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Compt rend soc de biol 68:535, 1910 the destructive action of the digestive enzymes leads us to believethat it is in inactive form that secretin is absorbed likeepinephrin, it cannot pass through the digestive tract bayliss andstarling state that it is destroyed by one hour tryptic digestion lalou62 worked with the action on secretin of pepsin, dog gastricjuice, pancreatic juice, succus entericus and erepsin, and found ineach case a destructive effect, even almost after mixing. And afterfive minutes over 75 per cent of the activity had disappeared matuso36 introduced 30 c c of active secretin into the intestine, removed it five minutes later, and found that no activity remained other methods of administration have been tried subcutaneousinjections are practically negative matuso, 36 hallion83and intrapleural injections are likewise negligible bayliss andstarling55 83 hallion. Presse méd 20:433, 1912 starling63 finds that continued intravenous injections of secretin ina healthy dog produces after a time severe symptoms of collapse, which, he believes, are due to change in the intestinal mucous membrane causedby the entry and non-neutralization of the strongly alkaline pancreaticjuice intestinal digestion seems little affected in achylia gastrica stockton, 84 ehrman and lederer, 85 bayliss and starling32 thismay be due to other secretin stimulants as fats, or to the action ofthe nervous mechanisms meltzer86 84 stockton. In osier and mccrae modern medicine 3:19, 1914 85 ehrman and lederer. Deutsch med wchnschr 35:879, 1909 86 meltzer, s j. The factors of safety in animal structure andanimal economy, j a m a , feb 23, 1907, p 655 the destruction of secretin by human gastric juicewe have carried out in detail experiments on the digestive effect ofhuman gastric juice on secretin our results in every respect confirmthe findings of lalou, 62 who worked with commercial pepsin and doggastric juice, but are even more striking because of the much superiorquality of pure human gastric juice methods -- the human gastric juice was obtained from mr v , thegastric fistula case of our laboratory the chemical and digestivecharacters of his juice are discussed in a recent paper 87 in thedifferent experiments, different samples of gastric juice were used the secretin employed was always freshly prepared digestion wascarried out in the incubator at 38 c with the reaction of 0 4 percent acid, and the end of the period was marked by either boilingthe mixture or in the first two experiments by turning the mixturealkaline the action of the preparation, we proved, was not influencedby the method used the dogs on which the preparations were testedwere prepared for carotid blood pressure, injection into the externaljugular vein, and cannula in the pancreatic duct, essentially themethods of bayliss and starling32 being employed the preparationswere injected at body temperature after being neutralized and filtered except for the addition of normal salt solution instead of gastricjuice, the control injections of secretin were submitted to exactly thesame treatment as the other preparations 87 carlson. Am jour physiol 38:248, 1915 results -- our results are embodied in table 1 we assured ourselvesbefore beginning the series that incubation of secretin with boiledgastric juice produced no change it is to be noted in the table thateach experiment is a unit complete in itself, beginning and endingwith a control injection of secretin special attention is called tothe marked destruction that follows contact of human gastric juicewith secretin for merely one minute in experiment 4, using 1 c c of human gastric juice, the action fell to 14 drops from an originalsecretion of 21. In experiment 5, using 8 c c of gastric juice, theaction fell to 6 drops from an original secretion of 20 of interestalso is the rate at which we get complete destruction of secretin this is practically 2 hours for 2 c c with secretin giving originally110 drops experiment 2, fig 1, or 30 minutes for 5 c c with asecretin giving originally 53 drops experiment 6 these results arepractically parallel, though they were obtained with different samplesof gastric juice and in different experiments table 1 -- the destruction of secretin by human gastric juice | | secretion of pancreatic juice in drops | -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- no |quan-|10 c c c| the secretin after incubation |10 c c of | tity|secretin| with human gastric juice |secretin exper-|of |control -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -control iment|gas- |-- begin-| | | | | | |-- end of | tric| ning |dig |secre-|dig |secre-|dig |secre-|experi- |juice|experi- |time, | tion |time, | tion |time, | tion | ment |used, | ment |hrs |rate |hrs |rate |hrs |rate | |c c | | | | | | | | -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 1 | 2 | 28 |6 | 0 |4 | 0 |2 | 0 | 16 2 | 2 | 110 |2 | 7 |1-1/2| 18 |1 | 18 | 41 3 | 2 | 40 |1 | 7 | 3/4| 7 | 1/4 | 8 | 31 4 | 1 | 21 | 1/2| 11 | 1/4| 12 | 1/60| 14 | 18 5 | 8 | 20 | 1/2| 1 | 1/4| 3 | 1/60| 6 | 18 6 | 5 | 53 | 1/2| 2 | | | | | -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- we also tried the effect of keeping the digestive time constant andvarying the amount of gastric juice employed increasing the quantityof gastric juice used increases the quantity of secretin destroyed table 2 table 2 -- experiment 7* pancreatic preparation juice drops 10 c c secretin 20 10 c c secretin digested with 0 5 c c gastric juice 15 10 c c secretin digested with 3 c c gastric juice 13 10 c c secretin digested with 10 c c gastric juice 8* the digestive time was kept constant at fifteen minutes the gastricjuice used had been diluted with stomach washings the reader will observe in table 1 that the results obtained fromthe control injection of secretin at the beginning of the experimentis uniformly greater than that obtained after several injections ofdigested secretin in view of the established fact that equal quantities of secretin cangenerally be relied on to produce results, 21 one might suggest thatthe injections of the split products of secretin have inhibited to essaydegree the action of the pancreas we can submit the data in table 3in support of this view, showing among other things that the action ofsecretin is not influenced by previous injections of inert depressorsubstances, though it by the injection of the cleavage products ofsecretin the various injections in the experiments were made at aboutfifteen-minute intervals we have carefully analyzed the reaction in blood pressure that followsthe injection of the various preparations we find no constant effect digested secretin gives a fall in blood pressure that is at times less, at times equal, and at other times greater fig 1 than that producedby the original preparation besides the bearing that it has on the therapeutic use of secretin, this destructive action of the digestive enzymes is also of primephysiologic interest failure to realize it has led to misconceptionsas to the intrinsic nature of secretin table 3 -- experiments 8 and 9 pancreatic preparations juice drops experiment 8. 10 c c secretin, five injections of inert depressor substances 29 10 c c secretin, two injections of completely digested secretin 28 10 c c secretin, eight injections of inert depressor substances 16 10 c c secretin 16 experiment 9.

Thus:tinctura nucis vomicae, u buy college entry level essay s p. Elixir gentianae, n f substances described in new and nonofficial remedies -- in the body ofthe book will be described simple proprietary substances and theirpreparations. Proprietary mixtures if they have originality or otherimportant qualities which, in the judgment of the council, entitle themto such place, and important, nonproprietary, unofficial articles the council recommends that when the latter are prescribed, theybe indicated by the abbreviation, “n n r , ” thus insuring to theprescriber the quality of these articles laid down in the book proprietary mixtures -- a mixture will be considered as proprietary, and therefore requiring consideration by the council for admissionto the book or appendix, if it contains any proprietary article. Ifit is marketed under a name which is in any way protected, or ifits manufacturer claims for it any unusual therapeutic qualities proprietary mixtures which are marketed in conformity with therules are listed in the appendix of the book under the names of therespective manufacturers such proprietary mixtures are not admittedto the body of the book, save in the exceptional paper cited in thepreceding paragraph nonproprietary mixtures of official substances -- since the ingredientsof such mixtures do not require consideration by the council, andsince the mixtures are not open to the proprietary abuses which callfor the work of the council, it is not necessary that they should beinvestigated by the council the physician must judge whether suchmixtures should be directed to be prepared by the pharmacist, orwhether he is justified in ordering a ready-made preparation if hedecides to use a ready-made, nonproprietary preparation, he must judgefor himself whether it is marketed in accordance with the rules itshould, however, be remembered that the application of a trade name toany substance makes it proprietary explanation of rule 1.

Upper lid discolored. Abrasionof skin under right ear. Deep red mark around neck eyeballs notprominent. Eyelids closed. Corneæ dull. Pupils a little dilated bothlenses fractured brain normal. Spinal cord normal heart empty 86 dyer. Same trans , 1869, pp 72-75 - man hung one eye showedfracture of lens, the other lens showed fine lines a second paperhowed dislocation of a cataractous lens a third showed fissure oflens 87 green.

Let the alum and sublimatum, being in powder, boil in the waters, in a vessel with a narrow mouthtill half be consumed, buy college entry level essay when it has stood five days, strain it physical wines vinum absynthitis or wormwood wine college take a handful of dried wormwood, for every gallon ofwine, stop it in a vessel close, and so let it remain in steep. So isprepared wine of rosemary flowers, and eye-bright culpeper it helps cold stomachs, breaks wind, helps the windcholic, strengthens the stomach, kills worms, and helps the greensickness rosemary-flower wine, is made after the same manner it is good againstall cold diseases of the head, consumes flegm, strengthens the gums andteeth eye-bright wine is made after the same manner it wonderfully clearsthe sight being drank, and revives the sight of elderly men. A cup ofit in the morning is worth a pair of spectacles all other wines are prepared in the same manner the best way of taking any of these wines is, to drink a draught ofthem every morning you may, if you find your body old or cold, makewine of any other herb, the virtues of which you desire. And make itand take it in the same manner vinum cerassorum nigrorum or wine of black cherries college take a gallon of black cherries, keep it in a vessel closestopped till it begin to work, then filter it, and an ounce of sugarbeing added to every pound, let pass through hippocrates’ sleeve, andkeep in a vessel close stopped for use vinum helleboratum or helleborated wine college take of white hellebore cut small, four ounces, spanishwine two pounds, steep it in the sun in a phial close stopped, in thedog days, or other hot weather vinum rubellum college take of stibium, in powder, one ounce, cloves sliced twodrams, claret wine two pounds, keep it in a phial close shut vinum benedictum college take of crocus metallorum, in powder, one ounce, mace onedram, spanish wine one pound and an half, steep it vinum antimoniale or antimonial wine college take of regulus of antimony, in powder, four ounces, steepit in three pounds of white wine in a glass well stopped, after thefirst shaking let the regulus settle culpeper these last mentioned are vomits, and vomits are fittingmedicines for but a few, the mouth being ordained to take innourishment, not to cast out excrements, and to regulate a man bodyin vomiting. And doses of vomits require a deeper study in physic, than i doubt the generality of people yet have. I omit it therefore atthis time, not because i grudge it my country, but because i would notwillingly have them do themselves a mischief, i shall shortly teachthem in what diseases vomits may be used, and then, and not till then, the use of vomits vinum scilliticum or wine of squills college take of a white squill of the mountains, gathered about therising of the dog star, cut it in thin pieces, and dried for a month, one pound, put it in a glass bottle, and pour to it eight pounds offrench wine, and when it hath stood so four days, take out the squill the virtues of this are the same with vinegar of squills, only it ishotter physical vinegars acetum distillatum or distilled vinegar college fill a glass or stone alembick with the best vinegar to thethird writing, separate the flegm with a gentle fire, then encrease thefire by degrees, and perform the work acetum rosarum or rose vinegar college take of red rose buds, gathered in a dry time, the whitescut off, dried in the shade three or four days, one pound, vinegareight sextaries, set them in the sun forty days, then strain out theroses, and repeat the infusion with fresh ones after the same manner is made vinegar of elder flowers, rosemaryflowers, and clove-gilliflowers culpeper for the virtues of all vinegars, take this one onlyobservation, they carry the same virtues with the flowers whereof theyare made, only as we said of wines, that they were better for coldbodies then the bare simples whereof they are made. So are vinegarsfor hot bodies besides, vinegars are often, nay, most commonly usedexternally, viz to bathe the place, then look amongst the simples, and see what place of the body the simple is appropriated to, and youcannot but know both what vinegar to use, and to what place to apply it acetum scilliticum or vinegar of squils college take of that writing of the squill which is between theoutward bark and the bottom, cut in thin slices, and placed thirty orforty days in the sun or essay remiss heat, then a pound of them beingcut small with a knife made of ivory or essay white wood being put ina vessel, and six pounds of vinegar put to them. Set the vessel, beingclose stopped, in the sun thirty or forty days, afterwards strain it, and keep it for use culpeper a little of this medicine being taken in the morningfasting, and walking half an hour after, preserves the body in health, to extreme old age, as sanius tried, who using no other medicine butthis, lived in perfect health till one hundred and seventeen years ofage it makes the digestion good, a long wind, a clear voice, an acutesight, a good colour, it suffers no offensive thing to remain in thebody, neither wind, flegm, choler, melancholy, dung, nor urine, butbrings them forth.

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