pig 1 was injected peritoneally with 1 c c of chlorlyptus, guinea-pig 2 with 2 c c of chlorlyptus, guinea-pig 3 with 3 c c of chlorlyptus, guinea-pig 4 with 4 c c and guinea-pig 5 with 5 c c 5 per cent respectively guinea-pig 6 was used as a control and not injected result. Guinea-pigs 1 and 2 did not show any appreciable disturbance guinea-pig 3 was sick for four days, after which it gradually recovered but it became sick again after one week and died ten days after the injection guinea-pig 4 died over night guinea-pig 5 died six hours after injection guinea-pig 5 was injected at 11:30 with 5 c c chlorlyptus ten minutes after the injection it was lying relaxed, respiration and heart normal, conjunctive reflex present one hour after the injection the animal seemed to present symptoms resembling those of narcosis. Respiration and heart were normal after four hours there was no change in the condition of the guinea-pig except that the respiration was irregular five and a half hours after it showed prostration with irregular respiration and heart action six hours after injection the animal was dead autopsy.

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“formamint is pentamethanallactose, 5 choh c₁₂h₂₂o₁₁ it is an original combination of formaldehyde with lactose, a definite chemical compound the formaldehyde molecule is locked up in it until solution in the saliva takes place, when the formaldehyde is liberated in its nascent state and is therefore active without being irritant ”furthermore the makers contend that this new chemical compound isentirely harmless for example, daus, 5 in an article on “thedisinfectant action of formic aldehyde on mucous law school admission essay service membranes, ” declares. “no indication of irritant or other injurious action made its appearance even after large doses the urine remained free from albumin and sugar ”such statements as these are found in the advertising literature. “formamint tablets are absolutely harmless and innocuous, even to little children ” “when dissolved in the saliva, formamint tablets liberate slowly nascent formaldehyde in a most active yet non-irritant form ”they maintain that formamint is not only absolutely harmless, butactually beneficial to the tissues it may be used “to tone up andstrengthen the tissues, prevent hoarseness, and allay irritation insingers, public speakers, ” etc the claims urged as to its germicidal power are indeed glittering this“new chemical compound” is claimed to liberate formaldehyd in essay newand peculiar condition which, while it has a soothing and tonic effecton the cells of the human tissues, can at the same time quickly killany form of bacterial life “dissolving readily, it releases its germicidal, antiseptic qualities, which impregnate the saliva and are carried naturally and easily around the mouth and in the deepest crevices of the throat-- destroying the germs where they are causing the mischief formamint prevents and destroys infectious germ life in a soothing grateful way ” “in the saliva it frees a germicide, fatal to germs but harmless to the most delicate membranes and flowing into every tiny corner of the gums, tonsils and throat, into places where no gargle ever reaches, it most effectively disinfects the throat ”the claims as to the preventive and curative effects of the preparationcover a large portion of the category of human ailments and distresses the following quotations indicate essay of its supposed properties. “ it is therefore self-evident that formamint should be looked upon as a necessary writing of the treatment of all forms of tonsillitis ” “the value of formamint is equally great in diphtheric tonsillitis, or as a prophylactic ” “the extraordinary success which i had with formamint in a school epidemic of scarlet fever during may and june, 1907, was the determining factor which induced me to abandon the use of inhalations, gargles, local applications in the treatment of diseases of the throat, and to use formamint exclusively for the future ” “there are naturally thesis similar conditions in which formamint may be used as a prophylactic, notably scarlet fever, mumps, streptococcal and staphylococcal sore throats, ‘milk outbreaks’ of sore throat, drain throats, hospital throats, and the like ” “formamint tablets are indicated in angina, tonsillitis, pharyngitis, stomatitis, gingivitis, glossitis, ulceration, spongy or bleeding gums, pyorrhea alveolaris, ‘smoker sore throat, ’ abscess or boils, etc ” “as a prophylactic against diphtheria, scarlet fever, influenza, measles, epidemic poliomyelitis, and other pathogenic micro-organisms to neutralize putrefaction products in and about the teeth, correct fermentative processes, deodorize and purify the breath, etc ” “to tone up, and strengthen the tissues, prevent hoarseness and allay irritation in singers, public speakers, neutralize the effects of dust-infection or disinfect the saliva or sputum in influenza, tuberculosis, etc ”one man declares that along with specific constitutional treatment he“had the best results from the use of formamint tablets” in a case ofsyphilitic ulceration of the tongue in short, formamint is recommended for the treatment or preventionof almost everything, from a bad breath to such grave conditions asscarlet fever, diphtheria and tuberculosis, conditions in which adelay in proper treatment-- for instance, in diphtheria, a failure toadminister antitoxin-- may result in the death of the patient a series of investigations was therefore undertaken in order todiscover whether the extravagant claims regarding the germicidal powerof formamint could be verified experimental datatwo fifty-cent bottles of wulfing formamint were purchased in theopen market and were kept well stoppered to prevent deterioration qualitative tests showed the presence of formaldehyd and the amount wasdetermined quantitatively by the hydrogen peroxid method as given bysutton 23 the results were respectively, 1 99 per cent and 2 03 percent of formaldehyd 23 sutton. Volumetric analysis, edition 10, p 390 illustration. Two formamint advertisements reproduced in miniaturetypical of those appearing in a certain type of medical journals essay determinations were made of the germicidal power of formamintin vitro, that is, under controlled laboratory conditions atwenty-four-hour plain agar culture of staphylococcus aureus waswashed off in 10 c c of sterile 0 85 per cent sodium chloridsolution a 1:100, 000 dilution of this was made in each of three flaskscontaining 100 c c of sterile saliva flask 1 contained 1 per cent offormamint, flask 2, 5 per cent. Flask 3, containing no formamint, waskept as a control at intervals samples were removed and dilutions madeand plated in duplicate on standard agar the plates were incubatedtwenty-four hours at 37 c , and plates containing less than 200colonies were counted the results are given in table 1 after sevendays there was no appreciable difference in the plates another test was made by adding a 1 per cent formamint solution toplain agar plates inoculated with b coli a twenty-four-hour plainagar culture of b coli was washed off in 10 c c of sterile 0 85 percent sodium chlorid solution a 1:1, 000, 000 dilution was made of thisand 1 c c added to each plate varying amounts of 1 per cent solutionof formamint were added to each plate they were incubated seventy-twohours at 37 c after seven days’ incubation the count was the same theresults are given in table 2 another experiment was made thus. One loopful of a twenty-four-hourplain agar culture of streptococcus lacticus was mixed with a tubeof north medium one loopful from the inoculated tube was mixed with asecond tube of north medium both tubes were poured into petri dishesand allowed to cool one half of each plate was well smeared with a 10per cent solution of formamint in saliva after twenty-four hours’incubation at 37 c , only a few colonies appeared on the side to whichthe formamint had been applied, while the other half was thicklycovered with colonies table 1 -- showing time in which cultures of staphylococcus aureus werekilled by different amounts of formamint amount of formamint| period of |average count| count on flask in saliva |standing at 37 c | when plated |of saliva without per cent | hours | | formamint -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 1 | 3 | 32 | 3200 1 | 6 | 0 | 7000 5 | 1 | few | 5000 5 | 2 | 0 | 4100 5 | 3 | 0 | 3200* 5 | 6 | 0 | 7000* -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- * the last two observations were made at the same time as on the 1 percent solutions this work so far corroborates that reported in the literature quotedby the manufacturers but the fact that a compound is a germicide whenbrought into intimate contact with bacteria in a solution or medium ina test tube or flask does not prove that it will be effective when usedin the human throat the alleged germicidal actionan attempt was made to discover whether or not the claims advanced bythe manufacturers as to the perfect germicidal action of formamint inall the nooks and crannies of the mouth and throat could be confirmed table 2 -- count of b coli cultures with different amounts of formamint no c c of 1 per cent formamint 0 0 1 0 3 0 5 0 7 1 0 1 5 2 0 3 0 count 160 33 39 26 15 12 2 0 0 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- the first step in attacking this problem was to make comparative countsof the number of bacteria in the throat before and after the use offormamint the methods employed were as follows. The throat was gargledwith 50 c c of sterile 0 85 per cent sodium chlorid solution ineach case the same length of time, as far as possible, was used in theprocess the liquid was collected in a sterile flask the gargling in aseries of experiments was begun not less than two hours after a meal after essay preliminary work the following dilutions of the 50 c c ofsalt solution were found sufficient. 1:1, 000, 1:10, 000 and 1:100, 000 plates were made in duplicate from each dilution and incubatedseventy-two hours at 37 c the counts were made on plates containingless than 200 colonies except where otherwise noted standard agar wasused the mediums were always prepared in the same way all the work was carried out under conditions as nearly naturalas possible the formamint was taken according to the directionsaccompanying the trade package every opportunity was given theformamint to penetrate all the crypts and recesses about the mouthand throat the tablet was allowed to dissolve as slowly as possible, the time usually being five to six minutes, and saliva was thoroughlyforced around the mouth before being swallowed plating was alwaysdone immediately after gargling so that no growth could occur in thesalt solution the results are given in table 3 the numbers areaverage counts from several plates and calculated to show the number ofbacteria washed out by the 50 c c of salt solution table 3 -- showing that formamint does not greatly decrease the numberof bacteria in the throat | | |no found |no found | time |amount of|in throat |in throat conditions of test | since |formamint| before | after |preceding| used | use of | use of | test | |formamint |formamint -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- normal | | 0 | 15, 600, 000| normal | 1 hour | 0 | 38, 500, 000| normal | 1 hour | 0 | 30, 500, 000| normal | | 0 | 12, 500, 000| normal | 1 hour | 0 | 14, 500, 000| | 1 hour | 0 | 23, 500, 000| tablet dissolved in mouth | 6 days | 1 tablet| | 15, 000, 000 and throat gargled one | | | | hour later | | | | throat again gargled two | 1 hour | 0 | | 10, 050, 000 hours after formamint | | | | was used | | | | normal | 7 days | 0 | 62, 000, 000| normal | 1 hour | 0 | 72, 500, 000| normal | | | 61, 000, 000| tablets were taken, one | 2 days | 12 | | 39, 100, 000 per hour, and throat | | | | gargled onehour after | | | | last tablet was taken | | | | throat was again gargled 2| 1 hour | 0 | | 59, 000, 000 hours after taking last | | | | tablet | | | | normal | 5 days | 0 | 35, 000, 000| normal | 1 hour | 0 | 62, 000, 000| normal | 1 hour | 0 | 72, 000, 000| one tablet was taken each | 4 days | 24 | |175, 000, 000 half hour for 12 hours | | tablets | | consecutively throat was| | | | gargled one hour after | | | | last tablet was taken | | | | throat was again gargled | 1 hour | 0 | |168, 750, 000 two hours after last | | | | tablet was taken | | | | normal | 3 days | 0 |129, 600, 000| normal | 1 hour | 0 |177, 000, 000| normal | 1 hour | 0 |147, 000, 000| normal | 3 days | 0 | 79, 000, 000| one tablet was taken | 1 hour | 1 | | 83, 200, 000 immediately after preced-| | | | ing gargle throat was | | | | again gargled at end of | | | | one hour | | | | throat was again gargled 2| 1 hour | 0 | |134, 750, 000 hours after tablet was | | | | taken | | | | normal conditions except | 19 days | 0 | 32, 600, 000| that mouth and teeth were| | | | throughly washed with | | | | soap just before gargling| | | | same as above | 1 hour | 0 | 33, 125, 000| same as above | 1 hour | 0 | 40, 375, 000| teeth were not washed | 2 days | 0 | 33, 500, 000| otherwise normal con- | | | | ditions | | | | same as above | 1 hour | 0 | 43, 330, 000| same as above | 1 hour | 0 | 54, 000, 000| same as above | 1 hour | 0 | 50, 000, 000| same as above | 1 hour | 0 | 67, 000, 000| mouth and teeth thoroughly| 2 days | 0 | 5, 270, 000| washed with soap just | | | | before throat was gargled| | | | same as above | 1 hour | 0 | 10, 916, 000| same as above | 1 hour | 0 | 8, 275, 000| normal conditions, but 1 | 3 days | 0 |228, 750, 000| c c of sterile rabbit | | | | blood was added to each | | | | plate | | | | count from the same gargle| 0 | 0 | 60, 625, 000| as above no blood used | | | | in the plates | | | | normal conditions, but | 1 hour | 0 |431, 250, 000| count was made on blood | | | | agar | | | | count from the same gargle| 0 | 0 | 59, 625, 000| asabove no blood used in| | | | the plates | | | | normal conditions, count | 2 days | 0 |683, 300, 000| was made on blood agar | | | | same gargle as above, but | 0 | 0 | 58, 500, 000| count was made on plain | | | | agar | | | | one tablet was taken just | 1 hour | 1 tablet| |558, 300, 000 after preceding gargle | | | | after one hour throat was| | | | again gargled count on | | | | blood agar | | | | same gargle as above, but | 0 | 1 tablet| | 55, 875, 000 count was made on plain | | | | agar | | | | normal conditions | 2 days | 0 | 79, 125, 000| one tablet was taken just | 1 hour | 1 tablet| | 56, 250, 000 ten minutes before gargle| 16 min | | | was made | | | | normal conditions | 2 days | 0 | 46, 750, 000| one tablet was taken just | 1 hour | 1 tablet| | 38, 500, 000 ten minutes before throat| | | | was gargled | | | | teeth and mouth were thor-| 5 days | 0 | 47, 370, 000| oughly washed with soap | | | | just before gargle was | | | | made | | | | teeth washed as above and | 1 hour | 1 tablet| | 21, 225, 000 1 tablet taken 10 minutes| | | | before gargle was made | | | | -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- finally a determination was made of the number of streptococci in thethroat before and after the use of formamint the throat was gargledin the manner previously described the streptococcus count was madeby the dilution method as given by heinemann 24 culture tubes wereused instead of fermentation tubes one per cent dextrose broth wasthe medium employed one cubic centimeter was added to each of a seriesof ten tubes for each dilution and the following dilutions were used:1:10, 000, 1:100, 000 and 1:1, 000, 000 24 heinemann. Laboratory guide in bacteriology, p 86 the results given in table 4 are the average count from a number ofdilutions and are reported as the total number washed out by the50 c c of salt solution table 4 -- showing that formamint fails to reduce the number ofstreptococci in the throat | | | no found | no found | time | amount of | in throat | in throat conditions | since | formamint | before | after of test | preceding | used | use of | use of | test | | formamint | formamint -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- - normal | | 0 | 1, 200, 000 | | | | | one tablet was| | | | taken and | | | | throat gargled| | | | one hour later| 4 days | 1 tablet | |14, 750, 000 | | | | normal | 3 days | 0 | 9, 950, 000 | | | | | one tablet was| | | | taken and | | | | throat gargled| | | | ten minutes | | | | later | 1 hour | 1 tablet | | 8, 000, 000 discussionthe contention that formamint contains formaldehyd was confirmed byanalysis the manufacturers also maintain that formamint is a new, definitechemical compound, consisting of five molecules of formaldehyd andone molecule of lactose, and that when dissolved in the saliva theformaldehyd is liberated in essay new and peculiar form, which theycall nascent formaldehyd this new kind of formaldehyd is, accordingto the advertising literature, especially powerful in its germicidalproperties and at the same time has absolutely no irritating or harmfuleffects not a chemical compoundthoms, 25 retained as an expert by the german government, decided, after a series of chemical investigations, that formamint was nota definite chemical compound, but that it was probably a solidsolution of formaldehyd in lactose he proved that when the processof manufacture was carried out in exactly the way called for by theformamint patents, compounds containing a greater or less per cent offormaldehyd could be made while the other properties remained similarto those of formamint the composition of the final product dependedon the proportion of the components used in the process thereforeformamint did not form a safe means of uniform dosage 25 thoms.