5 Paragraph Essay

Rather quiet during next two hours morning of vii 5 paragraph essay 1 19, lies on stomach. Quiet. Does not eat very much pain reflexes good vii 2 19, still depressed.

“in chills and fever malaria and other blood dicrasias, chlorax is indicated as an internal 5 paragraph essay antiseptic and it exerts a beneficial effect on the course of these diseases ”the claims made for chlorax are exaggerated and misleading number “3”according to the label, number “3” is “a stable chlorine remedy for thepurification of the blood, ” with the composition. “free chlorine, 0 35 per cent. Calcium chloride, 0 30 per cent. Mercurous chloride, 0 03 per cent. Lithium chloride, 0 04 per cent. Calcium hydrate, 0 01 per cent. Opium, 0 02 per cent. Ethyl alcohol, 0 10 per cent. Water to 100 writings ”it will be noticed that the composition claimed for number “3” isessentially similar to that claimed for chloron it differs fromchloron in that the amounts of essay of the constituents are essaywhatgreater, and in that, like chlorax, it contains essay tincture of opium the a m a chemical laboratory reports that the free chlorin in aspecimen of number “3” was 0 024 gm in 100 c c and the total active “available” chlorin 0 173 gm per hundred c c , or about 50 per cent of the claimed amount the examination indicates that number “3” is ofunreliable composition the chlorine products company, inc , submittedno clinical evidence for number “3” to which it refers as “our syphilisremedy ” it stated that two physicians had used the preparation “withgood results, ” and admitted that “the company requires further evidencebefore pushing it ”the council declared “chloron, ” “chlorax” and “number ‘3’” in conflictwith the rules governing admission to new and nonofficial remedies allare of unreliable composition conflict with rule 1 the therapeuticclaims made for the preparations are not substantiated by acceptableevidence and are unwarranted and misleading chloron is inferior as anantiseptic to the well-known surgical solution of chlorinated soda onaccount of its low chlorin content and uncontrolled reaction thereis no warrant for the claim that chlorax is useful in the treatmentof “kidney conditions, ” “diabetes, ” “acute infections, ” “blooddicrasias, ” “lithemias and rheumatism, ” and “nervous conditions, ” noris there warrant for the claim that “number ‘3’” is a remedy for thepurification of the blood or a “syphilis remedy” conflict with rule 6 the names of these pharmaceutical mixtures are not descriptive of theircomposition conflict with rule 8 all three preparations are irrational no evidence has been furnishedthat the lithium salt is of value in the mixtures it is not rationalto combine an active chlorin preparation and a mercury salt in onemixture, nor is there evidence that the addition of opium to thepreparations proposed for internal use is of value or rational experimentation with number “3” as a “syphilis remedy” is to beseverely condemned in that those on whom it is used will in themeantime be deprived of efficient medication conflict with rule10 -- from reports of council on pharmacy and chemistry, 1919, p 70 elarson omitted from n n r report of the council on pharmacy and chemistrythe council has authorized publication of the following reportannouncing the omission of elarson from new and nonofficial remedies w a puckner, secretary elarson, now sold by the winthrop chemical company, inc , was formerlysold in the united states by the bayer co , inc it was admitted to newand nonofficial remedies in 1914 the circular issued by the winthrop chemical co contains severalstatements markedly at variance with the results of an investigationmade, at the request of fischer, by joachimoglu arch f exper path u pharmakol 78:1914 the circular states that elarson containsabout 13 per cent arsenic joachimoglu found from 10 8 to 11 1 percent to be present the circular states further. “the fact that elarson represents a lipoid-like chemical combination of arsenic has an important bearing upon its absorption and utilization in the system there is good reason to believe that when arsenic is administered in a stable, lipoid-like combination, as in elarson, it is more readily taken up by the cells and more completely utilized than when given in the customary manner ” “as regards the behavior of elarson in the system, it has been shown that its active constituent, chlorarseno-behenol, is almost completely absorbed in this form, probably as a chlor-behenolate of sodium or potassium ”as a matter of fact, joachimoglu found that very little arsenic wasabsorbed when elarson was given to dogs and rabbits.

And the root hereof is also thready and abiding place they grow in meadow and pastures both wet and dry, and by thehedges time they flower in may for the most writing, and the seed is ripe injuly and august government and virtues they are both herbs of venus, and thereforestrengthening the writings both internal and external, which she rules the decoction of the former of those being drank, is good to fret andbreak the stone, provoke the urine, 5 paragraph essay stays inward bleeding, and healsinward wounds the herb or flower bruised and put into the nostrils, stays their bleeding likewise. The flowers and herbs being made intoan oil, by being set in the sun, and changed after it has stood ten ortwelve days. Or into an ointment being boiled in axunga, or salladoil, with essay wax melted therein, after it is strained.

. “hangingafter death, ” case 50 judicial hanging 76 maclaren. Indian med gaz , 1873, viii , p 234 - three paper ofjudicial hanging. Hung at the same time and cut down and necroscopybegun forty minutes afterward. Drop twelve inches in the first andthird there were reflex movements for a few minutes after drop fell first man, age 40. Pupils slightly dilated. No protrusion of tongueor eyeballs. Mark of cord above thyroid cartilage. No discharge ofsemen or fæces. Ecchymosis under cord, left side. Dislocation of atlasfrom axis. Odontoid ligaments ruptured. Transverse ligament uninjured brain and membranes much congested.

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Arch gén de méd 191:1482, 5 paragraph essay 1903 82 wertheimer and duvillier. Compt rend soc de biol 68:535, 1910 the destructive action of the digestive enzymes leads us to believethat it is in inactive form that secretin is absorbed likeepinephrin, it cannot pass through the digestive tract bayliss andstarling state that it is destroyed by one hour tryptic digestion lalou62 worked with the action on secretin of pepsin, dog gastricjuice, pancreatic juice, succus entericus and erepsin, and found ineach case a destructive effect, even almost after mixing. And afterfive minutes over 75 per cent of the activity had disappeared matuso36 introduced 30 c c of active secretin into the intestine, removed it five minutes later, and found that no activity remained other methods of administration have been tried subcutaneousinjections are practically negative matuso, 36 hallion83and intrapleural injections are likewise negligible bayliss andstarling55 83 hallion. Presse méd 20:433, 1912 starling63 finds that continued intravenous injections of secretin ina healthy dog produces after a time severe symptoms of collapse, which, he believes, are due to change in the intestinal mucous membrane causedby the entry and non-neutralization of the strongly alkaline pancreaticjuice intestinal digestion seems little affected in achylia gastrica stockton, 84 ehrman and lederer, 85 bayliss and starling32 thismay be due to other secretin stimulants as fats, or to the action ofthe nervous mechanisms meltzer86 84 stockton. In osier and mccrae modern medicine 3:19, 1914 85 ehrman and lederer. Deutsch med wchnschr 35:879, 1909 86 meltzer, s j. The factors of safety in animal structure andanimal economy, j a m a , feb 23, 1907, p 655 the destruction of secretin by human gastric juicewe have carried out in detail experiments on the digestive effect ofhuman gastric juice on secretin our results in every respect confirmthe findings of lalou, 62 who worked with commercial pepsin and doggastric juice, but are even more striking because of the much superiorquality of pure human gastric juice methods -- the human gastric juice was obtained from mr v , thegastric fistula case of our laboratory the chemical and digestivecharacters of his juice are discussed in a recent paper 87 in thedifferent experiments, different samples of gastric juice were used the secretin employed was always freshly prepared digestion wascarried out in the incubator at 38 c with the reaction of 0 4 percent acid, and the end of the period was marked by either boilingthe mixture or in the first two experiments by turning the mixturealkaline the action of the preparation, we proved, was not influencedby the method used the dogs on which the preparations were testedwere prepared for carotid blood pressure, injection into the externaljugular vein, and cannula in the pancreatic duct, essentially themethods of bayliss and starling32 being employed the preparationswere injected at body temperature after being neutralized and filtered except for the addition of normal salt solution instead of gastricjuice, the control injections of secretin were submitted to exactly thesame treatment as the other preparations 87 carlson. Am jour physiol 38:248, 1915 results -- our results are embodied in table 1 we assured ourselvesbefore beginning the series that incubation of secretin with boiledgastric juice produced no change it is to be noted in the table thateach experiment is a unit complete in itself, beginning and endingwith a control injection of secretin special attention is called tothe marked destruction that follows contact of human gastric juicewith secretin for merely one minute in experiment 4, using 1 c c of human gastric juice, the action fell to 14 drops from an originalsecretion of 21. In experiment 5, using 8 c c of gastric juice, theaction fell to 6 drops from an original secretion of 20 of interestalso is the rate at which we get complete destruction of secretin this is practically 2 hours for 2 c c with secretin giving originally110 drops experiment 2, fig 1, or 30 minutes for 5 c c with asecretin giving originally 53 drops experiment 6 these results arepractically parallel, though they were obtained with different samplesof gastric juice and in different experiments table 1 -- the destruction of secretin by human gastric juice | | secretion of pancreatic juice in drops | -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- no |quan-|10 c c c| the secretin after incubation |10 c c of | tity|secretin| with human gastric juice |secretin exper-|of |control -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -control iment|gas- |-- begin-| | | | | | |-- end of | tric| ning |dig |secre-|dig |secre-|dig |secre-|experi- |juice|experi- |time, | tion |time, | tion |time, | tion | ment |used, | ment |hrs |rate |hrs |rate |hrs |rate | |c c | | | | | | | | -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 1 | 2 | 28 |6 | 0 |4 | 0 |2 | 0 | 16 2 | 2 | 110 |2 | 7 |1-1/2| 18 |1 | 18 | 41 3 | 2 | 40 |1 | 7 | 3/4| 7 | 1/4 | 8 | 31 4 | 1 | 21 | 1/2| 11 | 1/4| 12 | 1/60| 14 | 18 5 | 8 | 20 | 1/2| 1 | 1/4| 3 | 1/60| 6 | 18 6 | 5 | 53 | 1/2| 2 | | | | | -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- we also tried the effect of keeping the digestive time constant andvarying the amount of gastric juice employed increasing the quantityof gastric juice used increases the quantity of secretin destroyed table 2 table 2 -- experiment 7* pancreatic preparation juice drops 10 c c secretin 20 10 c c secretin digested with 0 5 c c gastric juice 15 10 c c secretin digested with 3 c c gastric juice 13 10 c c secretin digested with 10 c c gastric juice 8* the digestive time was kept constant at fifteen minutes the gastricjuice used had been diluted with stomach washings the reader will observe in table 1 that the results obtained fromthe control injection of secretin at the beginning of the experimentis uniformly greater than that obtained after several injections ofdigested secretin in view of the established fact that equal quantities of secretin cangenerally be relied on to produce results, 21 one might suggest thatthe injections of the split products of secretin have inhibited to essaydegree the action of the pancreas we can submit the data in table 3in support of this view, showing among other things that the action ofsecretin is not influenced by previous injections of inert depressorsubstances, though it by the injection of the cleavage products ofsecretin the various injections in the experiments were made at aboutfifteen-minute intervals we have carefully analyzed the reaction in blood pressure that followsthe injection of the various preparations we find no constant effect digested secretin gives a fall in blood pressure that is at times less, at times equal, and at other times greater fig 1 than that producedby the original preparation besides the bearing that it has on the therapeutic use of secretin, this destructive action of the digestive enzymes is also of primephysiologic interest failure to realize it has led to misconceptionsas to the intrinsic nature of secretin table 3 -- experiments 8 and 9 pancreatic preparations juice drops experiment 8. 10 c c secretin, five injections of inert depressor substances 29 10 c c secretin, two injections of completely digested secretin 28 10 c c secretin, eight injections of inert depressor substances 16 10 c c secretin 16 experiment 9. 10 c c secretin control, beginning of experiment 21 10 c c secretin, after thirty minutes incubation with 1 c c boiled gastric juice 27 10 c c secretin, after thirty minutes incubation with 1 c c fresh gastric juice 11 10 c c secretin control, end of experiment 18the findings of lalou, confirmed by us, explain the anomaly that hasled delezenne88 to put forward the antisecretin theory 88 delezenne and pozerski. Jour de physiol , 14:540, 1912 secretin has no action when given by mouthit is a constant claim that so thesis and complex are the factorsconcerned in physiologic processes, that it is not unusual for clinicaldeductions to establish themselves in the face of a priori laboratorydicta we considered it desirable, therefore, to test the action ofsecretin, orally administered, in the most direct manner, and the onefreest from possible criticism with this in view, we performed aseries of experiments on normal unanesthetized dogs having permanentpancreatic fistulas method -- in the operations for permanent pancreatic fistulas wefollowed closely the technic developed by pawlow, 89 and withexcellent results the dogs maintain themselves in splendid conditionif proper care is taken this consists in feeding them only with breadand milk, and giving sodium bicarbonate daily the dogs were giventhis treatment in the evening so that experimental procedure might becarried on in the day with empty stomach under constant conditions freshly prepared secretin in large quantities was given by stomachtube to these dogs, and the response of the pancreas studied andcompared with the response obtained from control preparations the samepreparation was generally not given on consecutive days 89 pawlow.