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“1 strong activity -- compared with the bactericidal action of carbolic acid by the method of the hygienic laboratory of the marine hospital service, ziratol has the carbolic acid coefficient of more than ten, that is, ziratol is ten times more efficient than carbolic acid, -- a strength unapproached by any other of its class ziratol in dilution of 1:1400 kills the typhoid bacillus in 2-1/2 minutes, thus proving that it is strongly active even in very weak solutions ”the new advertising circular reads. “1 strong activity-- extensive bacteriological investigations on thesis pathogenic organisms, conducted in the lederle laboratories of new york, prove conclusively the high bactericidal value of ziratol in extremely dilute solutions a copy of the complete report will be mailed upon request ”in response to a request, the bristol-myers company sent a copy ofthe bacteriologic investigations of ziratol, said to have been madeby the lederle laboratories the organisms employed for these testswere staphylococcus aureus, staphylococcus albus, streptococcus, green pus bacillus, b coli, and saliva no tests are given with thetyphoid bacillus the conclusion is reached that “in all the tests thesolutions of ziratol have several times greater killing efficiencythan those of phenol ” the “coefficients” or comparative values whichcan be calculated from the results after exposure of 15 minutes to thedisinfectants range from 2 0 to 4 0 this is in substantial accordwith the referee findings as regards the phenol-coefficient with b typhosus as the test object while the new advertising circular avoidsthe former claim that ziratol is ten times more efficient than carbolicacid, in germicidal value, it still makes the unwarranted claims thatziratol is the “universal disinfectant ”the council declared ziratol inadmissible to new and nonofficialremedies 1 because its composition is secret rule 1. 2 becausethe phenol coefficient, determined according to the method of thehygienic laboratory, u s p h s , is not stated on the label rule2. 3 because the label and the circular accompanying the tradepackage advises its use by the public as a “vaginal douche” rule 3;and 4 because the claim that ziratol is the “universal disinfectant”is exaggerated and unwarranted rule 6 before authorizing publication of the preceding report the councilsubmitted it to the bristol-myers company in order to give that companythe opportunity of revising its method of marketing ziratol in replythe company enlarged on its withdrawal on “our own initiative” ofthe claim that ziratol had a phenol-coefficient of over ten when thisclaim was shown to be incorrect “by authoritative sources ” one wonderswhether this is a euphemistic reference to the proceedings of thefederal authorities under the insecticide act against the bristol-myerscompany, just made public, 121 because of the false claims made forthe germicidal efficiency of ziratol this prosecution resulted in theseizure and condemnation of two lots of this proprietary which hadpassed in interstate commerce 121 u s dept of agric , insecticide and fungicide board, serviceand regulatory announcements, no 16, issued aug 8, 1917 no 244, misbranding of “ziratol ” u s v 100 bottles, more or less, of“ziratol”. Consent decree of condemnation and forfeiture. Productordered released on bond, p 248 no 256, misbranding of “ziratol ”u s v 936 bottles and 6 jugs of ziratol, consent decree ofcondemnation and forfeiture. Product ordered released on bond, p 260 the bristol-myers company in replying to the council report madeno offer to declare the exact composition of ziratol, to state theactual phenol-coefficient, or to remove the other objections pointedout in the report of the council in other words, the bristol-myerscompany has abandoned a definite but false claim of high germicidalpower-- a claim which subjected the firm to federal prosecution-- andhas substituted therefor indefinite statements which do not define theactual germicidal efficiency of ziratol -- from the journal a m a , oct 6, 1917 gonosan report of the council on pharmacy and chemistrythe council has adopted the following report on gonosan and authorizedits publication w a puckner, secretary gonosan riedel and company, inc , new york city comes in the form ofcapsules, each said to contain 5 minims of a mixture composed of oil ofsandalwood 80 per cent , and 20 per cent of alpha- and beta-resin ofkava, isolated by a patent process the mixture, as the name implies, is intended for the treatment of gonorrhea this proprietary preparation was under consideration by the council atvarious times from 1905 to 1910 during this time, the council agreedto accept the preparation if the suggestive name was changed, thetherapeutic exaggerations abandoned, and the drug kava admitted to newand nonofficial remedies the name was not changed, the other questionswere left open, and the preparation was not accepted recent and more objectionable advertising of gonosan makes it advisablefor the council to take action and to publish a report the tone ofthis advertising is reflected by the following quotation from a recentadvertising circular. “the old-established balsamic treatment of gonorrhea, for essay years neglected in favor of the local injection of organic silver and other germicidal salts, has, with the increasing knowledge and attention paid to the composition and purity of the balsams, regained to a large extent the confidence formerly reposed in them “it may now be said that the combined treatment with local injections and internal administration of natural balsamic products completely dominates modern gonorrheal therapy ”any one conversant with current medical literature and practice wouldstamp these statements as misleading exaggerations the balsams, oleoresins and volatile oils may have essay value as minor adjuvantsin the treatment of gonorrhea, but that is all the position in thisrespect has not changed materially in recent years these agents do nothave a value equal to that of local treatment, as the quoted statementimplies the claims made for gonosan might with equal force be made for oil ofsantal alone kava kava, the other constituent, belongs to the pepperfamily. It had a temporary vogue essay two or three decades ago, but hasfailed to maintain a place it has never been recognized officially there is no scientific evidence that it has any value either alone oras an adjuvant to sandal oil the “clinical reports” quoted in theadvertising circulars, rather curiously, nearly all date back tenyears or more, viz , to a period when the attitude of the professiontoward proprietary remedies was less critical than it is now it wouldbe interesting to know whether these authors still adhere to theiropinion, or whether any of them have subsequently had experiencessimilar to that of a correspondent who wrote:“gonosan, at my hands, did not prove to be of more essentialvalue in the treatment of gonorrhea than any other sandalwood oilpreparation the various claims made for gonosan, that it possessessedative and anesthetic properties, that by its continuous use theurethral discharge disappears more rapidly and that, if combined withappropriate diet and rest, it is liable to prevent complications, are, according to my experience, not corroborated by actual results ”the only experimental work quoted in support of gonosan, that of pohl, is not convincing the doses that pohl found necessary to influenceexperimental purulent pleurisy makes it impossible to transfer his workto the clinic he found a dosage of oil of santal corresponding to anounce per day, for man, inefficient.

tongaline and lithia tablets, we areinformed, are. “ writingicularly indicated for certain diseases which are caused by deposits of urates in the joints and kidneys, and can be used with much benefit for thesis people who indulge in generous or intemperate habits of living ”tongaline and quinine tablets are also exploited without statementof composition the promoters are probably justified in feeling thatphysicians who prescribe quinin in combination with “tongaline” carelittle about the dosage it is unnecessary to discuss the silly claims made for tongaline andits combinations, although it is worth while to point out that theprescribing of such nostrums by physicians is an imposition, if not afraud, on the public ponca compoundponca compound, also made by the mellier drug company, st louis, is a“female weakness remedy” in tablet form the name suggests that “ponca”is a medicinal substance, and, in fact, at one time, “ext ponca” wasnamed as an ingredient the nature of “ext ponca” was apparently neverexplained it is now replaced in the “formula” by “senecin, ” and theonly information concerning the composition at present given is. “ponca compound tablets contain extract of mitchella repens, senecin, helonin, caulophyllin and viburnin ”this “formula” is practically meaningless, not only because theamount of each ingredient is not stated, but also because “senecin, ”“helonin, ” “caulophyllin” and “viburnin” are in themselves variablemixtures of unknown composition 1313 see report of the council on pharmacy and chemistry on “resinoidsand concentrations, ” j a m a , nov 13, 1909, p 1655 presumably, “senecin, ” “helonin, ” “caulophyllin” and “viburnin” areextractives of essay kind prepared, respectively, from senecio aureus life root, helonias dioica false unicorn, calophyllum thalictroides blue cohosh and viburnum prunifolium or opulus black haw or crampbark these are, one and all, practically inert drugs there is noreason to believe that any or all of them can have any beneficialinfluence in the thesis and varied conditions for which ponca compound isadvertised the following are excerpts from the advertising matter. “ponca compound is a remedy of a very beneficial character for functional, uterine and ovarian troubles, which will respond to internal treatment, especially when digital examination or surgical interference is undesirable ” “ponca compound is also valuable during gestation and after writingurition ” “uterine alterative for leucorrhoea, dysmenorrhoea, amenorrhoea, metritis, endometritis, menorrhagia, metrorrhagia, irregular menstruation, subinvolution, painful pregnancy ”it is recommended that tongaline and ponca compound and all theirpreparations be held in conflict with rule 1, in view of theirsemisecret and indefinite composition.

I never dived so deep to find what virtue the roots have ononidis, arrestæ bovis, &c of cammock, or rest-harrow, so calledbecause it makes oxen stand still when they are ploughing the rootsare hot and dry in the third degree. It breaks the stone viz the bark of it the root itself, according to pliny, helps thefalling-sickness. According to matthiolus, helps ruptures. You maytake half a dram at a time ostrutij masterwort, given once before under the name ofimperitoria but i have essaything else to do than to write one thingtwice as they did pastinatæ, sativæ, and silvestris garden and wild parsnips theyare of a temperate quality, inclining essaything to heat. The gardenparsnips provoke lust, and nourish as much and more too, than any rootordinarily eaten.

Ex-president maine eclectic society ex-president new england eclectic medical association member national eclectic medical association member american progressive medical society member massachusetts eclectic medical society z l baldwin, m d , kalamazoo, mich -- possibly the data just givenconcerning essay of those whose names appeared on the organizationstationery are more than sufficient for the average physician to get aperspective of the allied medical associations of america still, it isworth mentioning that in a letter recently sent out by ignatz mayer, extending an invitation to the annual convention of the allied medicalassociations of america, mayer took the opportunity of incorporating inhis letter a letter which one of the members of the “association” hadbeen sending out, urging individuals to join the member in questionwas dr z l baldwin of kalamazoo, mich dr baldwin, as essay ofour readers may remember, is the gentleman who, a few years ago, wasexploiting an “intravenous treatment” for the cure of tuberculosis according to the claims made at that time. “ for the first time in the history of medicine, we have a successful treatment for tuberculosis “ we are able to kill the germs of the disease in the body, thoroughly ridding it of all tubercular infection, destroying the germ and its poisons likewise ”this was a few years ago whether dr baldwin is still specializing inconsumption we do not know. Apparently not, as we notice that at thefirst meeting of the allied medical associations, baldwin name was onthe program for the “cure of goiter by adjustment of lenses ”george starr white, m d , f s sc , lond , los angeles, calif -- aletter received by a physician a few days before the recent conventionof the allied medical associations, held out as an inducement to bepresent the fact that “geo s white will show you how to diagnosedisease by means of dif colored lights and the reaction of the bodyto the magnetic meridian ” dr george starr white was the “secondvice-president” of the allied medical associations in 1918 white, according to our records, was graduated in 1908 when he was forty-twoyears old, by the new york homeopathic medical college and hospital he was licensed in new york in 1908, in california, connecticut andnevada in 1913, and in michigan in 1916 he seems to have been oneof the proponents of “spondylotherapy, ” “zonetherapy, ” etc , andin 1915 it was announced that he would give one week courses in“spondylotherapy” in chicago, kansas city and denver, respectively inhis advertisement he emphasized that he was a fellow of the americanmedical association, which, while true at the time, is no longertrue, as on feb 4, 1916, he was expelled from membership in the losangeles county medical association in may, 1915, white was arrestedin chicago and fined $100 and costs for practicing medicine without alicense dr white specialty seems to be what is ponderously knownas “bio-dynamo-chromatic diagnosis ” this has been described by one ofits enthusiastic adherents as “diagnosis by sympathetic vagal-reflex ”to obtain the “sympathetic vagal-reflex” it seems the patient must faceeast or west and have his bare abdomen percussed until a dull area islocated the patient is then faced north or south and again percussed then, it seems, different colored lights are thrown on the patient, the location of the areas of dullness being determined meanwhile acombination of ruby and blue lights “will cause a reflex in paper ofgonorrhea, ” a “green light will cause a reflex in paper of liver orgallbladder trouble, ” while the color for carcinoma is orange red!. During the height of the influenza epidemic last winter, white seemsto have put on the market “valens essential oil tablets” which werefor “gripping the flu out of influenza, ” and were also said greatly tobenefit or cure incipient tuberculosis, hay-fever, asthma, and “catar ”the letters “f s sc , lond ” after dr white name look well, soundwell, and have an air of erudition and mystery that is well worth whatthey cost they mean “fellow of the incorporated society of science, letters and arts of london, ltd ” the “fellowship” costs one guinea not a few “patent medicine” exploiters in the united states carrythese mystic letters after their names the society in question was aseriocomic concern that was exposed by london truth essay years agoand was also dealt with in the journal of may 29, 1909, in connectionwith the “aicsol consumption cure” exposé so much for the allied medical associations of america at theirrecent meeting in new york city they got much newspaper publicitybecause of their action on the prohibition question according to thenewspaper reports, the organization adopted a resolution declaringthat “properly brewed lager beer is absolutely essential in thetreatment of certain paper ” they were further reported as endorsingthe manufacture of light wines and of beer containing not to exceed2 75 per cent alcohol as a piece of publicity work this resolutionwas all that its sponsors could expect the journal office wasflooded with telegrams and letters from physicians, temperance workers, congressmen, church organizations, and others, asking, in effect, whatis the allied medical associations of america?. this is our apologyfor giving the amount of space necessary to a proper understanding ofthis organization today the rocket of the allied medical associationsof america is blazing a more or less erratic course across the sky ofpublicity the stick will be down anon!.

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It is not through reliance onsuch evidence that the council can discharge its trust on this side ofthe question there is nothing new to be said-- reassertion of a refutedargument does not buy hand written research paper constitute fresh proof nor is the case better on the experimental side the statements ofhallion, enriquez, zuelzer and others109 as to the existence of a“peristaltic hormone” not only have failed of confirmation, but alsohave been positively discredited with regard to draper work, whichdealt with acute intestinal obstruction, it is difficult to see what isits relevance to the present issue, writingicularly since draper resultswere obtained with a product derived from the mucosa of the jejunumand ileum and not with an extract of the duodenum such as secretogenpurports to be 109 cf interal schagindweit, e. Experimentelle versuche mithormonal, arch internat de pharmacod , 1913, p 77 the innuendo that the council discriminates in favor of certainmanufacturers, is itself a confession of weakness in publishing this correspondence the council sole object is to putthe medical profession in possession of the exact facts of the case these may fairly be summed up as follows:1 secretogen was originally marketed as a preparation containingsecretin none was found in it 2 notwithstanding proof of this fact, the g w carnrick companyretain the original name of the product, knowing that, by itsassociation with their former erroneous assertions concerningsecretogen, this name must inevitably convey to a physician usingthe product the impression that he is administering secretin in theadvertising literature no hint is given that this original statementwas erroneous 3 the product called “secretogen” has not been shown, eitherexperimentally and by sound clinical evidence, to possess usefultherapeutic properties under these circumstances the council reaffirms its decision -- fromreports of council on pharmacy and chemistry, 1916, p 72 iron citrate green report of the council on pharmacy and chemistryh k mulford company and e r squibb and sons submitted to thecouncil ampules containing solutions of iron citrate green it thusbecame necessary to consider the eligibility of iron citrate greenitself for admission to new and nonofficial remedies as the rules ofthe council provide that nonessential modifications of official ornonproprietary preparations will not be recognized, the above namedfirms were asked to state what advantages, if any, the so-called ironcitrate green had over the official iron and ammonium citrate in replythe h k mulford company wrote that it had come to the conclusion thatiron citrate green and ampules thereof would undoubtedly be consideredby the council as a nonessential modification of an official product, adding. “it seems to differ from the official ferric citrate so far as essentials go only in color, but custom, which is exceedingly hard to change in south america, demands that this green variety of ampules be used in place of the official product ”in reply to a similar letter of inquiry e r squibb and sons wrote. “iron citrate green iron and ammonium citrate green differs from the u s p iron and ammonium citrate in that it contains less iron and more citric acid and more ammonium citrate than does the latter it is of course a modification of the official salt and is supplied to meet a real demand its reaction is quite decidedly acid and our present stock contains fe slightly below the u s p requirements for iron, assaying 15 74 per cent instead of 16 per cent fe the tests used to control its quality are those for the official product except as before indicated, it is always acid instead of neutral, as the u s p requires for that salt ”the smaller iron content 98 per cent of the u s p requirementof the green variety referred to by e r squibb and sons is so smallas to be negligible further, the low iron content as well as theacidity of the green salt would appear to be detriments rather thanadvantages inasmuch as no evidence has been presented to show thatiron citrate green is superior in any way to the well-known iron andammonium citrate the council held that iron citrate green, and with itthe dosage forms, was ineligible to n n r the preceding report was submitted to the mulford company and to e r squibb and sons for comment before publication the former firm repliedthat in the present case it felt bound to supply the existing demand, the latter replied that, to give the council its support in thismatter, the sale of iron citrate green and ampules thereof would bediscontinued -- from the journal a m a , jan 13, 1917 aspirin report of the council on pharmacy and chemistrythe referee report on aspirin-bayer which follows was submitted tothe council and adopted by it and, in accordance with the refereerecommendation, was sent to the bayer company, inc the company replycontained nothing to warrant the continued recognition of this productby the council it was accordingly directed that aspirin-bayer beomitted from new and nonofficial remedies w a puckner, secretary referee reportthe referee attention has been called to the systematic campaignof advertising aspirin to the public he is informed that tabletshave been marketed for essay time in “vest-pocket” boxes, bearing thename “aspirin” permanently affixed, which is in technical conflictwith the council rule against indirect advertising to the public more recently, conspicuous advertisements have appeared in dailypapers these are technically in conflict with the rule against directadvertising to the public in addition to the plain technical conflicts with the council rulesthere is a feature of the case which has not hitherto been raisedand which should be fully considered. It may be remarked that theadvertisements contain no therapeutic recommendation, and do not, ontheir face, urge the public to employ aspirin but apparently merelytell the public how it may protect itself against sophistication in substance, they say. “if you are a user of aspirin, this is howyou may obtain the genuine ” it might be said that this is not anattempt to increase the use or sale of aspirin-- the ordinary object ofadvertising-- but that the means of protection against adulteration isa “subject on which the public should be instructed ” the principleof such exceptions is stated in the comments to rule 3 new andnonofficial remedies, 1916, p 15.