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The root is essaywhat long and black, with thesis strings and fibresthereat place it grows naturally in thesis pastures and wood sides inhertfordshire, wiltshire, and kent, and other places of this land time it flowers in may and june, abides after seedtime green allthe winter government and virtues venus claims the herb as her own ladies’mantle is very proper for those wounds that have inflammations, andis very effectual to stay bleeding, vomitings, fluxes of all sorts, bruises by falls or otherwise, and helps ruptures. And such women ashave large breasts, causing them to grow less and hard, being bothdrank and outwardly applied. The distilled water drank for 20 daystogether helps conception, and to retain the birth. If the women doessaytimes also sit in a bath made of the decoction of the herb it isone of the most singular wound herbs that is, and therefore highlyprized and praised by the germans, who use it in all wounds inward andoutward, to drink a decoction thereof, and wash the wounds therewith, or dip tents therein, and put them into the wounds, which wonderfullydries up all humidity of the sores, and abates inflammations therein it quickly heals all green wounds, not suffering any corruption toremain behind, and cures all old sores, though fistulous and hollow lavender being an inhabitant almost in every garden, it is so well known, thatit needs no description time it flowers about the end of june, and beginning of july government and virtues mercury owns the herb. And it carries hiseffects very potently lavender is of a special good use for all thegriefs and pains of the head and brain that proceed of a cold cause, as the apoplexy, falling-sickness, the dropsy, or sluggish malady, cramps, convulsions, palsies, and often faintings it strengthens thestomach, and frees the liver and spleen from obstructions, provokeswomen courses, and expels the dead child and after-birth theflowers of lavender steeped in wine, helps them to make water thatare stopped, or are troubled with the wind or cholic, if the placebe bathed therewith a decoction made with the flowers of lavender, hore-hound, fennel and asparagus root, and a little cinnamon, is veryprofitably used to help the falling-sickness, and the giddiness orturning of the brain. To gargle the mouth with the decoction thereof isgood against the tooth-ache two spoonfuls of the distilled water ofthe flowers taken, helps them that have lost their voice, as also thetremblings and passions of the heart, and faintings and swooning, notonly being drank, but applied to the temples, or nostrils to be smelledunto. But it is not safe to use it where the body is replete with bloodand humours, because of the hot and subtile spirits wherewith it ispossessed the chymical oil drawn from lavender, usually called oil ofspike, is of so fierce and piercing a quality, that it is cautiouslyto be used, essay few drops being sufficient, to be given with otherthings, either for inward or outward griefs lavender-cotton it being a common garden herb, i shall forbear the description, onlytake notice, that it flowers in june and july government and virtues it is under the dominion of mercury itresists poison, putrefaction, and heals the biting of venomous beasts:a dram of the powder of the dried leaves taken every morning fasting, stops the running of the reins in men, and whites in women the seedbeaten into powder, and taken as worm-seed, kills the worms, not onlyin children, but also in people of riper years. The like doth the herbitself, being steeped in milk, and the milk drank. The body bathed withthe decoction of it, helps scabs and itch ladies-smock, or cuckow-flower this is a very pretty ornament to the sides of most meadows descript the root is composed of thesis small white threads fromwhence spring up divers long stalks of winged leaves, consisting ofround, tender, dark, green leaves, set one against another upon amiddle rib, the greatest being at the end, amongst which arise updivers tender, weak, round, green stalks, essaywhat streaked, withlonger and smaller leaves upon them.

The side being bathed withit, it easeth pains in the spleen, cleanseth filthy corroding gnawingulcers iva arthritica the same with camæpytis iuncus oderatus the same with schœnanthus labrum veneris the same with dipsacus lactuca lettice cold and moist, cools the inflammation of thestomach, commonly called heart-burning. Provokes sleep, resistsdrunkenness, and takes away the ill effects, of it. Cools the blood, quenches thirst, breeds milk, and is good for choleric bodies, and suchas have a frenzy, or are frantic it is more wholeessay eaten boiledthan raw logabus, herba leporina a kind of trefoil growing in france andspain let them that live there look after the virtues of it lavendula lavender. Hot and dry in the third degree. The templesand forehead bathed with the juice of it. As also the smell of theherb helps swoonings, catalepsis, falling-sickness, provided it be notaccompanied with a fever see the flowers laureola laurel the leaves purge upward and downward. They are goodfor rheumatic people to chew in their mouths, for they draw forth muchwater laurus bay-tree the leaves are hot and dry, resist drunkenness, they gently bind and help diseases in the bladder, help the stinging ofbees and wasps, mitigate the pain of the stomach, dry and heal, openobstructions of the liver and spleen, resist the pestilence lappa minor the lesser burdock lentiscus mastich-tree both the leaves and bark of it stop fluxes being hot and dry in the second degree spitting and evacuations ofblood, and the falling out of the fundament lens palustris duckmeat. Cold and moist in the second degree, helpsinflammations, hot swellings, and the falling out of the fundament, being warmed and applied to the place lepidium piperites dittander, pepperwort, or scar-wort. A hot fierysharp herb, admirable for the gout being applied to the place. Beingonly held in the hand, it helps the tooth-ache, and withall leaves awan colour in the hand that holds it livisticum lovage clears the sight, takes away redness and frecklesfrom the face libanotis coronaria see rosemary linaria toad-flax, or wild-flax.

But the bile salts are best administered alone, or incombination with such laxatives as may be deemed necessary by thephysician while keeping in mind the fact that different patientsshow the widest difference in their reaction to laxatives, makingcombinations of these agents in fixed proportion irrational phenolphthalein was assignment help services popularized by nostrum makers. And while it hasessay therapeutic value, this has been greatly overestimated, and itshould be used only in amounts deemed necessary for each patient, preferably alone succinate of sodium was introduced as a saline cathartic, with theclaim that it exerts an antiseptic action on the biliary passages andgallbladder there is no satisfactory evidence to substantiate thisclaim the council maintains a liberal attitude toward new preparations, butit feels that it is impossible to determine the value of the severalconstituents of such complex mixtures when used as such. It holdsthat these mixtures are superfluous and that the several substancesof which they are composed should be used singly or at most withgreater attention to the individual requirements of the patient than ispossible when these fixed mixtures are prescribed despite the fact that these mixtures have been in use for more thannine years, there is no satisfactory evidence that they possess anyadvantage over the simple laxatives or the preparations of bile orpancreatic extract they are therefore held to be in conflict with rule10, and the council has directed that they be not included in n n r after dec 31, 1918 having adopted the preceding report, the council, in accordance withits regular procedure, submitted this to fairchild bros and foster forcomment the following reply was received. We are entirely at variance with you in the arbitrary conclusion expressed concerning the inimical influence of mixtures on therapeutic progress, the practice of medicine and the public welfare if the combinations of holadin and bile salts, etc , in capsules, were ever properly within the scope of new and nonofficial remedies, they should be retained if, however, complex mixtures are to be held as, a priori, unworthy of consideration, the rejection of all would naturally be a logical proceeding we believe that the writingicular combination of holadin and bile salts etc , have been clearly in the line of therapeutic progress-- a natural evolution, improvement and development for thesis years combinations of pancreatic extract and ox gall had naturally suggested themselves when we realized the fact that the bile salts were quite clearly the active principles of the bile, and that they must necessarily exist in greatly varying percentages in the official inspissated or ox gall, and also because these ox gall products of pharmacy were of extremely varying density, even from that of treacle to resin-- and of other objectionable character, we undertook to prepare bile salts these combinations are now further justified in view of physiological considerations, the simultaneous secretion of the pancreas and bile, and the state of our knowledge of the function of bile salts, and as co-ferments, promoting and supplementing the pancreas enzymes the question suggested as to whether the cholagogic action of ox gall and bile salts has been overestimated seems to us no clear purport the bile salts are obviously employed as the means of administering and thus realizing whatever properties this secretion may have in medicine, of which the cholagogic action is by no means the only consideration as for phenolphthalein, which is credited with purely laxative properties, we are at a loss to see any bearing in the remark that phenolphthalein was popularized by nostrum makers we cannot see that the physician or chemist estimate of phenolphthalein, its properties and uses, can be in the least degree influenced one way or the other by the statement that “phenolphthalein has been popularized by nostrum makers ” the phenolphthalein and succinate of soda combinations were originally both prescribed, and we have simply placed them at the service of the physician without other exploitation of them than that designed to call attention to their use in the conditions indicated these combinations are offered in a form which may be administered by the mouth with the best promise of introducing the substance more directly in the intestinal tract during the digestion period or at such interval after or prior to, the digestion period, as would best, in the judgment of the physician, meet the indications these writingicular combinations are especially desirable in these “fixed forms” since they are stable and reliable resources at the command of the physicians, the enzymes retaining their stability and potency without material deterioration for thesis years, and they naturally possess the advantages which are obviously due to the character of the writingicular pancreas and bile products used in the combinations furthermore, the hygroscopic and soluble organic substances in admixture cannot extemporaneously be so prepared in sealed capsules as to be readily available under the practical requirements of prescribing and dispensing and we do not believe that those who practice medicine will be in accord with your view that the pancreas substance should necessarily be administered alone, or the bile substance alone it now appears that these combinations are to be dropped from new and nonofficial remedies in consequence of the view, so stated, that in clinical experience “for more than nine years there is no satisfactory evidence that they possess any advantage over the simple laxatives or preparations of bile or pancreatic extract ” in reply to this we would simply make the following comment. During these “nine years” these combinations have inevitably been put to an informing clinical trial, because of the fact that they have been employed with success in disorders of the pancreas and bile functions and often in chronic and serious paper where the clinical conditions were obvious and unmistakable the reports of these paper come to us from physicians widely separated and each of his own independent initiative it would seem gratuitous, to say the least, to state that the observers are “disinterested, ” since it is quite clear that there is no other interest than that of the practitioner and his patient it is not a case of a new drug or combinations of new remedies, but simply resources which, upon well grounded reasons, both from a theoretical and material standpoint, justify clinical trial, and with results which would seem from any ordinary human standpoint to be satisfactory clinical evidence as to the interpretation of competent clinical evidence by the council, we would, in view of the circumstances and without comment, ask to embody in this text this rule. “clinical evidence ”-- “to be acceptable, the clinical evidence must offer objective data with such citation of authority as will enable the council to confirm the facts and establish the scientific value of the conclusions drawn clinical data are worthless when the author is not cited the facts on which claims with regard to the value of a remedy are based must have been rendered accessible for investigation and confirmation by disinterested observers, either through publication or through the records of a hospital or other institution ” to discredit these combinations would seem to us not only unjustified, but sterile of any real advancement in medicine, or of anything in the way of helpfulness to the patient in the class of paper in which these products have been resorted to with benefit. This on no other ground really than the opinion “that they have no advantage over the simple preparations themselves ” naturally we shall continue to prepare these products and shall continue to take such action as we deem best to bring them to the attention of the physician, for the conduct of our business must remain in the hands of those who are personally responsible for it and it is now forty years since we took up this line of work and with the declared intention of devoting ourselves to the applied science of the digestive ferments and “to their development and practical application in every useful purpose in medicine ” we have been consistently in sympathy with the fundamental purpose of the council, which must first rest upon fact as to the character of the products offered as medicinal agents the weight of evidence justifies the position that these writingicular products rationally should be, and as a matter of fact are, of important special service in the utilization of these organic secretions in medicine as explained in the preceding report, the council holds that complexmixtures of remedial agents are from every point of view inimicalto therapeutic progress and therefore to the public welfare theyare especially objectionable because it is impossible to determineaccurately the effects which follow the simultaneous administrationof a number of drugs having dissimilar actions, and because such apractice tends strongly to discourage careful consideration of thespecial needs of individual patients without which there can be notherapeutic progress on the contrary, with their use, therapeutictreatment becomes haphazard and mere guesswork the dismissal of the holadin and bile salts mixtures does not involvethe question of the usefulness of holadin or of bile salts alone. Onthe contrary, the possible usefulness of these preparations is admittedin the report it is the combination of holadin, bile salts, sodiumsuccinate and phenolphthalein to which objection is made the statement of fairchild bros and foster that “these combinationsare now further justified in view of physiological considerations”is essaywhat misleading it is true that bile and the pancreaticsecretion cooperate in intestinal digestion, but there is no evidencethat in every case in which there is a deficiency of one of thesesecretions there is also a deficiency of the other, and it is an axiomof scientific therapeutics that no drug or remedial agent should beadministered except to fill a definite want otherwise the practice oftherapeutics becomes mere empiricism the properties of phenolphthalein are not in the least influenced bythe manner of its introduction, as messrs fairchild bros and fosteremphasize. But the important fact in this connection is that thepopular conception of their actions is greatly influenced by the modeof introduction, and phenolphthalein has been widely advertised in avariety of conditions, so that the popular notion concerning it is notthat of scientific therapeutics in short, the entire argument of messrs fairchild bros and fosterconcerning the exploitation of these preparations may be summed up bysaying that they have been used by clinicians who believe that goodresults have followed their use, and that the firm will thereforecontinue to supply the demand the tendency of essay to use anythingbrought to their notice, and the readiness of manufacturers to marketanything that physicians will use, presents the greatest obstacleto therapeutic progress there was never a nostrum so irrational orworthless that honest but undiscriminating clinicians could not befound who reported wonderful results from its use according to fairchild bros and foster, these holadin and bile saltsmixtures have been in use for essay nine years yet the council is notaware of any investigation of their merits that meets the requirementsof scientific research the council is not acquainted with a single clinical investigation oftheir action under conditions which afford satisfactory evidence oftheir therapeutic value it is obviously wholly insufficient for a clinician to report that theuse of a mixture was followed by good results the fallacy of sucharguments was demonstrated long ago he must make a comparison of theresults obtained with the remedial agent with those obtained in asnearly similar conditions as possible except for the use of the agent we are not aware that any such study of the mixtures in question hasbeen made it is in the last degree irrational to hold that becausebile salts are the active constituents of bile, therefore such complexmixtures as these are necessary -- from reports of council on pharmacyand chemistry, 1918, p 59 liquor santaiva, s & d , omitted from n n r report of the council on pharmacy and chemistrythe following report explaining the omission from new and nonofficialremedies of liquor santaiva, s & d , has been authorized forpublication w a puckner, secretary so far the council has applied rule 10 concerning the recognition ofmixtures with the greatest leniency compatible with consistency whenthere has been a reasonable doubt concerning the value of a mixture, ithas frequently directed that rule 10 should not apply, pending furtherclinical trial of such mixture in no instance has subsequent experience shown that a strictinterpretation of the rule would have worked hardship or injustice thecouncil feels that there is no longer any warrant for the admission ofcomplex mixtures to new and nonofficial remedies or for the retentionof any that have been admitted, unless definite evidence of thetherapeutic value of such combinations is available the council being engaged in the annual revision of new and nonofficialremedies, the referee in charge of santal preparations reported thatthe three year period of acceptance had expired for liquor santaiva sharp & dohme the referee held that liquor santaiva, s & d , declared to be asolution of santal oil and copaiba with aromatic oils, in a mixtureof alcohol and water, is plainly in conflict with the currentinterpretation of rule 10, because there was no sound evidenceto indicate that any useful end is gained by the simultaneousadministration of santal oil and copaiba in any proportion, and thatso, of course, there is no evidence of the special advantage in thefixed proportions represented by the mixture he pointed out that theformula is essentially a survival of the discredited shotgun gonorrheamixtures and therefore recommended that its acceptance be not continued the council agreed to the recommendation of the referee and directedthat liquor santaiva, s & d , be omitted from new and nonofficialremedies -- from reports of council on pharmacy and chemistry, 1918, p 66 maltzyme, maltzyme with cascara sagrada, maltzyme with cod liver oil, maltzyme ferrated and maltzyme with yerba santa omitted from n n r report of the council on pharmacy and chemistrythe following report explaining the omission from new and nonofficialremedies of the maltzyme preparations has been authorized forpublication w a puckner, secretary in 1916, the council voted to omit maltzyme with hypophosphites, andmaltzyme with phosphate of iron, quinine and strychnine at thattime the labels used on the maltzyme preparations still in new andnonofficial remedies contained a list of maltzyme combinations whichincluded those which had been dismissed as the council does not permitan accepted article to be used as a means of advertising an articlenot accepted, it voted to continue the following preparations fora period of three years on condition that reference to the deletedarticles be omitted from the labels when those then in stock had beenused up. Maltzyme, maltzyme with cascara sagrada, maltzyme with codliver oil, maltzyme ferrated and maltzyme with yerba santa while themaltzyme company made no definite agreement to revise its advertisingpropaganda in accordance with the council requirements, the maltzymepreparations were retained in the belief that in due time the requiredrevision of the labels would be made the council being engaged in preparing the 1919 edition of new andnonofficial remedies, the referee in charge of malt extracts reportedthat the maltzyme company had not revised its labels in accordance withthe stipulation of the council the referee further reported he hadbecome convinced that the claim that maltzyme is “rich in malt enzymes”is unwarranted and that the term “maltzyme” malt plus enzyme ismisleading. This because of the recognized instability of malt extracts jour a m a , march 30, 1912, p 954 and because the maltzymecompany makes no definite statement with regard to the diastase maltenzyme content of its preparations 126 for this reason it hadbeen the referee intention to propose the deletion of all maltzymepreparations when their period of acceptance expired in 1919 as, however, the present maltzyme preparations are in contravention withthe council requirements, he recommended that the acceptance of thesepreparations be canceled now 126 manufacturers are warned by the dewritingment of agriculture, through the bureau of chemistry, that combinations claiming to containdigestive enzymes must be active when sold if preparations tend todeteriorate in a short time, each lot should be dated and not soldafter the period when they become inactive while every manufacturermust be considered innocent until proved guilty, and ignorant untilproved knowing, it is a matter of knowledge that manufacturers havemarketed their various digestive mixtures with full appreciation oftheir worthlessness -- jour a m a , dec 19, 1914, p 2234 the council agreed to the recommendation of the referee and directedthat maltzyme, maltzyme with cascara sagrada, maltzyme with cod liveroil, maltzyme ferrated, and maltzyme with yerba santa be omitted fromn n r -- from reports of council on pharmacy and chemistry, 1918, p 67 methaform omitted from n n r report of the council on pharmacy and chemistrythe following report explaining the omission from new and nonofficialremedies of methaform has been authorized for publication w a puckner, secretary methaform is the proprietary name applied by f stearns & co tochlorbutanol being engaged in the annual revision of new and nonofficial remedies, and the term of acceptance for methaform having expired, a tradepackage was purchased to determine if the product was marketed incompliance with the rules of the council it was then found that acircular was wrapped with the trade package which advertised methaforminhalant, a preparation not accepted for new and nonofficial remedies for obvious reasons, the council does not countenance the use of anaccepted article as a means of advertising an article not accepted accordingly f stearns & co was advised that the council wouldbe obliged to withdraw the acceptance of methaform unless theobjectionable circular was omitted from the methaform packages stearns & co did not give the requested assurance, and therefore thecouncil directed that methaform be omitted from new and nonofficialremedies -- from reports of council on pharmacy and chemistry, 1918, p 68 pineal gland, red bone-marrow and thymus gland and their preparations omitted from n n r report of the council on pharmacy and chemistrythe following report explaining the omission from new and nonofficialremedies of pineal gland, red bone-marrow and thymus gland and theirpreparations has been authorized for publication w a puckner, secretary pineal gland, red bone-marrow and thymus gland were admitted to newand nonofficial remedies when these products gave promise of havingtherapeutic value the term of acceptance for the preparations of pineal gland, redbone-marrow and thymus gland having expired, the referee in charge ofanimal organ preparations recommended in his report for the annualrevision of n n r that these products and the general articlesdescribing them be omitted from new and nonofficial remedies he heldthat the experimental and clinical experience with them leads to theconclusion that they are without value in accordance with the recommendation of the referee, the council votedthat the following preparations be omitted from new and nonofficialremedies.

It helps digestion and is a remedyfor a surfeit the juice or the water, being assignment help services dropped into the eyesor ears, helps dimness of sight and deafness. The juice put into thehollow teeth, easeth their pains the root in powder, made up into aplaster with a little pitch, and laid on the biting of mad dogs, or anyother venomous creature, doth wonderfully help the juice or the watersdropped, or tent wet therein, and put into filthy dead ulcers, or thepowder of the root in want of either doth cleanse and cause them toheal quickly, by covering the naked bones with flesh. The distilledwater applied to places pained with the gout, or sciatica, doth give agreat deal of ease the wild angelica is not so effectual as the garden. Although it may besafely used to all the purposes aforesaid amaranthus besides its common name, by which it is best known by the florists ofour days, it is called flower gentle, flower velure floramor, andvelvet flower descript it being a garden flower, and well known to every onethat keeps it, i might forbear the description. Yet, notwithstanding, because essay desire it, i shall give it it runs up with a stalk acubit high, streaked, and essaywhat reddish towards the root, but verysmooth, divided towards the top with small branches, among which standlong broad leaves of a reddish green colour, slippery. The flowers arenot properly flowers, but tuffs, very beautiful to behold, but of nosmell, of reddish colour. If you bruise them, they yield juice of thesame colour, being gathered, they keep their beauty a long time. Theseed is of a shining black colour time they continue in flower from august till the time the frostnips them government and virtues it is under the dominion of saturn, and isan excellent qualifier of the unruly actions and passions of venus, though mars also should join with her the flowers dried and beateninto powder, stop the terms in women, and so do almost all other redthings and by the icon, or image of every herb, the ancients atfirst found out their virtues modern writers laugh at them for it;but i wonder in my heart, how the virtues of herbs came at first tobe known, if not by their signatures. The moderns have them from thewritings of the ancients.

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In fact, the chlorination appearsto have accomplished nothing more than a considerable destruction orweakening of the eucalyptus oil as far as the referee can judge, thisobject could have been accomplished just as effectively by dilutingordinary eucalyptus oil with essay indifferent solvent the manufacturer of chlorlyptus contends that if the experimentalfindings are against his product, it should be judged by the clinicaldata the clinical evidence, however, is not decisive it shows thatwounds healed and infections were prevented or successfully combated inpaper in which chlorlyptus was used in combination with good surgery, but it does not show how much of the result was due to the surgery andhow much, if any, to the use of chlorlyptus even if it were grantedas probable that the chlorlyptus contributed to the favorable outcome, it would still be a question whether it equals other establishedantiseptics, or whether it possesses any material advantages overdiluted eucalyptus oil until these points are established the clinicalreports cannot offset the unfavorable results of the laboratoryinvestigation the manufacturer has endeavored to obtain more convincing clinicalreports, but the lack of success in this direction during the past ninemonths gives little encouragement that acceptable clinical evidencewill be available within a reasonable time believing that the information which has been obtained should be madeavailable to the profession, the council authorized publication ofthis statement and also of the detailed report the council voted notto accept chlorlyptus for new and nonofficial remedies because of theunfavorable results of the laboratory investigation, but with theagreement that the product would receive further consideration shouldmore convincing clinical data become available i detailed reports summarized reports chemical nature of chlorlyptuschlorlyptus is prepared by chlorinating eucalyptus oil until ithas bound 30 per cent of chlorin “chlorlyptol” is prepared in ananalogous manner from eucalyptol there has been essay confusion as tothe composition. But the principal constituent is now stated to be “adichloride of eucalyptus oil, ” to which the formula c₁₀h₁₆ocl₂ hasbeen assigned it differs from the “chlorinated eucalyptus oil, ” asordinarily used for making dichloramin-t solutions, and which containsonly 2/3 per cent of chlorin availability of chlorin in chlorlyptusthe chlorin content of chlorlyptus is almost entirely firmly bound, and therefore not “available, ” in contrast to the group of so-calledchlorinated antiseptics i e , the hypochlorite and chloramin type for instance, it does not directly liberate iodin from iodid itcontains a very small quantity of free hydrochloric acid, or perhapsessay acid esters, and liberates a little more on prolonged contact withwater. But the total quantity liberated under reasonable conditions isvery small according to hawk data, they correspond only to 1/8 percent hcl even after standing with water overnight and to only 1/5 percent of hcl after two weeks the referee has shown that this quantityof acid has no therapeutic significance the “bound” chlorin of chlorlyptus, being chemically inactive, wouldhave no more practical significance than the bound chlorin in commonsalt the “ozone” said to be used during the preparation, to expel thehcl, has also practically disappeared, to judge by the slowness withwhich iodin is liberated from potassium iodid acid formationessay constituents of chlorlyptus hydrolyze slowly and to a slightdegree with the liberation of a trace of free hydrochloric acid according to the data of hawk report, the free acidity, in termof hcl, is 1/12 per cent on standing with water over night, thisincreases to 1/8 per cent on this basis, hawk proposed a theory that the claimed antisepticeffects of chlorlyptus are due to the continuous liberation ofhydrochloric acid experiments by the referee show this to be untenable the traces ofacid are neutralized and absorbed by the tissues so rapidly that anacid reaction is not maintained these experiments are described in theappendix they were submitted to the manufacturers, who in the name of mr weeks may 9, 1919 concede this conclusion and state that “there is nodoubt that the referee statements as to action in mouth, contactwith living tissue and improbability that the acidity is effectivelyantiseptic is correct, and i am willing to accept the refereestatement as conclusive in this respect ” bacterial culture experimentsmr weeks submitted a statement by hawk to the effect that chlorlyptushas a phenol coefficient of 2 6, determined by the standard hygieniclaboratory procedure he also quotes rockefeller war hospital that chlorlyptus killsstaphylococcus aureus in concentra of 1 dram. 1 gallon about1:1, 000, but not in more dilute solutions more recently, he presented a more comprehensive report by rivas, whichis reproduced in the appendix the essential results are tabulatedherewith this tabulation shows that chlorlyptus fails to kill theorganisms after an hour exposure of the following concentrations. Typhoid in bouillon, 10 per cent of chlorlyptus staphylococci in pus, 5 per cent of chlorlyptus staphylococci in serum, 1 per cent of chlorlyptus it seems to the referee that a substance that is ineffective with anhour exposure to these concentrations is not at all likely to kill orcheck bacteria under clinical conditions in other words, it is not anantiseptic in the ordinary sense the referee is not impressed by the superior power attributed by rivasto chlorlyptus in the presence of pus inefficiency of 10 per cent forone-half hour or of 5 per cent for two hours seems a failure ratherthan a success the referee also notes the absence of any data as tothe relative efficiency of chlorlyptus against staphylococci in pus andin bouillon the data on serum indicate that chlorlyptus is much weakerthan phenol and show that it is less effective in the presence of pusthan in other mediums the referee fails to grasp the bearing of the oil experiments on anyclinical condition moreover, the inconstant results mentioned by rivassuggest the possibility that the incorporation of the bacteria in oilmay have prevented their effective distribution in the culture medium if any significance is to be attached to these experiments, they shouldbe checked by controls, without antiseptics summary of rivas’ in vitro experiments minimal maximal germicidal not germicidal concentrations concentrations typhoid bacilli in bouillon. Chlorlyptus exp 3 10%, 2 to 4 hours 10% for 1 hour 5% for 2 hours eucalyptus oil exp 1 5% within 5 minutes no data phenol exp 5 1% within 10 min no data streptococci and staphylococci in olive oil. Chlorlyptus exps 7 and 8 1%, almost at once, no data essaytimes eucalyptus oil no data no data phenol exps 9 and 10 1%, almost at once, no data staphylococci in pus.