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if the profession can be thus successfully exploited one can no longer wonder at the following which every new ‘ic’ and ‘ism’ acquires ”it is a pity that the medical profession generally does not react tothe dionol and similar advertising as does our correspondent as theconcern continues to do business, the presumption is that at leastessay physicians are using dionol as was pointed out in the journalof jan 26, 1918, dionol seems to be a glorified and esoteric formof petrolatum the exploitation of dionol is based on help with spanish homework the followingtheory. 1 the brain is a generator of neuro-electricity. 2 thenerves are the conductors of this electricity.

The therapeutic value of organic phosphoruscompounds, j a m a , feb 13, 1915, p 573 1 in various tissues of the animal body, enzymes have been found whichhydrolyze complex organic phosphorus compounds so as to liberate thephosphorus in the form of inorganic phosphates 2 metabolism studies of the phosphorus balance with diets containinginorganic phosphorus compounds, as compared with diets containingorganically bound phosphorus, are essaywhat conflicting in theirresults the balance of evidence, however, is in favor of the view thatthere is no difference between organically combined phosphorus andinorganic salts with respect to the phosphorus balance 3 experiments indicate that the organism thrives on and supplies itsphosphorus needs quite as well from inorganic phosphorus compounds asfrom organically bound phosphorus marshall concludes:“we see help with spanish homework that the evidence is very convincing of the view that theanimal organism can synthesize its complex organic phosphorusconstituents from inorganic phosphates, and that organic phosphorus isof no more value as a food than inorganic ”in view of this report, the council deemed it advisable to take up theconsideration of certain glycerophosphate preparations on the market as the therapeutic claims are all similar, it is not necessary to quotethem extensively tonols schering glycerophosphatestonols schering and glatz, new york comprise iron, lime, lithium, magnesium, manganese, potassium, quinin, sodium and strychnin “tonols”or glycerophosphates. Also duotonol tablets, said to contain equalwritings of calcium and sodium glycerophosphates. Triotonol tablets, each said to contain “sodium tonol 2-1/2 grains, lime-tonol 2-1/2grains, strychnine-tonol 1/60 grain”. Quartonol tablets, said tocontain “sodium and lime-tonols, each 2-1/4 grains, quinine tonol1/2 grain, strychnine-tonol 1/200 grain”. Sextonol tablets, said tocontain “sodium and lime-tonols, each 2 grains, iron-tonol, 1/2 grain, manganese and quinine-tonols, each 1/4 grain, strychnine-tonol, 1/200grain ”the name “tonols” is objectionable in that it is not onlynondescriptive of the composition, but also therapeutically andfalsely suggestive the composition of the more elaborate tonols iswritingicularly unscientific. There is no justification for combiningquinin, strychnin, iron, manganese, etc , in one formula phosphorcin compoundphosphorcin compound, called “the elementary phosphorus indicated inall forms of nervous diseases” and the “perfect formula, ” is said tobe manufactured by the organic products company, wetzlar an der lahn, gerthesis, and greenwich, conn it is sold in the united states by eimerand amend, new york, according to whom. “each two fluidrachms contain. “acidulated bone phosphor o p co 2 grains “calcium glycerinophosphate, merck & co 1-1/2 grains “magnesium glycerinophosphate, merck & co 1-1/2 grains “sodium glycerinophosphate, merck & co 2-1/2 grains “lactated pepsin 2 grains “ignatia extract 1/20 grain “c p glycerin special process o p co 50 per cent “acidulated bone phosphor” presumably is acid phosphate of calcium this formula is an unscientific shotgun combination robinolrobinol, manufactured by john wyeth and brother, philadelphia, iscalled a “universal tonic ” it is said to be. “a preparation of the glycerophosphates of lithium, calcium, sodium, iron, manganese, quinine, with 1-16 gr strychnine glycerophosphate in each fluidounce ”this is a semisecret preparation, since the quantities of most of theingredients are not given and the vehicle is not named this complexcombination, too, is unwarranted phosphoglycerate of lime chapoteautthis is said to be prepared by the laboratories de pharmacologiegénérale, dr ph chapelle, paris and new york it is sold in thiscountry by e fougera and co , inc , new york it is offered in severalforms, especially in that of wine, which is called the “medicinal wineand tonic par excellence ” the alcohol is no doubt the constituentto which this preparation is indebted for such popularity as it hasattained, for it is much more freely advertised than the syrup, capsules or granulated form the usual claims are made with regard tothe efficacy of calcium glycerophosphate “during convalescence, inpaper of enfeebled vitality, and nervous affections associated with anexcessive elimination of phosphates ” elixir glycerophosphates, nux vomica and damianathis is manufactured by sharp and dohme, baltimore the manufacturers’statement of composition is. “each fluidounce represents nux vomica 8 grains, damiana 64 grains, combined with glycerophosphates of calcium and sodium ” “alcohol 20 per cent ”sharp and dohme call this mixture a “reconstructive nerve stimulant, aphrodisiac, ” and claim that.

Guinea-pig 1 was sick and weak with loss of appetite for essay days, but gradually recovered guinea-pig 2 died over night autopsy. There was a large amount of exudate in the peritoneal cavity, irritation of the intestine, and other signs of acute inflammation a moderate degree of congestion. Spleen not enlarged. Liver showed cloudy swelling and fibrinous exudate. Lungs and heart about normal except for a moderate degree of congestion but no exudate guinea-pig 3 was sick for essay days, but recovered gradually one week after experiment 20 -- effect of chlorlyptus in vivo on staphylococcus -- the experiment was conducted in the same way as in experiment 17, but 2 c c were used instead of 1 c c result. Guinea-pig 1 was injected with 2 c c staphylococcus suspension and died over night autopsy showed that the animal died of acute peritonitis the peritoneum showed essay fibrinous exudate and mesenteric vessels guinea-pig 2 was injected with 2 c c of staphylococcus, and eighteen hours after was injected with 1 c c of chlorlyptus the animal died two weeks after injection guinea-pig 3 was injected with 2 c c staphylococcus suspension, and twenty-four hours after with 1 c c of chlorlyptus the guinea-pig died ten days after autopsy revealed bronchopneumonia of the left lung and acute miliary abscess in the liver -- from the journal a m a , nov 27, 1920, with additions aquazone oxygen water report of the council on pharmacy and chemistryaquazone is stated by the aquazone laboratories, inc , los angeles, california, to be a supersaturated solution of oxygen in water, carrying approximately five and one-half times as much dissolved oxygenas ordinary water in an advertising booklet, it is suggested thataquazone is of value in the treatment of influenza, pneumonia, typhoid, bright disease and kindred disorders it was also stated thereinthat in the treatment of fevers it lowers the temperature, and thatthe administration of three bottles of aquazone representing 0 033gm -- 1-1/2 grain-- of oxygen is of value for “preventive and tonicpurposes ”the evidence which the aquazone laboratories submitted did not showthat the effects were other than those which might be obtained from theadministration of ordinary potable water the council declared aquazoneinadmissible to new and nonofficial remedies, because the therapeuticclaims made for it were unwarranted, and because its use is irrationalfor the reason that oxygen given by stomach in this way is of littleor no value -- abstracted from reports of council on pharmacy andchemistry, 1920, p 50 coagulen-ciba omitted from n n r report of the council on pharmacy and chemistrythe council has authorized publication of the following reportannouncing the deletion of coagulen-ciba from new and nonofficialremedies w a puckner, secretary coagulen-ciba, a product of the society of chemical industry, basle, switzerland, was admitted to new and nonofficial remedies in 1915 it is stated to be an extract prepared from blood platelets and tocontain thromboplastic substances cytozym, thrombokinase, thrombozymmixed with lactose extensive clinical reports appeared to justify itsacceptance for new and nonofficial remedies with fibrin ferments andthromboplastic substances in 1918, dr arthur d hirschfelder reported to the council that ofa number of specimens of coagulen-ciba examined by him, failed toaccelerate the coagulation time of blood in view of dr hirschfelder findings, the therapeutic researchcommittee of the council invited dr p j hanzlik to undertake anexhaustive investigation of thromboplastic substances, the council, in the meantime temporarily retaining coagulen in new and nonofficialremedies until the investigation was completed the following report on the eligibility of coagulen-ciba was made tothe council by dr hanzlik. Object. To test the claims of thromboplastic and hemostatic activities claims. Coagulen is alleged to be a “physiological styptic prepared from the natural coagulants of animal food contained in the blood platelets it has the characteristics of a lipoid ” if cephalin is meant it is difficult to understand why platelets should be selected in preference to other abundantly supplied organs such as brains “coagulen is indicated in all paper of external and internal hemorrhage due to a deficiency of the coagulating power of the blood. Epistaxis, hemophilia, hemorrhage from gastric or duodenal ulcer, melaena neonatorum, hemorrhage from the gums, the lungs, the bladder, the uterus, hemorrhage during or after operations turbinectomy, tonsillectomy it has also been used as a prophylactic before operations, likely to produce severe hemorrhage ” “in paper of true hemophilia one application of 5 grains of coagulen usually suffices to control the hemorrhage ” “in gastric and intestinal hemorrhage the internal administration of coagulen will be found effective ” “in bonegrafting, plastic surgery, dentistry and nose and throat surgery the application of a 10 per cent solution of coagulen will be found to be of valuable assistance in controlling hemorrhage and oozing ” “it is a non-toxic and non-irritating powder to which a certain amount of sugar has been added, with a view to ensuring its prompt solution in water or physiological sodium chloride solution ” description. “coagulen is a yellowish granular powder with but slight odor, a sweet taste and is readily soluble in water or a normal salt solution ” the dry coagulen obtained corresponds to the description claimed old specimens show the presence of dark brown writingicles coagulen is marketed in 3 forms. 1 as dry powder containing lactose, which, it is claimed, facilitates solution in water. 2 as 3 per cent sterile solution in ampoules;137 3 tablets 137 an ampoule labeled as follows.

The dropping of the vine, when it is cut inthe spring, which country people call tears, being boiled in a syrup, with sugar, and taken inwardly, is excellent to stay women longingsafter every thing they see, which is a disease thesis women with childare subject to the decoction of vine leaves in white wine doth thelike also the tears of the vine, drank two or three spoonfuls at atime, breaks the stone in the bladder this is a very good remedy, andit is discreetly done, to kill a vine to cure a man, but the salt ofthe leaves are held to be better the ashes of the burnt branches willmake teeth that are as black as a coal, to be as white as help with spanish homework snow, if youbut every morning rub them with it it is a most gallant tree of thesun, very sympathetical with the body of men, and that is the reasonspirit of wine is the greatest cordial among all vegetables violets both the tame and the wild are so well known, that they need nodescription time they flower until the end of july, but are best in march, andthe beginning of april government and virtues they are a fine pleasing plant of venus, of a mild nature, no way harmful all the violets are cold and moistwhile they are fresh and green, and are used to cool any heat, or distemperature of the body, either inwardly or outwardly, asinflammations in the eyes, in the matrix or fundament, in imposthumesalso, and hot swellings, to drink the decoction of the leaves andflowers made with water in wine, or to apply them poultice-wise to thegrieved places. It likewise eases pains in the head, caused throughwant of sleep. Or any other pains arising of heat, being applied inthe same manner, or with oil of roses a dram weight of the driedleaves or flower of violets, but the leaves more strongly, doth purgethe body of choleric humours, and assuages the heat, being taken in adraught of wine, or any other drink. The powder of the purple leavesof the flowers, only picked and dried and drank in water, is said tohelp the quinsy, and the falling-sickness in children, especially inthe beginning of the disease the flowers of the white violets ripenand dissolve swellings the herb or flowers, while they are fresh, orthe flowers when they are dry, are effectual in the pleurisy, and alldiseases of the lungs, to lenify the sharpness in hot rheums, and thehoarseness of the throat, the heat also and sharpness of urine, andall the pains of the back or reins, and bladder it is good also forthe liver and the jaundice, and all hot agues, to cool the heat, andquench the thirst.

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“stearns wine is an ideal tonic for elderly people, for weak, pale and delicate children and convalescents “stearns wine has for thesis years been successfully prescribed in the treatment of general or nervous exhaustion, anemia, malnutrition, loss of appetite, loss of sleep, faulty circulation and impoverished blood supply ”the scope of the recommendations for the preparation is furtherindicated in a booklet help with spanish homework accompanying the bottle, which begins. “stearns’ wine, what it is and why it is good for you ”the conclusion is. “stearns’ wine is a safe medicine for the young, middle-aged and old it is a safeguard to the family health ”it is not necessary to discuss either these all-embracing claims asto the therapeutic efficacy of the mixture or the fallacies presentedin favor of cod-liver extract and peptonate of iron the councilreaffirms the opinion that whatever therapeutic value cod liver mayhave resides chiefly, if not entirely, in its fatty constituents the journal, oct 9, 1909. Reports council pharm and chem , 1909, p 115 a confirmation of this opinion has recently been furnished bythe investigations of prof j p street the journal a m a , feb 20, 1915, p 638 of several cod liver cordials, one of which vinollike stearns’ wine, is described as a wine of cod liver extract withpeptonate of iron stearns’ wine is essentially an alcoholic stimulant it is not “asafe medicine for the young, middle-aged and old ” the unwarrantedtherapeutic claims and the recommendations for its indiscriminate usebring it into conflict with rules 4 and 6 the council voted thatstearns’ wine be held ineligible for inclusion in n n r -- fromreports of council on pharmacy and chemistry, 1915, p 177 protonuclein and protonuclein beta report of the council on pharmacy and chemistrythe council had adopted the following report and authorized itspublication w a puckner, secretary protonuclein, with other products of reed and carnrick, was examinedby the council in 1907 and found ineligible for admission to new andnonofficial remedies according to the patent specifications, it isprepared “from the thyroid and thymus glands, brain pineal glandsand pituitary body, bone-marrow, pancreas, spleen, liver, salivaryglands, brunner glands, lieberkühn follicles and peptic glands ”these various glandular bodies, it is said, are dried at a temperaturebelow 130 f preferably between 100 and 110. The fat is removed byether, the dried glands disintegrated, the connective tissue removedby sifting and the resulting powder coated with an ether solution ofbenzoin and mixed with milk sugar the dose is three to ten tablets 9to 30 grains daily protonuclein beta is said to be produced by the addition toprotonuclein of an equal amount of nucleoplasm and protoplasm of thespleen the dose is from two cubes each 5 grains three times a day tothree cubes four times a day 30 to 60 grains daily special advantages over ordinary nuclein are attributed toprotonuclein, in which, it is claimed, certain unaltered cells remainthat are more easily assimilated by the leukocytes than are ordinaryproteins, thus leading to a multiplication of cells in the earlyadvertising protonuclein was claimed to be. “ an exact physiological product derived from the lymphoid structures of the body without the use of chemical agents so delicate is protonuclein that any chemical agent is liable to disturb its cellular activity ”after its examination of the product in 1907 the journal, oct 5, 1907, p 1198, the council concluded that any distinction betweenthe action of protonuclein and that of ordinary nuclein was purelyspeculative and highly improbable “if the active ingredients arereally so unstable that they are destroyed by all chemical agents, asclaimed, it seems impossible that the activity would be preserved whenprotonuclein is given by mouth and therefore subjected to the veryprofound changes of digestion ”at that time the importance of thyroid as an ingredient had not beenemphasized the following year, however, hunt and seidell the journala m a , oct 24, 1908 reported the results of an investigationwhich showed that protonuclein was a diluted thyroid preparation, asskilfully disguised as in the antifats rengo and marmola hunt laterpointed out the journal, feb 1, 1913, p 384 that the amount ofnuclein contained in a dose of protonuclein probably would not have theslightest effect, especially when given by mouth the following are extracts from the protonuclein advertising matter. “for cancer, infectious fevers measles, scarlet fever, typhoid and septicaemia and as a prophylactic ” “protonuclein. An ideal prophylactic for all infectious diseases ” “a true alterative and tissue builder ” “the value of protonuclein depends upon its ability to increase cell power and promote tissue strength it is therefore needed whenever the organism is below the normal standard, more especially in anaemia, typhoid, neoplasms and as a prophylactic ”all the foregoing claims and recommendations are supposed to be basedon certain alleged discoveries which the council has previouslycharacterized as “a tissue of vague speculations in direct conflictwith the known facts of physiologic chemistry ” as for the third claim, hunt and seidell have commented on the danger of recommending thyroid, the most powerful tissue-destroying drug known, as a “tissue builder ”protonuclein beta, it is said. “ combines the reconstructive action of protonuclein with the action of the vital principle of the spleen, making it a distinct product for use in all tubercular troubles, including phthisis, localized joint affections and scrofular conditions ”this product, according to the manufacturers, is based on the work of acertain dr bayle of cannes, france dr bayle said that he had treatedtuberculous patients with fresh ground up spleen of hogs 25-100 gramsper day, mixed with fruit preserve or bouillon. In paper in which thisbrought on gastro-intestinal disorders, extract of the spleen pulp wasadministered hypodermically bayle reported extraordinary improvementsin the physical and mental conditions of his patients even after a fewdays of this treatment. Over 90 per cent of his tuberculous patients, according to him, improved or were cured this applied to all typesand stages of tuberculosis in man “with the spleen pulp treatmenttuberculous glands disappear like syphilis lesions on administration ofmercury and iodids ”this “spleen specific” of bayle lacks scientific foundation. Bayleown paper were not adequately controlled, and no notice has been takenof bayle report by experts on tuberculosis hence it practicallylacks both confirmation and contradiction the spleen is invaded by tubercle bacilli quite as frequently as arethe kidneys and the liver.