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Afterwhich come small flat pouches containing the seed, which is very small, but of a sharp taste place it grows commonly upon old stone and brick walls, andessaytimes in gravelly grounds, especially if there be grass or mossnear assignment helpers to shadow it time they flower very early in the year, essaytimes in january, andin february. For before the end of april they are not to be found government and virtues it is held to be exceedingly good forthose imposthumes in the joints, and under the nails, which they callwhitlows, felons, andicorns and nail-wheals nep, or catmint descript common garden nep shoots forth hard four-square stalks, with a hoariness on them, a yard high or more, full of branches, bearing at every joint two broad leaves like balm, but longer pointed, softer, white, and more hoary, nicked about the edges, and of a strongsweet scent the flowers grow in large tufts at the tops of thebranches, and underneath them likewise on the stalks thesis together, ofa whitish purple colour the roots are composed of thesis long stringsor fibres, fastening themselves stronger in the ground, and abide withgreen leaves thereon all the winter place it is only nursed up in our gardens time and it flowers in july, or thereabouts government and virtues it is an herb of venus nep is generallyused for women to procure their courses, being taken inwardly oroutwardly, either alone, or with other convenient herbs in a decoctionto bathe them, or sit over the hot fumes thereof. And by the frequentuse thereof, it takes away barrenness, and the wind, and pains of themother it is also used in pains of the head coming of any cold cause, catarrhs, rheums, and for swimming and giddiness thereof, and is ofspecial use for the windiness of the stomach and belly it is effectualfor any cramp, or cold aches, to dissolve cold and wind that afflictthe place, and is used for colds, coughs, and shortness of breath thejuice thereof drank in wine, is profitable for those that are bruisedby an accident the green herb bruised and applied to the fundament andlying there two or three hours, eases the pains of the piles. The juicealso being made up into an ointment, is effectual for the same purpose the head washed with a decoction thereof, it takes away scabs, and maybe effectual for other writings of the body also nettles nettles are so well known, that they need no description. They may befound by feeling, in the darkest night government and virtues this is also an herb mars claims dominionover you know mars is hot and dry, and you know as well that winter iscold and moist. Then you may know as well the reason why nettle-topseaten in the spring consume the phlegmatic superfluities in the body ofman, that the coldness and moistness of winter hath left behind theroots or leaves boiled, or the juice of either of them, or both madeinto an electuary with honey and sugar, is a safe and sure medicineto open the pipes and passages of the lungs, which is the cause ofwheezing and shortness of breath, and helps to expectorate toughphlegm, as also to raise the imposthumed pleurisy.

If you applythe herb to the privities, it draws forth the dead child it helps theyellow jaundice, spleen, and gravel in the kidneys dioscorides saithit helps such as are assignment helpers bitten by a venomous beast, whether it be takeninwardly, or applied to the wound. Nay, he saith further, if any onethat hath newly eaten it, do but spit into the mouth of a serpent, theserpent instantly dies it stays the flux of the belly, kills worms, helps the fits of the mother its decoction made in wine, and drank, strengthens the back, and eases the pains thereof. It helps bruisesand falls, and is as gallant a remedy to drive out the small pox andmeasles as any is. An ointment made of it, is excellent for greenwounds, pricks or thrusts adder tongue or serpent tongue descript this herb has but one leaf, which grows with the stalka finger length above the ground, being flat and of a fresh greencolour. Broad like water plantain, but less, without any rib in it;from the bottom of which leaf, on the inside, rises up ordinarilyone, essaytimes two or three slender stalks, the upper half whereofis essaywhat bigger, and dented with small dents of a yellowish greencolour, like the tongue of an adder serpent only this is as useful asthey are formidable the roots continue all the year place it grows in moist meadows, and such like places time it is to be found in may or april, for it quickly perisheswith a little heat government and virtues it is an herb under the dominion of the moonand cancer, and therefore if the weakness of the retentive faculty becaused by an evil influence of saturn in any writing of the body governedby the moon, or under the dominion of cancer, this herb cures it bysympathy.

“while scientists have been striving through the centuries to compound remedies for man various ills, nature, greatest chemist of them all, has been working wonders in her crucibles and has achieved results far beyond man greatest expectation ” assignment helpers “nature chief handicap has been the difficulty of placing her gifts in the hands of those whom she would benefit by accident or fate, as you will, one of nature greatest medicinal products has just been discovered it is the mineral given the name of akoz by john d mackenzie, president and manager of the natura company of san francisco, which is now giving this rare remedy of nature to the public ”the circular then describes how the power of the “rare remedy” to curerheumatism is claimed to have been discovered and asserts that. “akoz was subjected to every known scientific test before being presented to the public it was practically determined that the ore contained a new element having radium-like qualities but containing nothing poisonous or harmful ” “after the curative virtues of akoz for rheumatism, stomach trouble, eczema, catarrh, piles, ulcers and numerous other ailments had been fully established in chemical laboratory, hospital clinic, and the private practice of physicians in various writings of the world, mr mackenzie effected the organization of the natura company ”this product, put up in the form of “akoz medicinal mineral water, akozointment, akoz powder and akoz suppositories, ” was submitted to thecouncil on pharmacy and chemistry for consideration essay years ago withthe claims that “akoz” itself consists essentially of zinc sulphid, barium sulphate and aluminum oxid the submitted analysis did notdeclare the presence of lead or of uranium though “special tests” forthe latter had been “run ” without checking the claimed composition, the council at that time refused recognition to akoz because therewas no evidence submitted for the very extravagant and altogetherimprobable therapeutic claims after the council had concluded the consideration of akoz a letterwas received from a california physician stating that according to ananalysis submitted to him akoz contained 0 34 per cent of lead in theform of lead sulphate the correspondent held that, while the leadsulphate did not pass into solution, persons drinking the supernatantliquid from akoz the “medicinal mineral water” is made by adding akozto ordinary water might inadvertently swallow essay of the powder hewas inclined to believe that this might account for a case of leadpoisoning which had been observed in a patient who had been taking akoz inasmuch as it has been demonstrated by carlson and woelfel carlson, a j , and woelfel, a. Solubility of lead sulphate and basic leadcarbonate in human gastric juice in hygiene of the paintertrade by alice hamilton, bull of u s bureau of labor statisticsno 120, may 13, 1913, pp 22-32 that even small quantities of leadsulphate when taken into the system for a long time, have produced leadpoisoning, the laboratory deemed it important that the products beexamined for lead a specimen of “akoz powder” submitted to the council by the naturacompany and contained in a sifter-top can was taken for analysis thecontents of the can were thoroughly mixed to determine the presence oflead essay of the powder was extracted with ammonium acetate solution details of analysisqualitative tests showed the presence of lead and sulphate in theammonium acetate solution the presence of lead was demonstrated by the black precipitate withhydrogen sulphid, the yellow precipitate with potassium chromate andthe typical yellowish crystalline precipitate with potassium iodin the presence of sulphates in the ammonium acetate solution was shown bythe formation of a precipitate with barium chlorid solution and aceticacid two 2 gm samples a and b were taken for the quantitativedetermination of lead each was treated repeatedly with a saturatedsolution of ammonium acetate until the filtered ammonium acetatesolution gave no appreciable precipitate with potassium chromatesolution the ammonium acetate extractions from each specimen werecombined and treated with hydrogen sulphid, the precipitated leadsulphid filtered off and washed, and ignited with sulphuric acid at alow heat the crucible with the residue of lead sulphate was cooled andweighed a yielded 0 0469 gm , or 2 34 per cent , lead sulphate b yielded 0 0440 gm , or 2 20 per cent , lead sulphate while the laboratory has no evidence to show that the amount oflead-sulphate thus found to be present is likely to prove harmful, thefollowing cautionary letter was sent to the natura company. “according to information which you sent to the council on pharmacy and chemistry your product “akoz” does not contain lead in view of reports received ascribing symptoms, resulting from the internal use of akoz, to chronic lead poisoning, an examination of a specimen of akoz powder, which you sent to the council, was made this examination indicates the presence in akoz powder of about 2 2 per cent lead sulphate in view of the disastrous results likely to follow the internal use of products containing even small amounts of lead, the above is submitted to you for your consideration ”no reply to the foregoing was received from the natura company -- fromreports a m a chemical laboratory, 1916, p 103 sodium acetate in warming bottlesrecently the laboratory attention was called to the “thermorwaterless hot bottle, ” manufactured by the royal thermophor salesco , new york the following claims appear in one of the advertisingpamphlets. “there is moist heat ” “rubber hot-water ?. ?. ?. naturally give a moist heat ” it thermor gives a dry heat “the ‘thermor’ bottle is not a hot-water bottle-- it acts on a principle that is entirely different and new ” “ gives you first, last and all the time a fixed degree of dry usable heat-- a heat that holds steadily at 125 degrees for fully twelve hours-- you will easily see why it is that ‘thermor’ relieves and cures where hot-water bottles fail ”the bottle was nickel plated, 8-3/8 inches in diameter and 1-1/2 inchesthick, and in appearance resembled an exaggerated closed ingersollwatch the bottle is not flexible and weighs 3-1/2 pounds the contentsconsisted essentially of sodium acetate this salt melts when heated when it cools the temperature inside the bottle is relativelyconstant, as it will remain at the “freezing point” until all ofthe sodium acetate has solidified the duration of the time that itremains warm when well wrapped is simply in inverse proportion to theconductivity of the surrounding environment when two ordinary towelswere carefully arranged about it, the air between the bottle and thewrappings was maintained at a temperature of 40-50 c 104-122 f fora period of eight hours the company implication that the heat given out by the thermorbottle differs from that given out by an ordinary hot-water bottle isan absurdity the use of sodium acetate in the preparation of warmingbottles has been in practice thesis years, and is not “a principle thatis entirely different and new ” furthermore, the therapeutic claimsare extravagant -- from reports a m a chemical laboratory, 1916, p 105 anti-syphilitic compound sweenya specimen of anti-syphilitic compound sweeny, sold by the nationallaboratories of pittsburgh, was received from a physician the package 1 ounce size has been opened by the sender and about three fourths ofthe contents removed from the rather indefinite statements in the literature of themanufacturer it is gathered that the preparation is claimed to be a“sterile, oily emulsion” which contains 1/20 grain of mercuric benzoatein each 5 minims, together with essay sodium chlorid according toinformation furnished by the laboratory correspondent, the priceasked for the preparation is $15 an ounce the quantity of the preparation received was too small to permit acomplete examination, but, from the tests which it was possible tomake, the preparation appears to be an aqueous solution containingessay suspended matter and small quantities of mercuric benzoateand a chlorid, presumably sodium chlorid there was no evidence ofthe presence of an “oily emulsion ” quantitative tests indicatedthe presence of a mercuric salt, equivalent to about 0 2783 gm ofcrystallized mercuric benzoate per 100 c c this corresponds to about0 00086 gm in each 5 minims, or about 26 5 per cent of the amountclaimed -- from reports a m a chemical laboratory, 1916, p 106 “ambrine” and paraffin filmsf paul nicholas leech, ph d f contribution from the chemical laboratory of the american medicalassociation in the last year or so, the hot-wax or paraffin treatment of burns hasbeen widely discussed both in medical and lay periodicals although thetreatment is simply a modification of the well-known use of oil andointments, it has received unusual attention, owing to the widespreadsensationalism following the exploitation in france of a secret andtherefore mysterious mixture, “ambrine, ” the formula of dr barthe desandfort owing to this publicity, it seemed desirable to investigatethe chemical composition, and to compare its physical properties withother waxlike substances “ambrine” is promoted as a dressing for burns, frostbites, neuritis, varicose ulcers, phlebitis, neuralgia, rheumatism, sciatica, gout, etc it is a smoky-appearing substance, resembling paraffin in consistencyand without odor for application, “ambrine” is melted and applied tothe wound either with a brush or with a specially devised atomizer itcools quickly, and leaves a solid, protecting film illustration. - - - - - - - - - - - - - - - - - | hyperthermality a reality | | | | hyperthermality is a fact, however, through the | | agency of a keri-resinous product which has been | | used in france since 1900 under the name of | | l’ambrine hyperthermine, as the remedial agent | | will be known in this country, is a combination | | of several kinds of waxes and resins, scientific- | | ally blended and containing no medicinal elements | | whatever it comes in the form of waxy flakes it | | melts at 124° and on cooling resembles a dark | | colored wax | | | | hyperthermine is the discovery of dr barthe de | | sandfort, an eminent retired french naval surgeon | | and a member of numerous foreign medical societies | | he | - - - - - - - - - - - - - - - - - “ambrine” has been exploited in the united states for essay time to physicians it was sold under the name “hyperthermine ” above isa photographic reproduction reduced of a portion of a bookletdescribing “hyperthermine, ” which has been in the journal office foressay years illustration. - - - - - - - - - - - - - - - - - | hyperthermine field | | | | hyperthermine can be used in practically all in- | | flammatory conditions during the past ten years, | | under the name of l’ambrine, our product has been | | widely used in the hospitals in france, as well as | | in private practice, and we have very thesis clinical | | reports on a variety of subjects its greatest use | | has been in such conditions as sciatica, lumbago, | | articular and muscular rheumatism, gout, arthritis, | | burns of all degrees, pneumonia, bronchitis, orchit-| | is, buboes, soft chancres, peritonitis, dysmenor- | | rhea, adenitis, mastitis, periostitis, synovitis, | | conjunctivitis, iritis, irido-choroiditis, abscess- | | es, bruises, furuncles, whitlow, paronychia, car- | | buncles, moist eczema and similar dermatological | | affections, and varicose and tubercular ulcers | - - - - - - - - - - - - - - - - - photographic reproduction reduced from the “hyperthermine” “ambrine” booklet recommending it for use in rheumatism, gout, pneumonia, buboes, dysmenorrhea, eczema, tuberculous ulcers, etc it is said that de sandfort “stumbled on this treatment byaccident ”165 being a sufferer from rheumatism, he had been benefitedby hot mud baths. On returning home he sought a substitute, and finallymade a mixture of paraffin, oil of amber and amber resin this wasapplied hot, serving as a firm poultice “years later, he went onservice to a railway in china and was in yunnan at the time of theincendiary insurrection, and thesis badly burned chinese were broughtin for treatment remembering that ambroise paré treated such paperwith hot oil, he tried the effect of covering the burn with his meltedambrine, which at once glazes over, forming a coat impervious to theair, and his patients ceased to suffer ”166165 the outlook, jan 17, 1917, p 100 166 med rec , new york, jan 27, 1917, p 160 “ambrine” has been sold in america under two names. “hyperthermine, ” asexploited to physicians, and “thermozine, ” as advertised to the public physical comparison alone shows that ambrine as now sold differsfrom “hyperthermine” of a few years ago.

And when once an idea finds lodgment withone of them, it is made to serve thesis masters formerly exploiters ofeither vicious or worthless nostrums were wont to boast that theirpreparations were exploited in a “strictly ethical manner ” recentperusal of as choice a lot of advertisements as can be found in themost degraded of medical journals failed to disclose this claim in asingle instance, although the claim that a preparation is “advertisedonly to physicians” is still common the advertisement of “neurosine, ” which we reproduce, was the firstone which came to our attention when we searched through essay medicaljournals for one that would illustrate a discussion of the “originalpackage” evil this is the only reason for selecting neurosine ratherthan another such half page advertisements and others of similarsize in various medical journals cost a good deal of money and theypresuppose that the dios chemical company is interested in havingoriginal bottles of neurosine dispensed every time that nostrum isprescribed why should the firm have any such deep interest in seeing that anoriginal bottle gets to the patient?. why should it be necessaryto do anything more than see that the genuine mixture reaches thepatient?. does it seem within the bounds of reason that substitutionis so commonly practiced by pharmacists that this firm must go tolarge expense to prevent the substitution of spurious mixtures for itsproduct?. is dishonesty the rule among pharmacists?. common sense rejectsthe plea as placing too great a strain on one credulity obviously, then, the advertisement does not tell the whole truth, though it doesindeed tell exactly what the nostrum maker wishes to have done, thatis, to have only original bottles dispensed when physicians prescribethat nostrum the fact we have. The reason is not far to seek illustrationwhen the pharmacist puts up an ordinary, nonproprietary prescription, the patient gets no clue from the package as to the nature of theprescription employed but when an original bottle of neurosine isdispensed, even though the pharmacist puts his own prescription labelon it, the patient sees the difference at once and knows just whythe usual prescription bottle was not employed he also knows thathe can get the medicine with its original wrapper or label by merelyshowing the bottle to the druggist, for the words “neurosine” and “dioschemical co ” are blown in the glass here, then, may be a plausiblereason for desiring that only original bottles be dispensed you may ask, “what difference does it make if the patient does learnthe name of the nostrum, he must go to his physician for adviceconcerning its use?. ” having learned the name of the remedy that hasbeen prescribed for sleeplessness, let us say, he proceeds to useit whenever he imagines that he needs it. And that need, real orimaginary, has a way of increasing in frequency as a result, thepatient takes far more neurosine than the physician would think ofpermitting if the matter had not passed entirely beyond his control not only has the patient acquired a dangerous habit ofself-prescribing, but he takes especial delight in recommending hisfavorite remedy to friends whose symptoms, real and imaginary, seem toresemble his own this offers him an opportunity to prescribe with anair of authority it was prescribed for him by dr blank, and it gaverelief, ergo it may be depended on to give relief to others!. thus isthe basis laid for its general use by the laity, when this process ismultiplied sufficiently the statement is susceptible of easy proofby any one who cares to investigate the matter for himself there isprobably no physician worthy of the name who will attempt to denythat the promiscuous use of hypnotics and narcotics is dangerous, andcertainly no careful physician will deliberately place a narcotic inthe hands of patients to be used freely and without control since we have selected neurosine at random, so far as this writingiculardiscussion is concerned, it is worth while to inquire into itscomposition, the claims that have been made for it and the evidence, ifany exists, for or against its therapeutic value even the most activeof hypnotics are worse than useless if they are inferior to otherreadily available hypnotics, or if they have undesired side-actionsthat outweigh any advantages that they might otherwise have the council on pharmacy and chemistry investigated the literaturerelating to neurosine and published its report in the journal, jan 9, 1915, p 165 according to this report the manufacturers of neurosineclaimed that each fluidounce contained. Bromid of potassium, c p 40 grains bromid of sodium, c p 40 grains bromid of ammonium, c p 40 grains bromid of zinc 1 grain extract lupulin 32 grains cascara sagrada, fl ex 40 minims extract henbane 0 075 grain extract belladonna 0 075 grain extract cannabis indica 0 60 grain oil bitter almonds 0 60 grain aromatic elixirthis chemical blunderbuss was recommended for use in insomnia, hysteria, neurasthenia, migraine, neuralgia, delirium tremens, epilepsyand thesis other conditions also it was called an ideal calmative forchildren suffering from chorea, the exploiters claiming that “allauthorities recommend the bromids, hyoscyamus and cannabis indica inthis disease ” oliver t osborne, professor of therapeutics in yalemedical school, does not mention one of these three drugs in hisdiscussion of the medicinal treatment of chorea, in the handbook oftherapy, though he quotes several authorities in this article indeed, he does not mention one of the ten drugs included in the above formulaof neurosine in connection with the treatment of this disease it is acurious fact that osborne gives the greatest prominence to the use ofthat drug which is claimed to be wanting in the formula of neurosine, namely, hydrated chloral perhaps you may have seen temporary relief follow the administrationof neurosine in chorea, and may argue that theorizing is of littlevalue in the face of personal experience we shall not deny that essaymay have had that experience, for osborne calls attention to the factthat the success of any medicinal treatment must be judged in thelight of the fact that chorea is self-limited, and the intensity ofthe symptoms will abate in from two to four weeks in view of this, wewould hardly dispute the claim that one may administer narcotics, suchas those contained in neurosine, and the symptoms of chorea may abatein spite of such mistreatment in all the years that neurosine has beenexploited to physicians with such remarkable claims, we have never seena report of a careful clinical study in which the product has been usedunder the conditions which scientific investigation demands would youprescribe any nonproprietary preparations which had never been studiedclinically, if a horse-shoer or grocer boy told you it would cureepilepsy or malaria?. According to an editorial note appended to the report of the councilon neurosine, the dios chemical company consisted at that time 1915of j h chambers, his wife and two sons it appeared that chambersnever claimed to have any special knowledge of chemistry, pharmacy ormedicine, yet we find that he arrogated to himself or to his employeesthe right to offer therapeutic advice to the medical profession, andeven to direct them as to how they should prescribe a given mixture we essaytimes fail to see the forest because of the trees it may helpus to obtain a better perspective, in a problem that concerns usintimately, by resorting to a hypothetic case, if a close analogy ismaintained in order that we may see ourselves as others see us insuch a situation, let us consider the following imaginary case. Youbecome involved in a lawsuit in which an effort is made to deprive youof your property and your liberty you seek what you had reason tobelieve was competent legal advice. But, nevertheless, you lose yourcase and find yourself deprived of your property and your liberty nowlet us suppose further that you discover, when too late to permit youto correct your mistake, that your legal adviser we can hardly callsuch a man a lawyer had been acting all along under the guidance of aplumber who made no pretense of knowing anything about law how wouldyou feel regarding that pretended lawyer?. would you feel that you hadbeen treated fairly?. would you feel disposed to speak with all charityof him, to recommend him to those in need of legal advice?. You would probably feel toward such a lawyer as patients must feeltoward physicians who prescribe proprietary nostrums based oninformation and advice offered by those who, though without any specialknowledge of chemistry, pharmacy or medicine, will be benefitedfinancially if their information and advice are accepted and actedon -- from the journal a m a , april 27, 1918 anasarcin advertisingi i see index for other articles on anasarcin to the editor:-- as an old fellow of the a m a i beg to presentthe following facts to you, and to ask if anything can be done by youto expose the methods of these people. A concern calling itself “theanasarcin chem co ” of winchester, tenn , has caused to be sent tophysicians a chart on the subject of “diagnostics of renal diseases ”this chart contains eighteen plates, which were all taken withoutknowledge or permission of either myself or my publishers, williamwood & co , from the third edition of my book on “urinary analysisand diagnosis ” the plates are writingly composite plates, but mostlyportions of plates, exactly reproduced from my book i at once causedmy publishers to write to the anasarcin company. And a few days ago ireceived a letter from a dr h elliott bates of 118 east twenty-eighthstreet, new york, whose letterhead says, “medical advertising ” in thisletter the writer says that it was he who suggested the sending of sucha chart, and admits that all the plates were taken from my book inthis letter he offers to have a letter sent to every physician of thecountry “in which it is explicitly stated that the cuts on the chartwere taken from your book, and that complete information regardingthe matters treated on the chart can be found in your book ” in otherwords he offers to advertise my book free of cost to me, so that ishould take no further steps in the matter i consider this entirematter an outrage, and thought it best to write to you for advice, since my publishers seem to think that in spite of the violation of thecopyright nothing can be done besides the cuts, essay of the text on the chart is bodily taken frommy book, while essay of the other text, not taken from my book, butapparently compiled from different articles, is in writing entirely wrong, so much so that i must be ashamed of its being associated with any ofmy own work by giving this letter your early consideration, and advising me whatyou think it best for me to do, you would greatly oblige louis heitzman, m d , new york comment -- readers of the journal are, of course, familiar with thearticles246 that have been published on “anasarcin, ” the “dropsycure”!.

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Proprietary products assignment helpers. Thiswriting contains articles on proprietary medicinal preparations and themethods by which they are exploited, which have appeared in thejournal a m a writing iv contributions from the journal. Miscellany.