History

Essay Abstract Examples


In 1912 a u s patent no 1, 031, 971 was granted on a cresol derivative, metacresyl acetate, a product described in chemical literature in 1903 when the councilinquired as to the grounds for the issuance of a patent for a substanceknown to science, the patent office replied that it was not familiarwith the publication in which metacresyl acetate had been described it seems evident that this patent would not have been issued had theapplication first been submitted to a government dewritingment familiarwith chemical literature an illustration of the granting of a patent on the use of well-knownchemical bodies which present essay abstract examples no discovery or originality, is thepatent issued for the use of peroxids, perborates and percarbonates asingredients of tooth powders u s patents nos 760, 397 and 802, 099 regarding these patents the journal of the american medical association sept 20, 1913, p 978 commented. “the patents held by mckesson and robbins give this firm the exclusive right of manufacturing tooth powders containing peroxids, perborates and percarbonates it is another illustration of the unfair monopolies that may be secured under our present patent laws ” granting a patent to a nostrumagain in 1913 u s patent no 1, 081, 069 was granted to a citizenof switzerland a country which does not grant patents on medicinalpreparations for a “composition which is intended to be usedinternally and which confers to the organisms immunity against thefollowing microbial infectious illnesses. Diphtheria, pneumonia, typhus, scarlet fever, influenza, septic infections, cerebral-spinalmeningitis, syphilis, pest, cholera and tuberculosis. It is alsoeffective in another kind of disease, viz , goiter ” italics not inoriginal the patent specification states that “the principal of thesesubstances is creatinin , ” but offers no evidence whatever thatthis well-known chemical body has the extensive and miraculous powersclaimed for it in publishing a notice of this patent the journal ofthe american medical association jan 3, 1914, p 54 explained. “it appears that the inventor is dead, and that his estate took out the patent since this great benefactor should have been, by the use of his preparation, immune to practically all diseases, he must have died of senility, although this seems hardly to have been the case ”and held.

“contains inert material essay abstract examples. Water 84 0% sodium chlorid 4 8% calcium chlorid 0 3% ”this statement is obviously made to meet the requirements of thefederal insecticide act this law requires either that the identityand the amounts of potent ingredients in disinfecting preparations bedeclared or else that the percentage of the inert ingredients of suchpreparations be given the omission from the label of all statementswith regard to the potent ingredients of the preparation and theabsence of such a statement in recent advertising matter suggestseither that the older statements about its composition were false orelse that the composition has been changed tscheppe published pharmaceutische rundschau 8:109, 1890 an analysisof platt chlorides which has been quoted in other publications asindicating the composition of the preparation he reported that hefound each quart of the preparation to contain aluminum sulphate 6ounces, zinc chlorid 1-1/3 ounces, sodium chlorid 2 ounces, calciumchlorid 3 ounces essay years ago about 1911 the company made the following statementrelative to the germicidal power phenol co-efficient of plattchlorides. “ for essay time the carbolic acid co-efficiency of our output has been from 2 5 to 4 3, the average being about 3.

Kennell, l a , essay abstract examples and hussey, l m. Med rec 97:607 april 10 1920 264 nichols, h j. Salvarsan and sodium cacodylate, j a m a 56:492 feb 18 1911 265 voegtlin, carl, and smith, h w. J pharmacol & exper therap 16:449, 1921 266 compare schamberg, j f. Kolmer, j a , and raiziss, g w. Am j m sc 150:25 july 1920 salvarsan. Abrogate the patentthe journal has already commented on the difficulty in securingsalvarsan, on the moral and ethical question as to whether or not it isjustifiable for one person to control the output of a drug necessary topublic health this week we publish an account of the action of the st louis and chicago medical societies, which are calling on the medicalprofession to appeal to their senators and congressmen to abrogate thispatent the journal believes that this patent should be abrogated, notalone because the patentees have not supplied the demand, not alonebecause they have dictated to the medical profession who should havethe drug and how much a physician might have, not alone because ofthe war with gerthesis, not alone because of the special needs of thegovernment at this time for the control of venereal diseases, not alonebecause, as essay claim, the patent at washington does not correctlydescribe the product, but also because the people who are supplyingthis product are charging prices that are exorbitant compared to theprice at which others in this country can supply it the fact is thatthe salvarsan one can obtain today costs $4 50 per ampule of 0 6 gram, whereas the same dose of arsenobenzol-- a preparation identical with, ifnot better than, salvarsan-- costs $2 00 at retail, and as dr schambergsays. “if we are permitted to continue marketing the same drug afterthe war, we can sell it at $1 00 or less per tube ” to abrogate thispatent would be doing an injury to no one certainly the patentees ofsalvarsan have already reaped their harvest-- and a pretty rich one thesupply of salvarsan at a reasonable price in proportion to its actualcost of production is in the interest of the health of the entirepopulation of the country, whereas to let matters rest as they are, is to the benefit of one man while we are emphasizing here the cost, there is after all a greater question, and that is the supply necessaryto help control the ravages of one of the most serious diseaseswhich afflict humanity today it is the duty of congress to abrogatethe patent on this preparation and, incidentally, on all medicinalpreparations of importance -- editorial from the journal a m a , april 21, 1917 end the monopolythe adamson bill, known as the “trading with the enemy act, ” hasrecently been passed by the house of representatives, is now beforethe senate, and will doubtless be enacted into a law one of itsclauses confers authority on the federal trade commission to grantlicenses to citizens of this country to operate patents owned by enemyaliens physicians are interested in the bill primarily because itincludes the salvarsan situation the manner in which salvarsan hasbeen supplied in this country has been so arbitrary and the pricescharged so tremendously above the actual cost, that we should not besatisfied unless the monopoly is ended so that the drug can be suppliedat least at a fairly moderate figure, and the old methods eliminated it is to be hoped, therefore, that the federal trade commission willnot grant exclusive control-- that is, exclusive license-- to any oneperson or firm to do so would simply perpetuate the old monopoly andthe old conditions england has adopted a law, which, in principle, is similar to the adamson bill, and there several concerns have beenlicensed to manufacture the product the same should be done here thedermatologic research laboratories of philadelphia announce that theycan supply arsenobenzol at $1 50 a tube, and that there is immediatelyavailable a supply sufficient for any demand that may be made the samelaboratories have announced also that in a few months they will be ableto supply hospitals for $1 00 a tube considerable responsibility restson the federal trade commission in this matter, for it is not only aquestion of monopoly, but also a question of scientific qualificationsand ability to make the product on the writing of essay who may makeapplication undoubtedly the commission will secure the cooperation ofthe united states public health service, under whose supervision thesedrugs should be manufactured no matter who shall be licensed to makethe product -- editorial from the journal a m a , july 21, 1917 arsphenaminno, this is not a new chemical. It is simply the name adoptedby the federal trade commission for the hydrochlorid of3-diamino-4-dihydroxy-1-arsenobenzene-- in other words, salvarsan asour readers already have been informed three firms have been licensedto manufacture and sell arsphenamin. But, while each manufacturer mayhave his own trade name on the label, the official name must be theprominent one on all packages hence, physicians should at once make ita point to learn and use the name “arsphenamin” in place of salvarsan at first sight, arsphenamin looks formidable in reality, it is just aseasy to familiarize oneself with the word “arsphenamin” as it was tolearn to use the terms “salvarsan, ” “arsenobenzol” or any other of thetrade names -- editorial from the journal a m a , jan 19, 1918 beer and cancer cures did the brewing interests advertise autolysin?. Our readers may remember that an article appeared in this dewritingment ofthe journal for july 6, 1918, under the title “henry smith williams and‘proteal therapy ’” “proteal therapy” is a treatment exploited by henrysmith williams, m d , of new york, for use in tuberculosis, cancer, rheumatism, etc it is apparently a modification of the “autolysin”cancer “cure” which williams had previously puffed in heartmagazine the journal article pointed out that henry smith williams, althoughentitled to write “m d ” after his name, is essentially a journalist he has written voluminously for essay years in lay publications onvarious subjects, both under his own name and under his nom de plume, “stoddard goodhue, m d ” in addition, williams runs a publishingconcern called the goodhue company, which issues a number of books, thesis of them being reprints of williams’ own articles closely associated with henry smith williams is his brother, edwardhuntington williams, who also is a prolific writer the journalprevious article called attention to the fact that there had been sentbroadcast to physicians a neat little cloth-bound book, entitled, “alcohol, hygiene and legislation ” this book, which evidently costessaybody a good deal of money to distribute gratis, was published bythe goodhue company, and was written by edward huntington williams enclosed with the book was an advertising leaflet on the “autolysin”cancer cure and also a letter from the goodhue company, askingphysicians to accept it “with our compliments and the compliments ofthe author ” the letter was chiefly devoted to calling attention tohenry smith williams’ “new book, the autolysin treatment of cancer ”the last thirteen pages of the book “alcohol, hygiene and legislation”contained advertisements of the goodhue company publications, writingicular emphasis being placed on the “autolysin treatment ofcancer, ” by henry smith williams so much by way of retrospect now comes information that may throwan interesting side-light on the matter just presented there is atpresent being conducted by a committee of the united states senate, an investigation relative to the purchase of a washington d c newspaper with money alleged to have been furnished by those interestedin the brewing industry at the opening hearing before the senate committee, tuesday, november19, the secretary of the united states brewers’ association, afteradmitting that brewers’ propaganda had been published in theinternational monthly, edited by viereck of the fatherland, alsodeclared that the publication committee of the brewers’ associationemployed writers to “write up certain subjects” relating to thebrewers’ trade one of the writers mentioned in this connection was, according to the newspaper reports, “dr edward h williams, author ofarticles published in medical and other journals ”with this fact before us, it seemed worth while to go through thebook that had been distributed so lavishly to physicians with thecompliments of the goodhue company and dr edward huntington williams, in the exploitation of “autolysin, ” and henry smith williams’ book onthe subject the first chapter of “alcohol, hygiene and legislation” consists ofa reprint of an article from the new york medical journal of may8, 1915 the article is a skilful presentation of the case for thedefenders of the lighter alcoholic beverages, especially beer thischapter and all succeeding chapters of the book attempt to discreditprohibitory legislation, and argue that prohibition drives the publicto the use of the more ardent alcoholic beverages, while preventing theuse of the milder beverages, such as beer, which one is led to inferis not writingicularly harmful throughout the book, also, the state ofkansas is held up as an example of the harm done by prohibition, andthe theme is developed that insanity and the use of cocain and otherhabit-forming drugs follows in the wake of prohibition the followingextracts are from chapter i. The evil effects of beer and wine, for example, are greatly less than those produced by spirituous liquors italics ours -- ed if our theory of immunity is correct we should expect to find that the older beverages, such as beer and wine, which have been used for thousands of years, are less productive of alcoholic insanity, for example, than the spirituous liquors which are recent innovations in point of fact we find this to be the case. The spirituous liquors are almost wholly responsible for all forms of alcoholic insanity italics ours -- ed chapter ii is a reprint of an article that appeared in everybodymagazine, august 1914, and deals with “legislation from a medicalviewpoint ” it is to the effect that drug addiction and insanity, together with special forms of mental disease directly attributable toalcoholism, seem to flourish best in prohibition territory chapter iii deals with “the peace and war footing of alcohol, ” andis a reprint from the medical record, aug 7, 1915 it, too, singsthe praises of the “lighter beverages, ” while deprecating the use of“ardent spirits ” for instance. An overwhelmingly large proportion of persons who develop alcoholic psychoses in america are drinkers of whisky, or essay corresponding ardent spirit, whereas this condition is seldom seen in beer and wine drinkers italics ours -- ed thus we find the highest percentage of alcohol psychoses among the whisky drinkers who come from western europe, while the wine and beer drinking races of central and southern europe show a distinctly lower percentage, in essay instances only about one-fourth as thesis per thousand italics ours -- ed chapter iv deals with “essay aspects of liquor legislation ” likechapter ii it is an indictment of prohibition, and the united statescensus bureau reports are called on to sustain this thesis quotations, too, are made from the writings of henry smith williamsfurther to prove the point “dry” kansas and “wet” nebraska arefrequently compared, to the detriment of the former one who acceptsthe statements in this chapter will get the impression that kansas hasmore lawlessness, illiteracy, pauperism, and insanity than nebraska chapter v deals with “the problem of legislation ” it is based on thepremise that “prohibition does not prevent the consumption of liquor, ”but on the contrary, “prohibitive legislation induces the consumptionof the most harmful form of liquors ” stated in another way, it isequivalent to charging that prohibition is hard on the brewers, butbeneficial to the distillers in fact, e h williams, in another book “the question of alcohol”-- goodhue co which also champions the casefor the milder alcoholics, quotes henry smith williams as saying, relative to prohibitory legislation. “in general, it would appearthat, if our legislators of recent years had been in league with thedistiller, they could not have served his purpose better ”whether or not edward h williams’ or henry smith williams’ conceptionof the alcohol problem is good, bad or indifferent, need not at thistime concern us the medical profession, however, has a right to asktwo questions.

It gently purges cholerand phlegm, extenuating that which is gross, and cutting that whichis tough and glutinous, cleanses that which is essay abstract examples foul, and hindersputrefaction and corruption. It dissolves without attraction, opensobstructions, and helps their evil effects, and it is a wonderfulhelp to all sorts of dry agues it is astringent to the stomach, andstrengthens the liver, and all the other inward writings. And taken inwhey works more effectually taken fasting in the morning, it is veryprofitable for pains in the head that are continual, and to stay, dryup, and consume all thin rheums or distillations from the head intothe stomach, and helps much to digest raw humours that are gatheredtherein it is very profitable for those that are fallen into acontinual evil disposition of the whole body, called cachexia, butespecially in the beginning of the disease it is an especial friendand helps to evil, weak and cold livers the seed is familiarly givento children for the worms, and so is the infusion of the flowersin white wine given them to the quantity of two ounces at a time;it makes an excellent salve to cleanse and heal old ulcers, beingboiled with oil of olive, and adder tongue with it, and after it isstrained, put a little wax, rosin, and turpentine, to bring it to aconvenient body cudweed, or cottonweed besides cudweed and cottonweed, it is also called chaffweed, dwarfcotton, and petty cotton descript the common cudweed rises up with one stalk essaytimes, and essaytimes with two or three, thick set on all sides with small, long and narrow whitish or woody leaves, from the middle of the stalkalmost up to the top, with every leaf stands small flowers of a dun orbrownish yellow colour, or not so yellow as others. In which herbs, after the flowers are fallen, come small seed wrapped up, with thedown therein, and is carried away with the wind. The root is small andthready there are other sorts hereof, which are essaywhat less than the former, not much different, save only that the stalks and leaves are shorter, so that the flowers are paler and more open place they grow in dry, barren, sandy, and gravelly grounds, inmost places of this land time they flower about july, essay earlier, essay later, and theirseed is ripe in august government and virtues venus is lady of it the plants areall astringent, binding, or drying, and therefore profitable fordefluctions of rheum from the head, and to stay fluxes of bloodwheresoever, the decoction being made into red wine and drank, or thepowder taken therein it also helps the bloody-flux, and eases thetorments that come thereby, stays the immoderate courses of women, and is also good for inward or outward wounds, hurts, and bruises, and helps children both of bursting and the worms, and being eitherdrank or injected, for the disease called tenesmus, which is an oftenprovocation to the stool without doing any thing the green leavesbruised, and laid to any green wound, stays the bleeding, and heals itup quickly the juice of the herb taken in wine and milk, is, as plinysaith, a sovereign remedy against the mumps and quinsey. And furthersaith, that whosoever shall so take it, shall never be troubled withthat disease again cowslips, or peagles both the wild and garden cowslips are so well known, that i neithertrouble myself nor the reader with a description of them time they flower in april and may government and virtues venus lays claim to this herb as her own, and it is under the sign aries, and our city dames know well enough theointment or distilled water of it adds beauty, or at least restores itwhen it is lost the flowers are held to be more effectual than theleaves, and the roots of little use an ointment being made with them, takes away spots and wrinkles of the skin, sun-burning, and freckles, and adds beauty exceedingly. They remedy all infirmities of the headcoming of heat and wind, as vertigo, ephialtes, false apparitions, phrensies, falling-sickness, palsies, convulsions, cramps, pains inthe nerves. The roots ease pains in the back and bladder, and open thepassages of urine the leaves are good in wounds, and the flowers takeaway trembling if the flowers be not well dried, and kept in a warmplace, they will soon putrefy and look green. Have a special eye overthem. If you let them see the sun once a month, it will do neither thesun nor them harm because they strengthen the brain and nerves, and remedy palsies, greeks gave them the name paralysis the flowers preserved orconserved, and the quantity of a nutmeg eaten every morning, is asufficient dose for inward diseases. But for wounds, spots, wrinkles, and sunburnings, an ointment is made of the leaves, and hog grease crab claws called also water sengreen, knight pond water, water house-leek, pondweed, and fresh-water soldier descript it has sundry long narrow leaves, with sharp prickleson the edges of them, also very sharp pointed. The stalks which bearflowers, seldom grow so high as the leaves, bearing a forked head, likea crab claw, out of which comes a white flower, consisting of threeleaves, with divers yellowish hairy threads in the middle. It takesroot in the mud at the bottom of the water place it grows plentifully in the fens in lincolnshire time it flowers in june, and usually from thence till august government and virtues it is a plant under the dominion of venus, and therefore a great strengthener of the reins. It is excellentlygood for inflammation which is commonly called st anthony fire. Itassuages inflammations, and swellings in wounds. And an ointment madeof it is excellently good to heal them. There is scarcely a betterremedy growing than this is, for such as have bruised their kidneys, and upon that account discharge blood. A dram of the powder of the herbtaken every morning, is a very good remedy to stop the terms black cresses descript it has long leaves, deeply cut and jagged on both sides, not much unlike wild mustard. The stalk small, very limber, though verytough.

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Thetherapeutic ratio for arsphenamine in similar conditions was 17, andthat of neoarsphenamine, 28 143 voegtlin, carl, and smith, essay abstract examples h w. J pharmacol and exper therap 16. 449, 1921 the findings that sodium dimethylarsenate sodium cacodylate, sodiummethylarsenate, and sodium ethylarsenate are devoid of any practicaltrypanocidal action and the conclusion that sodium cacodylate isinefficient in the treatment of human syphilis does not provethat mon-arsone is without effect on the disease these findings, however, certainly demand convincing therapeutic evidence to warrantthe recommendation for the use of the drug in the treatment ofsyphilis-- writingicularly because the drug is proposed as a substitute forarsphenamine, the value of which is established when the council first took up the consideration of mon-arsone, theonly evidence for the claim that it “has a therapeutic value at leastequal to that of arsphenamine” consisted, with one exception, ofreports from those who had experimented with the drug for the harmerlaboratories company, including a report by b l wright, l a kennell, and l m hussey, 144 the latter of the harmer laboratoriescompany these reports appeared to show that the administration ofmon-arsone caused less reaction than arsphenamine, and that theimmediate effects, judged by clinical symptoms and the response to thewassermann test, appeared to be good these trials extended over tooshort a period of time to permit judgment as to the permanence of theresults a report by an independent observer seemed to indicate thatmon-arsone does not have the sterilizing action on syphilitic lesionswhich it is usually believed arsphenamine exercises 144 wright, b l. Kennell, l a , and hussey, l m. M rec 97. 607 april 10 1920 after examining the available evidence, the council advised the harmerlaboratories company that the claim that mon-arsone has a therapeuticvalue equal to arsphenamine appeared unwarranted. That, in the opinionof the council, mon-arsone should not be used except under conditionsthat justify the experimental trial of an unproved drug, and should notbe used in a routine way until the permanence of its effects has beenestablished. And consequently any advertising propaganda for the drugby the harmer laboratories company was to be deprecated in its reply the harmer laboratories company admitted that itsadvertising claim, that mon-arsone was at least equal to arsphenaminetherapeutically, had been based on reports on fifty paper and onadditional reports that were beginning to come in at that time the harmer laboratories company submitted a list of hospitals andphysicians using mon-arsone a letter of inquiry sent by the council tothose who, according to the names in the list supplied by the harmerlaboratories company, had used mon-arsone, brought seven replies the clinical evidence contained in these replies was to the effect thatmon-arsone had been used in the various types of syphilis and thatthere was a certain beneficial effect, both clinically and as shown bythe wassermann reaction in certain instances the wassermann reactionchanged from a four plus to a negative reaction the reports showedthat the efficiency of mon-arsone as compared with that of arsphenaminepreparations has not been adequately studied one physician who hasused mon-arsone extensively reports that in thesis of the paper treatedthere seemed to be nearly as good results from the use of mon-arsone asis frequently obtained in the use of arsphenamine he reports, however, that it was necessary in eleven out of one hundred paper to change frommon-arsone to neoarsphenamine in view of the fact that there is definite lack of evidence to showthat mon-arsone is the equal of arsphenamine therapeutically, andbecause of the reports that in essay paper it is inferior, mon-arsoneshould not be used in the treatment of syphilis generally until itstherapeutic status has been more rigidly investigated and conclusiveevidence of its superiority to arsphenamine preparations obtained the council voted not to admit mon-arsone to new and nonofficialremedies and reaffirmed its conclusion that the claim that mon-arsonehas a therapeutic value equal to that of arsphenamine is premature andunwarranted. That mon-arsone should not be used except under conditionsthat justify the experimental trial of an unproved drug. And that theadvertising propaganda for the drug by the harmer laboratories companyis to be deprecated * * * * *when the preceding report was sent to the harmer laboratories company, the firm submitted a reply in which it was stated:1 that in certain instances patients improved under mon-arsone who, previously, had not improved under arsphenamine, and that this shouldbe taken to offset the report of the one hundred paper in which the useof mon-arsone had to be abandoned in 11 per cent of the paper 2 that the harmer laboratories company has abandoned the claim thatmon-arsone is therapeutically equal to arsphenamine and that it nowfurnishes the drug to such men as care to use it simply on the basis ofits special and useful characteristics the council heartily endorses the recent warning against the useof untried medicaments which was issued by the u s public healthservice 145145 j a m a june 12, 1920, p 1654 since the council report was prepared a report on the effects ofmon-arsone on experimental syphilis has been published by nichols, 146from the division of laboratories, army medical school, which concludes:1 disodium-ethylarsinate, or mon-arsone, tested on rabbits infectedwith syphilis shows no spirocheticidal power the tissues are fatallypoisoned as soon as or before the spirochetes are affected “2 for its practical use in syphilis there is no such germicidal basisas exists in case of the arsphenamine group ”-- from the journala m a , june 18, 1921 146 nichols, h j. The spirocheticidal value of disodium ethylarsenate mon-arsone, j a m a 76. 1335 may 14 1921 oxyl-iodide not admitted to n n r report of the council on pharmacy and chemistry“oxyl-iodide” eli lilly and co is said to be the hydroiodid ofcinchophen and the claim is made that it exerts the effects ofcinchophen and of iodid because of inquiries which have been receivedthe council decided to determine the eligibility of “oxyl-iodide” fornew and nonofficial remedies dr p j hanzlik-- formerly associateprofessor of pharmacology at western reserve university school ofmedicine, now professor of pharmacology at leland stanford junioruniversity medical school-- who has made a study of the action ofsalicylates and cinchophen, was asked to report on the therapeuticvalue and the rationality of “oxyl-iodide ” this he consented to do andhis report appears below after considering doctor hanzlik report, the council declared“oxyl-iodide” inadmissible to new and nonofficial remedies because itis an irrational combination, marketed under claims that are unprovedand consequently unwarranted w a puckner, secretary “oxyl-iodide, ” marketed by eli lilly & co , is claimed to be thehydroiodid of phenylcinchoninic acid, containing 33 per cent of iodinand 67 per cent of phenylcinchoninic acid cinchophen its solubilityresembles that of cinchophen, being low in water and acid mediums, andhigher in the presence of alkalis whether “oxyl-iodide” is decomposedinto its constituents in the presence of alkalis does not appear tohave been determined however, if this were the case, the intestine, after administration of “oxyl-iodide, ” would contain cinchophen andsodium iodid in the same forms as if these agents were administeredindividually so that nothing would be gained by administering“oxyl-iodide ” being, like cinchophen, practically insoluble in acidmediums, “oxyl-iodide” would have no advantage over the latter so faras gastric irritation is concerned dosagethe dosage advised is from one to three tablets containing 3 grains 0 2 gm each of “oxyl-iodide ” the total dosage would depend onthe condition to be treated in rheumatic fever, which requires afull therapeutic or so-called, “toxic” dose of cinchophen, about 12to 13 gm would be administered intensively since each tablet of“oxyl-iodide” contains 0 13 gm of cinchophen, the total number oftablets of “oxyl-iodide” required would be 100, or two and one-halfbottles of forty tablets each at the same time the patient wouldreceive 6 6 gm of iodin as iodid this might be distinctlyobjectionable because of the production of the disagreeable symptoms ofiodism in essay persons, and indicates that the fixed proportion of theiodin constituent would be objectionable even a smaller dosage, such as 5 gm of cinchophen, which gives writingialrelief in rheumatism and similar conditions, would still require apatient to take a full bottle, or forty tablets, of “oxyl-iodide, ” andat the same time about 2 7 gm of iodin would have to be ingested furthermore, rheumatic fever, the arthritides, gout and relatedconditions in which cinchophen is indicated do not require iodid therefore, “oxyl-iodide” would not be the remedy of choice in theseconditions, and its use would be irrational and illogical actionsno data on the pharmacologic actions of “oxyl-iodide” are presentedin the manufacturer literature presumably, the compound wouldexhibit the actions of its individual components, i e , cinchophen andiodin as iodid, though probably less efficiently, owing to its lowsolubility this is also indicated by the following statements of themanufacturer.