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12:71, 1919 show thefollowing:direct application to wounds -- the widely quoted results of thegynecologist k abel, on the footpad of cats, were found to be quiteunreliable when the experiment is properly controlled, the resultsare either negative or the bleeding may be increased quantitativeexperiments on wounds of the footpad of dogs showed that cotarnininvariably increased the bleeding equally negative or unfavorableresults were obtained with wounds to the comb of roosters, and to theliver and spleen direct action on vessels -- the results of perfusion experiments werevariable, but, in general, showed a vasodilation action instead ofconstriction this holds true also of the uterine vessels the vesselsin the living animal rabbit ear were also unaffected systemic administration -- the bleeding from an irrigated wound wasnot modified directly by intravenous injection of cotarnin salts, butvaried merely with the state of the blood pressure the evidence for the inefficiency of cotarnin salts as hemostaticsseemed so conclusive as to warrant the council in rescinding theacceptance of styptol, and directing the omission of the generalarticle on cotarnin salts and the description of styptol from new andnonofficial remedies -- from the journal a m a , nov 22, 1919 micajah wafers and micajah suppositories report of the council on pharmacy and chemistry“micajah medicated wafers” and “micajah suppositories, ” sold bymicajah & co , warren, pa , are declared inadmissible to “new andnonofficial remedies” because 1 their composition is essentiallysecret rule 1. 2 name of neither of these mixtures is indicativeof its composition rule 8. 3 of exaggerated and unwarrantedtherapeutic claims rule 6, and 4 the therapeutic advice whichaccompanies the trade packages constitutes an indirect advertisement tothe public rule 4 w a puckner, secretary micajah medicated wafers formerly called “micajah medicateduterine wafers” were analyzed in the a m a chemical laboratory in1910 they were found to consist essentially of dried “burnt” alum, boric acid and borax, in approximately the following proportions. Alum, dried 59 86 per cent borax, dried 15 62 per cent boric acid 5 67 per cent water of hydration 18 85 per cent there are a number of drugs that are more or less effective in thetreatment of local lesions of mucous membranes and the skin theyare classed as astringents among these are included alum, boraxand boric acid every physician has used them to say that a waferconsists of alum, borax and boric acid inspires but little awe butthere is essaything much more mysterious and impressive in declaringthat a wafer “consists of an astringent and antiseptic base, in whichare incorporated certain medicaments which both locally and afterabsorption, contribute to the astringent, antiphlogistic, depletive, soothing and healing action of the product ” this gives the impressionthat essay powerful and almost incomprehensible factors are at work yet, after all is said and done, the substances contained in micajahmedicated wafers are just the homely old alum, boric acid and borax in addition to “micajah medicated wafers, ” micajah & co also put out“micajah suppositories for hemorrhoids ” these have been examined inthe a m a chemical laboratory and, like the “medicated wafers” havebeen found to contain alum, boric acid and borax-- and these substancespractically alone-- incorporated in cocoa butter the company claimsthat “to these have been added ammonii ichthyosulphonate, balsam ofperu, ext belladonae ” the a m a chemists report, however, that ifextract of belladonna is present at all it is in amounts too small tobe detected by the method commonly employed in the chemical examinationof alkaloidal drugs the chemists report further that while ammoniumichthyosulphonate and balsam of peru both have a decided odor and aredark in color, the suppositories have but little color and the odor ofthe cocoa butter that forms their base is not covered by these drugs;obviously, therefore, if ammonium ichthyosulphonate and balsam of peruare present at all it is in amounts utterly insufficient to exert anytherapeutic effect it would be hard to find better examples of mischievous proprietarymedicines than these two products of the micajah company “twinsof efficiency, ” they are called in an advertising pamphlet thecomposition is not stated a physician using the “twins” does soabsolutely in the dark to him they are secret preparations he isencouraged to use them in a great variety of conditions in which otherdrugs are much more useful inevitably, physicians using them will belikely to overlook, or pass over, new growths, specific infections anddiseases that require radical remedial measures in addition to misleading and exaggerated claims, there is a referenceto a report from the usual “well-known and reliable bacteriologicallaboratory ” the excerpts published from this report of an unnamedlaboratory are sufficiently vague to incriminate no one from time to time it is worth while to emphasize facts regardingproprietary medicines that while obvious are essaytimes forgotten forthis reason attention is directed to micajah uterine wafers andmicajah suppositories -- from the journal a m a , nov 29, 1919 alkalithia report of the council on pharmacy and chemistryalkalithia was introduced at a time when it was believed that theadministration of lithium salts served to remove uric acid from thesystem the product was considered by the council in 1906, and foundineligible for new and nonofficial remedies no report, however, waspublished at that time because of inquiries received, the council examined the current claimsfor alkalithia, and authorized publication of the report which appearsbelow w a puckner, secretary keasbey and mattison company effervescent alkalithia is sold with thefollowing statement of composition. “each dose or heaping teaspoonful contains 1 grain of caffeine, 10 grains each of bi-carbonates of soda and potash, and 5 grains of carbonate of lithia ”the a m a chemical laboratory reports that alkalithia is aneffervescent mixture which contains alkaline carbonates andbicarbonates together with caffein, free tartaric acid and free citricacid the major portion of the alkali carbonates and bicarbonatesis converted into citrates and tartrates when the preparation isdissolved in water-- as is done before it is taken an excess of alkaliis present, however, as the solution has an alkaline reaction each“heaping teaspoonful” which was found to be about 4 85 gm containsabout 0 044 gm of caffein the manufacturers claim 0 0648 gm perheaping teaspoonful as taken, alkalithia, therefore, representscaffein in a solution of alkali tartrate, citrate and bicarbonatecontaining free carbonic acid if it is assumed that all of thetartrate and citrate in alkalithia is converted into carbonate inthe organism, a “heaping teaspoonful” of alkalithia would representabout 2 9 gm of sodium bicarbonate this assumption is, however, notcorrect, for it is known that tartrates are not completely convertedinto carbonates in the organism according to the label on the bottle, this mixture of caffein andalkali salts is “a common sense remedy for the relief and treatmentof conditions dependent upon perverted metabolism as manifested byneuralgic, rheumatic, cardiac and renal symptoms ” wrapped with a tradepackage is a circular in which is discussed the “uric acid diathesis”as “a cause of rheumatism in its various forms, calculus, gravel andinflammation of the bladder and kidneys, asthma, hay fever, catarrh, quinsy and bronchitis, eczema, hives, itching and burning of the skin, palpitation of the heart and cold hands and feet, dizziness, mentaldepression, melancholia, neuralgia, chorea, hysteria, numbness and agreat variety of purely nervous symptoms ” the arguments for the useof alkalithia as “a safe and scientific treatment for the uric aciddiathesis” found in the circular constitute an indirect appeal to thelaity conflict with rule 4 in the circular matter sent direct to the physicians, keasbey andmattison claim that in rheumatism, alkalithia is prescribed by themedical profession more often than any other remedy the claim is madethat, “in five minutes the urine will be discolorized and analysis willshow it to be loaded with urates ” the manufacturers further assert. “you can change the character of the urinary secretion in a few minutes completely” by alkalithia, and “in nine paper out of ten, when the doctor prescribes ‘alkalithia’ his patient greatly improves, or gets well ”the firm advises that “renal insufficiency” be determined by the oldmethod of multiplying the ounces of urine in twenty-four hours by thelast two numbers of the specific gravity, adding 10, which gives thenumber of grains of solids excreted in the twenty-four hours if thisis low, no matter what the cause, they advise alkalithia, “that idealeliminant ”the council declared alkalithia inadmissible to new and nonofficialremedies because the claims made on the label and the circularaccompanying the trade package lead the public to its detriment todepend on this preparation rule 4. And because the therapeutic claimsare unwarranted rule 6 -- from reports of council on pharmacy andchemistry, 1919, p 65 arhovin omitted from n n r report of the council on pharmacy and chemistryarhovin is a solution of dephenylamine, thymol benzoate and ethylbenzoate, marketed by schering and glatz, inc it was omitted fromnew and nonofficial remedies because the therapeutic claims made forthe preparation were unwarranted and because the firm had refused todiscontinue the distribution of the advertising which contained theobjectionable claims prior to jan 1, 1919 when the report whichappears below explaining the dismissal was submitted to schering andglatz, inc , the firm again promised a revision of its advertising, but refused discontinuance of the objectionable circular before jan 1, 1920 since arhovin is still marketed with unwarranted therapeuticclaims, the council has authorized publication of this report w a puckner, secretary the attention of the firm schering and glatz, inc , was called tomisleading statements in its booklet for arhovin in 1915, and in 1918the firm was informed that unless the misleading statements werewithdrawn before jan 1, 1919, arhovin would be omitted from new andnonofficial remedies the following quotations are taken from the circular in question, andillustrate the character of the claims to which objection was made.

“have you any information in regard to customized writing paper this writingy and his treatment for cancer?. this is the first i have heard of any such work having been done one wonders if it is presented in good faith or if the money god has overcome the gentleman scientific spirit ” “is this just one more of them?. why a roan horse?. essay people might want serum from a nice bay or calico cow pony ”the literature referred to comes in an envelop bearing the name of“t j glover, research laboratory, toronto, canada, ” but mailed, apparently, from new york city the enclosures are a single sheetcircular signed thomas joseph glover and entitled “etiology of cancer, ”a “directions” slip and a card quoting prices in the circular dr glover states that he has prepared a serum from immunized horses, “between ages of seven and nine years, of the roan type, ” and hasinjected this intramuscularly “into patients in the advanced stages ofcancer and noticed that it has a specific action on every known type ofcancer ” further. “up to the present time i have apparently cured cancer of the face, eye, nose, lip, mouth, tongue, stomach, bowel, bladder, breast and uterus ”in addition to the circular, was a small leaflet giving directions forthe injection of the serum and also a card bearing dr glover nameand toronto address and reading. -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- | this is to advise you that dr t j glover serum | | for the treatment of cancer can now be had by | | application to office at above address | | | | price five dollars per treatment five treatments | | minimum number sent at one time | | | | send money by post-office money order or certified cheque | | | | directions for treatment with each order | -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- this advertising material, which is evidently being widely circulatedin the united states, would indicate that the glover researchlaboratory had received a permit from the united states public healthservice licensing the interstate sale of this serum in the unitedstates no such license has been issued the journal briefly reported in the dewritingment of medical news, oct 30, 1920, that the academy of medicine of toronto had appointed acommittee to investigate the claims made for the glover “cancer serum ”in the meantime, the most charitable thing that can be said is that the“treatment” is in the experimental stage and the reported results havenot been corroborated by independent investigators -- from the journala m a , jan 1, 1921 the toronto academy of medicine reports unfavorably on glover cancer serumthe method of exploitation of the alleged cancer serum being put outby dr t j glover of toronto, canada, was briefly discussed in thisdewritingment of the journal for january 1 at that time it was pointedout that the medical profession of the united states was being widelycircularized by dr glover and that, while the letters purported tocome from toronto, they were, in fact, mailed from new york city sincethis article appeared the circularization seems to have continuedundiminished and physicians in various writings of the united states havesent in the glover advertising material oddly enough, the matter nowsent out, while identical in every respect with that dealt with inthe previous article, bears a different return address on the back ofthe envelop the envelops are the same. But the legend “t j gloverresearch laboratory, 538 jarvis st , toronto, canada, ” has been crudelycrossed out and there has been substituted by means of a rubber stampthe legend “mrs stewart, 309 w 54th st , new york ” still laterletters have been modified to the extent that the letters “rs” of“mrs ” have been cut out of the stamp and it now reads “m   stewart ”there has now come to hand a report just published by a specialcommittee appointed by the council of the academy of medicine, toronto, to investigate the glover serum the report of this committee may besummed up by one of its closing paragraphs, which reads. “the data which your committee has been able to obtain have not convinced it that the results of treatment obtained by the use of dr glover serum are better than those obtained by similar methods introduced by others, and which have ultimately disappointed the hopes entertained of them ”the committee report deals with the claims that dr glover has madefor his serum, both experimental and clinical it seems that dr glover has claimed that, experimentally, he had 1 cultured cancercells and from these cells had isolated and cultured an organism whichhe declared was confined to, and present in, every type of cancer. 2 produced cancer in a number of animals by inoculation with thesecells and organisms. 3 obtained a serum-- from a horse that had beeninjected with cultures of these cells and organisms-- which, wheninjected into experimental animals rendered them immune to inoculation, and 4 produced improvement or cure in paper of human cancer by theinjection of his serum the committee reported that it was unableto obtain any evidence to substantiate dr glover claims on theexperimental aspect of the question as dr glover had refused to permitrepresentatives of the committee to visit his laboratory. Had refusedthe request of the committee to be allowed to examine his cultures andexperimental material. Had not acceded to the request of the committeethat he demonstrate his ability to culture cancer cells and organismsand to produce cancer by inoculation or to immunize animals against it the committee attempted also to collect information which wouldenable it to pass on the clinical claims made by dr glover, first, as to whether he has succeeded in producing cures, either regularlyor occasionally, in paper definitely established as cancer and, second, to enable the committee to decide whether his serum in paperdefinitely established as cancer produces improvement beyond that whichoccasionally occurs spontaneously or under palliative measures on bothof these points, the committee reported that it found no evidence towarrant the hope that a specific cure for cancer has been discovered bydr glover or that the serum had produced a cure in any case definitelyestablished as cancer it should be understood, that the committee investigations andfindings were completed before the present advertising campaign of theglover serum was initiated -- from the journal a m a, feb 5, 1921 glyco-thymoline and poliomyelitisone characteristic of the “patent medicine” business is that it tradeson fear should an epidemic occur the market is flooded with newnostrums purporting to cure or prevent the disease in question, whilethe manufacturers of older “patent medicines” revamp their advertisingso as to make it appear that their preparations are all that standbetween the scourge and the public one has but to remember “peruna”exploitation of the yellow fever epidemic in new orleans essay years agoand the way in which the exploiters of “pond extract” played on thefears of the public at the time of the former meningitis epidemic innew york city at present the public is much exercised over the epidemic of infantileparalysis anticipating that the nostrum fraternity would attempt toreap a golden harvest from the public distress, the federal officialsissued a bulletin of warning on the subject naturally, the bulletinwas addressed to the lay public, the government assuming thatphysicians knew enough to avoid being misled by any such advertisingcampaigns apparently, the assumption is too broad at any rate, themanufacturers of “glyco-thymoline” are circularizing physicians, one ofwhom writes as follows. To the editor:-- i am enclosing circular letter that i received this morning which seems to me almost a crime i do not suppose that there is any way to prevent anything of this sort, but it is certainly a shame to attempt to deceive people in this way as i recollect, glyco-thymoline is almost inert, practically no more efficient than dobell solution e fletcher ingals, m d , chicago the circular letter referred to was on the stationery of kress & owencompany, manufacturers of glyco-thymoline it read. Dear doctor:-- regarding infantile paralysis, it is conceded that the source of infection is through the nose, mouth and throat taking this measure to be correct, we believe that there is no safer prophylactic measure than the use of glyco-thymoline, with three writings of water, as a mouth, tooth and nasal wash, by means of the k & o nasal douche and the toothbrush glyco-thymoline tends to promote exosmosis, and prevents the absorption of the germ or toxic matter we would be glad to send you samples of both glyco-thymoline and the douche should you so desire with best wishes, we beg to remain, yours very truly, kress & owen company glyco-thymoline has been discussed in these pages a report of thecouncil on pharmacy and chemistry pointed out that this “patentmedicine” is simply a weak antiseptic, so feeble that even in fullstrength it does not kill staphylococcus aureus in four hoursand is of little, if any, greater therapeutic value than sterilesalt solution yet, glyco-thymoline has been recommended by itsmanufacturers, either directly or inferentially, for such diseasesas diphtheria, ophthalmia neonatorum and consumption today itsmanufacturers put it forward as one of the safest prophylacticmeasures against infantile paralysis and have the effrontery to makethis suggestion, not to the uninstructed public but to the medicalprofession presumably, as a business organization, the concernbelieves it will convince a sufficient number of physicians of thetherapeutic efficacy of its product to pay for the cost of thisadvertising campaign if it appraises the situation correctly thereneed no longer be any wonder expressed that in the recent suit againstthe journal, “patent medicine” makers were able to enlist the help ofmedical men -- from the journal a m a , sept 16, 1916 glykeron.

Guinea-pigs weighing on the average of 400 gm may be injected peritoneally with one or two c customized writing paper c or intrapleurally with 0 5 to 1 c c of chlorlyptus without having fatal results from the injection experiment 16 -- toxic and irritant action of eucalyptus oil -- three normal guinea-pigs were used for the experiment guinea-pig 1 was injected with 1 c c of oil of eucalyptus in the peritoneum, and guinea-pig 2 with 0 5 c c in the pleural cavity guinea-pig 3 was used as a control result. Guinea-pig 1 died about three hours after injection, and guinea-pig 2 about two hours after the injection autopsy. Both guinea-pigs showed marked congestion and a moderate degree of exudate in the peritoneum experiment 17 -- toxic and virulent action of eucalyptus -- three normal guinea-pigs were selected for the experiment, as in experiment 16 the injection was made in the pleural cavity guinea-pig 1 was injected with 0 5 c c and guinea-pig 2 with 1 c c of eucalyptus oil result. Guinea-pig 1 died the following day, and guinea-pig 2 one hour after the injection experiment 18 -- toxic and irritant action of dichloramin-t, 0 5 per cent in chlorcozane -- one guinea-pig was used for each experiment guinea-pig 1 was injected with 0 5 c c and guinea-pig 2 with 1 c c of dichloramin-t peritoneally result. Both animals became restless immediately after the injection, and died twelve hours after of acute hemorrhagic peritonitis experiment 19 -- effect of chlorlyptus on staphylococcus suspended in salt solution and one of that solution injected into the peritoneum of the guinea-pig -- three guinea-pigs were used for the experiment guinea-pig 1 was injected with 0 5 c c of staphylococcus suspension as control guinea-pig 2 was given the same, and immediately after received 1 c c of chlorlyptus guinea-pig 3 was injected with the same amount, and chlorlyptus was injected twenty-four hours after injection results. Guinea-pig 1 was sick and weak with loss of appetite for essay days, but gradually recovered guinea-pig 2 died over night autopsy. There was a large amount of exudate in the peritoneal cavity, irritation of the intestine, and other signs of acute inflammation a moderate degree of congestion.

And is an especial remedy for joint aches, andswollen knees, that come by the falling down of humours the broom rape also is not without its virtues the decoction thereof in wine, is thought to be as effectual to voidthe stone in the kidney or bladder, and to provoke urine, as the broomitself the juice thereof is a singular good help to cure as well greenwounds, as old and customized writing paper filthy sores and malignant ulcers the insolate oil, wherein there has been three or four repetitions of infusion of the topstalks, with flowers strained and cleared, cleanses the skin from allmanner of spots, marks, and freckles that rise either by the heat ofthe sun, or the malignity of humours as for the broom and broom-rape, mars owns them, and is exceeding prejudicial to the liver, i supposeby reason of the antipathy between jupiter and mars. Therefore if theliver be disaffected, minister none of it buck-horn plantain descript this being sown of seed, rises up at first with small, long, narrow, hairy, dark green leaves like grass, without any divisionor gash in them, but those that follow are gashed in on both sides theleaves into three or four gashes, and pointed at the ends, resemblingthe knags of a buck horn whereof it took its name, and being wellwound round about the root upon the ground, in order one by another, thereby resembling the form of a star, from among which rise up divershairy stalks, about a hand breadth high, bearing every one a small, long spiky head, like to those of the common plantain having such likebloomings and seed after them the root is single, long and small, withdivers strings at it place they grow in sandy grounds, as in tothill-fields bywestminster, and divers other places of this land time they flower and seed in may, june, and july, and their greenleaves do in a manner abide fresh all the winter government and virtues it is under the dominion of saturn, and isof a gallant, drying, and binding quality this boiled in wine anddrank, and essay of the leaves put to the hurt place, is an excellentremedy for the biting of the viper or adder, which i take to be oneand the same the same being also drank, helps those that are troubledwith the stone in the reins or kidneys, by cooling the heat of thewriting afflicted, and strengthens them. Also weak stomachs that cannotretain, but cast up their meat it stays all bleeding both at mouth ornose. Bloody urine or the bloody-flux, and stops the lask of the bellyand bowels the leaves hereof bruised and laid to their sides that havean ague, suddenly ease the fits. And the leaves and roots applied tothe wrists, works the same effect the herb boiled in ale and wine, andgiven for essay mornings and evenings together, stays the distillationof hot and sharp rheums falling into the eyes from the head, and helpsall sorts of sore eyes buck horn it is called hart-horn, herba-stella and herba-stellaria, sanguinaria, herb-eve, herb-ivy, wort-tresses, and swine-cresses descript they have thesis small and weak straggled branches trailinghere and there upon the ground. The leaves are thesis, small and jagged, not much unlike to those of buck-horn plantain, but much smaller, and not so hairy the flowers grow among the leaves in small, rough, whitish clusters. The seeds are smaller and brownish, of a bitter taste place they grow in dry, barren, sandy grounds time they flower and seed when the rest of the plantains do government and virtues this is also under the dominion of saturn;the virtues are held to be the same as buck-horn plaintain, andtherefore by all authors it is joined with it the leaves bruised andapplied to the place, stop bleeding the herbs bruised and applied towarts, will make them consume and waste in a short time bugle besides the name bugle, it is called middle confound and middlecomfrey, brown bugle, and by essay sicklewort, and herb-carpenter;though in essex we call another herb by that name descript this has larger leaves than those of the self-heal, butelse of the same fashion, or rather longer. In essay green on the upperside, and in others more brownish, dented about the edges, essaywhathairy, as the square stalk is also which rises up to be half a yardhigh essaytimes, with the leaves set by couples, from the middle almost, whereof upwards stand the flowers, together with thesis smaller andbrowner leaves than the rest, on the stalk below set at distance, andthe stalk bare between them. Among which flowers, are also small onesof a blueish and essaytimes of an ash colour, fashioned like the flowersof ground-ivy, after which come small, round blackish seeds the rootis composed of thesis strings, and spreads upon the ground the white flowered bugle differs not in form or greatness from theformer, saving that the leaves and stalks are always green, and neverbrown, like the other, and the flowers thereof are white place they grow in woods, copses, and fields, generally throughoutengland, but the white flowered bugle is not so plentiful as the former time they flower from may until july, and in the mean time perfecttheir seed the roots and leaves next thereunto upon the ground abidingall the winter government and virtues this herb belongs to dame venus.

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what now remainsfor you, but to love your husbands, and not to be customized writing paper wanting to your poorneighbours?. wild tansy stays the lask, and all the fluxes of blood inmen and women, which essay say it will do, if the green herb be worn inthe shoes, so it be next the skin. And it is true enough, that it willstop the terms, if worn so, and the whites too, for ought i know itstays also spitting or vomiting of blood the powder of the herb takenin essay of the distilled water, helps the whites in women, but moreespecially if a little coral and ivory in powder be put to it it isalso recommended to help children that are bursten, and have a rupture, being boiled in water and salt being boiled in water and drank, iteases the griping pains of the bowels, and is good for the sciaticaand joint-aches the same boiled in vinegar, with honey and allum, and gargled in the mouth, eases the pains of the tooth-ache, fastensloose teeth, helps the gums that are sore, and settles the palate ofthe mouth in its place, when it is fallen down it cleanses and healsulcers in the mouth, or secret writings, and is very good for inwardwounds, and to close the lips of green wounds, and to heal old, moist, and corrupt running sores in the legs or elsewhere being bruisedand applied to the soles of the feet and hand wrists, it wonderfullycools the hot fits of agues, be they never so violent the distilledwater cleanses the skin of all discolourings therein, as morphew, sun-burnings, &c as also pimples, freckles, and the like. And droppedinto the eyes, or cloths wet therein and applied, takes away the heatand inflammations in them thistles of these are thesis kinds growing here in england which are so wellknown, that they need no description. Their difference is easily knownon the places where they grow, viz place essay grow in fields, essay in meadows, and essay among thecorn.