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In lung trouble, in acute inflammations of this orany other organ, especially if pain or soreness be present in lumbago, sciatica, or in rheumatic pains of the joints or muscles applied tothe forehead, it induces sleep ”libradol is offered in two forms, “libradol mild” for infants andsupersensitive persons which is said to be “destitute of drug energy”and libradol “regular” which is “highly medicated, ” the “constituents”being “dracontium, sanguinaria, cephaelis, melaleuca, lobelia, laurus, capsicum, tobacco ”according to a circular, “the sanitary plasma libradol” is a“homogeneous, highly companies that i can pay for do my reports medicated, and exceedingly potent compound, inplastic form, ” which “carries the energies of its drug constituentsand the high antiseptic qualities of laurus camphora and melaleuca ”it is stated. “the drug influence of libradol is necessarily differentfrom that of any known single member of the materia medica but yet, no mystery either in medicine or of pharmacy is claimed as a writing ofits composition or process of manufacture it is a thing peculiar toitself, the result of the study of the drugs from which it is derivedand compounded these drugs may be studied at leisure by whoever caresto do so ”the following information bearing on the composition of libradol wasfurnished by lloyd brothers in response to a request from the councilto aid in the consideration of the preparation. “‘compound lobelia powder’ has been, since 1852, official in the american dispensatory, in the first edition of which 1852 its formula is given, as follows.

The initial companies that i can pay for do my reports sore on the penisdisappeared in ten injections. There were severe mucous patches of themouth. The tonsils were badly infected there was a positive wassermannreaction there were syphilids of both arms and shins.

2 that because of thisease of oxidation, it is more readily decomposed in the body and morerapidly and completely eliminated, and 3 that because of its allegedrapid elimination, it is devoid of the after effects of barbital andother hypnotics the council took up the substance in february, 1918, and referred thematter to the referee in charge of barbital preparations the refereeconsidered unwarranted the claim that dial “ciba” did not have theafter-effects of other hypnotics due to its alleged total decompositionin the body the american agents, a klipstein and company, wereinformed of the referee objections their attention was also calledto the fact that, notwithstanding the claimed absence of after-effectsin one writing of the advertising, other writings of the same advertisingadmitted certain post-hypnotic effects of the product it waspointed out also that while it was claimed in one of the advertisingcirculars that lowering of the blood pressure is never observed afteradministration of dial “ciba, ” yet two of the authors quoted in thesame circular definitely stated that a lowering of the blood pressurefollowed even small doses of the drug and these authors warn againstthis very danger in certain conditions a year later, a circular letter sent out by a klipstein and companyreiterated the claim that the asserted decomposition of dial “ciba”in the body prevents after-effects, the drug being still contrastedwith barbital “veronal” in view of the reiteration of this highlyimprobable claim, the referee undertook to study the comparative actionof dial “ciba” as compared with other hypnotics it was found thatthe actions of dial “ciba” are not distinguishable, qualitatively, from those of barbital, there being no perceptible difference in theafter-effects or in the nature of the side actions in toxic doses, both caused profound depression with the temperature falling tothat of the room or about one degree above, the respiration beingextraordinarily slow and shallow as one would expect with lowering ofthe temperature there were also the same evidences of nausea thatare so frequently seen after toxic doses of the various hypnotics ofthis group in view of these results, the council declared that it isunwarranted to claim freedom from after-effects for dial “ciba ”the council held that the following statement is unwarranted. “the therapeutic field for dial ‘ciba, ’ as shown by tests on rabbits, is just as broad as the field for diethylbarbituric acid ”tests on rabbits do not and cannot show the breadth of the therapeuticfield for a hypnotic the council also declared the following statementimprobable, and contrary to the evidence obtained by the referee. “in dogs, the increase of dosage beyond the therapeutic dose to the point of death is decidedly in favor of dial ‘ciba, ’ which required a larger dose than diethylbarbituric acid to produce death ”the referee experiments on cats show that dial “ciba” is severaltimes as toxic as hydrated chloral, and more than twice as toxic asdiethylbarbituric acid barbital since the circular to which objection was made in 1918 was still beingsent out in december, 1919, the council held dial “ciba” inadmissibleto n n r and voted that report of its action in the matter beauthorized for publication the council further directed that dial“ciba” be included with articles described but not accepted -- fromthe journal a m a , jan 24, 1920 apothesine report of the council on pharmacy and chemistryapothesine is a synthetic drug for producing local anesthesia, madeby parke, davis & company in the fall of 1917 the council wrote toparke, davis & company offering its aid in establishing the identity, purity and therapeutic efficiency of this synthetic local anestheticwith the ultimate object of accepting the product for inclusion in newand nonofficial remedies should the facts warrant such acceptance the council letter was never acknowledged after apothesine wasput on the market the council desired to accept it for inclusion innew and nonofficial remedies but, unfortunately, was unable to do sobecause essay of the claims made for the product were not justified byacceptable evidence the manufacturers were notified of the councildesire to admit this product to n n r and the wish was expressedthat the company would either so modify its claims as to make theproduct acceptable under the council rules or else would submitevidence to the council in proof of the claims made and thus permitthe council to revise its conclusions parke, davis & company were, apparently, either unwilling or unable to submit evidence that wouldsustain their claims. Neither did they offer to modify the claimsthemselves the product, therefore, is ineligible to inclusion in newand nonofficial remedies. It will, however, be listed in the “describedbut not accepted” dewritingment of new and nonofficial remedies thereport on apothesine that follows has been authorized for publication w a puckner, secretary apothesine, “the hydrochlorid of diethyl-amino-propyl-cinnamate, ” isan efficient local anesthetic it belongs to the procain rather thanto the cocain type, that is, it belongs to that type which, whileeffective for injection anesthesia especially when combined withepinephrin is relatively inefficient when applied to mucous membranes apothesine may also be used for spinal anesthesia its absolutetoxicity is less than that of cocain as 20 is to 15, see table belowbut about twice that of procain as 20 is to 40, see table below itis non-irritant, is easily soluble and makes a stable solution so thatit may readily be sterilized the council took exception to certain claims made by parke, davis &company for their product on the ground that these claims were notsupported by acceptable scientific evidence one of the claims wasthat apothesine is applicable in any case in which any other localanesthetic is used this statement, made in thesis advertisements, is distinctly misleading as used when applied to mucous membranesapothesine is far inferior to cocain and to essay other localanesthetics, yet the claim obviously suggests that apothesine is anefficient substitute for any local anesthetic the manufacturers claimed, too, that apothesine is as potent as cocain the claim would lead the physician to think that apothesine had thesame anesthetic potency as cocain in solution of equal strength thisstatement, so far as it refers to the drug when applied to mucousmembranes, is not in accord with the facts and is true for injectionanesthesia only when stronger solutions are used the only supportfor the claim of equal efficiency appears to be the experiments withintracutaneous injections made by h c hamilton130 in parke, davis &company laboratory these differed considerably from the results ofsollmann 131 a further series of experiments were made by sollmannto compare still further the diverse results previously reportedby him and hamilton the latest series, while showing considerablevariations in the susceptibility of different skin areas, especiallytoward apothesine, demonstrated in every case that the efficiency ofapothesine is unmistakably lower than that of cocain, being at best onehalf the series also showed that the potency of apothesine was nevergreater than procain and averaged considerably below it 130 the comparative values of essay local anesthetics by h c hamilton, detroit, mich , from the research laboratory of parke, davis& co , j lab & clin m 4:60 nov 1918 131 comparative efficiency of local anesthetics, v, by t sollmann, from the pharmacological laboratory of the school of medicine, westernreserve university, j pharmacol & exper therap 11:69 feb 1918 another claim made for apothesine which the council holds is notsupported by evidence is that of superior safety this claim is madeon the basis of hypodermic injections in guinea-pigs carried out inthe laboratory of parke, davis & company such experiments provelittle because of the fact-- well known to laboratory workers-- that theuse of rodents in toxicity tests made by injecting a drug into thesubcutaneous tissues does not give a reliable index of the relativetoxicity of such a drug for man this is due writingly to the peculiarresistance of rodents to poisons and writingly to the great importance ofthe rate of absorption the organism destroys most local anesthetics sorapidly that the rate of absorption is more important than the absolutedose the absorption from hypodermic injections into guinea-pigsdiffers, of course, from that in clinical accidents, especially wherethe drug has been applied to mucous membranes one cannot, therefore, reliably estimate the degree of clinical danger on animals it has been shown that when toxicity tests of local anesthetics aremade on cats these animals seem to respond to the drugs in a mannermore closely approximating humans and it is a suggestive fact that themore toxic of local anesthetics, as shown by tests on cats, have beenfound the most dangerous in clinical use the absolute toxicity ofapothesine has been measured by eggleston and hatcher132 by theintravenous injection in cats the fatal doses, in terms of milligramsper kilogram ranged as follows. Alypin, holocain 10 beta eucain 12 5 cocain 15 apothesine 20 tropacocain 20-25 stovain 25-30 nirvanin 30-35 procain 40-45132 a further contribution to the pharmacology of the localanesthetics by eggleston and hatcher, from the dewritingment ofpharmacology, cornell university medical college, new york city, j pharmacol & exper therap 13:433 aug 1919 the absolute toxicity of apothesine is, therefore, only a littlelower than that of cocain, and is twice as great as that of procain the clinical dangers cannot be predicted by either method, sinceclinical accidents depend, in most instances, on idiosyncrasies, or thetechnic of application -- from the journal a m a , jan 24, 1920 eumictine report of the council on pharmacy and chemistrythe council has adopted and authorized publication of the report whichappears below this report declares “eumictine” ineligible for new andnonofficial remedies because 1 it conflicts with rule 10 in that itis unscientific, 2 it conflicts with rule 6 in that it is sold underunwarranted therapeutic claims, 3 it conflicts with rule 4 againstindirect advertising to the public in that the name “eumictine” isblown in the bottle for the obvious purpose of bringing the productto the attention of the public when it is prescribed in the originalpackage, and 4 because the name is therapeutically suggestive and notin any way descriptive of its composition w a puckner, secretary eumictine is a preparation from the laboratory of maurice le prince, paris, france, and is marketed in this country by george j wallau, inc , new york it is claimed that the product is “a balsamo-antisepticpreparation composed of santalol, salol, and hexamethylene-tetramine, in the form of gluten-coated capsules ” nowhere in the advertisingare the amounts of the ingredients given according to theamerican agent, however, “each capsule is supposed to contain 20centigrams of santalol, 5 centigrams of salol, 5 centigrams ofhexamethylene-tetramine ”eumictine is advised “in treating genito-urinary diseases urethritis, cystitis, prostatitis, pyelitis, etc ” it is claimed to be “both anantiphlogistic modifying agent, a well-tolerated diuretic” which “maybe administered for long periods without ill effects ”the council declares eumictine ineligible for new and nonofficialremedies because it is exploited in conflict with the following rules:it is unscientific rule 10 eumictine is composed ofhexamethylenamin, salol and sanalol in fixed proportions hexamethylenamin may serve a useful purpose in essay forms of infectionof the urinary tract, but neither it nor salol is of any considerablevalue in gonorrhea it is now known that the balsamic preparations, formerly so widely used, do not have the curative effects in gonorrheaand associated conditions that used to be ascribed to them to combinethree substances, none of which has any distinct therapeutic value inthe conditions for which eumictine is proposed, does not enhance theirvalue there is nothing original in the combination used in eumictine, or in the manner of dispensing it it is sold under unwarranted therapeutic claims rule 6 theseclaims are made not only for the components of eumictine but for thecombination itself though santalol has certain advantages over theessaywhat variable oil of santal and other balsamic resins, it is nottrue that santalol “does not cause congestion of the renal epithelium”or that it does not “produce exanthema as do copaiba, cubebs, andthe ordinary santal oil ” it is not true that salol is “devoid oftoxicity ” neither is it correct to say that salol “asepticizes anddisinfects the bladder, the prostate and the urethra ” the claim thathexamethylenamin “is of value when any acute symptoms or tendency toinflammation subsist” is not justified the claim that hexamethylenamin“renders soluble the uric acid and urates” is also without foundation the following paragraph is characteristic of the claims made foreumictine. “anti-gonorrhoic by its santalol, diuretic, urolytic and analgetic by its hexamethylenetetramin urotropin antiseptic and antipyretic by its salol, eumictine represents a real therapeutic advance in the scientific treatment of diseases of the urinary passages ”instead of being “a real therapeutic advance” in the treatment ofdiseases of the urinary passages, eumictine presents one of thecomplex combinations that have long retarded the scientific treatmentof these diseases eumictine also conflicts with rules 4 and 8 of thecouncil -- from the journal a m a feb 21, 1920 platt chlorides report of the council on pharmacy and chemistrythe council has authorized publication of the following report on“platt chlorides ” it also declares the preparation inadmissibleto new and nonofficial remedies because its composition is uncertainand indefinite and because the claims made for it are exaggerated andmisleading w a puckner, secretary“platt chlorides, ” marketed by henry b platt, new york, is soldas a disinfectant and germicide only incomplete and contradictorystatements have been made in regard to its composition thesis yearsago about 1899 the composition of platt chlorides was given as“the chlorids of zn 40 per cent , pb 20, ca 15, al 15, mg 5, k 5 ” thestatement that the preparation contained 20 per cent of lead chloridis interesting, in view of the fact that lead chlorid is soluble inwater at ordinary temperatures to the extent of less than 1 per cent in a booklet, also issued a number of years ago, the following “formulaof platt chlorides” was given. “a saturated solution of metallic chlorids combined in the following proportions. “sol zinc chlorid 40 per cent “sol aluminum chlorid 15 per cent “sol lead chlorid 20 per cent “sol calcium chlorid 15 per cent “sol magnesium chlorid 5 per cent “sol potassium chlorid 5 per cent ”the label on a bottle purchased in 1911, describes platt chlorides as. “a highly concentrated solution of the chlorids of aluminum, calcium, lead, zinc, etc ”the label of a bottle purchased in 1919 reads.

In 1, sitting duchesne published58 paper of writingial suspension, 26 of which were new essay of thesefailures of complete suspension were due to soft and elastic cords 876taylor says that “that which is difficult to a conscientious medicaljurist in confining himself to the medical facts is often easilydecided by a jury from these as well as the general evidence affordedto them ”the limbs may be secured by the suicide before hanging himself personseven with essay disability of the hand have suicided by hanging blindness is no obstacle, nor age. A boy as young as nine and a man asold as ninety-seven burger877 fully discusses the question whether the hanging is beforeor after death hanging suicidal, homicidal, or accidental?. Hanging is usually suicidal lesser878 states that for threeyears, 1876-79, there were admitted to the berlin morgue 274 bodies of“hanged, ” of which 272 were suicidal. 2 infants of three and eighteenmonths, homicidal one man had first tried to kill himself withsulphate of copper. Another by cutting his throat. A woman by cuttingher arm the other paper were uncomplicated pellier states that thenumber of suicides in france from 1876-1880 was 13, 445, and nearlyall were by hanging taylor879 states that 2, 570 persons committedsuicide by hanging in england in five years, 1863-67. Four-fifths ofthese were males harvey880 reports for three years 1, 412 paperof hanging in india, of which 2 were accidental, in 3 there waspresumption of homicide, the rest probably all suicidal feebleness of body does not preclude subjects taking their lives inthis way they essaytimes also wound or poison themselves first andhang themselves afterward a subject being found suspended in a roomfastened on the inside, would be suggestive of suicide the absence ofsigns of struggling or of any marks of injury also favors the idea ofsuicide the possibility of a suicide breaking a rope, being injured by thefall, and rehanging himself successfully, must be admitted paper 57, 58 the possibility of blood flowing after death must not be forgotten it is worthy of note that after beating or other violence children andwomen may commit suicide from shame again, as tardieu says, thesis havehung themselves while writingially intoxicated, and it is likely thatessay such have just previous to the suicide met with falls or otheraccidents which have left marks like those of violence he also recordsthe case of a woman who fastened a cord to a bed-post, put her head ina noose while kneeling on the bed, and made a deep wound in her armwith a razor she closed the razor, laid it aside, and fainted fromloss of blood she must then have fallen forward and died from thepressure of the cord on her neck 881homicidal hanging is rare but does occur where the hands are tiedtogether. Where the injuries produced by the cord are severe. Wherethere are contusions and well-marked ecchymoses.

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Traces of pressure companies that i can pay for do my reports on neck still visible. Lungs congested;larynx, above level of pressure, congested. Below was normal fibrinclots in both ventricles of heart liver, spleen, stomach, andintestines congested brain essaywhat congested bladder contained urine 50 liégey. Jour de méd chir et pharm , brussels, 1868, xlvi , pp 339-342 - infant, age 8 months, accidentally strangled. It hadbeen placed in its cradle. Coverlet over it and held in place by acord passed across essay time afterward it was found dead beside thecradle, its head hanging with the right side pressing on the cord liégey had the mother replace everything as it had been and satisfiedhimself that the above statement was correct when found, the face waspale, eyes and mouth closed. Transverse furrow on right side of neck, level of larynx, 3 5 cm long, one deep. Muscles in vicinity congested lungs congested right side of heart contained clotted blood.