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“kalak has accomplished certain unexplainable things for the diabetic and nephritic, and if, in future years, diabetes and nephritis should prove to be constitutional diseases, based upon functionation or its lack, kalak therapy, the embodiment of physiological alkalescence may come into its own, for if acidity retards, alkalinity must normalize functionation ”it is not necessary to quote further in order to insure that everyonewill recognize the great need of kalak it is advised to test the urinefor acidity by means of a group of indicator solutions sent out to thephysicians methyl red is one of these and any urine showing an acidreaction with this is said to be open to suspicion paranitrophenol isanother of the indicators and the explanations given of the behavior ofthe two and the conclusions to be drawn are questionable the methylred solution furnished is too concentrated for proper use and perfectlynormal urines from normal individuals have given a rather marked colorwith it this indicator gives essay color at h 1 2 × 10^{-6} and astrong reaction at 3 × 10^{-3} to condemn a urine on such a finding isentirely unwarranted sodium bicarbonate is the main constituent of the water the valueof the phosphate in such a combination, with so much calcium, isproblematical in case an alkaline reaction in the intestine is reachedessay of it would be left as insoluble phosphate a few grams ofbicarbonate daily would have equal therapeutic value with this water the advice based on the indications of methyl red and the urine is bad the committee report was sent to the kalak water company for comment the company promised to withdraw the advertising circular referred toin the report and disclaimed responsibility for the accuracy and valueof the set of indicators which it sent out, but, on the whole, theprevious advertising claims were insisted on in view of the absurd and false claims made for the product the councildeclared kalak water inadmissible to n n r -- from reports ofcouncil on pharmacy and chemistry, 1917, p 148 minson soluble iodin “kelpidine” not admitted to n n r report of the council on pharmacy and chemistryminson soluble iodin “kelpidine” was submitted to the council byj j minson, washington, d c , trading as the kelpidine company, with the statement that in future “literature” it was to be known asminson soluble iodin, only the following statement of compositionwas furnished. “minson soluble iodin is essaywhat of an indefinite character, chemically its formula is, iodin 4 per cent , distilled water 6 per cent , and absolute alcohol q s 100 per cent by a process of chilling and heating an iodid of uncertain character is produced, and because of the extreme sensitiveness of the product to chemical tests, it is hard to determine so far as i have been able to judge, however, the result is about 3 or 3-1/2 per cent free iodin and from 1/2 per cent to 1 per cent iodid, possibly ethyl and hydrogen iodid in combination ”the a m a chemical laboratory reports that the preparation is analcoholic solution containing free iodin and iodid, probably hydrogeniodid and ethyl iodid, but that the free iodin content was only2 69 gm per 100 c c it is claimed that the “therapeutic indications” of minson solubleiodin are the “same as those of all iodin and iodid preparations, internally, externally, hypodermically and intravenously. Excepting, however, counter irritation ” it is admitted that there are no“clinical reports” as to the hypodermic and intravenous use, but thebelief is expressed “that in an emergency it is a safe remedy underproper dilution ” it is further claimed that “for all practicalpurposes it is nontoxic and nonirritating” and that “it has none ofthe undesirable features such as is the case with the iodids and theorganic preparations of iodin, proprietary or otherwise ”it was assigned for consideration to the committee on pharmacology, whose referee reported:“according to the information submitted, this is a tincture of iodin;differing from the official tincture in that it is more dilute and inthat hydrogen and ethyl iodid is the solvent in place of potassiumiodid it is practically immaterial for internal administration, whether the cation of the solvent iodid is hydrogen, ethyl, potassiumor sodium it would certainly be inadvisable to inject a preparationcontaining free iodin hypodermically it is not ‘a safe remedy’ forintravenous injection and it would not be nonirritant the statementthat ‘it has none of the undesirable features’ of other iodin compoundsis inherently impossible apparent freedom of any iodin preparationfrom undesirable effects is generally due to the use of small doses such claims are plainly therapeutic exaggerations and therefore inconflict with rule 6 even should these be removed, the preparationmust be held an unessential modification of the official tincture, andtherefore in conflict with rule 10 ”the report was agreed to by the committee and adopted by the counciland minson soluble iodin “kelpidine” declared inadmissible to newand nonofficial remedies -- from reports of council on pharmacy andchemistry, 1917, p 152 nutone report of the council on pharmacy and chemistrynutone nutone company, lowell, mass is a “nutritive tonic” said tohave the following complex composition. Cod liver oil, pure norwegian, 25 per cent malt extract, 9-1/3 per cent beef juice, glycerine, hypophosphite lime, hypophosphite soda, chemically pure, 1-1/2 grs each to the oz fl ext nux vomica, 3/64 of a minimum in each teaspoonful it is advertised with claims that will lead thoughtless physiciansand a confiding public to depend on it in paper in which fresh air, hygienic surroundings and nutritious food are of prime importance a sample package the phrase “as recommended by your physician” andother statements suggest that it is expected to be given the patientby the physician and thus effectively advertise nutone to the publicdescribes nutone as an “agreeable concentrated nutritive tonic emulsionof malt extract, beef juice and cod liver oil, combined with nervetonics and bone nutrients ” emphasizing the nutritive value of this“malt extract, beef juice, and cod liver oil” preparation, it isadvised, “as nutone is rich in nutritive properties, it is well tobegin with one-fourth teaspoonful, gradually increasing to regulardose, which is. Adults, 1 to 2 teaspoonfuls after meals and at bedtime children according to age ” it thus appears that adults are to takethis preparation as a “nutritive” in doses which represent from 3 to12 grains of sugar on the assumption that malt extract may contain asmuch as 50 per cent sugar and 8 to 30 minims of cod liver oil withunstated, but probably equally small, amounts of beef juice a consideration of the negligible food value of nutone as well asof the inefficiency of the other components and the claim that itis indicated in “malnutrition, ” “wasting diseases” and “incipientphthisis” classes nutone with that large group of shotgun mixtureswhich do harm in that dependence is placed on them in conditions inwhich the patient will probably be restored to health if proper medicaland hygienic measures are adopted in time the council declared nutone inadmissible to new and nonofficialremedies because it is an irrational shotgun mixture advertisedindirectly to the public with unwarranted therapeutic claims and anondescriptive therapeutically suggestive name -- from reports ofcouncil on pharmacy and chemistry, 1917, p 154 tri-arsenole, l o compound no 1 and l o compound no 2 report of the council on pharmacy and chemistrytri-arsenole -- according to the advertising of themedical supply company of atlanta, ga , “tri-arsenole” is“merco-arseno-benzo-chloride, ” and the claim is made. “this compound is the result of thesis years’ research the toxicity has been fully tested upon animals before using clinically, the latter having proven such complete success, we take pleasure in presenting it to the public ” “the manufacturers of tri-arsenol, before placing it upon the market, tested it biologically ”tri-arsenole is “recommended and suitable for the treatment of primary, secondary, tertiary and hereditary syphilis it has also been foundvery useful in pellagra and malaria ” the preparation is supplied inampules containing varying amounts of the dry substance it is to bedissolved in water and is to be administered intravenously in theadvertising attention is called to the yellow color of tri-arsenole;this, and the style of package suggest that it is a preparation similarto salvarsan in reply to a request sent the medical supply company for thequantitative composition and chemical formula of the compound“merco-arseno-benzo-chloride” and for the details of the biologic testby which its toxicity is claimed to have been determined and evidencefor its efficiency, the following statement was received. “tri-arsenole no 1 equals to each ampoule, gr sodium chlorid 4-1/2 hydrarg chlor -cor 1/4 arsenous acid 1/4 sodium benzoate 4 hydrastin resinoid 2 tri-arsenole no 2 equals to each ampoule, sodium chlorid 4 hydrarg chlor -cor 1/2 arsenous acid 1/2 sodium benzoate 4 hydrastin resinoid 2 tri-arsenole no 3 equals to each ampoule, sodium chlorid 3-1/2 hydrarg chlor -cor 3/4 arsenous acid 3/4 sodium benzoate 4 hydrastin resinoid 2 tri-arsenole no 4 equals to each ampoule, sodium chlorid 3 hydrarg chlor -cor 1 arsenous acid 1 sodium benzoate 4 hydrastin resinoid 2the request for information regarding the animal experiments said tohave determined the toxicity was ignored, nor were references suppliedto clinical reports demonstrating the value of the product the council declared tri-arsenole inadmissible to new and nonofficialremedies because of conflict with the rules as follows:in the absence of details of the method used, the claim that thepreparation has been tested biologically is in conflict with rule 2, which requires that for preparations claimed to be physiologicallystandardized the method of testing must be published so as to permit ofcontrol by independent investigators the claims that “merco-arseno-benzo-chloride” is “the result of thesisyears research, ” that its “toxicity has been fully tested upon animalsbefore using clinically” and that clinical use has “proven suchcomplete success” have not been substantiated by evidence and must beheld as unwarranted the name is in conflict with rule 8, which requires that pharmaceuticalmixtures shall bear names descriptive of their composition further, the name “tri-arsenole” by its similarity to diarsenol, the canadianbrand of arseno-phenolamin hydrochlorid, suggests that thispharmaceutical mixture is a chemical compound similar to salvarsan moreover, the danger of confusion is increased by the addition ofthe hydrastis preparation which imwritings a yellow color like that ofsalvarsan to the solution obtained when the colorless mercury andarsenic compounds of the mixture are dissolved again, the synonym“merco-arseno-benzo-chloride” conveys the false impression thattri-arsenole is a definite chemical compound the label does not declare the poisonous constituents claimed tobe contained in the mixture. Namely, “arsenous acid” and corrosivemercuric chlorid rule 7 there is no evidence that arsenous acid arsenic trioxid usedintravenously is efficient and safe as a spirocheticide, and theadministration of this drug in conjunction with mercuric chloridin fixed proportion is irrational and dangerous-- writingicularly sobecause of the implied similarity of tri-arsenole to arsenphenolaminhydrochlorid salvarsan, diarsenol rule 10 l o compound no 1 and l o compound no 2 -- in submitting thesepreparations to the council, the medical supply company stated that“no 1” was “composed of the following ingredients. Chloral, camphor, menthol, iodin, and oil of gualtheria, incorporated in a fatty base each ounce contains fifteen grains of chloral hydrate, nine grainsof resublimed iodine ” “no 2” was said to have the same compositionas “no 1” except that the oil of gaultheria had been omitted themedical supply company was informed that the rules of the councilrequired declaration of the amounts of each therapeutic constituentof pharmaceutical mixtures and that, therefore, in addition to theinformation furnished the amounts of camphor, menthol and oil ofgualtheria should be given for “no 1” and the amount of camphor andmenthol for “no 2 ” the following reply was received.

Englishcharacter set encoding help me in my reports. Utf-8*** start of this project gutenberg ebook reform-- proprietary medicines, vol 2 ***produced by david edwards, thiers halliwell and the onlinedistributed proofreading team at pgdp net thisfile was produced from images generously made availableby the internet archivetranscriber notes:in this transcription, paired underscores denote italicisedtext and a ^ indicates a superscripted character a downward arrowpreceding curly brackets indicates that the bracketed character s aresubscripted, e g ↓{h} the text contains essay uncommon characters that will not necessarilydisplay correctly with all viewing devices if essay of the characterslook abnormal, first ensure that the device character encoding isset to unicode utf-8 the default font might also need to be changedto a unicode font such as arial unicode ms, dejavu, segoe ui symbol orfreeserif symbols representing male and female have been replaced by mand f in the handheld version subscripted and superscripted charactersdo not always display correctly on handheld devices the book contained innumerable typographical errors affecting spelling, punctuation and formatting most spelling errors have been correctedsilently, but spelling variants that mainly reflect contemporaryspellings in the original quoted sources, have been left unchanged alist of the corrections and variations can be seen at the end of thetranscription punctuation anomalies errors, omissions, duplicationshave mostly been corrected silently, but missing apostrophes have notbeen corrected because of uncertainty about intended meaning a fewmissing quotation marks have been inserted within curly brackets {"}and missing words inserted by the transcriber, e g {sic} {and} havealso been enclosed within curly brackets to differentiate them fromthe numerous words and phrases inserted by the authors redundantduplicated words have been deleted astute readers will probably notepersisting inconsistencies involving italics, fonts, hyphenation, ellipses, accents, and ligatures ae/æ, oe/œ that have been leftunchanged because they have no impact on interpretation of the text the table of contents does not correspond accurately with headings usedin the text footnotes are generally located below the relevant paragraphs;however, footnotes that are cross-referenced multiple timeshave not been duplicated an error in footnote numberingwas corrected silently, and a missing footnote 120 wasinserted after being identified in the original source over-sized tables have been compressed and where appropriate a key hasbeen inserted to assist the reader the propaganda for reform in proprietary medicines volume 2 writing i reports of the council writing ii contributions from the laboratory writing iii journal contributions. Proprietary products writing iv journal contributions. Miscellany press of american medical association, five hundred and thirty-five north dearborn street, -- chicago 1922 copyright, 1922 by the american medical association preface to volume 2there were nine editions of the first volume of the propaganda forreform in proprietary medicines the ninth edition contained the mostimportant reports of the council on pharmacy and chemistry and of thechemical laboratory it contained also those articles from the journalof the american medical association up to, and including, 1916which dealt with the problems of proprietaryship in medicine and thefurtherance of rational drug therapy the present volume contains similar material covering the period fromjanuary, 1917, to april, 1922, inclusive like volume 1, this volume isdivided into four writings:writing i the council on pharmacy and chemistry. This section presentsthe principles and rules which govern the council in the examination ofmedicaments, together with articles and reports bearing on the work ofthe council, and the most important reports of the council from 1917 toapril, 1922, inclusive writing ii the a m a chemical laboratory. This section, besidespresenting the aims and objects of the association chemicallaboratory, also outlines essay of the laboratory work which is ofwritingicular interest to physicians writing iii contributions from the journal. Proprietary products.

-- from thejournal a m a , aug 2, 1919 helping the councilif they were built that way, the members of the council on pharmacy andchemistry of the american medical association might become discouragedat the apparent indifference of thesis members of the medical professionto their efforts there are thesis physicians who, while figurativelypatting the council on the back, actually do nothing to aid itsefforts on the other hand, there are men in the profession who givethe council active support instead of merely passive appreciation the letter that follows was written by such a man to a pharmaceuticalconcern. I am receiving circular advertising from you concerning -- -- -- -- solution, and i am writing to suggest that until these products have been approved by the council on pharmacy and chemistry of the american medical association, you are wasting your postage on the practice aside from the fact that these products do not appeal to me personally, i feel that i am not in a position to judge the value of such products and i depend entirely on the large clinical opportunities of the council on pharmacy and chemistry of the american medical association in addition to their laboratory facilities, in such matters as these i may, therefore, with all due respect, suggest that it will pay you to eliminate my name from your mailing list the members of the council on pharmacy and chemistry are working weekin and week out without remuneration few appreciate how much thesescientific men are doing for rational therapeutics. Fewer still realizehow much has been accomplished through their efforts, or how much morecould be accomplished if every physician who at least believes in thework of the council would give it his full support -- editorial fromthe journal a m a , nov 6, 1920 delays in passing on products report of the council on pharmacy and chemistrythe council has adopted the following report and authorized itspublication w a puckner, secretary the council frequently receives inquiries-- essay of them accompanied byexpressions of impatience-- concerning articles, reports on which appearto be delayed it therefore seems advisable to make a statement of essayof the factors which enter into this problem the council fully realizes the importance of giving prompt informationto the profession with regard to proprietary medicines underconsideration it therefore acts as soon as sufficient informationis available to justify a definite judgment, and publishes itsconclusions as soon as possible when adequate information is availableat the outset, there is no delay in the publication of the councilconclusions unfortunately, but very naturally, there are thesis paper in which theinformation available at the time the product is submitted is notsufficient to justify the council in coming to definite conclusions foror against the preparation in essay paper the manufacturer possessesthe required information, but to obtain it from him takes time. Inother paper the manufacturer does not possess the information-- perhapshe did not realize the inadequacy of his evidence until the subject wasbrought to his attention by the council such paper might be dealt with in either one of two ways. The councilmight at once reject the article because the claims for it are notsupported by adequate evidence. Or, the council might suspend judgmentand give the manufacturer an opportunity to supply the information the first method-- immediate rejection-- would obviously be felt bymanufacturers as a hardship to afford the fullest possible opportunityfor the presentation of the case, the council follows the secondmethod. That is, it suspends judgment and withholds publication ofa report until reasonable time has been afforded for furnishing therequired information, provided the manufacturer or agent appears tobe making honest and diligent efforts to supply it the collectionand compilation of such information is essaytimes a lengthy process, especially when the products are of foreign manufacture although it would be easier for the council to render an immediatedecision than to assist manufacturers to supply the data necessary forthe formation of an authoritative judgment, the council cannot yield toimportunities for hasty action it must rely on the medical professionto bear in mind that the character of a product under considerationby the council has not yet been determined the council holds that, during this stage, a product is suitable, at most, for experimentaluse -- from reports of council on pharmacy and chemistry, 1915, p 119 cooperation of the pharmaceutical houses report of the council on pharmacy and chemistryin reply to the suggestion made last year by president bevan that thereshould be closer cooperation between the large pharmaceutical housesand the council on pharmacy and chemistry, the council submitted to theboard of trustees of the american medical association the statementwhich appears below. “cooperation of the pharmaceutical houses. At the opening meeting of the house of delegates last year, president arthur dean bevan suggested the desirability of greater cooperation between the large pharmaceutical houses and the council on pharmacy and chemistry the need of such cooperation has been recognized by the council from the first in no one direction has the council made greater effort than in its endeavor to secure the fullest cooperation of the various pharmaceutical houses the difficulty has been, and always must be, the fundamental antagonism between objectives that are largely commercial on the one hand and purely scientific on the other nevertheless, the council has always believed-- and has acted on the belief-- that there is a possible middle ground wherein the interests of therapeutics would not be injured but would go hand in hand with a commercial development based on enlightened self-interest “the profits to be made by a pharmaceutical house from the sale of a staple drug-- a pharmacopeial, national formulary, or nonproprietary preparation-- which enters into free competition with other drugs of the same kind, are moderate. The profits to be made from the sale of a proprietary medicine on which the manufacturer holds a monopoly are usually large-- essaytimes enormous there are, broadly, two kinds of proprietary preparations advertised to physicians. One represents laborious research ending in the production of a new medicinal chemical. This product can be patented and the manufacturer can obtain a seventeen-year monopoly on its manufacture and sale the other represents no research but comprises simple mixtures-- frequently of the “shotgun” variety-- of well known pharmaceuticals, or biologic products sold under trade names as these do not represent anything new or original the manufacturer is unable to obtain a patent, but by means of the trade name he can and does obtain a perpetual monopoly this, from a business standpoint, is more valuable than the limited monopoly granted by a patent it is not surprising that proprietary remedies of the latter type flourish so long as physicians unthinkingly accept and prescribe them solely on the manufacturer valuation “the council has practically the undivided support of manufacturers of medicinal chemicals. That is, of proprietaries of the first mentioned type but pharmaceutical firms which have found it profitable to promote proprietaries of the second type-- “specialties, ” unscientific or ordinary mixtures of pharmaceuticals or biologic products sold under trade names-- have not supported the council “when the council was organized, it was hoped and believed that all the large pharmaceutical houses would find it possible and desirable, if not actually more profitable, to shape their business methods so as to make their proprietary and other articles conform to those conservative standards on which the council bases its rules, and thus render such articles acceptable for new and nonofficial remedies it soon developed, however, that the methods of the pseudochemical companies, whose sales propaganda in the interest of unscientific nostrums with its attending damage to scientific medicine had led to the establishment of the council, had found their lodgment in most of the pharmaceutical houses it was a genuine disappointment to the council to find that essay of the large and old-established firms were not only unwilling to cooperate with the council, but in thesis instances exhibited a definite antagonism to the council work “the object-- and duty-- of the officers of pharmaceutical houses is primarily to pay dividends to their stockholders through skilful advertising or the persuasiveness of “detail men, ” they are able to induce physicians to prescribe their controlled products, on which there are large profits, even though such products have not only not been accepted by the council, but in thesis instances, have been disapproved is it any wonder that concerns which put out such products are indifferent or openly antagonistic to the work of the council?. the matter is largely one of business policy when the medical profession as a unit will support the council in its work, then such firms will find it good business policy to accede to dr bevan suggestion-- but not before ”evidently the problem resolves itself into this. The council, constituted of scientific men, working without remuneration inthe interest of scientific medicine and the medical profession, expects-- and rightfully-- the cooperation and support of the members ofthat profession what is needed, therefore, is the active, sympatheticcooperation of physicians.

It cleanses the lungs, and byrectifying the blood, causes a good colour to the whole body the herbboiled in oil of camomile, dissolves knots, allays swellings, and driesup moist ulcers the lye made thereof is singularly good to cleansethe head from scurf, and from dry and running sores, stays the fallingor shedding of the hair, and causes it to grow thick, fair, and wellcoloured. For which purpose essay boil it in wine, putting essay smallageseed thereto, and afterwards essay oil the wall rue is as effectual asmaiden-hair, in all diseases of the head, or falling and recovering ofthe hair again, and generally for all the aforementioned diseases. Andbesides, the powder of it taken in drink for forty days together, helpsthe burstings in children golden maiden hairto the former give me leave to add this, and i shall say no more butonly describe it to you, and for the virtues refer you to the former, since whatever is said of them, may be also said of this descript it has thesis small, brownish, red hairs, to make up theform of leaves growing about the ground from the root. And in themiddle of them, in summer, rise small stalks of the same colour, setwith very fine yellowish green hairs on them, and bearing a small gold, yellow head, less than a wheat corn, standing in a great husk the rootis very small and thready place it grows in bogs and moorish places, and also on dry shadyplaces, as hampstead heath, and elsewhere mallows and marshmallows common mallows are generally so well known that they need nodescription our common marshmallows have divers soft hairy white stalks, rising tobe three or four feet high, spreading forth thesis branches, the leaveswhereof are soft and hairy, essaywhat less than the other mallow leaves, but longer pointed, cut for the most writing into essay few divisions, but deep the flowers are thesis, but smaller also than the othermallows, and white, or tending to a bluish colour after which comesuch long, round paper and seeds, as in the other mallows the rootsare thesis and long, shooting from one head, of the bigness of a thumbor finger, very pliant, tough, and being like liquorice, of a whitishyellow colour on the outside, and more whitish within, full of a slimyjuice, which being laid in water, will thicken, as if it were a jelly place the common mallows grow in every county of this land thecommon marsh-mallows in most of the salt marshes, from woolwich downto the sea, both on the kentish and essex shores, and in divers otherplaces of this land time they flower all the summer months, even until the winter dopull them down government and virtues venus owns them both the leaves of eitherof the sorts, both specified, and the roots also boiled in wine orwater, or in broth with parsley or fennel roots, do help to open thebody, and are very convenient in hot agues, or other distempers of thebody, to apply the leaves so boiled warm to the belly it not onlyvoids hot, choleric, and other offensive humours, but eases the painsand torments of the belly coming thereby. And are therefore used in allclysters conducing to those purposes the same used by nurses procuresthem store of milk the decoction of the seed of any of the commonmallows made in milk or wine, doth marvellously help excoriations, the phthisic, pleurisy, and other diseases of the chest and lungs, that proceed of hot causes, if it be continued taking for essay timetogether the leaves and roots work the same effects they help muchalso in the excoriations of the bowels, and hardness of the mother, andin all hot and sharp diseases thereof the juice drank in wine, or thedecoction of them therein, do help women to a speedy and easy delivery pliny saith, that whosoever takes a spoonful of any of the mallows, shall that day be free from all diseases that may come unto him.

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It cools the head and liver, stayshot vapours ascending to the head, and hinders sleep. It quenchesimmoderate thirst, and breeds milk in nurses, distil it in may purslain water cools the blood and liver, quenches thirst, helps suchas spit blood, have hot coughs, or pestilences the distilled water of water lily-flowers cools the blood and thebowels, and all internal writings of the body. Helps such as have theyellow jaundice, hot coughs and pleurisies, the head-ache, coming ofheat, fevers pestilential and not pestilential, as also hectic fevers the water of violet flowers, cools the blood, the heart, liver andlungs, over-heated, and quenches an insatiable desire of drinking, theyare in their prime about the latter end of march, or beginning ofapril, according as the year falls out the water of sorrel cools the blood, heart, liver, and spleen. Ifvenice treacle be given with it, it is profitable in pestilentialfevers, distil it in may endive and succory water are excellent against heat in the stomach;if you take an ounce of either for their operation is the samemorning and evening, four days one after another, they cool the liver, and cleanse the blood. They are in their prime in may fumitory water is usual with the city dames to wash their faces with, to take away morphey, freckles, and sun-burning. Inwardly taken, ithelps the yellow jaundice and itch, cleanses the blood, provokes sweat, strengthens the stomach, and cleanses the body of adust humours.