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That mon-arsone should not be used except under conditionsthat justify the free essay scorer experimental trial of an unproved drug. And that theadvertising propaganda for the drug by the harmer laboratories companyis to be deprecated * * * * *when the preceding report was sent to the harmer laboratories company, the firm submitted a reply in which it was stated:1 that in certain instances patients improved under mon-arsone who, previously, had not improved under arsphenamine, and that this shouldbe taken to offset the report of the one hundred paper in which the useof mon-arsone had to be abandoned in 11 per cent of the paper 2 that the harmer laboratories company has abandoned the claim thatmon-arsone is therapeutically equal to arsphenamine and that it nowfurnishes the drug to such men as care to use it simply on the basis ofits special and useful characteristics the council heartily endorses the recent warning against the useof untried medicaments which was issued by the u s public healthservice 145145 j a m a june 12, 1920, p 1654 since the council report was prepared a report on the effects ofmon-arsone on experimental syphilis has been published by nichols, 146from the division of laboratories, army medical school, which concludes:1 disodium-ethylarsinate, or mon-arsone, tested on rabbits infectedwith syphilis shows no spirocheticidal power the tissues are fatallypoisoned as soon as or before the spirochetes are affected “2 for its practical use in syphilis there is no such germicidal basisas exists in case of the arsphenamine group ”-- from the journala m a , june 18, 1921 146 nichols, h j. The spirocheticidal value of disodium ethylarsenate mon-arsone, j a m a 76. 1335 may 14 1921 oxyl-iodide not admitted to n n r report of the council on pharmacy and chemistry“oxyl-iodide” eli lilly and co is said to be the hydroiodid ofcinchophen and the claim is made that it exerts the effects ofcinchophen and of iodid because of inquiries which have been receivedthe council decided to determine the eligibility of “oxyl-iodide” fornew and nonofficial remedies dr p j hanzlik-- formerly associateprofessor of pharmacology at western reserve university school ofmedicine, now professor of pharmacology at leland stanford junioruniversity medical school-- who has made a study of the action ofsalicylates and cinchophen, was asked to report on the therapeuticvalue and the rationality of “oxyl-iodide ” this he consented to do andhis report appears below after considering doctor hanzlik report, the council declared“oxyl-iodide” inadmissible to new and nonofficial remedies because itis an irrational combination, marketed under claims that are unprovedand consequently unwarranted w a puckner, secretary “oxyl-iodide, ” marketed by eli lilly & co , is claimed to be thehydroiodid of phenylcinchoninic acid, containing 33 per cent of iodinand 67 per cent of phenylcinchoninic acid cinchophen its solubilityresembles that of cinchophen, being low in water and acid mediums, andhigher in the presence of alkalis whether “oxyl-iodide” is decomposedinto its constituents in the presence of alkalis does not appear tohave been determined however, if this were the case, the intestine, after administration of “oxyl-iodide, ” would contain cinchophen andsodium iodid in the same forms as if these agents were administeredindividually so that nothing would be gained by administering“oxyl-iodide ” being, like cinchophen, practically insoluble in acidmediums, “oxyl-iodide” would have no advantage over the latter so faras gastric irritation is concerned dosagethe dosage advised is from one to three tablets containing 3 grains 0 2 gm each of “oxyl-iodide ” the total dosage would depend onthe condition to be treated in rheumatic fever, which requires afull therapeutic or so-called, “toxic” dose of cinchophen, about 12to 13 gm would be administered intensively since each tablet of“oxyl-iodide” contains 0 13 gm of cinchophen, the total number oftablets of “oxyl-iodide” required would be 100, or two and one-halfbottles of forty tablets each at the same time the patient wouldreceive 6 6 gm of iodin as iodid this might be distinctlyobjectionable because of the production of the disagreeable symptoms ofiodism in essay persons, and indicates that the fixed proportion of theiodin constituent would be objectionable even a smaller dosage, such as 5 gm of cinchophen, which gives writingialrelief in rheumatism and similar conditions, would still require apatient to take a full bottle, or forty tablets, of “oxyl-iodide, ” andat the same time about 2 7 gm of iodin would have to be ingested furthermore, rheumatic fever, the arthritides, gout and relatedconditions in which cinchophen is indicated do not require iodid therefore, “oxyl-iodide” would not be the remedy of choice in theseconditions, and its use would be irrational and illogical actionsno data on the pharmacologic actions of “oxyl-iodide” are presentedin the manufacturer literature presumably, the compound wouldexhibit the actions of its individual components, i e , cinchophen andiodin as iodid, though probably less efficiently, owing to its lowsolubility this is also indicated by the following statements of themanufacturer. “the analgesic action of ‘oxyl-iodide’ is gradual a wordof caution is necessary to those who may expect immediate relief frompain ” therefore, why use “oxyl-iodide” in place of more dependableanalgesics, such as salicylate or cinchophen the following statementsappear far-fetched.

Outwardly, an oil ointment, or plaister of it, is most admirable for thegout, to cool the veneral heat of the reins in the french pox. Tostop the toothache, being applied to the aching side. To allay allinflammations, and to help the diseases before premised hedge hyssop divers sorts there are of this plant. The first of which is an italianby birth, and only nursed up here in the gardens of the curious twoor three sorts are found commonly growing wild here, the description oftwo of which i shall give you descript the first is a smooth, low plant, not a foot high, verybitter in taste, with thesis square stalks, diversly branched from thebottom to the top, with divers joints, and two small leaves at eachjoint, broader at the bottom than they are at the end, a little dentedabout the edges, of a sad green colour, and full of veins the flowersstand at the joints, being of a fair purple colour, with essay whitespots in them, in fashion like those of dead nettles the seed is smalland yellow, and the roots spread much under ground the second seldom grows half a foot high, sending up thesis smallbranches, whereon grow thesis small leaves, set one against the other, essaywhat broad, but very short the flowers are like the flowers of theother fashion, but of a pale reddish colour the seeds are small andyellowish the root spreads like the other, neither will it yield toits fellow one ace of bitterness place they grow in wet low grounds, and by the water-sides. Thelast may be found among the bogs on hampstead heath time they flower in june or july, and the seed is ripe presentlyafter government and virtues they are herbs of mars, and as choleric andchurlish as he is, being most violent purges, especially of cholerand phlegm it is not safe taking them inwardly, unless they be wellrectified by the art of the alchymist, and only the purity of themgiven. So used they may be very helpful both for the dropsy, gout, and sciatica. Outwardly used in ointments they kill worms, the bellyanointed with it, and are excellently good to cleanse old and filthyulcers black hellebore it is also called setter-wort, setter-grass, bear-foot, christmas-herb, and christmas-flowers descript it hath sundry fair green leaves rising from the root, each of them standing about an handful high from the earth. Each leafis divided into seven, eight, or nine writings, dented from the middleof the leaf to the point on both sides, abiding green all the winter;about christmas-time, if the weather be any thing temperate, theflowers appear upon foot stalks, also consisting of five large, round, white leaves a-piece, which essaytimes are purple towards the edges, with thesis pale yellow thumbs in the middle. The seeds are dividedinto several cells, like those of columbines, save only that they aregreater. The seeds are in colour black, and in form long and round theroot consists of numberless blackish strings all united into one head there is another black hellebore, which grows up and down in the woodsvery like this, but only that the leaves are smaller and narrower, andperish in the winter, which this doth not place the first is maintained in gardens the second is commonlyfound in the woods in northamptonshire time the first flowers in december or january. The second infebruary or march government and virtues it is an herb of saturn, and therefore nomarvel if it has essay sullen conditions with it, and would be farsafer, being purified by the art of the alchymist than given raw ifany have taken any harm by taking it, the common cure is to take goatmilk. If you cannot get goat milk, you must make a shift with suchas you can get the roots are very effectual against all melancholydiseases, especially such as are of long standing, as quartan agues andmadness. It helps the falling sickness, the leprosy, both the yellowand black jaundice, the gout, sciatica, and convulsions. And this wasfound out by experience, that the root of that which grows wild in ourcountry, works not so churlishly as those do which are brought frombeyond sea, as being maintained by a more temperate air the root usedas a pessary, provokes the terms exceedingly.

And often using it, helps the dropsy and the itch, and those who have old sores in theirlegs, or other writings of the body the juice thereof taken fasting, isheld to be of singularly good use against the pestilence the distilledwater, with a little sugar and a little good treacle mixed therewith the writingy upon the taking being laid down to sweat a little hasthe same effect the juice dropped into the eyes, cleanses them fromfilms and cloudiness which darken the sight, but it is best to allaythe sharpness of the juice with a little breast milk it is good inall old filthy corroding creeping ulcers wheresoever, to stay theirmalignity of fretting free essay scorer and running, and to cause them to heal morespeedily. The juice often applied to tetters, ring-worms, or other suchlike spreading cankers, will quickly heal them, and rubbed often uponwarts, will take them away the herb with the roots bruised and bathedwith oil of camomile, and applied to the navel, takes away the gripingpains of the belly and bowels, and all the pains of the mother. Andapplied to women breasts stays the overmuch flowing of the courses the juice or decoction of the herb gargled between the teeth that ach, eases the pain, and the powder of the dried root laid upon any aching, hollow or loose tooth, will cause it to fall out the juice mixed withessay powder of brimstone is not only good against the itch, but takesaway all discolourings of the skin whatsoever. And if it chance that ina tender body it causes any itchings or inflammations, by bathing theplace with a little vinegar it is helped another ill-favoured trick have physicians got to use to the eye, andthat is worse than the needle. Which is to take away the films bycorroding or gnawing medicine that i absolutely protest against 1 because the tunicles of the eyes are very thin, and therefore sooneaten asunder 2 the callus or film that they would eat away, is seldom of an equalthickness in every place, and then the tunicle may be eaten asunder inone place, before the film be consumed in another, and so be a readierway to extinguish the sight than to restore it it is called chelidonium, from the greek word chelidon, whichsignifies a swallow. Because they say, that if you put out the eyes ofyoung swallows when they are in the nest, the old ones will recovertheir eyes again with this herb this i am confident, for i have triedit, that if we mar the very apple of their eyes with a needle, she willrecover them again.

Control period, 189 gm milk av daily yield for 6 days nutrolactis period 8 c c nutrolactis by stomach tube, 72 gm milk av daily yield for 11 days dog 3. Control period, 93 gm milk av daily yield for 8 days nutrolactis period 8 c c nutrolactis on bread, 17 gm milk av daily yield for 5 days dog 4. Control period, 28 gm milk av daily yield for 7 days nutrolactis period 8 c c nutrolactis by stomach tube, 47 gm milk av daily yield for 6 days 10 c c nutrolactis by stomach tube, 43 gm milk av daily yield for 8 days control period, 41 5 gm milk av daily yield for 6 days nutrolactis period 10 c c nutrolactis by stomach tube, 33 5 gm milk av daily yield for 4 days dog 5. Control period, 67 gm milk av daily yield for 6 days nutrolactis period 10 c c nutrolactis on bread, 81 gm milk av daily yield for 6 days dog 6. Control period, 40 gm milk av daily yield for 5 days nutrolactis period 10 c c nutrolactis by stomach tube, 33 gm milk av daily yield for 8 days control period, 26 gm milk av daily yield for 4 days dog 7. Control period, 283 gm milk av daily yield for 9 days nutrolactis period 10 c c nutrolactis by stomach tube, 155 gm milk av daily yield for 15 days 15 c c nutrolactis by stomach tube, 82 gm milk av daily yield for 6 days control period, 33 gm milk av daily yield for 3 days dog 8. Control period, 238 gm milk av daily yield for 8 days nutrolactis period 20 c c nutrolactis on bread, 223 gm milk av daily yield for 4 days 20 c c nutrolactis on bread, 46 gm milk av daily yield for 6 days dog 9. Control period, 223 gm milk av daily yield for 6 days nutrolactis period 10 c c nutrolactis on bread, 178 gm milk av daily yield for 15 days 15 c c nutrolactis on bread, 146 gm milk av daily yield for 5 days comment and conclusiongoat 1 had already been lactating for over two months, and the yieldwas gradually decreasing at the time the observations were begun theadministration of galega did not check this decrease goat 2 shouldhave been a very favorable subject, for the kid was about a week oldat the time the observations were begun both galega and nutrolactiscaused a decrease in milk yield of this animal this decrease isperhaps writingly due to the animal distaste for the drugs and herconsequent failure to eat as well as during the control periods administration of nutrolactis was accompanied by an increase in milkin only two animals, dog 4 and dog 5 a detailed examination of therecords of these two dogs shows that in both paper there was aprogressive increase in milk yield during the control period and thatadministration of the drug failed to accelerate this increase on thecontrary, the curve for dog 5 takes a sudden drop immediately after thefirst administration of the drug the records of dogs 6 and 7 show that the yield during the secondcontrol period is lower than that of the preceding periods althoughthe administration of the drug in both paper was followed by a decreasein the yield, it may be urged that the drug has essay lactagogue action, for its discontinuance was followed by a decrease in yield thiseffect, however, is also apparent rather than real, for the data show agradual falling off in yield during the period of administration of thedrug, which decrease was not accelerated by withdrawing the drug our data show that galega and nutrolactis, when taken by mouth, and the elements of suggestion excluded, had no beneficial effecton lactation-- at least in so far as the quantity of milk isconcerned -- from the journal a m a , may 26, 1917 the russell emulsion and the russell prepared green bone report of the council on pharmacy and chemistrythe following report on “the russell emulsion” and “the russellprepared green bone, ” marketed by the standard emulsion company, wassubmitted to the council by a referee the council endorsed the reportand authorized its publication w a puckner, secretary the russell emulsion is put up in a neat package and advertised in anattractive pamphlet, on the cover of which we are told. “truth alwaysjustifies the superlative degree ” as what follows in the booklet andin the printed circulars certainly does not lack superlatives, this isdoubtless a warning in addition to the pamphlet and circular advertising, the product seemsto be systematically boomed by a lecture scheme in which one dr haguetalks before medical societies and distributes advertising matter the lecture is succeeded by a follow-up letter scheme through whichmatter is sent to members of the society hague ostensibly discusses“lime starvation in tuberculosis, ” but medical societies soon learnedto estimate his work as essentially to advertise the russell products last april the medical society of the state of pennsylvania sent outa circular letter to its county organizations on the subject of therussell-hague propaganda which opens in this way:“you have doubtless received a letter from dr william grant hague ofnew york, offering to address your county society on tuberculosis after due investigation, it is respectfully suggested that it may notbe desirable to ask him to address your society ”the statements in the pamphlet and circular published are typical ofthe whole method of exploitation for example, can such claims as thesebe surpassed by the veriest quack?. “science cannot improve the means employed in producing the russell emulsion ” “genius has not devised better methods than are used in manufacturing the russell emulsion ” “money cannot buy better products than are used in the russell emulsion ” “experience cannot suggest a more nutritious combination of fats than we use in the russell emulsion ”the emulsion is said to be made of equal writings of beef-fat, coconut, peanut and cottonseed oils, held in suspension by albumin the latterwe are told is applied to each globule of the emulsion by an “elaboratetechnical process” devised by dr russell the mixture is everywherespoken of as a “physiological” emulsion, but the word is always inquotation marks why it is called “physiological” is not clear, but theterm may be counted on to impress the unthinking or the unscientific numerous false and exaggerated statements are made about this“physiological” emulsion with reference to food value for instance. “the nutritional value of fats differ. The nutritional value of these fats and their increased efficiency by combination over all others have been determined by extensive clinical observation ”and also.

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H p loomis, m d. Roswell park, m d. Irving c rosse, m d. f p vandenbergh, m d.