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Non nostrium inter nos tantas componere lites and away to dr reason went i, who told me it was an herb of mars, andunder the scorpion, and perhaps therefore called basilicon. And it isno marvel if it carry a kind of virulent quality with it being appliedto the place bitten by venomous beasts, or stung by a wasp or hornet, it speedily draws the poison to it. Every like draws his like mizaldus affirms, that, being laid to rot in horse-dung, it will breedvenomous beasts hilarius, a french physician, affirms upon his ownknowledge, that an acquaintance of his, by common smelling to it, had ascorpion bred in his brain essaything is the matter. This herb and ruewill not grow together, no, nor near one another. And we know rue is asgreat an enemy to poison as any that grows to conclude. It expels both birth and after-birth. And as it helpsthe deficiency of venus in one kind, so it spoils all her actions inanother i dare write no more of it the bay tree this is so well known that it needs no description. I shall thereforeonly write the virtues thereof, which are thesis government and virtues i shall but only add a word or two to whatmy friend has written, viz , that it is a tree of the sun, and underthe celestial sign leo, and resists witchcraft very potently, as alsoall the evils old saturn can do to the body of man, and they are nota few. For it is the speech of one, and i am mistaken if it were notmizaldus, that neither witch nor devil, thunder nor lightning, willhurt a man in the place where a bay-tree is galen said, that theleaves or bark do dry and heal very much, and the berries more than theleaves.

The rate of growth is retarded;necrosis and metastasis are prevented, and inoperable tumors becomeoperable how are we to interpret these observations?. how are we toexplain the fact that they are the almost invariable accompanimentof the most diverse methods of treatment?. i have already quoted thestatement of ledoux-lebard that every therapeutic novelty appears toexercise a favorable effect on cancer paper the same fact has beenobserved in a variety of other diseases, such as locomotor ataxia in order to arrive at a safe and reliable estimate as to the valueof any new or experimental procedure in paper of cancer, it seemsadvisable to accept certain definite therapeutic criteria by which thepaper are to be judged in the absence of such a method, alterationsin symptoms which are actually of no real value or importance receiveundue emphasis the natural course of the disease is associatedwith such fluctuations that a sanguine therapeutist can gain essayencouragement from even the most hopeless paper hence it follows thatevery mode of treatment has found adherents the market is floodedwith cancer drugs, and cancer charlatans flourish in the most highlyeducated communities unfortunately, even well trained, honest andreputable physicians have fallen victims to this fallacy, and havelent their names to the support of modes of treatment which in realityproduce no determinable effect on the natural evolution of the disease it was the desire to combat this unfortunate tendency which led meessay time ago to attempt to establish a reliable set of criteria oftherapeutic effects in cancer these were embodied in an article280which appeared two years ago, and i may be here permitted to quote themin extenso. Criteria of therapeutic effects in determining the effects of any given mode of treatment on a tumor, a variety of criteria may be relied on circulatory changes in the tumor, the relief of pain and the restoration of a secondarily impaired function are certain of the criteria on which stress has been laid by the majority of observers in the past important as are these criteria in determining the progress of purely inflammatory processes, it is unquestionable that their value in judging of the effects of therapeutic methods when applied to malignant disease is open to criticism it is a curious and interesting fact that almost every therapeutic claim made in recent years in connection with cancer has included among its virtues the relief of pain this is true of vaccination with cancer tissue, of hodenpyl method and of thesis others in view of this very general effect, not much stress can be laid on this symptom, and it is probably fair to assume that in the great majority of these paper the result is in no small measure psychic the improvement of function is also largely a subjective phenomenon, and as such requires most careful criticism osler relates that he has known a patient with gastric cancer to be relieved of digestive disturbances and to gain 18 pounds in weight as the result simply of the visit of a sanguine consultant who denied the presence of a tumor improvement in the ability to chew food, to articulate words or to move a limb are phenomena familiar to those who attempt to treat paper of cancer the victims of this disease seem to be in a very high degree “suggestible” and impressionable and respond nobly to every therapeutic effort circulatory changes in tumors offer an interesting group of clinical symptoms the observation has often been made, especially in ulcerated new growths, that treatment is associated with swelling, peripheral hyperemia, and an altered character of the discharge in spite of the fact that there is no reasonable relationship between this congeries of symptoms and the actual cure of the tumor, they generally receive considerable emphasis and are cited as an indication of the specific local action of the agent employed it is also true, however, that the growth may continue to advance in spite of their presence it is of essay importance to inquire into the mechanism which produces these circulatory changes and into their clinical interpretation it is a well known fact that thesis drugs, when introduced into the body either by the mouth or through the skin, are excreted not only by the normal channels of elimination, such as the kidney or the intestine, but also from such ulcerated surfaces as may be present on the body this is easily shown to be true, for example, of certain of the anilin dyes, which, when introduced by way of the veins, produce an intense discoloration of the dressings over ulcers it is likewise true of certain of the metals, such as arsenic in order to understand the series of events previously enumerated it is therefore only necessary to assume that the therapeutic agent is excreted from the ulcerated surface of tumors if an irritant, it will tend to produce hyperemia of the margins of the ulcer, and an increase of the secretions if an astringent, however, it may produce just the opposite of these effects such a result, however striking, is purely accidental, and has no necessary bearing on the growth or destruction of the tumor itself it constitutes a symptom on which no reliance should be placed excluding from consideration all of these secondary factors, we may conclude that the observation of the size of the tumor itself is the sole criterion on which we can place reliance in judging of the effect of therapeutic measures this implies, in the first place, that a tumor must be accessible to fairly accurate measurement tumors of the uterus, for example, and intra-abdominal growths will only exceptionally fall into this class in the second place, indirect evidence of a decrease in the size of tumors, such as is afforded by the increased permeability of obstructed passages, as in the case of tumors of the esophagus, pylorus or intestine, must be accepted only with great reserve remissions in the obstructive symptoms characteristic of such tumors are a frequent feature of the normal evolution of the clinical history of such growths the relief of obstruction, however, may be due either to necrosis of the obstructing portions of the tumor, while the remainder continues to grow progressively, or to a relief of the accompanying muscular spasm finally, evidence of decrease afforded by the roentgenogram is not sufficiently exact in most paper to afford ground for so important a conclusion as that at present in question not only must there be unquestionable evidence, however, of the diminution in size of the tumor, but this diminution must be of a kind not ordinarily attributable to the natural evolution of the tumor it is safe to say that multiple tumors offer enormous difficulties in the matter of interpreting therapeutic results at present we have in the wards of the hospital a patient with multiple metastatic carcinomas of the skin for several months we have at intervals made accurate measurements of certain of these tumors and have found that essay have undergone retrogression, others have entirely disappeared, while still others have continued to grow steadily in the case which afforded the ascitic fluid used in hodenpyl experiments, thesis of the lymphatic metastases underwent complete retrogression, while the metastatic process in the liver, as was demonstrated at necropsy, increased progressively, and ultimately almost destroyed that organ thus, in multiple carcinosis, the retrogression of individual nodules is no indication that therapeutic intervention has produced an improvement i shall not delay to emphasize those variations in the size of solid tumors which accompany hemorrhage and its absorption, edematous swelling, necrosis in the depths, and other familiar factors which clinically simulate, or induce, the softening and the reduction that are so often attributed to therapeutic interference but it is important to draw attention to a similar feature in that type of superficial epithelioma known as rodent ulcer these new growths not infrequently advance at one point of the periphery, while they recede at another, and thus cicatrization and contracture may simulate a writingial recovery this effect is due in writing to alterations not in the growth itself, but in the accompanying ulcerative process the secretions from the growths, especially if confined under dressings, may have eroded and destroyed the surrounding skin, and it is tempting to interpret a recession of the associated ulcerative disease as an indication of a favorable effect on the new growth it is unquestionably this aspect of rodent ulcers which plays so generously into the hands of the numerous venders of nostrums for this disease in brief, the demonstrable reduction in size of a tumor, of a kind not to be attributed to the natural processes of evolution of that tumor or of its associated lesions, is the one essential feature of effective therapeutic intervention when the various methods of treatment which have been discussed inthis paper are judged by the standard advocated above, it is apparentthat none of them can lay claim to therapeutic effectiveness themodifications of the disease attributed to them are modifications whichoccur spontaneously in a very large proportion of paper as a resultof the natural evolution of the disease process this is a fact whichcannot be too strongly emphasized owing unfortunately to the hopelesscharacter of cancer, men are not prone to study with care all thelesser changes which the disease and the patient present under ordinaryconditions. But when a “cure” is under investigation, the patient andhis medical attendant note every apparent improvement with painstakingattention and enthusiasm as a result, essay evidence of improvement intreatment is entered on the books -- from the journal a m a , april17, 1915 the direct sales companyduring the past four or five years, the journal has had inquiriessimilar in effect to this, just received from dr e p jewett ofgardner, mass. “will you kindly inform me regarding a drug manufacturing company by the name of the direct sales company, buffalo, new york?. are their products standard and reliable so far as you know?. ”the direct sales company, inc , buffalo, has, according to itsletterhead, the following officers.

“the serum and iodized oil may be mixed for immediate use, but could not be put up only separate for the use of the profession and the therapy furnished dr watkins she mixed as used ”this statement throws no light on the discrepancies in the statementswith regard to the place of the iodinized oil in the treatment, namely. A the original statement that the oil was to be given a week afterthe serum. b white statement quoted earlier in this report thatthe oil “is only an adjunct or side treatment” and “is not always usedor indicated”. c the statement in dr watkins’ paper that the oiland the serum are given in combination the council declared the mark white goiter serum and mark whiteiodinized oil ineligible for new and nonofficial remedies andauthorized publication of this report editorial note on the mark white “serum”as essay of our readers will remember, on april 26, 1913, the journalcalled attention to the mark white preparation which at that time wasbeing exploited from denver the propaganda dewritingment has in its filesa number of letters sent out from the mark white concern at varioustimes one mailed in may, 1911, on the embossed stationery of “the markwhite goiter institute, ” exchange building, denver, was evidently ageneral letter sent to physicians, calling their attention to “the mostimportant medical discovery of the age ” “dr mark white, a graduateof the university of pennsylvania, ” said the letter, had discovered “asimple and harmless remedy” that would cure goiter “because of thedesire to preserve the secrecy of this remedy it is given only at theoffice here ” it was then suggested that the doctor might send thoseof his patients who were suffering from thyroidism to the “mark whitegoitre institute ” if he would do so he would be “given a commissionof $10, in paper of the $50 fee with the additional $5 for each $50increase ” it closed with essay casuistic arguments, presumably for thepurpose of overcoming the physician scruples, summing up the matterwith the statement. “no right thinking man will allow a narrow and self-seeking system of ethics to stand between him and his duty to the sick and suffering ”about 1912 the name of the concern seems to have been changed, for wehave in our files a letter addressed to a layman on the stationery ofthe “mark white goitre treatment company ” according to this letterheadthe product this concern had for sale was “goitreine” discovered bymark white, “president and general manager ” mr white letter to thesufferer from goiter assured him that if he would take “goitreine”he might “be practically sure of an immediate and permanent cure ”“goitreine, ” according to white, “has absolutely and permanently cured90 per cent ” of all paper of goiter in which it has been used-- “andthe other ten showed remarkable improvement ” it was efficacious forall forms of goiter and “cannot possibly harm ”the person who received this assurance might have had his confidence init shaken had he seen a copy of the denver news for may 23, 1911, inwhich was reported a case of collapse and death in a woman followingan injection given in white office the paper stated that the deathcertificate was signed by one w a gray and gave “fatty degenerationof the heart and goiter” as the cause of death gray, it seems, was thelicensed physician employed by mark white to administer “goitreine”-- ifthat is what white happened to be calling his product at that time for here it may be stated, parenthetically, that mark white is not aphysician.

Its stalks are not flat, but round. Its leaves are not solong, but more pointed as for the place we need not determine, fortheir name shews they grow in water government and virtues they are under the dominion of the moon, andbeing made into a poultice, are excellently good for hot inflammations, swellings, cankers, sore mouths and throats, being washed with thedecoction. It cleanses and strengthens the neck and throat, and helpsthose swellings which, when people have, they say the almonds of theears are fallen down it is excellently good for the rankness of thegums, a safe and present remedy for the king evil they are excellentfor the stone and gravel, especially the nuts, being dried they alsoresist poison, and bitings of venomous beasts campion, wild descript the wild white campion has thesis long and essaywhat broaddark green leaves lying upon the ground, and divers ribs therein, essaywhat like plantain, but essaywhat hairy, broader, but not so long the hairy stalks rise up in the middle of them three or four feet high, and essaytimes more, with divers great white joints at several placesthereon, and two such like leaves thereat up to the top, sending forthbranches at several joints also. All which bear on several foot-stalkswhite flowers at the tops of them, consisting of five broad pointedleaves, every one cut in on the end unto the middle, making them seemto be two a-piece, smelling essaywhat sweet, and each of them standingin a large green striped hairy husk, large and round below next to thestalk the seed is small and greyish in the hard heads that come upafterwards the root is white and long, spreading divers fangs in theground the red wild campion grows in the same manner as the white. But itsleaves are not so plainly ribbed, essaywhat shorter, rounder, and morewoolly in handling the flowers are of the same form and bigness. Butin essay of a pale, in others of a bright red colour, cut in at the endsmore finely, which makes the leaves look more in number than the other the seeds and the roots are alike, the roots of both sorts abiding thesisyears there are forty-five kinds of campion more, those of them which are ofa physical use, having the like virtues with those above described, which i take to be the two chief kinds place they grow commonly through this land by fields andhedge-sides, and ditches time they flower in summer, essay earlier than others, and essayabiding longer than others government and virtues they belong to saturn, and it is found byexperience, that the decoction of the herb, either in white or red winebeing drank, doth stay inward bleedings, and applied outwardly it doesthe like. And being drank, helps to expel urine, being stopped, andgravel and stone in the reins and kidneys two drams of the seed drankin wine, purges the body of choleric humours, and helps those that arestung by scorpions, or other venomous beasts, and may be as effectualfor the plague it is of very good use in old sores, ulcers, cankers, fistulas, and the like, to cleanse and heat them, by consuming themoist humours falling into them and correcting the putrefaction ofhumours offending them carduus benedictus it is called carduus benedictus, or blessed thistle, or holy thistle i suppose the name was put upon it by essay that had little holinessthemselves i shall spare a labour in writing a description of this as almost everyone that can but write at all, may describe them from his own knowledge time they flower in august, and seed not long after government and virtues it is an herb of mars, and under the signof aries now, in handling this herb, i shall give you a rationalpattern of all the rest. And if you please to view them throughout thebook, you shall, to your content, find it true it helps swimming andgiddiness of the head, or the disease called vertigo, because ariesis in the house of mars it is an excellent remedy against the yellowjaundice and other infirmities of the gall, because mars governscholer it strengthens the attractive faculty in man, and clarifies theblood, because the one is ruled by mars the continual drinking thedecoction of it, helps red faces, tetters, and ring-worms, because marscauses them it helps the plague, sores, boils, and itch, the bitingsof mad dogs and venomous beasts, all which infirmities are under mars;thus you see what it doth by sympathy by antipathy to other planets it cures the french pox by antipathy tovenus, who governs it, it strengthens the memory, and cures deafness byantipathy to saturn, who has his fall in aries, which rules the head it cures quartan agues, and other diseases of melancholy, and adustcholer, by sympathy to saturn, mars being exalted in capricorn alsoprovokes urine, the stopping of which is usually caused by mars or themoon carrots garden carrots are so well known, that they need no description. Butbecause they are of less physical use than the wild kind as indeedalmost in all herbs the wild are the most effectual in physic, as beingmore powerful in operation than the garden kinds, i shall thereforebriefly describe the wild carrot descript it grows in a manner altogether like the tame, but thatthe leaves and stalks are essaywhat whiter and rougher the stalks bearlarge tufts of white flowers, with a deep purple spot in the middle, which are contracted together when the seed begins to ripen, that themiddle writing being hollow and low, and the outward stalk rising high, makes the whole umbel to show like a bird nest the root small, long, and hard, and unfit for meat, being essaywhat sharp and strong place the wild kind grows in divers writings of this land plentifullyby the field-sides, and untilled places time they flower and seed in the end of summer government and virtues wild carrots belong to mercury, andtherefore break wind, and remove stitches in the sides, provoke urineand women courses, and helps to break and expel the stone. The seedalso of the same works the like effect, and is good for the dropsy, and those whose bellies are swelling with wind. Helps the cholic, thestone in the kidneys, and rising of the mother. Being taken in wine, orboiled in wine and taken, it helps conception the leaves being appliedwith honey to running sores or ulcers, do cleanse them i suppose the seeds of them perform this better than the roots. Andthough galen commended garden carrots highly to break wind, yetexperience teaches they breed it first, and we may thank nature forexpelling it, not they. The seeds of them expel wind indeed, and essaynd what the root marrs carraway it is on account of the seeds principally that the carraway iscultivated descript it bears divers stalks of fine cut leaves, lying upon theground, essaywhat like to the leaves of carrots, but not bushing sothick, of a little quick taste in them, from among which rises up asquare stalk, not so high as the carrot, at whose joints are set thelike leaves, but smaller and finer, and at the top small open tufts, orumbels of white flowers, which turn into small blackish seed, smallerthan the anniseed, and of a quicker and hotter taste the root iswhitish, small and long, essaywhat like unto a parsnip, but with morewrinkled bark, and much less, of a little hot and quick taste, andstronger than the parsnip, and abides after seed-time place it is usually sown with us in gardens time they flower in june and july, and seed quickly after government and virtues this is also a mercurial plant carrawayseed has a moderate sharp quality, whereby it breaks wind and provokesurine, which also the herb doth the root is better food than theparsnip. It is pleasant and comfortable to the stomach, and helpsdigestion the seed is conducing to all cold griefs of the head andstomach, bowels, or mother, as also the wind in them, and helps tosharpen the eye-sight the powder of the seed put into a poultice, takes away black and blue spots of blows and bruises the herb itself, or with essay of the seed bruised and fried, laid hot in a bag or doublecloth, to the lower writings of the belly, eases the pains of the windcholic the roots of carraway eaten as men do parsnips, strengthen the stomachof ancient people exceedingly, and they need not to make a whole mealof them neither, and are fit to be planted in every garden carraway comfits, once only dipped in sugar, and half a spoonful ofthem eaten in the morning fasting, and as thesis after each meal, is amost admirable remedy, for those that are troubled with wind celandine descript this hath divers tender, round, whitish green stalks, with greater joints than ordinary in other herbs as it were knees, very brittle and easy to break, from whence grow branches with largetender broad leaves, divided into thesis writings, each of them cut in onthe edges, set at the joint on both sides of the branches, of a darkblueish green colour, on the upper side like columbines, and of a morepale blueish green underneath, full of yellow sap, when any is broken, of a bitter taste, and strong scent at the flowers, of four leavesa-piece, after which come small long pods, with blackish seed therein the root is essaywhat great at the head, shooting forth divers longroots and small strings, reddish on the outside, and yellow within, full of yellow sap therein place they grow in thesis places by old walls, hedges and way-sidesin untilled places. And being once planted in a garden, especially essayshady places, it will remain there time they flower all the summer, and the seed ripens in the meantime government and virtues this is an herb of the sun, and under thecelestial lion, and is one of the best cures for the eyes. For, allthat know any thing in astrology, know that the eyes are subject to theluminaries. Let it then be gathered when the sun is in leo, and themoon in aries, applying to this time. Let leo arise, then may you makeinto an oil or ointment, which you please, to anoint your sore eyeswith i can prove it doth both my own experience, and the experience ofthose to whom i have taught it, that most desperate sore eyes have beencured by this only medicine.

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Letold men and women make much of this medicine, and they will either giveme thanks, or shew manifest ingratitude mustard seed hath the virtueof heat, discussing, ratifying, and drawing out splinters of bones, andother things of the flesh it is of good effect to bring down womencourses, for the falling-sickness or lethargy, drowsy forgetful evil, to use it both inwardly and outwardly, to rub the nostrils, foreheadand temples, to warm and quicken the spirits. For by the fiercesharpness it purges the brain by sneezing, and drawing down rheum andother viscous humours, which by their distillations upon the lungs andchest, procure coughing, and therefore, with essay, honey added thereto, doth much good therein the decoction of the seed made in wine, anddrank, provokes urine, resists the force of poison, the malignity ofmushrooms, and venom of scorpions, or other venomous creatures, if itbe taken in time. And taken before the cold fits of agues, alters, lessens, and cures them the seed taken either by itself, or with otherthings, either in an electuary or drink, doth mightily stir up bodilylust, and helps the spleen and pains in the sides, and gnawings in thebowels. And used as a gargle draws up the palate of the mouth, beingfallen down.